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Number of items: 38.

Cole, Alicia M., Myant, Kevin, Reed, Karen Ruth, Ridgway, Rachel A., Athineos, Dimitris, Van den Brink, Gijs, Muncan, Vanesa, Clevers, Hans, Clarke, Alan Richard, Sicinski, Peter and Sansom, Owen J. 2010. Cyclin D2-cyclin-dependent kinase 4/6 is required for efficient proliferation and tumorigenesis following Apc loss. Cancer Research 70 (20) , pp. 8149-8158. 10.1158/0008-5472.CAN-10-0315

Ashton, Gabrielle H., Morton, Jennifer P., Myant, Kevin, Phesse, Toby, Ridgway, Rachel A., Marsh Durban, Victoria, Wilkins, Julie A., Athineos, Dimitris, Muncan, Vanesa, Kemp, Richard, Neufeld, Kristi, Clevers, Hans, Brunton, Valerie, Winton, Douglas J., Wang, Xiaoyan, Sears, Rosalie C., Clarke, Alan Richard, Frame, Margaret C. and Sansom, Owen J. 2010. Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling. Developmental Cell 19 (2) , pp. 259-269. 10.1016/j.devcel.2010.07.015

Buchert, Michael, Athineos, Dimitris, Abud, Helen E., Burke, Zoe D., Faux, Maree C., Samuel, Michael S., Jarnicki, Andrew G., Winbanks, Catherine E., Newton, Ian P, Meniel, Valerie, Suzuki, Hiromu, Stacker, Steven A., Näthke, Inke S., Tosh, David, Huelsken, Joerg, Clarke, Alan Richard, Heath, Joan K., Sansom, Owen J. and Ernst, Matthias 2010. Genetic dissection of differential signaling threshold requirements for the Wnt/beta-Catenin pathway in vivo. PLOS Genetics 6 (1) , e1000816. 10.1371/journal.pgen.1000816
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Burke, Zoé D., Reed, Karen Ruth, Phesse, Toby, Sansom, Owen J., Clarke, Alan Richard and Tosh, David 2009. Liver zonation occurs through a β-catenin–dependent, c-Myc–independent mechanism. Gastroenterology 136 (7) , pp. 2316-2324. 10.1053/j.gastro.2009.02.063

Marsh Durban, Victoria, Winton, Douglas J., Williams, Geraint Trefor, Dubois, Nicole, Trumpp, Andreas, Sansom, Owen J. and Clarke, Alan Richard 2008. Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation. Nature Genetics 40 (12) , pp. 1436-1444. 10.1038/ng.256

Reed, Karen Ruth, Athineos, Dimitris, Meniel, Valerie, Wilkins, Julie Ann, Ridgeway, Rachel A., Burke, Zoe D., Muncan, Vanesa, Clarke, Alan Richard and Sansom, Owen J. 2008. B-catenin deficiency, but not Myc deletion, suppresses the immediate phenotypes of APC loss in the liver. Proceedings of the National Academy of Sciences of the United States of America 105 (48) , pp. 18919-18923. 10.1073/pnas.0805778105

Reed, Karen Ruth, Meniel, Valerie, Marsh Durban, Victoria, Cole, Alicia, Sansom, Owen J. and Clarke, Alan Richard 2008. A limited role for p53 in modulating the immediate phenotype of Apc loss in the intestine. BMC Cancer 8 , 162. 10.1186/1471-2407-8-162
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Phesse, Toby, Parry, Lee, Reed, Karen Ruth, Ewan, Kenneth Burnside Ramsay, Dale, Trevor Clive, Sansom, Owen J. and Clarke, Alan Richard 2008. Deficiency of Mbd2 attenuates Wnt induced tumourigenesis via deregulation of a novel Wnt inhibitor, Lect.2. Molecular and Cellular Biology 28 (19) , pp. 6094-6103. 10.1128/MCB.00539-08

Sansom, Owen J., Meniel, Valerie, Muncan, Vanesa, Phesse, Toby, Wilkins, Julie Ann, Reed, Karen Ruth, Vass, Keith, Athineos, Dimitris, Clevers, Hans and Clarke, Alan Richard 2007. Myc deletion rescues Apc deficiency in the small intestine. Nature 446 (7136) , pp. 676-679. 10.1038/nature05674

Sansom, Owen J., Mansergh, Fiona Catherine, Evans, Martin John, Wilkins, Julie and Clarke, Alan Richard 2007. Deficiency of SPARC suppresses intestinal tumorigenesis in APCMin/+ mice. Gut 56 , pp. 1410-1414. 10.1136/gut.2006.116921

Dikovskaya, Dina, Schiffmann, David, Newton, Ian P., Oakley, Abigail, Kroboth, Karin, Sansom, Owen J., Jamieson, Thomas J., Meniel, Valerie, Clarke, Alan Richard and Nathke, Inke S. 2007. Correction 176, p. 183. Journal of cell biology 176 (3) , p. 369. 10.1083/jcb.20061009920070116c

