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Number of items: 95.

Nomikos, Michail, Kashir, Junaid and Lai, Francis Antony 2017. The role and mechanism of action of sperm PLC-zeta in mammalian fertilisation. Biochemical Journal 474 (21) , pp. 3659-3673. 10.1042/BCJ20160521
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Benson, Matthew A., Tinsley, Caroline L., Waite, Adrian, Carlisle, Francesca, Sweet, Steve M. M., Ehler, Elisabeth, George, Christopher, Lai, Francis, Martin-Rendon, Enca and Blake, Derek 2017. Ryanodine receptors are part of the myospryn complex in cardiac muscle. Scientific Reports 7 (1) , 6312. 10.1038/s41598-017-06395-6
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Nomikos, Michail, Swann, Karl and Lai, Francis Anthony 2017. Fundamental role for sperm phospholipase C ζ in mammalian fertilization. In: De Jonge, Christopher J. and Barratt, Christopher L. R. eds. The Sperm Cell, Cambridge: Cambridge University Press, pp. 177-192. (10.1017/9781316411124.014)

Nomikos, Michail, Stamatiadis, Panagiotis, Sanders, Jessica Rose, Beck, Konrad, Calver, Brian Lewis, Buntwal, Luke, Lofty, Morgan, Sideratou, Zili, Swann, Karl and Lai, Francis Anthony 2017. Male infertility-linked point mutation reveals a vital binding role for the C2 domain of sperm PLCζ. Biochemical Journal 474 (6) , pp. 1003-1016. 10.1042/BCJ20161057
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Kashir, Junaid, Buntwal, Luke, Nomikos, Michail, Calver, Brian L., Stamatiadis, Panagiotis, Ashley, Peter, Vassilakopoulou, Vyronia, Sanders, David, Knaggs, Paul, Livaniou, Evangelia, Bunkheila, Adnan, Swann, Karl and Lai, Francis Anthony 2017. Antigen unmasking enhances visualization efficacy of the oocyte activation factor, phospholipase C zeta, in mammalian sperm. Molecular Human Reproduction 23 (1) , pp. 54-67. 10.1093/molehr/gaw073
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Nomikos, Michail, Thanassoulas, Angelos, Beck, Konrad, Theodoridou, Maria, Kew, Jasmine, Kashir, Junaid, Calver, Brian Lewis, Matthews, Emily, Rizkallah, Pierre, Sideratou, Zili, Nounesis, George and Lai, Francis Anthony 2016. Mutations in PLCd1 associated with hereditary leukonychia display divergent PIP2 hydrolytic function. FEBS Journal 283 (24) , pp. 4502-4514. 10.1111/febs.13939
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Handhle, Ahmed, Ormonde, Chloe E., Thomas, Nia Lowri, Bralesford, Catherine, Williams, Alan John, Lai, Francis Anthony and Zissimopoulos, Spyros 2016. Calsequestrin interacts directly with the cardiac ryanodine receptor luminal domain. Journal of Cell Science 129 (21) , pp. 3983-3988. 10.1242/jcs.191643
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Stanczyk, Paulina J., Lai, Francis Anthony and Zissimopoulos, Spyros 2016. Genetic and biochemical approaches for in vivo and in vitro assessment of protein oligomerization: The ryanodine receptor case study. Journal of Visualized Experiments (113) , e54271. 10.3791/54271

Swann, Karl and Lai, Francis Anthony 2016. The sperm phospholipase C-  and Ca2+ signalling at fertilization in mammals. Biochemical Society Transactions 44 (1) , pp. 267-272. 10.1042/BST20150221

Haverfield, Jenna, Nakagawa, Shoma, Love, Daniel, Tsichlaki, Elina, Nomikos, Michail, Lai, Francis Anthony, Swann, Karl and FitzHarris, Greg 2016. Ca2+ dynamics in oocytes from naturally-aged mice. Scientific Reports 6 , 19357. 10.1038/srep19357
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Swann, Karl and Lai, Francis Anthony 2016. Egg activation at fertilization by a soluble sperm protein. Physiological Reviews 96 (1) , pp. 127-149. 10.1152/physrev.00012.2015

