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Number of items: 110.

Yu, Zanzhe, Lambie, Mark, Chess, James, Williams, Andrew, Do, Jun-Young, Topley, Nicholas and Davies, Simon J. 2019. Peritoneal protein clearance is a function of local inflammation and membrane area whereas systemic inflammation and comorbidity predict survival of incident peritoneal dialysis patients. Frontiers in Physiology 10 , 105. 10.3389/fphys.2019.00105
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Elphick, Emma H., Teece, Lucy, Chess, James A., Do, Jun-Young, Kim, Yong-Lim, Lee, H. Bahl, Davison, Sara N., Topley, Nicholas, Davies, Simon J. and Lambie, Mark 2018. Biocompatible solutions and long-term changes in peritoneal solute transport. Clinical Journal of the American Society of Nephrology , CJN.02380218. 10.2215/CJN.02380218

Raby, Anne-Catherine, González-Mateo, Guadalupe T., Williams, Aled, Topley, Nicholas, Fraser, Donald, López-Cabrera, Manuel and Labeta, Mario 2018. Targeting toll-like receptors with soluble toll-like receptor 2 prevents peritoneal dialysis solution-induced fibrosis. Kidney International 94 (2) , pp. 346-362. 10.1016/j.kint.2018.03.014
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Chakera, A., Mulroney, K.T., Shak, H.J., McGuire, A.L., Eberl, Matthias and Topley, Nicholas 2018. Peritonitis in Peritoneal Dialysis patients: the case for rapid diagnosis, targeted treatment and monitoring to improve outcomes. European Medical Journal Nephrology 6 , pp. 56-64.
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Aufricht, Christoph, Beelen, Robert, Eberl, Matthias, Fischbach, Michel, Fraser, Donald, Jörres, Achim, Kratochwill, Klaus, LópezCabrera, Manuel, Rutherford, Peter, Schmitt, Claus-Peter, Topley, Nicholas and Witowski, Janusz 2017. Biomarker research to improve clinical outcomes of peritoneal dialysis: consensus of the European Training and Research in Peritoneal Dialysis (EuTRiPD) network. Kidney International 92 (4) , pp. 824-835. 10.1016/j.kint.2017.02.037
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Zavvos, Vasileios, Buxton, Anthony T., Evans, Caroline, Lambie, Mark, Davies, Simon J., Topley, Nicholas, Wilkie, Martin, Summers, Angela, Brenchley, Paul, Goumenos, Dimitrios S. and Johnson, Timothy S. 2017. A prospective, proteomics study identified potential biomarkers of encapsulating peritoneal sclerosis in peritoneal effluent. Kidney International 92 (4) , pp. 988-1002. 10.1016/j.kint.2017.03.030
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Liao, Chia-Te, Andrews, Robert, Wallace, Leah, Khan, Mohd, Kift-Morgan, Ann, Topley, Nicholas, Fraser, Donald and Taylor, Philip Rosser 2017. Peritoneal macrophage heterogeneity is associated with different peritoneal dialysis outcomes. Kidney International 91 (5) , pp. 1088-1103. 10.1016/j.kint.2016.10.030
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Catar, Rusan, Witowski, Janusz, Zhu, Nan, Lücht, Christian, Derrac Soria, Alicia, Uceda Fernandez, Javier, Chen, Lei, Jones, Simon, Fielding, Ceri A., Rudolf, Andras, Topley, Nicholas, Dragun, Duska and Jörres, Achim 2017. IL-6 trans-signaling links inflammation with angiogenesis in the peritoneal membrane. Journal of the American Society of Nephrology 28 (4) , pp. 1188-1199. 10.1681/ASN.2015101169
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Raby, Anne-Catherine, Colmont, Chantal, Kift-Morgan, Ann, Köhl, Jörg, Eberl, Matthias, Fraser, Donald, Topley, Nicholas and Labeta, Mario 2017. Toll-like receptors 2 and 4 are potential therapeutic targets in peritoneal dialysis-associated fibrosis. Journal of the American Society of Nephrology 28 (2) , pp. 461-478. 10.1681/ASN.2015080923
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Liuzzi, Anna Rita, Kift-Morgan, Ann, Lopez-Anton, Melisa, Friberg, Ida M., Zhang, Jingjing, Brook, Amy C., Roberts, Gareth W., Donovan, Kieron L., Colmont, Chantal S., Toleman, Mark A., Bowen, Timothy, Johnson, David W., Topley, Nicholas, Moser, Bernhard, Fraser, Donald J. and Eberl, Matthias 2016. Unconventional human T cells accumulate at the site of infection in response to microbial ligands and induce local tissue remodeling. Journal of Immunology 197 (6) , pp. 2195-2207. 10.4049/jimmunol.1600990
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Liao, Chia-Te, Rosas, Marcela, Davies, Luke, Giles, Peter, Tyrrell, Victoria, O'Donnell, Valerie, Topley, Nicholas, Humphreys, Ian, Fraser, Donald, Jones, Simon and Taylor, Philip 2016. IL-10 differentially controls the infiltration of inflammatory macrophages and antigen-presenting cells during inflammation. European Journal of Immunology 46 (9) , pp. 2222-2232. 10.1002/eji.201646528
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Guerrero-Romero, Fernando, Lambie, Mark, Chess, James, Do, Jun-Young, Noh, Hyunjin, Lee, Hi-Bahl, Kim, Yong-Lim, Summers, Angela, Williams, Paul Ford, Davison, Sara, Dorval, Marc, Topley, Nicholas and Davies, Simon John 2016. Peritoneal dialysate glucose load and systemic glucose metabolism in non-diabetics: results from the GLOBAL fluid cohort study. PLoS ONE 11 (6) , e0155564. 10.1371/journal.pone.0155564