Dikovskaya, Dina, Schiffmann, David, Newton, Ian P., Oakley, Abigail, Kroboth, Karin, Sansom, Owen J., Jamieson, Thomas J., Meniel, Valerie, Clarke, Alan Richard and Nathke, Inke S. 2007. Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis. Journal of cell biology 176 (2) , pp. 183-195. 10.1083/jcb.200610099

Sansom, Owen J., Meniel, Valerie, Wilkins, Julie Ann, Cole, Alicia M., Oien, Karin A., Marsh Durban, Victoria, Jamieson, Thomas J., Guerra, Carmen, Ashton, Gabrielle H., Barbacid, Mariano and Clarke, Alan Richard 2006. Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo. Proceedings of the National Academy of Sciences 103 (38) , pp. 14122-14127. 10.1073/pnas.0604130103

Stark, Lesley A., Reid, Kirsten, Sansom, Owen J., Din, Farhat V., Guichard, Sylvie, Mayer, Iain, Jodrell, Duncan I., Clarke, Alan Richard and Dunlop, Malcolm G. 2006. Aspirin activates the NF-κB signalling pathway and induces apoptosis in intestinal neoplasia in two in vivo models of human colorectal cancer. Carcinogenesis 28 (5) , pp. 968-976. 10.1093/carcin/bgl220

Reed, Karen Ruth, Sansom, Owen J., Hayes, Anthony Joseph, Gescher, Andreas J., Peters, Jefferey M. and Clarke, Alan Richard 2006. PPARδ status and mismatch repair mediated neoplasia in the mouse intestine. BMC Cancer 6 (113) 10.1186/1471-2407-6-113
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Muncan, Vanesa, Sansom, Owen J., Tertoolen, Leon, Phesse, Toby, Begthel, Harry, Sancho, Elena, Cole, Alicia M., Gregorieff, Alex, de Alboran, Ignacio Moreno, Clevers, Hans and Clarke, Alan Richard 2006. Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc. Molecular and Cellular Biology 26 (22) , pp. 8418-8426. 10.1128/MCB.00821-06
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Sansom, Owen J., Griffiths, David Francis Rees, Reed, Karen Ruth, Winton, Douglas J. and Clarke, Alan Richard 2005. Apc deficiency predisposes to renal carcinoma in the mouse. Oncogene 24 , pp. 8205-8210. 10.1038/sj.onc.1208956

Meniel, Valerie, Hay, Trevor, Douglas-Jones, Anthony Gordon, Sansom, Owen J. and Clarke, Alan R. 2005. Mutations in Apc and p53 synergize to promote mammary neoplasia. Cancer Research 65 (24) , pp. 410-6.

Hay, Trevor, Jenkins, Helen, Sansom, Owen J, Martin, Niall M. B., Smith, Graeme C. M. and Clarke, Alan Richard 2005. Efficient deletion of normal Brca2-deficient intestinal epithelium by poly(ADP-ribose) polymerase inhibition models potential prophylactic therapy. Cancer Research 65 (22) , p. 10145. 10.1158/0008-5472.CAN-05-1186

Sansom, Owen J., Bishop, Stefan Mark, Bird, Adrian and Clarke, Alan Richard 2005. MBD2 deficiency does not accelerate p53 mediated lymphomagenesis. Oncogene 24 (14) , pp. 2430-2432. 10.1038/sj.onc.1208166

Hay, Trevor, Patrick, Teresa, Winton, Douglas, Sansom, Owen J. and Clarke, Alan Richard 2005. Brca2 deficiency in the murine small intestine sensitizes to p53-dependent apoptosis and leads to the spontaneous deletion of stem cells. Oncogene 24 (23) , pp. 3842-3846. 10.1038/sj.onc.1208533

Ireland, Heather, Kemp, Richard, Houghton, Carol, Howard, Louise, Clarke, Alan Richard, Sansom, Owen J. and Winton, Douglas J. 2004. Inducible cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of β-catenin. Gastroenterology 126 (5) , pp. 1236-1246. 10.1053/j.gastro.2004.03.020

Marquez, Nuria, Chappell, Sally Claire, Sansom, Owen J., Clarke, Alan Richard, Teesdale-Spittle, Paul, Errington, Rachel Jane and Smith, Paul James 2004. Microtubule stress modifies intra-nuclear location of Msh2 in mouse embryonic fibroblasts. Cell Cycle 3 , pp. 662-671.