Nomikos, Michail, Sanders, Jessica Rose, Parthimos, Dimitris, Buntwal, Luke, Calver, Brian Lewis, Stamatiadis, Panagiotis, Smith, Adrian, Clue, Matthew, Sideratou, Zili, Swann, Karl and Lai, Francis Anthony 2015. Essential role of the EF-hand domain in targeting sperm phospholipase Cζ to membrane phosphatidylinositol 4,5-bisphosphate (PIP2). Journal of Biological Chemistry 290 (49) , pp. 29519-29530. 10.1074/jbc.M115.658443
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Vassilakopoulou, Vyronia, Calver, Brian, Thanassoulas, Angelos, Beck, Konrad, Hu, Handan, Buntwal, Luke, Smith, Adrian, Theodoridou, Maria, Kashir, Junaid, Blayney, Lynda, Livaniou, Evangelia, Nounesis, George, Lai, Francis and Nomikos, Michail 2015. Distinctive malfunctions of calmodulin mutations associated with heart RyR2-mediated arrhythmic disease. Biochimica et Biophysica Acta (BBA) - General Subjects 1850 (11) , pp. 2168-2176. 10.1016/j.bbagen.2015.07.001

Sanusi, Randa Taher, Yu, Yuansong, Nomikos, Michail, Lai, Francis Anthony and Swann, Karl 2015. Rescue of failed oocyte activation after ICSI in a mouse model of male factor infertility by recombinant phospholipase Cζ. Molecular Human Reproduction 21 (10) , pp. 783-791. 10.1093/molehr/gav042
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Nomikos, Michail, Sanders, Jessica R., Kashir, Junaid, Sanusi, Randa, Buntwal, Luke, Love, Daniel, Ashley, Peter, Sanders, David, Knaggs, Paul, Bunkheila, Adnan, Swann, Karl and Lai, Francis 2015. Functional disparity between human PAWP and PLCζ in the generation of Ca2+ oscillations for oocyte activation. Molecular Human Reproduction 21 (9) , pp. 702-710. 10.1093/molehr/gav034

Seidel, Monika, Lai, Francis Anthony and Zissimopoulos, Spyros 2015. Structural and functional interactions within ryanodine receptor: Figure 1. Biochemical Society Transactions 43 (3) , pp. 377-383. 10.1042/BST20140292

Domingo, Diana, Neco, Patricia, Fernandez-Pons, Elena, Zissimopoulos, Spyros, Molina, Pilar, Olaguee, Jose, Suarez-Mier, M. Paz, Lai, Francis, Gomez, Ana M. and Zorio, Esther 2015. Non-ventricular, clinical, and functional features of the RyR2R420Q mutation causing catecholaminergic polymorphic ventricular tachycardia. Revista Espanola de Cardiologia (English Edition) 68 (5) , pp. 398-407. 10.1016/j.rec.2014.04.023

Kashir, Junaid, Nomikos, Michail, Swann, Karl and Lai, Francis 2015. PLCζ or PAWP: revisiting the putative mammalian sperm factor that triggers egg activation and embryogenesis. Molecular Human Reproduction 21 (5) , pp. 383-388. 10.1093/molehr/gav009

Nomikos, Michail, Swann, Karl and Lai, Francis Anthony 2015. Is PAWP the 'real' sperm factor? Asian Journal of Andrology 17 (3) , pp. 444-446. 10.4103/1008-682X.142145

Seidel, Monika, Thomas, Nia Lowri, Williams, Alan J., Lai, Francis Anthony and Zissimopoulos, Spyros 2015. Dantrolene rescues aberrant N-terminus intersubunit interactions in mutant pro-arrhythmic cardiac ryanodine receptors. Cardiovascular Research 105 (1) , pp. 118-128. 10.1093/cvr/cvu240

Borko, Lubomir, Bauerova-Hlinkova, Vladena, Hostinova, Eva, Gasperik, Juraj, Beck, Konrad, Lai, Francis Anthony, Zahradnikova, Alexandra and Sevcik, Jozef 2014. Structural insights into the human RyR2 N-terminal region involved in cardiac arrhythmias. Acta Crystallographica Section D: Biological Crystallography 70 (11) , pp. 2897-2912. 10.1107/S1399004714020343
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Kashir, Junaid, Nomikos, Michail, Lai, Francis and Swann, Karl 2014. Sperm-induced Ca2+ release during egg activation in mammals. Biochemical and Biophysical Research Communications 450 (3) , pp. 1204-1211. 10.1016/j.bbrc.2014.04.078

