Rmst Is a novel marker for the mouse ventral mesencephalic floor plate and the anterior dorsal midline cells

Uhde, Christopher W., Vives, Joaquim, Jaeger, Ines and Li, Meng ORCID: https://orcid.org/0000-0002-4803-4643 2010. Rmst Is a novel marker for the mouse ventral mesencephalic floor plate and the anterior dorsal midline cells. PLoS ONE 5 (1) , e8641. 10.1371/journal.pone.0008641

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Abstract

The availability of specific markers expressed in different regions of the developing nervous system provides a useful tool to illuminate their development, regulation and function. We have identified by expression profiling a putative non-coding RNA, Rmst, that exhibits prominent expression in the midbrain floor plate region, the isthmus and the roof plate of the anterior neural tube. At the developmental stage when the ventral dopaminergic neuron territory is being established, Rmst expression appears to be restricted to the presumptive dopaminergic neurons of the ventral tegmental area that lies close to the ventral midline. Thus this study presents Rmst as a novel marker for the developing dopaminergic neurons in the mesencephalic floor plate as well as a marker for the dorsal midline cells of the anterior neural tube and the isthmic organizer.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences Medicine
Subjects:	Q Science > Q Science (General)
Publisher:	Public Library of Science
ISSN:	1932-6203
Funders:	Medical Research Council, Parkinsons Disease Society, Frame work six programme of the European Commission - Eurostemcell
Last Modified:	27 Oct 2022 08:40
URI:	https://orca.cardiff.ac.uk/id/eprint/63088

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