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Number of items: 48.

Munje, C., Hills, Robert Kerrin, Whetton, A., Burnett, A., Darley, Richard Lawrence and Tonks, Alex 2015. Cord blood-derived quiescent CD34+ cells are more transcriptionally matched to AML blasts than cytokine-induced normal human hematopoietic CD34+ cells. Gene Expression 16 (4) , pp. 169-175. 10.3727/105221615X14399878166159
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Agathanggelou, A., Weston, V. J., Perry, T., Davies, N. J., Skowronska, A., Payne, D. T., Fossey, J. S., Oldreive, C. E., Wei, W., Pratt, G., Parry, H., Oscier, D., Coles, Steven, Hole, Paul Spencer, Darley, Richard Lawrence, McMahon, M., Hayes, J. D., Moss, P., Stewart, G., Taylor, A. M. R. and Stankovic, T. 2015. Targeting the ataxia telangiectasia mutated-null phenotype in chronic lymphocytic leukemia with pro-oxidants. Haematologica 100 (8) , pp. 1076-1085. 10.3324/haematol.2014.115170

Coles, Simon J., Gilmour, Marie N., Reid, R., Knapper, Steven, Burnett, A. K., Man, Stephen Tzekwung, Tonks, Alex and Darley, Richard Lawrence 2015. The immunosuppressive ligands PD-L1 and CD200 are linked in AML T-cell immunosuppression: identification of a new immunotherapeutic synapse. Leukemia 29 (9) , p. 1952. 10.1038/leu.2015.62

Morgan, Rhys G., Ridsdale, Jenna, Tonks, Alex and Darley, Richard Lawrence 2014. Factors affecting the nuclear localization of β-Catenin in normal and malignant tissue. Journal of Cellular Biochemistry 115 (8) , pp. 1351-1361. 10.1002/jcb.24803

Zabkiewicz, Joanna, Pearn, Lorna, Hills, Robert, Morgan, Rhys G., Tonks, Alex, Burnett, Alan K. and Darley, Richard 2014. The PDK1 master kinase is over-expressed in acute myeloid leukemia and promotes PKC-mediated survival of leukemic blasts. Haematologica 99 (5) , pp. 858-864. 10.3324/haematol.2013.096487

Hole, Paul Spencer, Zabkiewicz, Joanna, Munje, Chinmay, Newton, Zarabeth, Pearn, Lorna, White, Paul Charles, Marquez, Nuria, Hills, Robert Kerrin, Burnett, Alan Kenneth, Tonks, Alex and Darley, Richard Lawrence 2013. Overproduction of NOX-derived ROS in AML promotes proliferation and is associated with defective oxidative stress signaling. Blood 122 (19) , pp. 3322-3330. 10.1182/blood-2013-04-491944

Morgan, Rhys G., Pearn, Lorna, Liddiard, Kate, Pumford, Sara Louise, Burnett, Alan Kenneth, Tonks, Alex and Darley, Richard Lawrence 2013. γ-Catenin is overexpressed in acute myeloid leukemia and promotes the stabilization and nuclear localization of β-catenin. Leukemia 27 (2) , pp. 336-343. 10.1038/leu.2012.221
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Daud, Siti Sarah, Pumford, Sara L, Gilmour, Marie N., Gilkes, Amanda F., Burnett, Alan Kenneth, Hills, Robert Kerrin, Tonks, Alex and Darley, Richard Lawrence 2012. Identification of the Wnt signalling protein, TCF7L2 as a significantly overexpressed transcription factor in AML [Abstract]. Blood 120 (21) , 1281.

Coles, Steven, Hills, Robert Kerrin, Wang, Edward Chung Yern, Burnett, Alan Kenneth, Man, Stephen Tzekwung, Darley, Richard Lawrence and Tonks, Alex 2012. Expression of CD200 on AML blasts directly suppresses memory T-cell function [Letter]. Leukemia 26 (9) , pp. 2148-2151. 10.1038/leu.2012.77
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Coles, Steven, Hills, Robert Kerrin, Wang, Edward Chung Yern, Burnett, Alan Kenneth, Man, Stephen Tzekwung, Darley, Richard Lawrence and Tonks, Alex 2012. Increased CD200 expression in acute myeloid leukemia is linked with an increased frequency of FoxP3+ regulatory T cells [Letter]. Leukemia 26 (9) , pp. 2146-2148. 10.1038/leu.2012.75
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Liddiard, Kate, Burnett, Alan Kenneth, Darley, Richard Lawrence and Tonks, Alex 2012. RUNX1-ETO deregulates the proliferation and growth factor responsiveness of human hematopoietic progenitor cells downstream of the myeloid transcription factor, MYCT1 [Letter]. Leukemia 26 (1) , pp. 177-179. 10.1038/leu.2011.188
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Coles, Steven, Man, Stephen Tzekwung, Hills, Robert Kerrin, Wang, Edward Chyng Yern, Burnett, Alan Kenneth, Darley, Richard Lawrence and Tonks, Alex 2011. CD200 inhibits memory Th1 cell function in acute myeloid leukaemia (AML)[Abstract]. Immunology 135 (S1) , p. 178. 10.1111/j.1365-2567.2011.03534.x

