ORCA
Online Research @ Cardiff
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Up a levelNumber of items: 15.
Chakroborty, Anand, Pritchard, Deiniol R., Bouillon, Marc E., Cervi, Anna, Kraehenbuehl, Rolf, Wild, Charlotte, Fenn, Caroline, Holdsworth, Peter, Capner, Colin, Padalino, Gilda, Forde-Thomas, Josephine E., Payne, Joseph, Smith, Brendan G., Fisher, Maggie, Lahmann, Martina, Baird, Mark S. and Hoffmann, Karl F.
2023.
Modified hederagenin derivatives demonstrate ex vivo anthelmintic activity against fasciola hepatica.
Pharmaceutics
15
(7)
, 1869.
10.3390/pharmaceutics15071869
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Padalino, Gilda, Coghlan, Avril, Pagliuca, Giampaolo, Forde-Thomas, Josephine E., Berriman, Matthew and Hoffmann, Karl F.
2023.
Using ChEMBL to complement schistosome drug discovery.
Pharmaceutics
15
(5)
, 1359.
10.3390/pharmaceutics15051359
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Caldwell, Nicola, Afshar, Rana, Baragaña, Beatriz, Bustinduy, Amaya L., Caffrey, Conor R., Collins, James J., Fusco, Daniela, Garba, Amadou, Gardner, Mark, Gomes, Mireille, Hoffmann, Karl F., Hsieh, Michael, Lo, Nathan C., McNamara, Case W., Nono, Justin Komguep, Padalino, Gilda, Read, Kevin D., Roestenberg, Meta, Spangenberg, Thomas, Specht, Sabine and Gilbert, Ian H.
2023.
Perspective on schistosomiasis drug discovery: highlights from a schistosomiasis drug discovery workshop at Wellcome Collection, London, September 2022.
ACS Infectious Diseases
9
(5)
, pp. 1046-1055.
10.1021/acsinfecdis.3c00081
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Padalino, Gilda, Celatka, Cassandra A., Rienhoff Jr., Hugh Y., Kalin, Jay H., Cole, Philip A., Lassalle, Damien, Forde-Thomas, Josephine, Chalmers, Iain W., Brancale, Andrea  ORCID: https://orcid.org/0000-0002-9728-3419, Grunau, Christoph and Hoffmann, Karl F.
2023.
Chemical modulation of Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) induces wide-scale biological and epigenomic changes.
Wellcome Open Research
8
, 146.
10.12688/wellcomeopenres.18826.1
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Giancotti, Gilda, Nannetti, Giulio ORCID: https://orcid.org/0000-0003-3227-1537, Padalino, Gilda, Landini, Martina, Santos-Ferreira, Nanci, Van Dycke, Jana, Naccarato, Valentina, Patel, Usheer, Silvestri, Romano, Neyts, Johan, Gozalbo-Rovira, Roberto, Rodríguez-Díaz, Jésus, Rocha-Pereira, Joana, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419, Ferla, Salvatore ORCID: https://orcid.org/0000-0002-5918-9237 and Bassetto, Marcella ORCID: https://orcid.org/0000-0002-2491-5868
2022.
Structural investigations on novel non-nucleoside inhibitors of human norovirus polymerase.
Viruses
15
(1)
, 74.
10.3390/v15010074
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Chakroborty, Anand, Pritchard, Deiniol, Bouillon, Marc E., Cervi, Anna, Cookson, Alan, Wild, Charlotte, Fenn, Caroline, Payne, Joseph, Holdsworth, Peter, Capner, Colin, O'Neill, Jenna, Padalino, Gilda, Forde-Thomas, Josephine, Gupta, Sandeep, Smith, Brendan G., Fisher, Maggie, Lahmann, Martina, Baird, Mark S. and Hoffmann, Karl F.
2022.
Flukicidal effects of abietane diterpenoid derived analogues against the food borne pathogen Fasciola hepatica.
Veterinary Parasitology
309
, 109766.
10.1016/j.vetpar.2022.109766
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Coghlan, Avril, Padalino, Gilda, O'Boyle, Noel M., Hoffmann, Karl F. and Berriman, Matthew
2022.
Identification of anti-schistosomal, anthelmintic and anti-parasitic compounds curated and text-mined from the scientific literature.
Wellcome Open Research
7
, 193.
