Browse by Current Cardiff authors

Hamdy, Rania, Elseginy, Samia A., Ziedan, Noha I., El-Sadek, Mohamed, Lashin, Elsaid, Jones, Arwyn T. and Westwell, Andrew D. 2020. Design, synthesis and evaluation of new bioactive oxadiazole derivatives as anticancer agents targeting Bcl-2. International Journal of Molecular Sciences 21 (23) , 8980. 10.3390/ijms21238980

Nödling, Alexander, Mills, Emily M., Li, Xuefei, Cardella, Davide, Sayers, Edward J., Wu, Shih-Hsiung, Jones, Arwyn T., Luk, Louis Y. P. and Tsai, Yu-Hsuan 2020. Cyanine dye mediated mitochondrial targeting enhances the anti-cancer activity of small-molecule cargoes. Chemical Communications 56 (34) , pp. 4672-4675. 10.1039/C9CC07931A

Wymant, Jennifer Mary, Sayers, Edward John, Muir, Duncan and Jones, Arwyn Tomos 2020. Strategic trastuzumab mediated crosslinking driving concomitant HER2 and HER3 endocytosis and degradation in breast cancer. Journal of Cancer 11 (11) , pp. 3288-3302. 10.7150/jca.32470

Giannakopoulou, Naya, Williams, Joseph B., Moody, Paul R., Sayers, Edward J., Magnusson, Johannes P., Pope, Iestyn, Payne, Lukas, Alexander, Cameron, Jones, Arwyn T., Langbein, Wolfgang, Watson, Peter and Borri, Paola 2020. Four-wave-mixing microscopy reveals non-colocalisation between gold nanoparticles and fluorophore conjugates inside cells. Nanoscale 12 (7) , pp. 4622-4635. 10.1039/C9NR08512B

Eissa, N.G., Sayers, E.J., Birch, D., Patel, S.G., Tsai, Y.-H., Nielsen, H. Mørck and Jones, Arwyn 2020. EJP18 peptide derived from the juxtamembrane domain of epidermal growth factor receptor represents a novel membrane-active cell-penetrating peptide. Biochemical Journal 477 (1) , pp. 45-60. 10.1042/BCJ20190452

Sayers, Edward J., Peel, Samantha E., Schantz, Anna, England, Richard M., Beano, Maya, Bates, Stephanie M., Desai, Arpan S., Puri, Sanyogitta, Ashford, Marianne B. and Jones, Arwyn T. 2019. Endocytic profiling of cancer cell models reveals critical factors influencing lipid nanoparticle mediated mRNA delivery and protein expression. Molecular Therapy 27 (11) , pp. 1950-1962. 10.1016/j.ymthe.2019.07.018

Woods, Ben, Dollerer, Daniel, Aikman, Brech, Wenzel, Margot, Sayers, Edward J., Kühn, Fritz E., Jones, Arwyn T. and Casini, Angela 2019. Highly luminescent metallacages featuring bispyridyl ligands functionalised with BODIPY for imaging in cancer cells. Journal of Inorganic Biochemistry 199 , 110781. 10.1016/j.jinorgbio.2019.110781

Lorenzer, Cornelia, Streußnig, Sonja, Tot, Emilia, Winkler, Anna-Maria, Merten, Hannes, Brandl, Fabian, Sayers, Edward J., Watson, Peter, Jones, Arwyn T., Zangemeister-Wittke, Uwe, Plückthun, Andreas and Winkler, Johannes 2019. Targeted delivery and endosomal cellular uptake of DARPin-siRNA bioconjugates: Influence of linker stability on gene silencing. European Journal of Pharmaceutics and Biopharmaceutics 141 , pp. 37-50. 10.1016/j.ejpb.2019.05.015

Wahlich, J., Desai, A., Greco, F., Hill, Kathryn, Jones, Arwyn T., Mrsny, R., Pasut, G., Perrie, Y., Seib, F. P., Seymour, L. W. and Uchegbu, I. F. 2019. Nanomedicines for the delivery of biologics. Pharmaceutics 11 (5) , 210. 10.3390/pharmaceutics11050210