Nomikos, Michail, Thanassoulas, Angelos, Beck, Konrad, Vassilakopoulou, Vyronia, Hu, Handan, Calver, Brian Lewis, Theodoridou, Maria, Kashir, Junaid, Blayney, Lynda Mary, Livaniou, Evangelia, Rizkallah, Pierre, Nounesis, George and Lai, Francis Anthony 2014. Altered RyR2 regulation by the calmodulin F90L mutation associated with idiopathic ventricular fibrillation and early sudden cardiac death. Febs Letters 588 (17) , pp. 2898-2902. 10.1016/j.febslet.2014.07.007

Gonzalez-Garcia, Jose Raul, Bradley, Josephine, Nomikos, Michail, Paul, Laboni, Machaty, Z., Lai, Francis Anthony and Swann, Karl 2014. The dynamics of MAPK inactivation at fertilization in mouse eggs. Journal of Cell Science 127 , pp. 2749-2760. 10.1242/jcs.145045
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Zissimopoulos, Spyros, Marsh, Jason, Stannard, Laurence, Seidel, Monika and Lai, Francis 2014. N-terminus oligomerization is conserved in intracellular calcium release channels. Biochemical Journal 459 (2) , pp. 265-273. 10.1042/BJ20131061

Nomikos, Michail, Theodoridou, Maria, Elgmati, Khalil, Parthimos, Dimitris, Calver, Brian, Buntwal, Luke, Nounesis, George, Swann, Karl and Lai, Francis 2014. Human PLCζ exhibits superior fertilization potency over mouse PLCζ in triggering the Ca2+ oscillations required for mammalian oocyte activation. Molecular Human Reproduction 20 (6) , pp. 489-498. 10.1093/molehr/gau011

Borko, Lubomir, Bauerova-Hlinkova, Vladena, Zahradnikova, Alexandra, Kostan, Julius, Beck, Konrad, Gasperik, Juraj, Hostinova, Eva, Lai, Francis Anthony and Sevcik, Jozef 2014. A regulatory component of the human ryanodine receptor 2 N-terminus. Biophysical Journal 106 (2) , 107A-107A. 10.1016/j.bpj.2013.11.661
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Nomikos, Michail, Sanders, Jessica Rose, Theodoridou, Maria, Kashir, Junaid, Matthews, Emily, Nounesis, George, Lai, Francis and Swann, Karl 2014. Sperm-specific post-acrosomal WW-domain binding protein (PAWP) does not cause Ca2+ release in mouse oocytes. Molecular Human Reproduction 20 (10) , pp. 938-947. 10.1093/molehr/gau056

Theodoridou, Maria, Nomikos, Michail, Parthimos, Dimitris, Gonzalez-Garcia, J., Elgmati, K., Calver, Brian Lewis, Sideratou, Z., Nounesis, G., Swann, Karl and Lai, Francis Anthony 2013. Chimeras of sperm PLCζ reveal disparate protein domain functions in the generation of intracellular Ca2+ oscillations in mammalian eggs at fertilization. Molecular Human Reproduction 19 (12) , pp. 852-864. 10.1093/molehr/gat070

Lam, A., Galione, A., Lai, Francis Anthony and Zissimopoulos, Spyros 2013. Hax-1 identified as a two-pore channel (TPC)-binding protein. FEBS Letters 587 (23) , pp. 3782-3786. 10.1016/j.febslet.2013.10.031

Blayney, Lynda Mary, Beck, Konrad, MacDonald, Ewan, D'Cruz, Leon G,, Nomikos, Michail, Griffiths, Julia, Thanassoulas, Angelos, Nounesis, George and Lai, Francis Anthony 2013. ATP interacts with the CPVT mutation-associated central domain of the cardiac ryanodine receptor. Biochimica et Biophysica Acta (BBA) - General Subjects 1830 (10) , pp. 4426-4432. 10.1016/j.bbagen.2013.05.038

Wu, Bei, Yamaguchi, Hiroo, Lai, Francis Anthony and Shen, Jie 2013. Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons. Proceedings of the National Academy of Sciences of the United States of America 110 (37) , pp. 15091-15906. 10.1073/pnas.1304171110

Zissimopoulos, Spyros, Viero, Cedric, Seidel, Monika, Cumbes, Bevan, White, Judith, Cheung, Iris, Stewart, Richard, Jeyakumar, Lois, Fleischer, Sidney, Mukherjee, Saptarshi, Thomas, Nia Lowri, Williams, Alan John and Lai, Francis Anthony 2013. Amino-terminus oligomerization regulates cardiac ryanodine receptor function. Journal of Cell Science n/a 10.1242/​jcs.133538