10.12688/wellcomeopenres.17987.1
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Hsieh, Michael H., Hulme, Benjamin J., Geyer, Kathrin K., Forde-Thomas, Josephine E., Padalino, Gilda, Phillips, Dylan W., Ittiprasert, Wannaporn, Karinshak, Shannon E., Mann, Victoria H., Chalmers, Iain W., Brindley, Paul J., Hokke, Cornelis H. and Hoffmann, Karl F.
2022.
Schistosoma mansoni α-N-acetylgalactosaminidase (SmNAGAL) regulates coordinated parasite movement and egg production.
PLoS Pathogens
18
(1)
, e1009828.
10.1371/journal.ppat.1009828
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Padalino, Gilda, El-Sakkary, Nelly, Liu, Lawrence J., Liu, Chenxi, Harte, Danielle S.G., Barnes, Rachel E., Sayers, Edward ORCID: https://orcid.org/0000-0002-2621-1119, Forde-Thomas, Josephine, Whiteland, Helen, Bassetto, Marcella, Ferla, Salvatore, Johnson, George, Jones, Arwyn T. ORCID: https://orcid.org/0000-0003-2781-8905, Caffrey, Conor R., Chalmers, Iain, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419 and Hoffmann, Karl F.
2021.
Anti-schistosomal activities of quinoxaline-containing compounds: From hit identification to lead optimisation.
European Journal of Medicinal Chemistry
226
, 113823.
10.1016/j.ejmech.2021.113823
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Dalton, John Pius, Gasan, Thomas A., Kuipers, Marije E., Roberts, Grisial H., Padalino, Gilda, Forde-Thomas, Josephine E., Wilson, Shona, Wawrzyniak, Jakub, Tukahebwa, Edridah M., Hoffmann, Karl F. and Chalmers, Iain W.
2021.
Schistosoma mansoni Larval Extracellular Vesicle protein 1 (SmLEV1) is an immunogenic antigen found in EVs released from pre-acetabular glands of invading cercariae.
PLoS Neglected Tropical Diseases
15
(11)
, e0009981.
10.1371/journal.pntd.0009981
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Padalino, Gilda, Chalmers, Iain W., Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419 and Hoffmann, Karl F.
2020.
Identification of 6-(piperazin-1-yl)-1,3,5-triazine as a chemical scaffold with broad anti-schistosomal activities.
Wellcome Open Research
5
, 169.
10.12688/wellcomeopenres.16069.2
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| Wang, Jipeng, Paz, Carlos, Padalino, Gilda, Coghlan, Avril, Lu, Zhigang, Gradinaru, Irina, Collins, Julie N. R., Berriman, Matthew, Hoffmann, Karl F. and Collins, James J. 2020. Large-scale RNAi screening uncovers therapeutic targets in the parasite Schistosoma mansoni. Science 369 (6511) , pp. 1649-1653. 10.1126/science.abb7699 |
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Padalino, Gilda, Whatley, Kezia C. L., Whiteland, Helen, Geyer, Kathrin K., Hulme, Benjamin J., Chalmers, Iain W., Forde-Thomas, Josephine, Ferla, Salvatore ORCID: https://orcid.org/0000-0002-5918-9237, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419 and Hoffmann, Karl F.
2019.
The repositioning of epigenetic probes/inhibitors identifies new anti-schistosomal lead compounds and chemotherapeutic targets.
PLOS Neglected Tropical Diseases
13
(11)
, e0007693.
10.1371/journal.pntd.0007693
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Padalino, Gilda, Ferla, Salvatore ORCID: https://orcid.org/0000-0002-5918-9237, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419, Chalmers, Iain W. and Hoffmann, Karl F.
2018.
Combining bioinformatics, cheminformatics, functional genomics and whole organism approaches for identifying epigenetic drug targets in Schistosoma mansoni.
International Journal for Parasitology: Drugs and Drug Resistance
8
(3)
, pp. 559-570.
10.1016/j.ijpddr.2018.10.005
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| Hsieh, Michael H., Roquis, David, Taudt, Aaron, Geyer, Kathrin K., Padalino, Gilda, Hoffmann, Karl F., Holroyd, Nancy, Berriman, Matt, Aliaga, Benoît, Chaparro, Cristian, Grunau, Christoph and Augusto, Ronaldo de Carvalho 2018. Histone methylation changes are required for life cycle progression in the human parasite Schistosoma mansoni. PLoS Pathogens 14 (5) 10.1371/journal.ppat.1007066 |
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