Patel, Sanjay G., Sayers, Edward J., He, Lin, Narayan, Rohan, Williams, Thomas L., Mills, Emily M., Allemann, Rudolf K., Luk, Louis Y. P., Jones, Arwyn T. and Tsai, Yu-Hsuan 2019. Cell-penetrating peptide sequence and modification dependent uptake and subcellular distribution of green florescent protein in different cell lines. Scientific Reports 9 (1) , -. 10.1038/s41598-019-42456-8

Hamdy, Rania, Elseginy, Samia, Ziedan, Noha, Jones, Arwyn and Westwell, Andrew 2019. New quinoline-based heterocycles as anticancer agents targeting Bcl-2. Molecules 24 (7) , p. 1274. 10.3390/molecules24071274

Gurney, Leo R. I., Taggart, Julie, Tong, Wing-Chiu, Jones, Arwyn T., Robson, Stephen C. and Taggart, Michael J. 2018. Inhibition of inflammatory changes in human myometrial cells by cell penetrating peptide and small molecule inhibitors of NFκB. Frontiers in Immunology 9 , 2966. 10.3389/fimmu.2018.02966

Sasso, Luana, Purdie, Laura, Grabowska, Anna, Jones, Arwyn Tomos and Alexander, Cameron 2018. Time and cell-dependent effects of endocytosis inhibitors on the internalization of biomolecule markers and nanomaterials. Journal of Interdisciplinary Nanomedicine 3 (2) , pp. 67-81. 10.1002/jin2.39

He, L., Sayers, E. J., Watson, P. and Jones, A. T. 2018. Contrasting roles for actin in the cellular uptake of cell penetrating peptide conjugates. Scientific Reports 8 (1) , 7318. 10.1038/s41598-018-25600-8

Sayers, Edward J., Magnusson, Johannes P., Moody, Paul R., Mastrotto, Francesca, Conte, Claudia, Brazzale, Chiara, Borri, Paola, Caliceti, Paolo, Watson, Peter, Mantovani, Giuseppe, Aylott, Jonathan, Salmaso, Stefano, Jones, Arwyn T and Alexander, Cameron 2018. Switching of macromolecular ligand display by thermoresponsive polymers mediates endocytosis of multi-conjugate nanoparticles. Bioconjugate Chemistry 29 (4) , pp. 1030-1046. 10.1021/acs.bioconjchem.7b00704

Kjos, Ingrid, Borg Distefano, Marita, Sætre, Frank, Repnik, Urska, Holland, Petter, Jones, Arwyn T., Engedal, Nikolai, Simonsen, Anne, Bakke, Oddmund and Progida, Cinzia 2017. Rab7b modulates autophagic flux by interacting with Atg4B. EMBO reports 18 (10) , pp. 1727-1739. 10.15252/embr.201744069

Roberts-Dalton, H. D., Cocks, A., Falcon-Perez, J. M., Sayers, E. J., Webber, J. P., Watson, P., Clayton, A. and Jones, A. T. 2017. Fluorescence labelling of extracellular vesicles using a novel thiol-based strategy for quantitative analysis of cellular delivery and intracellular traffic. Nanoscale 9 (36) , pp. 13693-13706. 10.1039/C7NR04128D

Brazzale, C., Mastrotto, F., Moody, P., Watson, P. D., Balasso, A., Malfanti, A., Mantovani, G., Caliceti, P., Alexander, C., Jones, A. T. and Salmaso, S. 2017. Control of targeting ligand display by pH-responsive polymers on gold nanoparticles mediates selective entry into cancer cells. Nanoscale 9 (31) , pp. 11137-11147. 10.1039/C7NR02595E

Hamdy, Rania, Ziedan, Noha, Ali, Samina, Bordoni, Cinzia, El-Sadek, Mohamed, Lashin, Elsaid, Brancale, Andrea, Jones, Arwyn Tomos and Westwell, Andrew D 2017. Synthesis and evaluation of 5-(1H-indol-3-yl)-N-aryl-1,3,4-oxadiazol-2-amines as Bcl-2 inhibitory anticancer agents. Bioorganic & Medicinal Chemistry Letters 27 (4) , pp. 1037-1040. 10.1016/j.bmcl.2016.12.061