Swann, Karl and Lai, Francis Anthony 2013. PLCζ and the initiation of Ca2+ oscillations in fertilizing mammalian eggs. Cell Calcium 53 (1) , pp. 55-62. 10.1016/j.ceca.2012.11.001

Nomikos, Michail, Yu, Yuansong, Elgmati, Khalil, Theodoridou, Maria, Campbell, Karen, Vassilakopoulou, Vyronia, Zikos, Christos, Livaniou, Evangelia, Amso, Nazar Najib, Nounesis, George, Swann, Karl and Lai, Francis Anthony 2013. Phospholipase Cζ rescues failed oocyte activation in a prototype of male factor infertility. Fertility and Sterility 99 (1) , pp. 76-85. 10.1016/j.fertnstert.2012.08.035

Gonzalez Garcia, Jose, Machaty, Zoltan, Lai, Francis Anthony and Swann, Karl 2013. The dynamics of PKC-induced phosphorylation triggered by Ca2+oscillations in mouse eggs. Journal of Cellular Physiology 228 (1) , pp. 110-119. 10.1002/jcp.24110

Zissimopoulos, Spyros, Viero, C, Seidel, Monika, Cumbes, Bevan, White, Judith, Cheung, I, Stewart, R cardiff?, Jeyakumar, L, Fleischer, S, Mukherjee, Saptarshi, Thomas, Nia Lowri, Williams, Alan John and Lai, Francis 2013. N-terminus oligomerization regulates the function of cardiac ryanodine receptors. Journal of Cell Science 126 (21) , pp. 5042-5051. 10.1242/jcs.133538

Zissimopoulos, Spyros, Seifan, Sara, Maxwell, Chloe, Williams, Alan John and Lai, Francis Anthony 2012. Disparities in the association of the ryanodine receptor and the FK506-binding proteins in mammalian heart. Journal of Cell Science 125 (7) , pp. 1759-1769. 10.1242/jcs.098012

Swann, Karl, Windsor, Shane, Campbell, Karen, Elgmati, Khalil, Nomikos, Michail, Zernicka-Goetz, Magdalena, Amso, Nazar Najib, Lai, Francis Anthony, Thomas, Adrian and Graham, Christopher 2012. Phospholipase C-ζ-induced Ca2+ oscillations cause coincident cytoplasmic movements in human oocytes that failed to fertilize after intracytoplasmic sperm injection. Fertility and Sterility 97 (3) , pp. 742-747. 10.1016/j.fertnstert.2011.12.013

Yu, Yuansong, Nomikos, Michail, Theodoridou, Maria, Nounesis, George, Lai, Francis Anthony and Swann, Karl 2012. PLCζ causes Ca2+ oscillations in mouse eggs by targeting intracellular and not plasma membrane PI(4,5)P2. Molecular Biology of the Cell 23 (2) , pp. 371-380. 10.1091/mbc.E11-08-0687
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Nomikos, Michail, Elgmati, Khalil, Theodoridou, Maria, Calver, Brian Lewis, Nounesis, George, Swann, Karl and Lai, Francis Anthony 2011. Phospholipase C binding to PtdIns(4,5)P2 requires the XY-linker region. Journal of Cell Science 124 (15) , pp. 2582-2590. 10.1242/jcs.083485

Lifshitz, Lawrence M., Carmichael, Jefrey D., Lai, Francis Anthony, Sorrentino, Vincenzo, Bellve, Karl, Fogarty, Kevin E. and ZhuGe, Ronghua 2011. Spatial organization of RYRs and BK channels underlying the activation of STOCs by Ca2+ sparks in airway myocytes. The Journal of General Physiology 138 (2) , pp. 195-209. 10.1085/jgp.201110626
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Nomikos, Michail, Elgmati, Khalil, Theodoridou, Maria, Calver, Brian Lewis, Cumbes, Bevan, Nounesis, George, Swann, Karl and Lai, Francis Anthony 2011. Male infertility-linked point mutation disrupts the Ca2+oscillation-inducing and PIP2hydrolysis activity of sperm PLCζ. Biochemical Journal 434 (2) , pp. 211-217. 10.1042/BJ20101772

Nomikos, Michail, Elgmati, Khalil, Theodoridou, Maria, Calver, Brian Lewis, Cumbes, Bevan, Nounesis, George, Swann, Karl and Lai, Francis Anthony 2011. Male infertility-linked point mutation disrupts the Ca2+ oscillation-inducing and PIP2 hydrolysis activity of sperm PLCζ [Erratum]. The Biochemical Journal 435 (3) , p. 791.