Lambie, Mark R., Chess, James, Summers, Angela M., Williams, Paul Ford, Topley, Nicholas and Davies, Simon J. 2016. Peritoneal inflammation precedes encapsulating peritoneal sclerosis: results from the GLOBAL fluid study. Nephrology Dialysis Transplantation 31 (3) , pp. 480-486. 10.1093/ndt/gfv440

Cho, Y., Johnson, D. W., Vesey, D. A., Hawley, C. M., Pascoe, E. M., Clarke, M. and Topley, Nicholas 2016. Higher dialysate matrix metalloproteinase-2 levels are associated with peritoneal membrane dysfunction. Peritoneal Dialysis International 36 (1) , pp. 16-25. 10.3747/pdi.2013.00274

Sanders, Andrew James, Owen, S., Topley, Nicholas, Kift-Morgan, Ann Patricia and Jiang, Wen Guo 2015. Implication of IL-7 in mesothelial paracellular resistance, migration and interaction with colorectal cancer cells [Abstract]. European Journal of Cancer 51 (S3) , S23-S24. 10.1016/S0959-8049(16)30079-X

Ji, K., Jia, Y., Gao, Y., Wei, C., Wu, Y., Topley, Nicholas, Kift-Morgan, Ann Patricia, Ji, J. and Jiang, Wen Guo 2015. The biological and in vivo impact of Yangzheng Xiaoji extract on the interaction between tumour and peritoneal mesothelial cells and peritoneal metastases of gastrointestinal tumours. European Journal of Cancer 51 , S462-S462.

Liao, Chia-Te, Fraser, Donald, Topley, Nicholas and Taylor, Philip 2015. Deciphering the peritoneal mononuclear phagocyte system in mice: Steady state and inflammation [Poster abstract]. Nephrology Dialysis Transplantation 30 (iii) , iii265. 10.1093/ndt/gfv180.25

Liao, Chia-Te, Fraser, Donald J., Topley, Nicholas and Taylor, Philip Russel 2015. Determining the identity and functional specialization of peritoneal mononuclear phagocytes in peritoneal dialysis patients. Nephrology Dialysis Transplantation 30 (S3) , iii264. 10.1093/ndt/gfv180.21

Jenkins, Robert, Liao, Chia-Te, Wallace, Leah, Bowen, Timothy, Topley, Nicholas, Taylor, Philip and Fraser, Donald 2015. Microrna regulation of macrophage phenotype in peritoneal fibrosis. Nephrology Dialysis Transplantation 30 (iii262) 10.1093/ndt/gfv180.15

Cho, Y., Johnson, D. W., Vesey, D. A., Hawley, C. M., Clarke, M. and Topley, Nicholas 2015. Utility of urinary biomarkers in predicting loss of residual renal function: the balANZ trial. Peritoneal Dialysis International 35 (2) , pp. 159-171. 10.3747/pdi.2013.00170

Cho, Y., Johnson, D. W., Vesey, D. A., Hawley, C. M., Pascoe, E. M., Clarke, M. and Topley, Nicholas 2015. Baseline serum interleukin-6 predicts cardiovascular events in incident peritoneal dialysis patients. Peritoneal Dialysis International 35 (1) , pp. 35-42. 10.3747/pdi.2013.00272

Eberl, Matthias, Friberg, Ida M., Liuzzi, Anna Rita, Morgan, Matthew and Topley, Nicholas 2014. Pathogen-specific immune fingerprints during acute infection: The diagnostic potential of human γδ T-cells. Frontiers in Immunology 5 , 572. 10.3389/fimmu.2014.00572
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Yehia, Maha, Muyoma, Grace, Topley, Nicholas and Collins, John F. 2014. The use of exchange-free periods alternating with daily exchanges of icodextrin in the initial treatment of peritoneal dialysis-associated peritonitis: a safety study. Peritoneal Dialysis International 34 (7) , pp. 810-813. 10.3747/pdi.2012.00347

Jiang, Wen G., Jia, Yongning, Ye, Lin, Ji, Ke, Gao, Yong, Wei, Cong, Wu, Yiling, Topley, Nicholas, Kift-Morgan, Ann Patricia and Ji, Jiafu 2014. The anti-peritoneal metastasis properties of Yangzheng Xiaoji, the potential role of hyaluronan and CD44 [Abstract]. Cancer Research 74 (19) , p. 4034. 10.1158/1538-7445.AM2014-4034

Fielding, Ceri A., Jones, Gareth Wyn, McLoughlin, Rachel Mary, McLeod, Louise, Hammond, Victoria J., Uceda, Javier, Williams, Anwen Sian, Lambie, Mark, Foster, Thomas L., Liao, Chia-Te, Rice, Christopher M., Greenhill, Claire J., Colmont, Chantal Sophie, Hams, Emily, Coles, Barbara, Kift-Morgan, Ann, Newton, Zarabeth, Craig, Katherine J., Williams, John David, Williams, Geraint Trefor, Davies, Simon J., Humphreys, Ian R., O'Donnell, Valerie Bridget, Taylor, Philip Russel, Jenkins, Brendan J., Topley, Nicholas and Jones, Simon Arnett 2014. Interleukin-6 signaling drives fibrosis in unresolved inflammation. Immunity 40 (1) , pp. 40-50. 10.1016/j.immuni.2013.10.022
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Cho, Yeoungjee, Johnson, David W., Vesey, David A., Hawley, Carmel M., Pascoe, Elaine M., Clarke, Margaret and Topley, Nicholas 2014. Dialysate interleukin-6 predicts increasing peritoneal solute transport rate in incident peritoneal dialysis patients. BMC Nephrology 15 (1) , 8. 10.1186/1471-2369-15-8
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Eberl, Matthias and Topley, Nicholas 2013. Pathogen-specific local immune fingerprints in acute disease: towards point-of-care diagnosis of bacterial infection [Abstract]. Immunology 140 , pp. 102-103.