Coles, Steven, Wang, Edward Chung Yern, Man, Stephen Tzekwung, Hills, Robert Kerrin, Burnett, Alan Kenneth, Tonks, Alex and Darley, Richard Lawrence 2011. CD200 expression suppresses natural killer cell function and directly inhibits patient anti-tumor response in acute myeloid leukemia. Leukemia 25 (5) , pp. 792-799. 10.1038/leu.2011.1

Hole, Paul Spencer, Darley, Richard Lawrence and Tonks, Alex 2011. Do reactive oxygen species play a role in myeloid leukemias? Blood 117 (22) , pp. 5816-5826. 10.1182/blood-2011-01-326025

Zabkiewicz, Joanna, Pearn, Lorna, Hills, Robert Kerrin, Morgan, Rhys G., Burnett, Alan Kenneth, Tonks, Alex and Darley, Richard Lawrence 2010. PDK1 overexpression in acute myeloid leukemia; Clinical significance and potential as a therapeutic target [Abstract]. Blood 116 (21) , pp. 892-893.

Morgan, Rhys Gareth, Pearn, Lorna, Liddiard, Kate, Hills, Robert Kerrin, Burnett, Alan Kenneth, Tonks, Alex and Darley, Richard Lawrence 2010. Distinct regulation of beta- and gamma-Catenin throughout hematopoietic development contrasts with their cooperative roles in acute myeloid leukemia [Abstract]. Blood 116 (21) , 1573.

Coles, Steven, Man, Stephen Tzekwung, Hills, Robert Kerrin, Wang, Edward Chung Yern, Burnett, Alan Kenneth, Darley, Richard Lawrence and Tonks, Alex 2010. Over-expression of CD200 un acute myeloid leukemia mediates the expansion of regulatory T-lymphocytes and directly inhibits natural killer cell tumor immunity [Abstract]. Blood 116 (21) , p. 218.

Liddiard, Kate, Hills, Robert Kerrin, Burnett, Alan Kenneth, Darley, Richard Lawrence and Tonks, Alex 2010. OGG1 is a novel prognostic indicator in acute myeloid leukaemia. Oncogene 29 (13) , pp. 2005-2012. 10.1038/onc.2009.462

Hole, Paul Spencer, Pearn, Lorna, Tonks, Amanda Jayne, James, Philip Eurig, Burnett, Alan Kenneth, Darley, Richard Lawrence and Tonks, Alex 2010. Ras-induced reactive oxygen species promote growth factor-independent proliferation in human CD34+ hematopoietic progenitor cells. Blood 115 (6) , pp. 1238-1246. 10.1182/blood-2009-06-222869

Yang, Jian, Darley, Richard Lawrence, Hallett, Maurice Bartlett and Evans, William Howard 2009. Low connexin channel-dependent intercellular communication in human adult hematopoietic progenitor/stem cells: Probing mechanisms of autologous stem cell therapy. Cell Communication and Adhesion 16 (5-6) , pp. 138-145. 10.3109/15419061003653763

Dewitt, Sharon, Darley, Richard Lawrence and Hallett, Maurice Bartlett 2009. Translocation or just location? Pseudopodia affect fluorescent signals. Journal of Cell Biology 184 (2) , pp. 197-203. 10.1083/jcb.200806047
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Tonks, Alex, Pearn, Lorna, Musson, Megan, Gilkes, Amanda F., Mills, Kenneth Ian, Burnett, Alan Kenneth and Darley, Richard Lawrence 2007. Transcriptional dysregulation mediated by RUNX1-RUNX1T1 in normal human progenitor cells and in acute myeloid leukaemia. Leukemia 21 (12) , pp. 2495-2505. 10.1038/sj.leu.2404961