Ziedan, Noha I, Hamdy, Rania, Cavaliere, Alessandra, Kourti, Malamati, Prencipe, Filippo, Brancale, Andrea, Jones, Arwyn T and Westwell, Andrew 2017. Virtual screening, SAR and discovery of 5-(indole-3-yl)-2-[(2-nitrophenyl)amino] [1,3,4]-oxadiazole as a novel Bcl-2 inhibitor. Chemical Biology and Drug Design 10.1111/cbdd.12936

Wymant, Jennifer, Moody, P., Sayers, Edward and Jones, Arwyn Tomos 2017. Poster 433: Receptor-antibody clustering induced endocytosis of HER2 has therapeutic potential in breast cancer. Presented at: EACR-AACR-SIC Special Conference 2017: The Challenges of Optimising Immuno and Targeted Therapies From Cancer Biology to the Clinic, Florence, Italy, 24-27 June 2017.

Wymant, Jennifer, Hiscox, Stephen, Westwell, Andrew, Urbe, Sylvie, Clague, Michael and Jones, Arwyn Tomos 2016. The Role of BCA2 in the endocytic trafficking of EGFR and significance as a prognostic biomarker in cancer. Journal of Cancer 7 (15) , pp. 2388-2407. 10.7150/jca.15055

Kandil, Sahar, Wymant, Jennifer, Kariuki, Benson, Jones, Arwyn Tomos, McGuigan, Christopher and Westwell, Andrew David 2016. Novel cis-selective and non-epimerisable C3 hydroxy azapodophyllotoxins targeting microtubules in cancer cells. European Journal of Medicinal Chemistry 110 , pp. 311-325. 10.1016/j.ejmech.2015.12.037

Gurney, Leo R. I., Robson, Stephen, Jones, Arwyn Tomos and Taggart, Michael 2016. Use of cell penetrating peptides to treat inflammatory responses in human uterine cells. Reproductive Sciences 23 , 292A-292A. 10.1177/1933719116641257

Moody, Paul R., Sayers, Edward J., Magnusson, Johannes P., Alexander, Cameron, Borri, Paola, Watson, Peter and Jones, Arwyn T. 2015. Receptor crosslinking: a general method to trigger internalization and lysosomal targeting of therapeutic receptor: ligand complexes. Molecular Therapy 23 (12) , pp. 1888-1898. 10.1038/mt.2015.178

Lemmer, Yolandy, Kalombo, Lonji, Pietersen, Ray-Dean, Jones, Arwyn Tomos, Semete-Makokotlela, Boitumelo, Van Wyngaardt, Sandra, Ramalapa, Bathabile, Stoltz, Anton C., Baker, Bienyameen, Verschoor, Jan A., Swai, Hulda S. and de Chastellier, Chantal 2015. Mycolic acids, a promising mycobacterial ligand for targeting of nanoencapsulated drugs in tuberculosis. Journal of Controlled Release 211 , pp. 94-104. 10.1016/j.jconrel.2015.06.005

Cilibrasi, Vincenzo, Tsang, Kwok Ying Ingrid, Morelli, Matteo, Solfa, Francesca, Wiggins, Helen, Jones, Arwyn Tomos and Westwell, Andrew David 2015. Synthesis of substituted carbamo(dithioperoxo)thioates as potential BCA2-inhibitory anticancer agents. Tetrahedron Letters 56 (20) , pp. 2583-2585. 10.1016/j.tetlet.2015.03.132

Bahnsen, Jesper Soborg, Franzyk, Henrik, Sayers, Edward John and Jones, Arwyn Tomos 2015. Cell-penetrating antimicrobial peptides - prospectives for targeting intracellular infections. Pharmaceutical Research 32 (5) , pp. 1546-1556. 10.1007/s11095-014-1550-9

Pereira, Paula, Pedrosa, Sílvia S., Wymant, Jennifer M., Sayers, Edward, Correia, Alexandra, Vilanova, Manuel, Jones, Arwyn Tomos and Gama, Francisco M. 2015. siRNA inhibition of endocytic pathways to characterize the cellular uptake mechanisms of folate functionalized glycol chitosan nanogels. Molecular Pharmaceutics 12 (6) , pp. 1970-1979. 10.1021/mp500785t