Nomikos, Michail, Swann, Karl and Lai, Francis Anthony 2011. Starting a new life: Sperm PLC-zeta mobilizes the Ca2+ signal that induces egg activation and embryo development. BioEssays 34 (2) , pp. 126-134. 10.1002/bies.201100127

Phillips, Sally Victoria, Yu, Yuansong, Rossbach, Andreas Michael, Nomikos, Michail, Vassilakopoulou, Vyronia, Livaniou, Evangelia, Cumbes, Bevan, Lai, Francis Anthony, George, Christopher H. and Swann, Karl 2011. Divergent effect of mammalian PLC-zeta in generating Ca2+ oscillations in somatic cells versus eggs. Biochemical Journal 438 , pp. 545-533. 10.1042/BJ20101581

Nomikos, Michail, Elgmati, Khalil, Theodoridou, Maria, Georgilis, Athena, Gonzalez-Garcia, J. Raul, Nounesis, George, Swann, Karl and Lai, Francis Anthony 2011. Novel regulation of PLCζ activity via its XY-linker. Biochemical Journal 438 , pp. 427-432. 10.1042/BJ20110953

Wakula, Paulina, Bisping, Egbert, Kockskämper, Jens, Post, Heiner, Brauer, Sabine, Deuter, Marion, Oehlmann, Ralph, Besenfelder, Urban, Lai, Francis Anthony, Brem, Gottfried and Pieske, Burkert 2011. CMV promoter is inadequate for expression of mutant human RyR2 in transgenic rabbits. Journal of Pharmacological and Toxicological Methods 63 (2) , pp. 180-185. 10.1016/j.vascn.2010.09.007

Yu, Yuansong, Dumollard, Remi, Rossbach, Andreas, Lai, Francis Anthony and Swann, Karl 2010. Redistribution of mitochondria leads to bursts of ATP production during spontaneous mouse oocyte maturation. Journal of Cellular Physiology 224 (3) , pp. 672-680. 10.1002/jcp.22171

Sedej, Simon, Heinzel, Frank R., Walther, Stefanie, Dybkova, Nataliya, Wakula, Paulina, Groborz, Jan, Gronau, Phillip, Maier, Lars S., Vos, Marc A., Lai, Francis Anthony, Napolitano, Carlo., Priori, Silvia G., Kockskamper, Jens. and Pieske, Burkert 2010. Na+-dependent SR Ca2+ overload induces arrhythmogenic events in mouse cardiomyocytes with a human CPVT mutation. Cardiovascular Research 87 (1) , pp. 50-59. 10.1093/cvr/cvq007

Blayney, Lynda Mary and Lai, Francis Anthony 2009. Ryanodine receptor-mediated arrhythmias and sudden cardiac death. Pharmacology & Therapeutics 123 (2) , pp. 151-177. 10.1016/j.pharmthera.2009.03.006

Zissimopoulos, Spryos, Thomas, Nia Lowri, Jamaluddin, Wan W. and Lai, Francis Anthony 2009. FKBP12.6 binding of ryanodine receptors carrying mutations associated with arrhythmogenic cardiac disease. Biochemical Journal 419 (2) , pp. 273-278. 10.1042/BJ20082324

Gomez, Ana Maria, Rueda, Angelica, Sainte-Marie, Yannis, Pereira, Laetitia, Zissimopoulos, Spyros, Zhu, Xinsheng, Schaub, Roxane, Perrier, Emeline, Perrier, Romain, Latouche, Celine, Richard, Sylvain, Picot, Marie-Christine, Jaisser, Frederic, Lai, Francis Anthony, Valdivia, Hector H. and Benitah, Jean-Pierre 2009. Mineralocorticoid modulation of cardiac ryanodine receptor activity is associated with downregulation of FK506-binding proteins. Circulation 119 (16) , pp. 2179-2187. 10.1161/CIRCULATIONAHA.108.805804
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Blayney, Lynda Mary, Jones, Jonathan-Lee, Griffiths, Julia and Lai, Francis Anthony 2009. A mechanism of ryanodine receptor modulation by FKBP12/12.6, protein kinase A, and K201. Cardiovascular Research 85 (1) , pp. 68-78. 10.1093/cvr/cvp273