Walsby, Elisabeth Jane, Gilkes, Amanda Frances, Tonks, Alex, Darley, Richard Lawrence and Mills, Kenneth Ian 2007. FUS expression alters the differentiation response to all-trans retinoic acid in NB4 and NB4R2 cells. British Journal of Haematology 139 (1) , pp. 94-97. 10.1111/j.1365-2141.2007.06756.x

Tonks, Alex, Hills, Robert Kerrin, White, Paul Charles, Rosie, B., Mills, Kenneth Ian, Burnett, Alan Kenneth and Darley, Richard Lawrence 2007. CD200 as a prognostic factor in acute myeloid leukaemia. Leukemia 21 (3) , pp. 566-568. 10.1038/sj.leu.2404559

Tonks, Alex, Hills, Robert Kerrin, White, Paul Charles, Rosie, B., Mills, Kenneth Ian, Burnett, Alan Kenneth and Darley, Richard Lawrence 2007. CD200 as a prognostic factor in acute myeloid leukaemia [Letter]. Leukemia 21 (3) , pp. 566-568. 10.1038/sj.leu.2404559

Pearn, Lorna, Fisher, Janet, Burnett, Alan Kenneth and Darley, Richard Lawrence 2007. The role of PKC and PDK1 in monocyte lineage specification by Ras. Blood 109 (10) , pp. 4461-9. 10.1182/blood-2006-09-047217

Omidvar, Nader, Pearn, Lorna, Burnett, Alan Kenneth and Darley, Richard Lawrence 2006. Ral is both necessary and sufficient for the inhibition of myeloid differentiation mediated by Ras. Molecular and cellular biology 26 (10) , pp. 3966-75. 10.1128/MCB.26.10.3966-3975.2006
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Tonks, Alex, Pearn, Lorna, Mills, Kenneth Ian, Burnett, Alan Kenneth and Darley, Richard Lawrence 2006. The sensitivity of human cells expressing RUNX1-RUNX1T1 to chemotherapeutic agents. Leukemia 20 (10) , pp. 1883-5. 10.1038/sj.leu.2404364

Tonks, Alex, Tonks, Amanda Jayne, Pearn, Lorna, Mohamad, Zulkhairi, Burnett, Alan Kenneth and Darley, Richard Lawrence 2005. Optimized retroviral transduction protocol which preserves the primitive subpopulation of human hematopoietic cells. Biotechnology Progress 21 (3) , pp. 953-958. 10.1021/bp0500314

Tonks, Alex, Tonks, Amanda Jayne, Pearn, Lorna, Pearce, Laurence, Hoy, Terence George, Couzens, Stephen, Fisher, Janet, Burnett, Alan Kenneth and Darley, Richard Lawrence 2004. Expression of AML1-ETO in human myelomonocytic cells selectively inhibits granulocytic differentiation and promotes their self-renewal. Leukemia 18 (7) , pp. 1238-1245. 10.1038/sj.leu.2403396

Tonks, Alex, Tonks, Amanda Jayne, Pearn, Lorna, Pearce, L., Hoy, T., Couzens, Stephen, Fisher, J., Burnett, Alan Kenneth and Darley, Richard Lawrence 2004. Expression of AML1-ETO in human myelomonocytic cells selectively inhibits granulocytic differentiation and promotes their self-renewal. Leukemia 18 (7) , pp. 1238-1245. 10.1038/sj.leu.2403396

Tonks, Alex, Pearn, Lorna, Tonks, Amanda Jayne, Pearce, Laurence, Hoy, Terence George, Phillips, Sarah, Fisher, Janet, Downing, James R., Burnett, Alan Kenneth and Darley, Richard Lawrence 2003. The AML-1 fusion gene promotes extensive self-renewal of human primary erythroid cells. Blood 101 (2) , pp. 624-632. 10.1182/blood-2002-06-1732

Tonks, Alex, Pearn, Lorna, Tonks, Amanda Jayne, Pearce, Laurence, Hoy, Terence George, Phillips, Sarah, Fisher, Janet, Downing, James R., Burnett, Alan Kenneth and Darley, Richard Lawrence 2003. The AML1-ETO fusion gene promotes extensive self-renewal of human primary erythroid cells. Blood 101 (2) , pp. 624-632. 10.1182/blood-2002-06-1732