Reed, Karen Ruth, Sansom, Owen J., Hayes, Anthony Joseph, Gescher, Andreas J., Winton, Douglas J., Peters, Jeffrey M. and Clarke, Alan Richard 2004. PPARδ status and Apc-mediated tumourigenesis in the mouse intestine. Oncogene 23 (55) , pp. 8992-8996. 10.1038/sj.onc.1208143

Sansom, Owen J., Bishop, Stefan Mark, Bird, Adrian and Clarke, Alan Richard 2004. MBD4 deficiency does not increase mutation or accelerate tumorigenesis in mice lacking MMR. Oncogene 23 (33) , pp. 5693-5696. 10.1038/sj.onc.1207767

Marquez, Nuria, Chappell, Sally Claire, Sansom, Owen J., Clarke, Alan Richard, Errington, Rachel Jane, Smith, Paul James and Court, Jonathan 2003. Single cell tracking reveals that Msh2 is a key component of an early-acting DNA damage-activated G2 checkpoint. Oncogene 22 (48) , pp. 7642-7648. 10.1038/sj.onc.1206876

Sansom, Owen J., Bishop, Stefan Mark, Court, Helen, Dudley, Sandra, Liskay, R. Michael and Clarke, Alan Richard 2003. Apoptosis and mutation in the murine small intestine: loss of MIh1- and Pms2-dependent apoptosis leads to increased mutation in vivo. DNA Repair 2 (9) , pp. 1029-1039. 10.1016/S1568-7864(03)00111-3

Sansom, Owen J., Zabkiewicz, Joanna, Bishop, Stefan Mark, Guy, Jackie, Bird, Adrian and Clarke, Alan Richard 2003. MBD4 deficiency reduces the apoptotic response to DNA-damaging agents in the murine small intestine. Oncogene 22 (46) , pp. 7130-7136. 10.1038/sj.onc.1206850

Screaton, Robert A., Kiessling, Stephan, Sansom, Owen J., Millar, Catherine B., Maddison, Kathryn, Bird, Adrian, Clarke, Alan Richard and Frisch, Steven M. 2003. Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: A potential link between genome surveillance and apoptosis. Proceedings of the National Academy of Sciences of the United States of America 100 (9) , pp. 5211-5216. 10.1073/pnas.0431215100

Sansom, Owen J., Berger, Jennifer, Bishop, Stefan Mark, Hendrich, Brian, Bird, Adrian and Clarke, Alan Richard 2003. Deficiency of Mbd2 suppresses intestinal tumorigenesis. Nature Genetics 34 (2) , pp. 145-147. 10.1038/ng1155

Gallagher, Ronald C. J., Hay, Trevor, Meniel, Valerie, Naughton, Catherine, Anderson, Thomas J., Shibata, Hiroyuki, Ito, Masaki, Clevers, Hans, Noda, Tetsuo, Sansom, Owen J., Mason, John O. and Clarke, Alan Richard 2002. Inactivation of Apc perturbs mammary development, but only directly results in acanthoma in the context of Tcf-1 deficiency. Oncogene 21 (42) , pp. 6446-6457. 10.1038/sj.onc.1205892

Toft, Neil J., Curtis, Lucy J., Sansom, Owen J., Leitch, Andrea L., Wyllie, Andrew H., te Riele, Hein, Arends, Mark J. and Clarke, Alan Richard 2002. Heterozygosity for p53 promotes microsatellite instability and tumorigenesis on a Msh2 deficient background. Oncogene 21 (41) , pp. 6299-6306. 10.1038/sj.onc.1205727

Sansom, Owen J. and Clarke, Alan Richard 2002. The ability to engage enterocyte apoptosis does not predict long-term crypt survival in p53 and Msh2 deficient mice. Oncogene 21 (38) , pp. 5934-5939. 10.1038/sj.onc.1205760

Millar, Catherine B., Guy, Jacky, Sansom, Owen J., Selfridge, Jim, MacDougall, Eilidh, Hendrich, Brian, Keightley,, Peter D., Bishop, Stefan Mark, Clarke, Alan Richard and Bird, Adrian 2002. Enhanced CpG Mutability and Tumorigenesis in MBD4-Deficient Mice. Science , pp. 403-405. 10.1126/science.1073354

Sansom, Owen J., Toft, Neil J., Winton, Douglas J. and Clarke, Alan Richard 2001. Msh-2 suppresses in vivo mutation in a gene dose and lesion dependent manner. Oncogene 20 (27) , pp. 3580-3584. 10.1038/sj.onc.1204449

Strathdee, Gordon, Sansom, Owen J., Sim, Alyson, Clarke, Alan Richard and Brown, Robert 2001. A role for mismatch repair in control of DNA ploidy following DNA damage. Oncogene 20 (15) , pp. 1923-1927. 10.1038/sj.onc.1204276

Clarke, Alan Richard and Sansom, Owen J. 2001. Analyzing tumor suppressor activities in the murine small intestine. Oncology Research 13 (6-10) , pp. 333-337. 10.3727/096504003108748537

Sansom, Owen J. and Clarke, Alan Richard 2000. P53 null mice: damaging the hypothesis? Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 452 (2) , pp. 149-162. 10.1016/S0027-5107(00)00089-0

This list was generated on Mon Aug 3 06:58:27 2020 BST.