Yu, Yuansong, Halet, Guillaume, Lai, Francis Anthony and Swann, Karl 2008. Regulation of diacylglycerol production and protein kinase C stimulation during sperm- and PLCζ-mediated mouse egg activation. Biology of the Cell 100 (11) , pp. 633-643. 10.1042/BC20080033

Curtis, Tim M., Tumelty, James, Stewart, Michael T., Arora, A. Rakha, Lai, Francis Anthony, McGahon, Mary K., Scholfield, C. Norman and McGeown, J. Graham 2008. Modification of smooth muscle Ca2+-sparks by tetracaine: evidence for sequential RyR activation. Cell Calcium 43 (2) , pp. 142-154. 10.1016/j.ceca.2007.04.016

Yin, Chang-Cheng, D'Cruz, Leon G. and Lai, Francis Anthony 2008. Ryanodine receptor arrays: not just a pretty pattern? Trends in Cell Biology 18 (4) , pp. 149-156. 10.1016/j.tcb.2008.02.003

Yu, Yuansong, Saunders, Christopher Matthew, Lai, Francis Anthony and Swann, Karl 2008. Preimplantation development of mouse oocytes activated by different levels of human phospholipase C zeta. Human Reproduction 23 (2) , pp. 365-373. 10.1093/humrep/dem350

George, Christopher H., Rogers, Sarah Ann, Bertrand, Benedicte M.A., Tunwell, Richard E.A., Thomas, Nia Lowri, Steele, Derek S., Cox, Eryl Vanessa, Pepper, Christopher John, Hazeel, Carolyn Jean, Claycomb, William C. and Lai, Francis Anthony 2007. Alternative splicing of ryanodine receptors modulates cardiomyocyte Ca2+ signalling and susceptibility to apoptosis. Circulation Research 100 (6) , pp. 874-883. 10.1161/01.RES.0000260804.77807.cf

Zissimopoulos, Spyros, Docrat, Naadiya and Lai, Francis Anthony 2007. Redox sensitivity of the ryanodine receptor interaction with FK506-binding protein. The Journal of Biological Chemistry 282 (10) , pp. 6976-6983. 10.1074/jbc.M607590200

George, Christopher H., Jundi, Hala, Thomas, Nia Lowri, Fry, Debra L. and Lai, Francis Anthony 2007. Ryanodine receptors and ventricular arrhythmias: Emerging trends in mutations, mechanisms and therapies. Journal of Molecular and Cellular Cardiology 42 (1) , pp. 34-50. 10.1016/j.yjmcc.2006.08.115

Fry, Debra, Jundi, Hala, Thomas, Nia Lowri, Lai, Francis Anthony and George, Christopher H. 2007. Modulating intracellular Ca2+ signaling using recombinant fragments of the human cardiac ryanodine receptor (RyR2). Biophysical Journal , 260A-260A.

George, Christopher H., Thomas, Nia Lowri, Williams, A. J. and Lai, Francis Anthony 2007. Ryanodine receptor mutations in arrhythmias: advances in understanding the mechanisms of channel dysfunction. Biochemical Society Transactions 35 (5) , pp. 946-951. 10.1042/BST0350946

George, Christopher and Lai, Francis Anthony 2007. Developing new anti-arrhythmics: clues from the molecular basis of cardiac ryanodine receptor (RyR2) Ca2+-release channel dysfunction. Current Pharmaceutical Design 13 (31) , pp. 3195-3211. 10.2174/138161207782341259

Liu, Nian, Colombi, Barbara, Memmi, Mirella, Zissimopoulos, Spyros, Rizzi, Nicoletta, Negri, Sara, Imbriani, Marcello, Napolitano, Carlo, Lai, Francis Anthony and Priori, Silvia G. 2006. Arrhythmogenesis in catecholaminergic polymorphic ventricular tachycardia: insights from a RyR2 R4496C knock-in mouse model. Circulation Research 99 (3) , pp. 292-8. 10.1161/01.RES.0000235869.50747.e1

Zissimopoulos, Spyros, West, Duncan J., Williams, Alan John and Lai, Francis Anthony 2006. Ryanodine receptor interaction with the SNARE-associated protein snapin. Journal of cell science 119 (11) , pp. 2386-2397. 10.1242/jcs.02936

George, Christopher H., Thomas, Nia Lowri and Lai, Francis Anthony 2006. Role of ryanodine receptor mutations in cardiac pathology: more questions than answers? Biochemical Society Transactions 34 (5) , pp. 913-918. 10.1042/BST0340913