Darley, Richard Lawrence, Pearn, Lorna, Omidvar, Nader, Sweeney, Marion Carol, Fisher, Janet, Phillips, Sarah, Hoy, Terence George and Burnett, Alan Kenneth 2002. Protein kinase C mediates mutant N-Ras-induced developmental abnormalities in normal human erythroid cells. Blood 100 (12) , pp. 4185-92. 10.1182/blood-2002-05-1358

McGlynn, Angela P., Padua, Rose Ann, Burnett, Alan Kenneth and Darley, Richard Lawrence 2000. Alternative effects of RAS and RAF oncogenes on the proliferation and apoptosis of factor-dependent FDC-P1 cells. Leukemia Research 24 (1) , pp. 47-54. 10.1016/s0145-2126(99)00159-9

Darley, Richard Lawrence, Pearn, Lorna and Burnett, Alan Kenneth 2000. Mutant RAS promotes amplification of primitive human erythroid cells. Blood 96 (11) , 92A-92A.

Darley, Richard Lawrence and Burnett, Alan Kenneth 1999. Mutant RAS inhibits neutrophil but not macrophage differentiation and allows continued growth of neutrophil precursors. Experimental Hematology 27 (11) , pp. 1599-1608. 10.1016/S0301-472X(99)00100-9

Darley, Richard Lawrence, Hoy, T. G., Robinson, L. and Burnett, Alan Kenneth 1998. Mutant N-RAS blocks granulocytic differentiation of human cd34+ cells. British Journal of Haematology 102 (1) , p. 289. 10.1111/j.1365-2141.1998.tb08997.x

Darley, Richard Lawrence, Hoy, T. G. and Burnett, Alan Kenneth 1998. Mutant N-RAS blocks granulocytic differentiation of human CD34(+) cells [Abstract]. British Journal of Haematology 101 (S) , p. 22.

Gallagher, Andrea P., Burnett, Alan Kenneth, Bowen, David T. and Darley, Richard Lawrence 1998. Mutant RAS selectively promotes sensitivity of myeloid leukemia cells to apoptosis by a protein kinase C-dependent process. Cancer Research 58 (9) , pp. 2029-2035.

Darley, Richard Lawrence, Gallagher, A. P., Bowen, D. T. and Burnett, Alan Kenneth 1997. Mutant RAS selectively promotes sensitivity of myeloid leukemia cells to apoptosis by a PKC-dependent process. Blood 90 (10) , p. 202.

Zaker, Farhad, Darley, Richard Lawrence, Sabah, Ala Al and Burnett, Alan Kenneth 1997. Oncogenic RAS genes impair erythroid differentiation of erythroleukaemia cells. Leukemia Research 21 (7) , pp. 635-640. 10.1016/S0145-2126(97)00022-2

Darley, Richard Lawrence, Hoy, Terence G., Baines, Paul, Padua, Rose Ann and Burnett, Alan Kenneth 1997. Mutant N-RAS induces erythroid lineage dysplasia in human CD34+ Cells. Journal of Experimental Medicine 185 (7) , pp. 1337-1348. 10.1084/jem.185.7.1337

Darley, Richard Lawrence, Baines, Paul, Hoy, Terence G., Padua, Rose Ann and Burnett, Alan Kenneth 1996. Mutant N-RAS alters the developmental potential of human CD34(+) cells in a lineage-specific manner. British Journal of Haematology 93 (S2) , p. 597.

Evely, R. S., Darley, Richard Lawrence, Gilkes, Amanda F., Goringe, A., Mirza, T. and Burnett, Alan Kenneth 1996. In-vivo modelling of myeloid malignancies using severe combined immunodeficient (SCID) mice [Abstract]. British Journal of Haematology 93 , p. 205.

Darley, Richard Lawrence, Baines, Paul, Hoy, T. G. and Burnett, Alan Kenneth 1995. Mutant N-RAS induces erythroid lineage dysplasia in human CD34(+) progenitor cells. Blood 86 (10) , p. 1665.

Gallagher, A., Padua, R. A., Alsabah, A., Burnett, Alan Kenneth and Darley, Richard Lawrence 1994. P21RAS expression in leukemogenesis and hematopoiesis. Blood 84 (10) , A605-A605.

Morris, Alan G., Darley, Richard Lawrence and Bateman, Wendy J. 1992. The loss of class II MHC antigen expression by ras-transformed murine fibroblasts passaged as tumours correlates with increased tumorigenicity but is not mediated by T cells. Cancer Immunology, Immunotherapy 35 (1) , pp. 46-52. 10.1007/BF01741054

This list was generated on Wed Nov 22 02:32:35 2017 GMT.