Tornillo, Giusy, Warrington, Lauren, Kendrick, Howard, Higgins, Adam T. ORCID: https://orcid.org/0000-0002-2906-8151, Hay, Trevor, Beck, Sam and Smalley, Matthew J. ORCID: https://orcid.org/0000-0001-9540-1146 2024. Conditional in vivo deletion of LYN kinase has little effect on a BRCA1 loss-of-function-associated mammary tumour model. Disease Models and Mechanisms 17 (1) , dmm050211. 10.1242/dmm.050211 |
Ordonez, Liliana, Tornillo, Giusy, Kendrick, Howard, Hay, Trevor and Smalley, Matthew John ORCID: https://orcid.org/0000-0001-9540-1146 2023. NOTCH and AKT signalling interact to drive mammary tumour heterogeneity. Cancers 15 (17) , 4324. 10.3390/cancers15174324 |
Ordonez, Liliana D., Melchor, Lorenzo, Greenow, Kirsty R., Kendrick, Howard, Tornillo, Giusy, Bradford, James, Giles, Peter ORCID: https://orcid.org/0000-0003-3143-6854 and Smalley, Matthew J. ORCID: https://orcid.org/0000-0001-9540-1146 2021. Reproductive history determines ErbB2 locus amplification, WNT signalling and tumour phenotype in a murine breast cancer model. Disease Models and Mechanisms 14 (5) , dmm048736. 10.1242/dmm.048736 |
Pires, Ana, Greenshields Watson, Alexander, Jones, Emma, Smart, Kathryn, Lauder, Sarah N., Somerville, Michelle, Milutinovic, Stefan ORCID: https://orcid.org/0000-0002-3163-3383, Kendrick, Howard, Hindley, James P., French, Rhiannon, Smalley, Matthew J. ORCID: https://orcid.org/0000-0001-9540-1146, Watkins, William John ORCID: https://orcid.org/0000-0003-3262-6588, Andrews, Robert, Godkin, Andrew ORCID: https://orcid.org/0000-0002-1910-7567 and Gallimore, Awen ORCID: https://orcid.org/0000-0001-6675-7004 2020. Immune remodelling of the extracellular matrix drives loss of cancer stem cells and tumor rejection. Cancer Immunology Research 8 (12) , 1520 - 1531. 10.1158/2326-6066.CIR-20-0070 |
Tornillo, Giusy, Knowlson, Catherine, Kendrick, Howard, Cooke, Joe, Mirza, Hasan, Aurrekoetxea-Rodriguez, Iskander, d.M. Vivanco, Maria, Buckley, Niamh E., Grigoriadis, Anita and Smalley, Matthew J. ORCID: https://orcid.org/0000-0001-9540-1146 2018. Dual mechanisms of LYN kinase dysregulation drive aggressive behaviour in breast cancer cells. Cell Reports 25 (13) , pp. 3674-3692. 10.1016/j.celrep.2018.11.103 |
Greenow, Kristy R., Zverev, Matthew, May, Stephanie, Kendrick, Howard, Williams, Geraint T. ORCID: https://orcid.org/0000-0003-3768-9940, Phesse, Toby ORCID: https://orcid.org/0000-0001-9568-4916 and Parry, Lee ORCID: https://orcid.org/0000-0002-4467-9196 2018. Lect2 deficiency is characterised by altered cytokine levels and promotion of intestinal tumourigenesis. Oncotarget 9 (92) , pp. 36430-36443. 10.18632/oncotarget.26335 |
Soady, Kelly J., Tornillo, Giusy, Kendrick, Howard, Meniel, Valerie, Olijnyk-Dallis, Daria, Morris, Joanna S., Stein, Torstein, Gusterson, Barry A., Isacke, Clare M. and Smalley, Matthew J. ORCID: https://orcid.org/0000-0001-9540-1146 2017. Receptor protein tyrosine phosphatase PTPRB negatively regulates FGF2-dependent branching morphogenesis. Development 144 (20) , pp. 3777-3788. 10.1242/dev.149120 |
Iglesias, Juan Manuel, Cairney, Claire J., Ferrier, Roderick K., McDonald, Laura, Soady, Kelly, Kendrick, Howard, Pringle, Marie-Anne, Morgan, Reginald O., Martin, Finian, Smalley, Matthew John ORCID: https://orcid.org/0000-0001-9540-1146, Blyth, Karen and Stein, Torsten 2015. Annexin A8 identifies a subpopulation of transiently quiescent c-Kit positive luminal progenitor cells of the ductal mammary epithelium. Plos One 10 (3) , e0119718. 10.1371/journal.pone.0119718 |