George, Christopher, Jundi, Hala, Walters, Nicola, Thomas, Nia Lowri, West, Robert Raynard and Lai, Francis Anthony 2005. Arrhythmogenic mutation-linked defects in ryanodine receptor autoregulation reveal a novel mechanism of Ca2+ release channel dysfunction. Circulation Research 98 (12) , pp. 88-97. 10.1161/01.RES.0000199296.70534.7c

Jones, Jonathan-Lee, Reynolds, Deborah Fidelis, Lai, Francis Anthony and Blayney, Lynda Mary 2005. Ryanodine receptor binding to FKBP12 is modulated by channel activation state. Journal of Cell Science (JCS) 118 (20) , pp. 4613-4619. 10.1242/jcs.02582

Nomikos, Michail, Blayney, Lynda Mary, Larman, Mark Graham, Campbell, Karen, Rossbach, Andreas, Saunders, Christopher Matthew, Swann, Karl and Lai, Francis Anthony 2005. Role of phospholipase C-zeta domains in Ca2+-dependent phosphatidylinositol 4,5-bisphosphate hydrolysis and cytoplasmic Ca2+ oscillations. Journal of biological chemistry 280 (35) , pp. 31011-31018. 10.1074/jbc.M500629200

George, Christopher H., Thomas, Nia Lowri and Lai, Francis Anthony 2005. Ryanodine receptor dysfunction in arrhythmia and sudden cardiac death. Future Cardiology 1 (4) , pp. 531-541. 10.2217/14796678.1.4.531

Yin, Chang-Cheng, Blayney, Lynda Mary and Lai, Francis Anthony 2005. Physical coupling between ryanodine receptor-calcium release channels. Journal of Molecular Biology 349 (3) , pp. 538-546. 10.1016/j.jmb.2005.04.002

Thomas, Nia Lowri, Lai, Francis Anthony and George, Christopher H. 2005. Differential Ca2+ sensitivity of RyR2 mutations reveals distinct mechanisms of channel dysfunction in sudden cardiac death. Biochemical and Biophysical Research Communications 331 (1) , pp. 231-238. 10.1016/j.bbrc.2005.02.194

Zissimopoulos, Spyros and Lai, Francis Anthony 2005. Interaction of FKBP12.6 with the cardiac ryanodine receptor C-terminal domain. The Journal of Biological Chemistry 280 (7) , pp. 5475-5485. 10.1074/jbc.M412954200

Lai, Francis Anthony, Yin, C. C., Han, H. and Wei, R. 2005. Two-dimensional crystallization of the ryanodine receptor Ca2+ release channel on lipid membranes. Journal of Structural Biology 149 (2) , pp. 219-224. 10.1016/j.jsb.2004.10.008

George, Christopher, Walters, N., Thomas, N. L., Yeung, W. Y., Reynolds, D. F. and Lai, Francis Anthony 2005. Visualisation of intra-RyR2 interactions in HL-1 cardiomyocytes: novel FRET probes reveal a structural basis for Ca2+ channel dysfunction in arrhythmogenesis. Biophysical Journal 88 (1) , 92A-92A.

Thomas, L., George, Christopher H. and Lai, Francis Anthony 2005. In situ characterisation of the Ca2+ sensitivity of cardiac RyR mutations reveals multiple mechanisms of channel dysfunction in sudden death. Biophysical Journal 88 (1) , 308A-309A.

George, Christopher, Yin, Chang Cheng and Lai, Francis Anthony 2005. Toward a molecular understanding of the structure-function of ryanodine receptor Ca2+ release channels. Cell Biochemistry and Biophysics 42 (2) , pp. 197-222. 10.1385/CBB:42:2:197

Rogers, N. T., Hobson, E., Pickering, S., Lai, Francis Anthony, Braude, P. and Swann, Karl 2004. Phospholipase Cζ causes Ca2+ oscillations and parthenogenetic activation of human oocytes. Reproduction 128 (6) , pp. 697-702. 10.1530/rep.1.00484

Thomas, Nia Lowri, George, Christopher and Lai, Francis Anthony 2004. Functional heterogeneity of ryanodine receptor mutations associated with sudden cardiac death. Cardiovascular Research 64 (1) , pp. 52-60. 10.1016/j.cardiores.2004.06.009