Lin, Chan-Yu, Roberts, Gareth Wyn, Kift-Morgan, Ann Patricia, Donovan, Kieron, Topley, Nicholas and Eberl, Matthias 2013. Pathogen-specific local immune fingerprints diagnose bacterial infection in peritoneal dialysis patients. Journal of the American Society of Nephrology 24 (12) , pp. 2002-2009. 10.1681/ASN.2013040332

Lambie, Mark, Chess, James Anthony, Donovan, Kieron, Kim, Yong Lim, Do, Jun Young, Lee, Hi Bahl, Noh, Hyunjin, Williams, Paul F., Williams, Andrew J., Davison, Sara, Dorval, Marc, Summers, Angela, Williams, John David, Bankart, John, Davies, Simon J. and Topley, Nicholas 2013. Independent effects of systemic and peritoneal inflammation on peritoneal dialysis survival. Journal of the American Society of Nephrology 24 (12) , pp. 2071-2080. 10.1681/ASN.2013030314

Fielding, Ceri Alan, Jones, Gareth Wyn, Taylor, Philip Russel, Jenkins, Brendan J., Topley, Nicholas and Jones, Simon Arnett 2013. IL-6 regulation of Th1 responses drives fibrosis in unresolved inflammation [Abstract]. Cytokine 63 (3) , p. 262. 10.1016/j.cyto.2013.06.082

Lin, Chan-Yu, Kift-Morgan, Ann Patricia, Moser, Bernhard, Topley, Nicholas and Eberl, Matthias 2013. Suppression of pro-inflammatory T-cell responses by human mesothelial cells. Nephrology Dialysis Transplantation 28 (7) , pp. 1743-1750. 10.1093/ndt/gfs612

Raby, Anne-Catherine, Holst, Benjamin, Le Bouder, Emmanuel Jerome, Diaz, Constantinou, Ferran, Edgardo, Conraux, Laurence, Guillemot, Jean-Claude, Coles, Barbara, Kift-Morgan, Ann Patricia, Colmont, Chantal Sophie, Szakmany, Tamas, Ferrara, Pascual, Hall, Judith Elizabeth, Topley, Nicholas and Labeta, Mario Oscar 2013. Targeting the TLR co-receptor CD14 with TLR2-derived peptides modulates immune responses to pathogens. Science Translational Medicine 5 (185) , 185ra64. 10.1126/scitranslmed.3005544

Bodenham, Tanya, Topley, Nicholas and Fraser, Donald James 2012. Peritoneal fibrosis is mouse strain dependent. Nephrology Dialysis Transplantation 28 (8) , pp. 1966-1969. 10.1093/ndt/gfs446

Aufricht, Christoph, Neuhofer, Wolfgang, Topley, Nicholas and Wörnle, Markus 2012. Peritoneal infection and inflammation. Mediators of Inflammation 2012 10.1155/2012/456985
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Opatrna, S., Lysak, D., Trefil, L., Parker, Clare Rhian and Topley, Nicholas 2012. Intraperitoneal IL-6 Signaling in Incident Patients Treated with Icodextrin and Glucose Bicarbonate/Lactate-Based Peritoneal Dialysis Solutions. Peritoneal Dialysis International 32 (1) , pp. 37-44. 10.3747/pdi.2010.00235

Dunn, Warwick B., Summers, Angela, Brown, Marie, Goodacre, Royston, Lambie, Mark, Johnson, Tim, Wilkie, Martin, Davies, Simon, Topley, Nicholas and Brenchley, Paul 2012. Proof-of-principle study to detect metabolic changes in peritoneal dialysis effluent in patients who develop encapsulating peritoneal sclerosis. Nephrology Dialysis Transplantation 27 (6) , pp. 2502-2510. 10.1093/ndt/gfr662

Colmont, Chantal Sophie, Raby, Anne-Catherine, Dioszeghy, Vincent, Le Bouder, Emmanuel, Foster, Thomas Lloyd, Jones, Simon Arnett, Labeta, Mario Oscar, Fielding, Ceri Alan and Topley, Nicholas 2011. Human peritoneal mesothelial cells respond to bacterial ligands through a specific subset of Toll-like receptors. Nephrology Dialysis Transplantation 26 (12) , pp. 4079-4090. 10.1093/ndt/gfr217

Davey, Martin S., Lin, Chan-Yu, Roberts, Gareth W., Heuston, Sinead, Brown, Amanda C., Chess, James A., Toleman, Mark A., Gahan, Cormac G. M., Hill, Colin, Parish, Tanya, Williams, John D., Davies, Simon J., Johnson, David W., Topley, Nicholas, Moser, Bernhard and Eberl, Matthias 2011. Human neutrophil clearance of bacterial pathogens triggers anti-microbial gamma delta T cell responses in early infection. Plos Pathogens 7 (5) , pp. 9-10. 10.1371/journal.ppat.1002040
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Davey, Martin S., Lin, Chan-Yu, Roberts, Gareth W., Heuston, S., Brown, A. C., Chess, James Anthony, Toleman, Mark Alexander Howard, Gahan, C. G. M., Hill, C., Parish, T., Williams, John David, Davies, S. J., Johnson, D. W., Topley, Nicholas, Moser, Bernhard and Eberl, Matthias 2011. Human neutrophil clearance of bacterial pathogens triggers anti-microbial γδ T cell responses in early infection. Plos Pathogens 7 (5) , e1002040. 10.1371/journal.ppat.1002040
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Jones, Gareth Wyn, Stumhofer, Jason S., Foster, Tom, Twohig, Jason Peter, Hertzog, Paul, Topley, Nicholas, Williams, Anwen Sian, Hunter, Christopher A., Jenkins, Brendan J., Wang, Edward Chung Yern and Jones, Simon Arnett 2011. Naive and activated T cells display differential responsiveness to TL1A that affects Th17 generation, maintenance, and proliferation. The FASEB Journal 25 (1) , pp. 409-419. 10.1096/fj.10-166843

