Normal white matter development from infancy to adulthood: Comparing diffusion tensor and high b value diffusion weighted MR images

Bashat, Dafna Ben, Sira, Liat Ben, Graif, Moshe, Pianka, Pazit, Hendler, Talma, Cohen, Yoram and Assaf, Yaniv 2005. Normal white matter development from infancy to adulthood: Comparing diffusion tensor and high b value diffusion weighted MR images. Journal of Magnetic Resonance Imaging 21 (5) , pp. 503-511. 10.1002/jmri.20281

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Abstract

Purpose To evaluate the sensitivity of high b value diffusion weight magnetic resonance imaging (DWI) in detecting normal white matter maturation, compare it to conventional diffusion tensor imaging (DTI), and to obtain normative quantitative data using this method. Materials and Methods High b value DWI (bmax = 6000 sec/mm2) using q-space analysis and conventional DTI (b = 1000 sec/mm2) were performed on 36 healthy subjects aged 4 months to 23 years. Fractional-anisotropy (FA), apparent-displacement, and apparent-probability values were measured in all slices and in six regions of interest (ROIs) of large fiber tracks. Values were correlated with each other and with age using regression analysis. Results FA, displacement, and probability indices from all slices were highly correlated with each other (r > 0.87, P < 0.0001) and with age (r > 0.82, P < 0.0001). All age-related changes in the six pre-determined ROIs were best fitted by mono-exponential functions. Changes in the splenium extended to a later age when compared with the genu of the corpus-callosum, while the centrum semi-ovale demonstrated the latest changes with age. Conclusions High b-value DWI and DTI showed changes in white matter from infancy through adulthood. However, high b-value detects a signal that is likely to originate mainly from the intra-axonal water population, and thus may represent different aspects of development and different sensitivity to pathology.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Neuroscience and Mental Health Research Institute (NMHRI)
Publisher:	John Wiley & Sons
ISSN:	1053-1807
Date of Acceptance:	16 December 2004
Last Modified:	21 Aug 2019 02:20
URI:	https://orca.cardiff.ac.uk/id/eprint/92223

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