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Daily energy expenditure and physical activity in survivors of childhood malignancy

Warner, Justin T, Bell, W, Webb, D. K. and Gregory, John Welbourn ORCID: https://orcid.org/0000-0001-5189-3812 1998. Daily energy expenditure and physical activity in survivors of childhood malignancy. Pediatric Research 43 (5) , pp. 607-613. 10.1203/00006450-199805000-00008

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Abstract

Changes in body composition, in particular the onset of obesity, may result from reductions in total daily energy expenditure (TDEE) as a consequence of relative physical inactivity. Children previously treated for acute lymphoblastic leukemia (ALL) become obese, yet the mechanism remains undefined. TDEE and physical activity levels [PAL = TDEE/basal metabolic rate (BMR)] were measured in 34 long-term survivors of ALL and compared with results from 21 survivors of other malignancies and 32 healthy sibling control subjects using the flex-heart rate technique. Body composition was measured by dual energy x-ray absorptiometry. The median TDEE was reduced in the ALL group (150 kJ x kg d(-1)) compared with other malignancies and controls (207 and 185 kJ x kg d(-1), respectively, p < 0.01). This reduction was accounted for mainly by a relative decrease in the PAL of the ALL group (1.24) compared with both other malignancies and controls (1.58 and 1.47, respectively, p < 0.01). TDEE and PAL were correlated with percentage body fat (r = -0.39, p < 0.001 and r = -0.24, p < 0.05, respectively). Obesity in survivors of ALL may, in part, be explained by a reduction in TDEE as a consequence of reduced PAL. The cause of such reduction is uncertain.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
R Medicine > RZ Other systems of medicine
Publisher: Lippincott, Williams & Wilkins
ISSN: 0031-3998
Last Modified: 27 Oct 2022 10:21
URI: https://orca.cardiff.ac.uk/id/eprint/69798

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