Raby, Anne-Catherine, Holst, Benjamin, Davies, James Anthony, Colmont, Chantal Sophie, Laumonnier, Yves, Coles, Barbara, Shah, Sanjoy, Hall, Judith Elizabeth, Topley, Nicholas, Köhl, Jörg, Morgan, Bryan Paul and Labeta, Mario Oscar 2011. TLR activation enhances C5a-induced pro-inflammatory responses by negatively modulating the second C5a receptor, C5L2. European Journal of Immunology 41 (9) , pp. 2741-2752. 10.1002/eji.201041350
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Clark, Stephen Robert, Guy, Christopher J., Scurr, Martin J., Taylor, Philip Russel, Kift-Morgan, Ann Patricia, Hammond, Victoria Jayne, Thomas, Christopher P., Coles, Barbara, Roberts, Gareth Wyn, Eberl, Matthias, Jones, Simon Arnett, Topley, Nicholas, Kotecha, Sailesh and O'Donnell, Valerie Bridget 2011. Esterified eicosanoids are acutely generated by 5-lipoxygenase in primary human neutrophils and in human and murine infection. Blood 117 (6) , pp. 2033-2043. 10.1182/blood-2010-04-278887

McLoughlin, Rachel Mary and Topley, Nicholas 2011. Switching on EMT in the peritoneal membrane: considering the evidence. Nephrology Dialysis Transplantation 26 (1) , pp. 12-15. 10.1093/ndt/gfq699

Lin, Chan-Yu, Roberts, Gareth W., Davey, Martin S., Chess, James Anthony, Fielding, Ceri Alan, Williams, John David, Davies, S. J., Johnson, D. W., Moser, Bernhard, Topley, Nicholas and Eberl, Matthias 2010. The HMB-PP producing capacity of the causative pathogen and local gamma delta T cell numbers predict clinical outcome from bacterial peritonitis. Immunology 131 , pp. 81-82.

Jones, Gareth Wyn, Stumhofer, J. S., Foster, T., Twohig, Jason Peter, Hertzog, P., Topley, Nicholas, Williams, Anwen Sian, Hunter, Catherine, Jenkins, Brian J., Jones, Simon Arnett and Wang, Edward Chung Yern 2010. Differential responsiveness of naive and activated T cells to TL1A that affect Th17 generation, maintenance and proliferation [Abstract]. Immunology 131 (s1) , p. 102. 10.1111/j.1365-2567.2010.03390.x

Coles, Barbara, Colmont, Chantal Sophie, Fielding, Ceri Alan, Kift-Morgan, Ann, Hams, Emily, Topley, Nicholas and Jones, Simon Arnett 2010. Local manipulation of IL-6 trans-signaling therapeutically enhances anti-microbial host defense [Abstract]. Cytokine 52 (1-2) , pp. 80-81. 10.1016/j.cyto.2010.07.335

Devuyst, Olivier, Margetts, Peter J. and Topley, Nicholas 2010. The pathophysiology of the peritoneal membrane. Journal of the American Society of Nephrology 21 (7) , pp. 1077-1085. 10.1681/ASN.2009070694

Jones, Gareth Wyn, McLoughlin, Rachel Mary, Hammond, Victoria Jayne, Parker, Clare Rhian, Williams, John, Malhotra, Raj, Scheller, Jurgen, Williams, Anwen, Rose-John, Stefan, Topley, Nicholas and Jones, Simon Arnett 2010. Loss of CD4+ T Cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells. The Journal of Immunology 184 (4) , pp. 2130-2139. 10.4049/jimmunol.0901528

Jones, Gareth Wyn, McLoughlin, R. M., Hammond, Victoria Jayne, Parker, Clare R., Williams, John D., Malhotra, R., Scheller, J., Williams, Anwen Sian, Rose-John, Stefan, Topley, Nicholas and Jones, Simon Arnett 2010. Loss of CD4(+) T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells. Journal of Immunology 184 (4) , pp. 2130-2139.

Page, Charlotte E., Smale, Shaun, Carty, Sara Madelaine, Amos, Nick, Lauder, Sarah Nicol, Goodfellow, Rhian Mair, Richards, Peter James, Jones, Simon Arnett, Topley, Nicholas and Williams, Anwen Sian 2010. Interferon-γ inhibits interleukin-1β-induced matrix metalloproteinase production by synovial fibroblasts and protects articular cartilage in early arthritis. Arthritis Research & Therapy 12 (2) , R49. 10.1186/ar2960

Page, Charlotte E., Smale, Shaun, Carty, Sara Madelaine, Amos, Nick, Lauder, Sarah Nicol, Goodfellow, Rhian Mair, Richards, Peter J., Jones, Simon Arnett, Topley, Nicholas and Williams, Anwen Sian 2010. Interferon-gamma inhibits interleukin-1 beta-induced matrix metalloproteinase production by synovial fibroblasts and protects articular cartilage in early arthritis. Arthritis Research and Therapy 12 (2) , R49.
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Ni, Jie, McLoughlin, Rachel Mary, Brodovitch, Alexandre, Moulin, Pierre, Brouckaert, Peter, Casadei, Barbara, Feron, Oliveer, Topley, Nicholas, Balligand, Jean-Luc and Devuyst, Olivier 2010. Nitric oxide synthase isoforms play distinct roles during acute peritonitis. Nephrology Dialysis Transplantation 25 (1) , pp. 86-96. 10.1093/ndt/gfp415

Pletinck, Anneleen, Consoli, Claudia, Van Landschoot, Maria, Steppan, Sonja, Topley, Nicholas, Passlick-Deetjen, Jutta, Vanholder, Raymond and Van Biesen, Wim 2010. Salt intake induces epithelial-to-mesenchymal transition of the peritoneal membrane in rats. Nephrology Dialysis Transplantation 25 (5) , pp. 1688-1696. 10.1093/ndt/gfq036