Soady, Kelly J., Kendrick, Howard, Gao, Qiong, Tutt, Andrew, Zvelebil, Marketa, Ordonez, Liliana D., Quist, Jelmar, Tan, David Wei-Min, Isacke, Clare M., Grigoriadis, Anita and Smalley, Matthew J. ORCID: https://orcid.org/0000-0001-9540-1146 2015. Mouse mammary stem cells express prognostic markers for triple-negative breast cancer. Breast Cancer Research 17 , 31. 10.1186/s13058-015-0539-6 |
Melchor, Lorenzo, Molyneux, Gemma, Mackay, Alan, Magnay, Fiona-Ann, Atienza, María, Kendrick, Howard, Nava-Rodrigues, Daniel, López-García, María Ángeles, Milanezi, Fernanda, Greenow, Kirsty, Robertson, David, Palacios, José, Reis-Filho, Jorge S. and Smalley, Matthew J. ORCID: https://orcid.org/0000-0001-9540-1146 2014. Identification of cellular and genetic drivers of breast cancer heterogeneity in genetically engineered mouse tumour models. Journal of Pathology 233 (2) , pp. 124-137. 10.1002/path.4345 |
Cowley, Michael, Garfield, Alastair S., Madon-Simon, Marta, Charalambous, Marika, Clarkson, Richard W. E. ORCID: https://orcid.org/0000-0001-7389-8673, Smalley, Matthew John ORCID: https://orcid.org/0000-0001-9540-1146, Kendrick, Howard, Isles, Anthony Roger ORCID: https://orcid.org/0000-0002-7587-5712, Parry, Aled J., Carney, Sara, Oakey, Rebecca J., Heisler, Lora K., Moorwood, Kim, Wolf, Jason B. and Ward, Andrew 2014. Developmental programming mediated by complementary roles of imprinted Grb10 in mother and pup. PLoS Biology 12 (2) , e1001799. 10.1371/journal.pbio.1001799 |
Regan, Joseph L., Sourisseau, Tony, Soady, Kelly, Kendrick, Howard, McCarthy, Afshan, Tang, Chan, Brennan, Keith, Linardopoulos, Spiros, White, Donald E. and Smalley, Matthew John ORCID: https://orcid.org/0000-0001-9540-1146 2013. Aurora A kinase regulates mammary epithelial cell fate by determining mitotic spindle orientation in a Notch-dependent manner. Cell Reports 4 (1) , pp. 110-123. 10.1016/j.celrep.2013.05.044 |
Zvelebil, Marketa, Oliemuller, Erik, Gao, Qiong, Wansbury, Olivia, Mackay, Alan, Kendrick, Howard, Smalley, Matthew John ORCID: https://orcid.org/0000-0001-9540-1146, Reis-Filho, Jorge S. and Howard, Beatrice A. 2013. Embryonic mammary signature subsets are activated in Brca1-/- and basal-like breast cancers. Breast Cancer Research 15 (2) , R25. 10.1186/bcr3403 |
Hopkins, S., Linderoth, E., Hantschel, O., Suarez-Henriques, P., Pilia, G., Kendrick, Howard, Smalley, Matthew John ORCID: https://orcid.org/0000-0001-9540-1146, Superti-Furga, G. and Ferby, I. 2012. Mig6 is a sensor of EGF receptor inactivation that directly activates c-Abl to induce apoptosis during epithelial homeostasis. Developmental Cell 23 (3) , pp. 547-559. 10.1016/j.devcel.2012.08.001 |
Smalley, Matthew John ORCID: https://orcid.org/0000-0001-9540-1146, Kendrick, Howard, Sheridan, Julie M., Regan, Joseph L., Prater, Michael D., Lindeman, Geoffrey J., Watson, Christine J., Visvader, Jane E. and Stingl, John 2012. Isolation of mouse mammary epithelial subpopulations: a comparison of leading methods. Journal of Mammary Gland Biology and Neoplasia 17 (2) , pp. 91-97. 10.1007/s10911-012-9257-1 |
