Cyclosporin A/alpha interferon-induced autologous graft-versus-host disease following peripheral blood stem cell transplant for chronic myeloid leukaemia: a clinico-pathological study [Case report]

Lim, S. H., Coleman, Sharon Louise, Bull, A., O'Callaghan, U., Evely, R. and Booth, M. 1997. Cyclosporin A/alpha interferon-induced autologous graft-versus-host disease following peripheral blood stem cell transplant for chronic myeloid leukaemia: a clinico-pathological study [Case report]. Bone Marrow Transplantation -Basingstoke then London- 20 (1) , pp. 83-85. 10.1038/sj.bmt.1700845

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Abstract

Autologous GVHD was induced using CsA and alpha-IFN in a patient undergoing autologous PBSCT for accelerated phase CML. We demonstrated that the autologous mixed lymphocyte reactions were extremely sensitive and specific for the detection of the GVHD when compared to skin biopsy. The resultant autologous GVHD was associated with an in vitro GVL effect, suggesting a potential clinical benefit of this therapeutic manoeuvre. The post-PBSCT period was associated with an improvement in normal haemopoiesis and reduction in the proportion of blood cells expressing the Philadelphia chromosome.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Uncontrolled Keywords:	GVHD; autologous; GVL
Publisher:	Nature Publishing Group
ISSN:	0268-3369
Last Modified:	19 Mar 2016 23:41
URI:	https://orca.cardiff.ac.uk/id/eprint/60607

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