Brewis, Ian Andrew and Topley, Nicholas 2010. Proteomics and peritoneal dialysis: early days but clear potential. Nephrology Dialysis Transplantation 25 (6) , pp. 1749-1753. 10.1093/ndt/gfq145

Opatrná, Sylvie, Lysák, Daniel, Trefil, Ladislav, Parker, Clare Rhian and Topley, Nicholas 2010. Intraperitoneal IL-6 system in icodextrin (I) and glucose (G) peritoneal dialysis (PD) solution [Abstract]. Kidney and Blood Pressure Research 33 (4) , p. 321. 10.1159/000319050

Cash, Hannes, Relle, Manfred, Menke, Julia, Brochhausen, Christoph, Jones, Simon Arnett, Topley, Nicholas, Galle, Peter R. and Schwarting, Andreas 2009. Interleukin 6 (IL-6) deficiency delays lupus nephritis in MRL-faslpr mice: the IL-6 pathway as a new therapeutic target in treatment of autoimmune kidney disease in systemic lupus erythematosus. The Journal of Rheumatology 37 (1) , pp. 60-70. 10.3899/jrheum.090194

Roberts, Gareth W., Baird, Duncan Martin, Gallagher, Kathleen M. E., Robinson, Rhiannon Elizabeth, Pepper, Christopher John, Williams, John David and Topley, Nicholas 2009. Functional effector memory T cells enrich the peritoneal cavity of patients treated with peritoneal dialysis. Journal of the American Society of Nephrology 20 (9) , pp. 1895-1900. 10.1681/ASN.2008101127

Eberl, Matthias, Roberts, Gareth Wyn, Meuter, Simone, Williams, John David, Topley, Nicholas and Moser, Bernhard 2009. A rapid crosstalk of human gamma delta T cells and monocytes drives the acute inflammation in bacterial infections. Plos Pathogens 5 (2) , p. 6. 10.1371/journal.ppat.1000308
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Nowell, Mari Ann, Williams, Anwen Sian, Carty, Sara Madelaine, Scheller, Jurgen, Hayes, Anthony Joseph, Jones, Gareth Wyn, Richards, Peter James, Slinn, Simon James, Ernst, Matthias, Jenkins, Brendan J., Topley, Nicholas, Rose-John, Stephen and Jones, Simon Arnett 2009. Therapeutic targeting of IL-6 trans signaling counteracts STAT3 control of experimental inflammatory arthritis. Journal of Immunology 182 (1) , pp. 613-622.

Morgan, Alwena Haf, Dioszeghy, Vincent, Maskrey, Benjamin, Thomas, Christopher P., Clark, Stephen Robert, Mathie, Sara A., Lloyd, Clare M., Kuhn, Hartmut, Topley, Nicholas, Coles, Barbara, Taylor, Philip Russel, Jones, Simon Arnett and O'Donnell, Valerie Bridget 2009. Phosphatidylethanolamine-esterified eicosanoids in the mouse: tissue localization and inflammation-dependent formation in Th-2 disease. Journal of Biological Chemistry 284 (32) , pp. 21185-21191. 10.1074/jbc.M109.021634

Fraser, Donald James and Topley, Nicholas 2009. Altering peritoneal membrane function: removing the GAG? Nephrology Dialysis Transplantation 24 (11) , pp. 3271-3273. 10.1093/ndt/gfp440

Raby, Anne-Catherine, Le Bouder, Emmanuel, Colmont, Chantal Sophie, Davies, James Anthony, Richards, Peter, Coles, Barbara, George, Christopher H., Jones, Simon Arnett, Brennan, Paul, Topley, Nicholas and Labeta, Mario Oscar 2009. Soluble TLR2 reduces inflammation without compromising bacterial clearance by disrupting TLR2 triggering. The Journal of Immunology 183 (1) , pp. 506-517. 10.4049/jimmunol.0802909

Eberl, Matthias, Roberts, Gareth Wyn, Meuter, Simone, Williams, John David, Topley, Nicholas and Moser, Bernhard 2008. Rapid differentiation of monocytes into inflammatory DCs through crosstalk with activated human T cells. Immunology 125 , p. 6.

Jones, Gareth Wyn, Stumhofer, J. S., Newton, Zarabeth, Gallimore, Awen Myfanwy, Ernst, M., Topley, Nicholas, Williams, Anwen Sian, Hunter, Catherine, Jenkins, Brian J., Wang, Edward Chung Yern and Jones, Simon Arnett 2008. TL1A/TNFSF15 promotes a STAT1-mediated suppression of IL-17-secreting T-helper cells [Abstract]. Immunology 125 (s1) , p. 62. 10.1111/j.1365-2567.2008.02974.x

Jenkins, Brendan J., Nadjovska, Meri, Greenhill, Claire, McLeod, Louise, Tye, Hazel, Kennedy, Catherine, Fielding, Ceri Alan, Topley, Nicholas, Jones, Simon Arnett, Ernst, Matthias and Hertzog, Paul J. 2008. Differential roles of IL-6 and IL-11 in inflammation and tumorigenesis [Abstract]. Cytokine 43 (3) , p. 243. 10.1016/j.cyto.2008.07.069

Hams, Emily, Colmont, Chantal Sophie, Dioszeghy, Vincent, Hammond, Victoria Jayne, Fielding, Ceri Alan, Williams, Anwen Sian, Tanaka, Minoru, Miyajima, Atsushi, Taylor, Philip Russel, Topley, Nicholas and Jones, Simon Arnett 2008. Oncostatin M receptor-β signaling limits monocytic cell recruitment in acute inflammation. Journal of Immunology 181 (3) , pp. 2174-2180.