Wiggins, Helen L., Wymant, Jennifer M., Solfa, Francesca, Hiscox, Stephen E., Taylor, Kathryn M., Westwell, Andrew D. and Jones, Arwyn T. 2015. Disulfiram-induced cytotoxicity and endo-lysosomal sequestration of zinc in breast cancer cells. Biochemical Pharmacology 93 (3) , pp. 332-342. 10.1016/j.bcp.2014.12.014

Webber, J. P., Spary, L. K., Sanders, A. J., Chowdhury, R., Jiang, W. G., Steadman, R., Wymant, J., Jones, A. T., Kynaston, H., Mason, M. D., Tabi, Z. and Clayton, A. 2015. Differentiation of tumour-promoting stromal myofibroblasts by cancer exosomes. Oncogene 34 (3) , pp. 290-302. 10.1038/onc.2013.560

He, Lin, Watson, Peter Duncan and Jones, Arwyn Tomos 2015. Visualizing actin architectures in cells incubated with cell-penetrating peptides. In: Langel, Ulo ed. Cell-Penetrating Peptides: Methods and Protocols, Vol. 1324. Methods in Molecular Biology, vol. 1324. Springer, pp. 247-259. (10.1007/978-1-4939-2806-4_16)

Sayers, Edward John, Cleal, Kez, Eissa, Noura Gamal, Watson, Peter Duncan and Jones, Arwyn Tomos 2014. Distal phenylalanine modification for enhancing cellular delivery of fluorophores, proteins and quantum dots by cell penetrating peptides. Journal of Controlled Release 195 , pp. 55-62. 10.1016/j.jconrel.2014.07.055

Kothayer, Hend, Elshanawani, Abdalla A., Abu Kull, Mansour E., El-Sabbagh, Osama I., Shekhar, Malathy P. V., Brancale, Andrea, Jones, Arwyn Tomos and Westwell, Andrew D. 2013. Design, synthesis and in vitro anticancer evaluation of 4,6-diamino-1,3,5-triazine-2-carbohydrazides and -carboxamides. Biorganic and Medicinal Chemistry Letters 23 (24) , pp. 6886-6889. 10.1016/j.bmcl.2013.09.087

Mart, Robert J., Errington, Rachel Jane, Watkins, Catherine Louise, Chappell, Sally Claire, Wiltshire, Marie, Jones, Arwyn Tomos, Smith, Paul James and Allemann, Rudolf Konrad 2013. BH3 helix-derived biophotonic nanoswitches regulate cytochrome c release in permeabilised cells. Molecular BioSystems 9 (11) , pp. 2597-2603. 10.1039/c3mb70246d

Hamdy, Rania, Ziedan, Noha, Ali, Samia, El-Sadek, Mohamed, Lashin, Elsaid, Brancale, Andrea, Jones, Arwyn Tomos and Westwell, Andrew D. 2013. Synthesis and evaluation of 3-(benzylthio)-5-(1H-indol-3-yl)-1,2,4-triazol-4-amines as Bcl-2 inhibitory anticancer agents. Biorganic and Medicinal Chemistry Letters 23 (8) , pp. 2391-2394. 10.1016/j.bmcl.2013.02.029

Cleal, Kez, He, Lin, Watson, Peter Duncan and Jones, Arwyn Tomos 2013. Endocytosis, intracellular traffic and fate of cell penetrating peptide based conjugates and nanoparticles. Current Pharmaceutical Design 19 (16) , pp. 2878-2894. 10.2174/13816128113199990297

Jones, Arwyn Tomos and Sayers, Edward John 2012. Cell entry of cell penetrating peptides and tales of tails wagging dogs. Journal of Controlled Release 161 (2) , pp. 582-591. 10.1016/j.jconrel.2012.04.003

Al Soraj, M., He, Lin, Peynshaert, Karen, Cousaert, Julie, Vercauteren, D., Braeckmans, K., De Smedt, S. C. and Jones, Arwyn Tomos 2012. siRNA and pharmacological inhibition of endocytic pathways to characterize the differential role of macropinocytosis and the actin cytoskeleton on cellular uptake of dextran and cationic cell penetrating peptides octaarginine (R8) and HIV-Tat. Journal of Controlled Release 161 (1) , pp. 132-141. 10.1016/j.jconrel.2012.03.015