George, Christopher, Jundi, Hala, Thomas, Nia Lowri, Scoote, Mark, Walters, Nicola, Williams, Alan John and Lai, Francis Anthony 2004. Ryanodine receptor regulation by intramolecular interaction between cytoplasmic and transmembrane domains. Molecular biology of the cell 15 (6) , pp. 2627-2638. 10.1091/mbc.E03-09-0688
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Larman, Mark Graham, Saunders, Christopher Matthew, Carroll, John, Lai, Francis Anthony and Swann, Karl 2004. Cell cycle-dependent Ca2+ oscillations in mouse embryos are regulated by nuclear targeting of PLCzeta. Journal of cell science 117 (12) , pp. 2513-2521. 10.1242/jcs.01109

Blayney, Lynda Mary, Zissimopoulos, Spyros, Ralph, Emma, Abbot, Eleanor, Matthews, Laura and Lai, Francis Anthony 2004. Ryanodine receptor oligomeric interaction: identification of a putative binding region. Journal of biological chemistry 279 (15) , pp. 14639-14648. 10.1074/jbc.M308014200

George, Christopher, Jundi, Hala, Thomas, N. L. and Lai, Francis Anthony 2004. Altered intra-RyR interaction associated with stress-induced ventricular tachycardia. Biophysical Journal 86 (1) , 49A-50A.

Thomas, L., George, Christopher H. and Lai, Francis Anthony 2004. Molecular mechanisms underlying RyR2 (Ca2+ release channel) dysfunction in stress-induced VT. Biophysical Journal 86 (1) , 49A-49A.

George, Christopher H., Higgs, Gemma and Lai, Francis Anthony 2003. Ryanodine receptor mutations associated with stress-induced ventricular tachycardia mediate increased calcium release in stimulated cardiomyocytes. Circulation Research 93 (6) , pp. 531-540. 10.1161/01.RES.0000091335.07574.86

George, Christopher, Higgs, Gemma, Mackrill, John J. and Lai, Francis Anthony 2003. Dysregulated ryanodine receptors mediate cellular toxicity: restoration of normal phenotype by FKBP12.6. Journal of biological chemistry 278 (31) , pp. 28856-28864. 10.1074/jbc.M212440200

George, Christopher, Sorathia, Rina, Bertrand, Benedicte M. A. and Lai, Francis Anthony 2003. In situ modulation of the human cardiac ryanodine receptor (hRyR2) by FKBP12.6. Biochemical Journal 370 (2) , pp. 579-589. 10.1042/BJ20021433

George, Christopher and Lai, Francis Anthony 2003. Transcriptional alterations mediated via dysregulated human cardiac ryanodine receptor (hRyR2). Biophysical Journal 84 (2) , 390A-390A.

Rogers, S. A., George, Christopher, Cox, E. V., Hazeel, C. and Lai, Francis Anthony 2003. Expression of human RyR2 splice variants. Biophysical Journal 84 (2) , 64A-64A.

Saunders, Christopher Matthew, Larman, Mark Graham, Parrington, John, Cox, Llewellyn J., Royse, Jillian, Blayney, Lynda Mary, Swann, Karl and Lai, Francis Anthony 2002. PLC zeta: a sperm-specific trigger of Ca(2+) oscillations in eggs and embryo development. Development 129 (15) , pp. 3533-3544.

George, Christopher and Lai, Francis Anthony 2002. In situ regulation of the human cardiac ryanodine receptor (hRyR2) by intramolecular interaction. Biophysical Journal 82 (1) , 624A-624A.

George, Christopher and Lai, Francis Anthony 2002. Cytoplasmic Ca2+ spiking via human RyR2 mediates cell death. Biophysical Journal 82 (1) , 61A-61A.

Kada, G., Blayney, Lynda Mary, Jeyakumar, L. H., Kienberger, F., Pastushenko, V. Ph., Fleischer, S., Schindler, H., Lai, Francis Anthony and Hinterdorfer, P. 2001. Recognition force microscopy/spectroscopy of ion channels: applications to the skeletal muscle Ca2+ release channel (RYR1). Ultramicroscopy 86 (1-2) , pp. 129-137. 10.1016/S0304-3991(00)00070-X

Llano, I., Gonzalez, J., Caputo, C., Lai, Francis Anthony, Blayney, Lynda Mary, Tan, Y. P. and Marty, A. 2000. Presynaptic calcium stores underlie large-amplitude miniature IPSCs and spontaneous calcium transients. Nature Neuroscience 3 (12) , pp. 1256-1265. 10.1038/81781

This list was generated on Sat Nov 17 07:55:02 2018 GMT.