Fielding, Ceri Alan, McLoughlin, Rachel Mary, McLeod, Louise, Colmont, Chantal Sophie, Najdovska, Meri, Grail, Dianne, Ernst, Matthias, Jones, Simon Arnett, Topley, Nicholas and Jenkins, Brendan J. 2008. IL-6 regulates neutrophil trafficking during acute inflammation via STAT3. Journal of Immunology 181 (3) , pp. 2189-2195.

Hams, Emily, Colmont, Chantal S., Dioszeghy, Vincent, Hammond, Victoria Jayne, Fielding, Ceri Alan, Williams, Anwen Sian, Tanaka, Minoru, Miyajima, Atsushi, Taylor, Philip Russel, Topley, Nicholas and Jones, Simon Arnett 2008. Oncostatin M receptor-beta signaling limits monocytic cell recruitment in acute inflammation. Journal of Immunology 181 (3) , pp. 2174-2180.

Jones, Gareth Wyn, Newton, Zarabeth, Nowell, Mari Ann, Jenkins, B. J., Ernst, M., Topley, Nicholas, Williams, Anwen Sian, Wang, Edward Chung Yern and Jones, Simon Arnett 2008. TL1A negatively regulates development of T helper 17 cells [Abstract]. Rheumatology 47 (S2) , II20-II20. 10.1093/rheumatology/kem509

Page, Charlotte E., Smale, Shaun, Lauder, Sarah Nicol, Carty, Sara Madelaine, Goodfellow, Rhian Mair, Jones, Simon Arnett, Topley, Nicholas and Williams, Anwen Sian 2008. Ifn gamma protects articular cartilage against IL-1 induced tissue injury in arthritis. C Page, S Smale, S Lauder, S Carty, R Goodfellow, S Jones, N Topley & A Williams. School of medicine, Cardiff University, Cardiff, CF14 4XN [Poster Abstract]. Rhuematology 47 (s2) , II177-II177. 10.1093/rheumatology/kem534

Dioszeghy, Vincent, Rosas, Marcela, Maskrey, Benjamin H., Colmont, Chantal Sophie, Topley, Nicholas, Chaitidis, Pavlos, Kühn, Hartmut, Jones, Simon Arnett, Taylor, Philip Russel and O'Donnell, Valerie Bridget 2008. 12/15-lipoxygenase regulates the inflammatory response to bacterial products in vivo. The Journal of Immunology 181 (9) , pp. 6514-6524.

Fielding, Ceri Alan and Topley, Nicholas 2008. Piece by piece: solving the puzzle of peritoneal fibrosis [Commentary]. Peritoneal Dialysis International 28 (5) , pp. 477-479.

Harris, Dean Anthony and Topley, Nicholas 2008. Peritoneal adhesions. British Journal of Surgery 95 (3) , pp. 271-272. 10.1002/bjs.6143

Harris, Dean Anthony and Topley, Nicholas 2008. Authors' reply: Peritoneal adhesions (Br J Surg 2008; 95: 271–272). British Journal of Surgery 95 (8) , p. 1072. 10.1002/bjs.6343

Opatrná, Sylvie, Lysák, Daniel, Klaboch, D., Parker, Clare Rhian, Šefrna, F. and Topley, Nicholas 2008. IL-6 signalling in chronic kidney disease (CKD) and peritoneal dialysis (PD) patients [Abstract]. Kidney and Blood Pressure Research 31 (6) , p. 385. 10.1159/000176536

Jones, Gareth Wyn, Newton, Zarabeth, Jenkins, B. J., Ernst, M., Topley, Nicholas, Williams, Anwen Sian, Wang, Edward Chung Yern and Jones, Simon Arnett 2007. TL1A counteracts the IL-6 control of the STAT3-mediated development of T helper 17 cells [Abstract]. Cytokine 39 (1) , pp. 18-19.

Hams, Emily, Dioszechy, Vincent, Colmont, Chantal Sophie, Hammond, Victoria Jayne, Fielding, Ceri Alan, Williams, Anwen Sian, Tanaka, Minoru, Miyajima, Atsushi, Taylor, Philip Russel, Topley, Nicholas and Jones, Simon Arnett 2007. Oncostatin M receptor signalling regulates monocytic cell trafficking during acute inflammation [Abstract]. Cytokine 39 (1) , p. 14. 10.1016/j.cyto.2007.07.053

Williams, Anwen Sian, Richards, Peter James, Thomas, Eleri, Carty, Sara Madelaine, Nowell, Mari Ann, Goodfellow, Rhian Mair, Dent, Colin Michael, Williams, Bryan Davies, Jones, Simon Arnett and Topley, Nicholas 2007. Interferon-γ protects against the development of structural damage in experimental arthritis by regulating polymorphonuclear neutrophil influx into diseased joints. Arthritis & Rheumatism 56 (7) , pp. 2244-2254. 10.1002/art.22732

Nowell, Mari Ann, Richards, Peter James, Fielding, Ceri Alan, Ognjanovic, Simona, Topley, Nicholas, Williams, Anwen Sian, Bryant-Greenwood, Gillian and Jones, Simon Arnett 2006. Regulation of pre-B cell colony-enhancing factor by STAT-3-dependent interleukin-6 trans-signaling: implications in the pathogenesis of rheumatoid arthritis. Arthritis & Rheumatism 54 (7) , pp. 2084-2095. 10.1002/art.21942

Monslow, Jamie, Williams, John David, Fraser, Donald James, Michael, Daryn Robert, Foka, Pelagia, Kift-Morgan, Ann Patricia, Luo, Dong Dong, Fielding, Ceri Alan, Craig, Kathrine Jane, Topley, Nicholas, Jones, Simon Arnett, Ramji, Dipak Purshottam and Bowen, Timothy 2006. Sp1 and Sp3 mediate constitutive transcription of the human hyaluronan synthase 2 gene. The Journal of Biological Chemistry 281 (26) , pp. 18043-18050. 10.1074/jbc.M510467200