Regan, J. L., Kendrick, Howard, Magnay, F.-A., Vafaizadeh, V., Groner, B. and Smalley, Matthew ORCID: https://orcid.org/0000-0001-9540-1146 2012. c-Kit is required for growth and survival of the cells of origin of Brca1-mutation-associated breast cancer. Oncogene 31 (7) , pp. 869-883. 10.1038/onc.2011.289 |
Wansbury, Olivia, Mackay, Alan, Kogata, Naoko, Mitsopoulos, Costas, Kendrick, Howard, Davidson, Kathryn, Ruhrberg, Christiana, Reis- Filho, Jorge, Smalley, Matthew John ORCID: https://orcid.org/0000-0001-9540-1146, Zvelebil, Marketa and Howard, Beatrice 2011. Transcriptome analysis of embryonic mammary cells reveals insights into mammary lineage establishment. Breast Cancer Research 13 (4) , R79. 10.1186/bcr2928 |
Molyneux, Gemma, Geyer, Felipe, Magnay, Fiona-Ann, McCarthy, Afshan, Kendrick, Howard, Natrajan, Rachael, MacKay, Alan, Grigoriadis, Anita, Tutt, Andrew, Ashworth, Alan, Reis-Filho, Jorge and Smalley, Matthew John ORCID: https://orcid.org/0000-0001-9540-1146 2010. BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells. Cell Stem Cell 7 (3) , pp. 403-417. 10.1016/j.stem.2010.07.010 |
Grigoriadis, Anita, Oliver, Gavin, Tanney, Austin, Kendrick, Howard, Smalley, Matthew John ORCID: https://orcid.org/0000-0001-9540-1146, Jat, Parmjit and Neville, A. Munro 2009. Identification of differentially expressed sense and antisense transcript pairs in breast epithelial tissues. BMC Genomics 10 (1) , 324. 10.1186/1471-2164-10-324 |
Huser, C. A., Pringle, M. A., Heath, V. J., Bell, A. K., Kendrick, Howard, Smalley, Matthew John ORCID: https://orcid.org/0000-0001-9540-1146, Crighton, D., Ryan, K. M., Gusterson, B. A. and Stein, T. 2009. TSC-22D1 isoforms have opposing roles in mammary epithelial cell survival. Cell Death and Differentiation 17 (2) , pp. 304-315. 10.1038/cdd.2009.126 |
Britt, Kara L., Kendrick, Howard, Regan, Joseph L., Molyneux, Gemma, Magnay, Fiona-Ann, Ashworth, Alan and Smalley, Matthew John ORCID: https://orcid.org/0000-0001-9540-1146 2009. Pregnancy in the mature adult mouse does not alter the proportion of mammary epithelial stem/progenitor cells. Breast Cancer Research 11 (2) , R20. 10.1186/bcr2245 |
Kendrick, Howard, Regan, Joseph, Magnay, Fiona-Ann, Grigoriadis, Anita, Mitsopoulos, Costas, Zvelebil, Marketa and Smalley, Matthew John ORCID: https://orcid.org/0000-0001-9540-1146 2008. Transcriptome analysis of mammary epithelial subpopulations identifies novel determinants of lineage commitment and cell fate. BMC Genomics 9 (1) , 591. 10.1186/1471-2164-9-591 |
Smalley, Matthew John ORCID: https://orcid.org/0000-0001-9540-1146, Iravani, M., Leao, M., Grigoriadis, A., Kendrick, Howard, Dexter, T., Fenwick, K., Regan, J. L., Britt, K., McDonald, S., Lord, C. J., Mackay, A. and Ashworth, A. 2007. Regulator of G-protein signalling 2 (RGS2) mRNA is differentially expressed in mammary epithelial subpopulations and overexpressed in the majority of breast cancers. Breast Cancer Research 9 (6) , R85. 10.1186/bcr1834 |
Sleeman, Katherine E., Kendrick, Howard, Ashworth, Alan, Isacke, Clare M. and Smalley, Matthew John ORCID: https://orcid.org/0000-0001-9540-1146 2006. CD24 staining of mouse mammary gland cells defines luminal epithelial, myoepithelial/basal and non-epithelial cells. Breast Cancer Research 8 (R7) 10.1186/bcr1371 |