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Number of items: 8.

McGuigan, Christopher, Madela, Karolina, Aljarah, Mohamed, Bourdin, Claire, Arrica, Maria, Barrett, Emma, Jones, Sarah Louise, Kolykhalov, Alexander, Bleiman, Blair, Bryant, K. Dawn, Ganguly, Babita, Gorovits, Elena, Henson, Geoffrey, Hunley, Damound, Hutchins, Jeff, Muhammad, Jerry, Obikhod, Aleksandr, Patti, Joseph, Walters, C. Robin, Wang, Jin, Vernachio, John, Ramamurty, Changalvala V. S., Battina, Srinivas K. and Chamberlain, Stanley 2011. Phosphorodiamidates as a promising new phosphate prodrug motif for antiviral drug discovery: application to anti-HCV agents. Journal of Medicinal Chemistry 54 (24) , pp. 8632-8645. 10.1021/jm2011673

McGuigan, Christopher, Madela, Karolina, Aljarah, Mohamed, Gilles, Arnaud, Battina, S. K., Ramamurty, C. V. S., Rao, C. S., Vernachio, J., Hutchins, J., Hall, A., Kolykhalov, A., Henson, G. and Chamberlain, S. 2011. Dual pro-drugs of 2 '-C-methyl guanosine monophosphate as potent and selective inhibitors of hepatitis C virus. Biorganic and Medicinal Chemistry Letters 21 (19) , pp. 6007-6012. 10.1016/j.bmcl.2011.06.013

Hutchins, Jeff T., McGuigan, Christopher, Chamberlain, Stanley D., Madela, Karolina W., Aljarah, Mohamed, Vernachio, John, Patti, Joseph M. and Henson, Geoffrey 2011. DMPK and Metabolism Studies of Nucleoside Phosphoramidates Including INX-08189, A Novel Double Pro-drug and Clinical Candidate for Hepatitis C Virus Therapy. Antiviral Research 90 (2) , A22-A23. 10.1016/j.antiviral.2011.03.006

Vernachio, John H., Bleiman, Blair, Bryant, K. Dawn, Chamberlain, Stanley, Hunley, Damound, Hutchins, Jeff, Ames, Brenda, Gorovits, Elena, Ganguly, Babita, Hall, Andrea, Kolykhalov, Alexander, Liu, Yule, Muhammad, Jerry, Raja, Nicholas, Walters, C. Robin, Wang, Jin, Williams, Karen, Patti, Joseph M., Henson, Geoffrey, Madela, Karolina, Aljarah, Mohamed, Gilles, Arnaud and McGuigan, Christopher 2011. INX-08189, a phosphoramidate prodrug of 6-O-Methyl-2'-C-Methyl Guanosine, is a potent inhibitor of Hepatitis C virus replication with excellent pharmacokinetic and pharmacodynamic properties. Antimicrobial Agents and Chemotherapy 55 (5) , pp. 1843-1851. 10.1128/AAC.01335-10
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Hall, A., Raja, N., Chamberlain, S. D., Gorovits, E., Henson, G. W., Hutchins, J. T., Muhammad, J., Patti, J., Vernachio, J., Wang, J., Madela, Karolina, Aljarah, Mohamed, Jones, Sarah Louise and McGuigan, Christopher 2010. Metabolite characterization of INX-189, a potent HCV inhibitor, in fresh human primary hepatocytes and human liver and kidney cell lines [abstract 1874]. Hepatology 52 (S1) , 1211A-1211A. 10.1002/hep.23996

Vernachio, J., Bryant, D., Chamberlain, S. D., Gorovits, E., Ganguly, B. S., Hall, A., Henson, G. W., Hunley, D. S., Hutchins, J. T., Muhammad, J., Patti, J., Walters, C. R., Wang, J., Madela, Karolina, Aljarah, Mohamed, Jones, Sarah Louise and McGuigan, Christopher 2010. In vitro and in vivo metabolism of INX-189, a potent HCV inhibitor, in rat and cynomolgus monkey hepatocytes [Abstract]. Hepatology 52 (S1) , 1218A-1219A. 10.1002/hep.23997

McGuigan, Christopher, Madela, Karolina, Aljarah, Mohamed, Gilles, Arnaud, Brancale, Andrea, Zonta, Nicola, Chamberlain, Stanley, Vernachio, John, Hutchins, Jeff and Hall, Andrea 2010. Design, synthesis and evaluation of a novel double pro-drug: INX-08189. A new clinical candidate for hepatitis C virus. Biorganic and Medicinal Chemistry Letters 20 (16) , pp. 4850-4854. 10.1016/j.bmcl.2010.06.094

McGuigan, Christopher, Gilles, Arnaud, Madela, Karolina, Aljarah, Mohamed, Holl, Sabrina, Jones, Sarah Louise, Vernachio, John, Hutchins, Jeff, Ames, Brenda, Bryant, K. Dawn, Gorovits, Elena, Ganguly, Babita, Hunley, Damound, Hall, Andrea, Kolykhalov, Alexander, Liu, Yule, Muhammad, Jerry, Raja, Nicholas, Walters, Robin, Wang, Jin, Chamberlain, Stanley and Henson, Geoffrey 2010. Phosphoramidate ProTides of 2'-C-Methylguanosine as highly potent inhibitors of hepatitis C virus. Study of their in vitro and in vivo properties. Journal of Medicinal Chemistry 53 (13) , pp. 4949-4957. 10.1021/jm1003792

This list was generated on Wed Nov 13 10:09:35 2019 GMT.