Richards, Peter James, Nowell, Mari Ann, Horiuchi, Sankichi, McLoughlin, Rachel Mary, Fielding, Ceri Alan, Grau, Sandra, Yamamoto, Naoki, Ehrmann, Michael, Rose-John, Stefan, Williams, Anwen Sian, Topley, Nicholas and Jones, Simon Arnett 2006. Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis. Arthritis & Rheumatism 54 (5) , pp. 1662-1672. 10.1002/art.21818

Fielding, Ceri Alan, McLoughlin, Rachel Mary, Colmont, Chantal Sophie, Kovaleva, Marina, Harris, Dean Anthony, Rose-John, Stefan, Topley, Nicholas and Jones, Simon Arnett 2005. Viral IL-6 blocks neutrophil infiltration during acute inflammation. The Journal of Immunology 175 (6) , pp. 4024-4029.

McLoughlin, Rachel Mary, Jenkins, Brendan J., Grail, Dianne, Williams, Anwen Sian, Fielding, Ceri Alan, Parker, Clare R., Ernst, Matthias, Topley, Nicholas and Jones, Simon Arnett 2005. IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation. Proceedings of the National Academy of Sciences of the United States of America (PNAS) ISSN 1091-6490 102 (27) , pp. 9589-9594. 10.1073/pnas.0501794102

Zhang, Xiao Liang, Topley, Nicholas, Ito, Takafumi and Phillips, Aled Owain 2005. Interleukin-6 regulation of transforming growth factor (TGF)-beta receptor compartmentalization and turnover enhances TGF-beta1 signaling. The Journal of Biological Chemistry 280 (13) , pp. 12239-12245. 10.1074/jbc.M413284200

Carty, S. M., Nowell, Mari Ann, Goodfellow, Rhian Mair, Topley, Nicholas, Jones, Simon Arnett, Williams, B. D. and Williams, Anwen Sian 2005. Interleukin 6 (IL-6) signalling in rheumatoid arthritis. Rheumatology 44 , I38-I38.

Topley, Nicholas, Michael, Daryn Robert and Bowen, Timothy 2005. CA125: holy grail or a poisoned chalice. Nephron Clinical Practice 100 (2) , c52-c54. 10.1159/000085033

Monslow, Jamie, Williams, John David, Guy, Carol, Price, Iain Kelsey, Craig, Kathrine Jane, Williams, Hywel John, Williams, Nigel Melville, Martin, John, Coleman, Sharon Louise, Topley, Nicholas, Spicer, Andrew P., Buckland, Paul Robert, Davies, Malcolm and Bowen, Timothy 2004. Identification and analysis of the promoter region of the human hyaluronan synthase 2 gene. The Journal of Biological Chemistry 279 (20) , pp. 20576-20581. 10.1074/jbc.M312666200

McLoughlin, Rachel Mary, Hurst, Suzanne Maria, Nowell, Mari Ann, Harris, Dean Anthony, Horiuchi, Sankichi, Morgan, Llinos Wyn, Yamamoto, Naoki, Wilkinson, Thomas S., Topley, Nicholas and Jones, Simon Arnett 2004. Differential regulation of neutrophil-activating chemokines by IL-6 and its soluble receptor isoforms. The Journal of Immunology 172 , pp. 5676-83.

Williams, John David, Topley, Nicholas, Craig, Kathrine Jane, MacKenzie, Ruth Kathryn, Pischetsrieder, Monika, Lage, Cristina and Passlick-Deetjen, Jutta 2004. The Euro-Balance Trial: The effect of a new biocompatible peritoneal dialysis fluid (balance) on the peritoneal membrane. Kidney International 66 (1) , pp. 408-418. 10.1111/j.1523-1755.2004.00747.x

Williams, John David, Craig, Kathrine Jane, Von Ruhland, Christopher John, Topley, Nicholas and Williams, Geraint Trefor 2003. The natural course of peritoneal membrane biology during peritoneal dialysis. Kidney International 64 (s88) , SS43-SS49. 10.1046/j.1523-1755.2003.08805.x

Nowell, Mari Ann, Richards, Peter James, Horiuchi, Sankichi, Yamamoto, Naoki, Rose-John, Stefan, Topley, Nicholas, Williams, Anwen Sian and Jones, Simon Arnett 2003. Soluble IL-6 receptor governs IL-6 activity in experimental arthritis: blockade of arthritis severity by soluble glycoprotein 130. The Journal of Immunology 171 (6) , pp. 3202-3209.

McLoughlin, Rachel Mary, Witowski, Janusz, Robson, Rachel L., Wilkinson, Thomas S., Hurst, Suzanne Maria, Williams, Anwen Sian, Williams, John David, Rose-John, Stefan, Jones, Simon Arnett and Topley, Nicholas 2003. Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation. The Journal of Clinical Investigation 112 (4) , pp. 598-607. 10.1172/JCI200317129
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Monslow, Jamie, Williams, John David, Norton, Nadine, Guy, Carol, Price, Iain Kelsey, Coleman, Sharon Louise, Williams, Nigel Melville, Buckland, Paul Robert, Spicer, Andrew P., Topley, Nicholas, Davies, Malcolm and Bowen, Timothy 2003. The human hyaluronan synthase genes: genomic structures, proximal promoters and polymorphic microsatellite markers. The International Journal of Biochemistry & Cell Biology 35 (8) , pp. 1272-1283. 10.1016/S1357-2725(03)00048-7

Williams, John David, Craig, Kathrine Jane, Topley, Nicholas and Williams, Geraint Trefor 2003. Peritoneal dialysis: changes to the structure of the peritoneal membrane and potential for biocompatible solutions. Kidney International 63 (s84) , S158-S161. 10.1046/j.1523-1755.63.s84.46.x

Wong, Teresa Y. H., Phillips, Aled Owain, Witowski, Janusz and Topley, Nicholas 2003. Glucose-mediated induction of TGF-beta 1 and MCP-1 in mesothelial cells in vitro is osmolality and polyol pathway dependent. Kidney International 63 (4) , pp. 1404-1416. 10.1046/j.1523-1755.2003.00883.x

Williams, John David, Craig, Kathrine Jane, Passlick-Deetjen, J., Topley, Nicholas, Lage, C. and Pishcetsrieder, M. 2002. Reduced systemic AGE formation with a low GDP solution (CAPD balance): data from the multicentre European balance trial. Journal of the American Society of Nephrology 13 (Supp S) , 199a-199a.

