Bipolar disorder and variation at a common polymorphism (A1832G) within exon 8 of the Wolfram gene

Middle, F., Jones, Ian Richard ORCID: https://orcid.org/0000-0001-5821-5889, McCandless, F., Barrett, T., Khanim, F., Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862, Lendon, C. and Craddock, Nicholas John ORCID: https://orcid.org/0000-0003-2171-0610 2000. Bipolar disorder and variation at a common polymorphism (A1832G) within exon 8 of the Wolfram gene. American Journal of Medical Genetics 96 (2) , pp. 154-157. 10.1002/(sici)1096-8628(20000403)96:2%3C154::aid-ajmg5%3E3.0.co;2-f

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Abstract

A number of linkage studies provide evidence consistent with the existence of a bipolar susceptibility gene on chromosome 4p16. The gene for Wolfram syndrome, a rare recessive neurodegenerative disorder, lies in this region and has recently been cloned. Psychiatric disturbances including psychosis, mood disorder, and suicide have been reported at increased frequency in Wolfram patients and in heterozygous carriers of a Wolfram mutation. In the current investigation we have undertaken a case-control association study using a single nucleotide polymorphism (causing an amino acid change) in exon 8 of the Wolfram gene in a UK Caucasian sample of 312 Diagnostic and Statistical Manual of Mental Disorders (fourth edition; DSM IV) bipolar I probands and 301 comparison individuals. We found no evidence that variation at this polymorphism influences susceptibility to bipolar disorder. It remains possible that variation at other sites within or near the Wolfram gene plays important roles in determining susceptibility to affective illness.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > R Medicine (General) R Medicine > RZ Other systems of medicine
Publisher:	Wiley
ISSN:	0148-7299
Last Modified:	27 Oct 2022 08:53
URI:	https://orca.cardiff.ac.uk/id/eprint/63672

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