McKenzie, R. K., Craig, Kathrine Jane, Lage, C., Williams, John David, Schaub, T., Passlick-Deetjen, J. and Topley, Nicholas 2002. Treatment with low GDP solution (CAPD balance) is associated with an increase in effluent CA125 and a decrease in HA content: data from the multi centre European balance trial. Journal of the American Society of Nephrology 13 (Supp) , 199a-200a.

Williams, John David, Craig, Kathrine Jane, Topley, Nicholas, Von Ruhland, Christopher John, Fallon, Maureen, Newman, Geoffrey Richard, MacKenzie, Ruth Kathryn and Williams, Geraint Trefor 2002. Morphologic changes in the peritoneal membrane of patients with renal disease. Journal of the American Society of Nephrology 13 (2) , pp. 470-479.

Robson, Rachel L., McLoughlin, Rachel Mary, Witowski, Janusz, Loetscher, Pius, Wilkinson, Thomas S., Jones, Simon Arnett and Topley, Nicholas 2001. Differential regulation of chemokine production in human peritoneal mesothelial cells: IFN-gamma controls neutrophil migration across the mesothelium in vitro and in vivo. The Journal of Immunology 167 (2) , pp. 1028-1038.

Hurst, Suzanne Maria, Wilkinson, Thomas S., McLoughlin, Rachel Mary, Jones, Suzanne, Horiuchi, Sankichi, Yamamoto, Naoki, Rose-John, Stefan, Fuller, Gerald M., Topley, Nicholas and Jones, Simon Arnett 2001. IL-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation. Immunity 14 (6) , pp. 705-714. 10.1016/S1074-7613(01)00151-0

Jones, Suzanne, Holmes, Clifford J., Krediet, Raymond T., Mackenzie, Ruth, Faict, Dirk, Tranaeus, Anders, Williams, John David, Coles, Gerald A. and Topley, Nicholas 2001. Bicarbonate/lactate-based peritoneal dialysis solution increases cancer antigen 125 and decreases hyaluronic acid levels. Kidney International 59 (4) , pp. 1529-1538. 10.1046/j.1523-1755.2001.0590041529.x

Williams, A., Goodfellow, Rhian Mair, Topley, Nicholas, Amos, Nick and Williams, Bryan Davies 2000. The suppression of rat collagen-induced arthritis and inhibition of macrophage derived mediator release by liposomal methotrexate formulations. Inflammation Research 49 (4) , pp. 155-161. 10.1007/s000110050575

Witowski, Janusz, Topley, Nicholas, Jörres, Achim, Liberek, Tomasz, Coles, Gerald A. and Williams, John D. 1995. Effect of lactate-buffered peritoneal dialysis fluids on human peritoneal mesothelial cell interleukin-6 and prostaglandin synthesis. Kidney International 47 (1) , pp. 282-293. 10.1038/ki.1995.36

Liberek, T., Topley, Nicholas, Jörres, A., Coles, G. A., Gahl, G. M. and Williams, John David 1993. Peritoneal dialysis fluid inhibition of phagocyte function: effects of osmolality and glucose concentration. Journal of the American Society of Nephrology 3 (8) , pp. 1508-1515.

Topley, Nicholas, Jörres, Achim, Luttmann, Werner, Petersen, Meryl M., Lang, M. Janine, Thierauch, Karl-Heinz, Müller, Christian, Coles, Gerald A., Davies, Malcolm and Williams, John D. 1993. Human peritoneal mesothelial cells synthesize interleukin-6: Induction by IL-1beta and TNFalpha. Kidney International 43 (1) , pp. 226-233. 10.1038/ki.1993.36

Topley, Nicholas, Alobaidi, H. M. M., Davies, Malcolm, COLES, Gerald A., Williams, John David and Lloyd, David 1988. The effect of dialysate on peritoneal phagocyte oxidative metabolism. Kidney International 34 (3) , pp. 404-411. 10.1038/ki.1988.195

Steadman, Robert, Topley, Nicholas, Jenner, D. E., Davies, M. and Williams, John David 1988. Type-1 fimbriate escherichia-coli stimulates a unique pattern of de-granulation by human polymorphonuclear leukocytes. Infection and Immunity 56 (4) , pp. 815-822.
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Steadman, Robert, Topley, Nicholas, MacKenzie, Ruth Kathryn, Davies, M. and Williams, John David 1988. Scarring potential, fimbrial type-alpha-hemolysin production and human neutrophil (pmn) activation by uropathogenic strains of escherichia-coli [Abstract]. Kidney International 33 (1) , p. 325.

Harber, M. J., Topley, Nicholas and Asscher, A. W. 1986. Virulence factors of urinary pathogens. Clinical Science 70 (6) , pp. 531-538.

Williams, John David, Topley, Nicholas, Alobaidi, H. M. and Harber, M. J. 1986. Activation of human polymorphonuclear leukocytes by particulate zymosan is related to both its major carbohydrate components - glucan and mannan. Immunology 58 (1) , pp. 117-124.

This list was generated on Sat Mar 23 04:05:16 2019 GMT.