Bailey, D., Carpenter, E. P., Coker, A., Coker, S., Read, J., Jones, Arwyn Tomos, Erskine, P., Aguilar, C. F., Badasso, M., Toldo, L., Rippmann, F., Sanz-Aparicio, J., Albert, A., Blundell, T. L., Roberts, N. B., Wood, S. P. and Cooper, J. B. 2012. An analysis of subdomain orientation, conformational change and disorder in relation to crystal packing of aspartic proteinases. Acta Crystallographica Section D: Biological Crystallography 68 (5) , pp. 541-552. 10.1107/S0907444912004817

Watkins, Catherine Louise, Sayers, Edward John, Allender, Christopher John, Barrow, David Anthony, Fegan, Christopher Daniel, Brennan, Paul and Jones, Arwyn Tomos 2011. Co-operative membrane disruption between cell-penetrating peptide and cargo: implications for the therapeutic use of the Bcl-2 converter peptide D-NuBCP-9-r8. Molecular Therapy 19 (12) , pp. 2124-2132. 10.1038/mt.2011.175

Vercauteren, Dries, Deschout, Hendrik, Remaut, Katrien, Engbersen, Johan F.J., Jones, Arwyn Tomos, Demeester, Jo, De Smedt, Stefaan C. and Braeckmans, Kevin 2011. Dynamic colocalization microscopy to characterize intracellular trafficking of nanomedicines. ACS Nano 5 (10) , pp. 7874-7884. 10.1021/nn2020858

Vercauteren, Dries, Piest, Martin, van der Aa, Leonardus J., Alsoraj, Monerah, Jones, Arwyn Tomos, Engbersen, Johan F. J., De Smedt, Stefaan C. and Braeckmans, Kevin 2011. Flotillin-dependent endocytosis and a phagocytosis-like mechanism for cellular internalization of disulfide-based poly(amido amine)/DNA polyplexes. Biomaterials 32 (11) , pp. 3072-3084. 10.1016/j.biomaterials.2010.12.045

Fricke, Thomas, Mart, Robert J., Watkins, Catherine Louise, Wiltshire, Marie, Errington, Rachel Jane, Smith, Paul James, Jones, Arwyn Tomos and Allemann, Rudolf Konrad 2011. Chemical synthesis of cell-permeable apoptotic peptides from in vivo produced proteins. Bioconjugate Chemistry 22 (9) , pp. 1763-1767. 10.1021/bc200338u

Fricke, Thomas, Mart, Robert J., Watkins, Catherine Louise, Jones, Arwyn Tomos and Allemann, Rudolf Konrad 2010. Click chemistry for the generation of cell permeable apoptotic peptides. Drug Discovery Today 15 (23-24) , p. 1088. 10.1016/j.drudis.2010.09.375

Sweeney, Michele, Watkins, Catherine Louise, Jones, Arwyn Tomos and Taggart, Michael J. 2010. Octaarginine mediated delivery of fluorescent cargo to human smooth muscle cells. Drug Discovery Today 15 (23-24) , p. 1085. 10.1016/j.drudis.2010.09.367

Gumbleton, Mark and Jones, Arwyn Tomos 2010. Cellular delivery of therapeutic macromolecules (CDTM) international Symposium 2010: lessons and progress from inter-disciplinary science. Drug Discovery Today 15 (23-24) , pp. 1079-180. 10.1016/j.drudis.2010.10.010

Al-Soraj, Monerah H., Watkins, Catherine Louise, Vercauteren, Dries, De Smedt, Stefaan, Braeckmans, Kevin and Jones, Arwyn Tomos 2010. siRNA versus pharmacological inhibition of endocytic pathways for studying cellular uptake of cell penetrating peptides and other drug delivery vectors. Drug Discovery Today 15 (23-24) , p. 1103. 10.1016/j.drudis.2010.09.411

Vercauteren, Dries, Vandenbroucke, Roosmarijn E., Jones, Arwyn Tomos, Rejman, Joanna, Demeester, Joseph, De Smedt, Stefaan C., Sanders, Niek N. and Braeckmans, Kevin 2010. The use of inhibitors to study endocytic pathways of gene carriers: Optimization and pitfalls. Molecular Therapy 18 (3) , pp. 561-569. 10.1038/mt.2009.281

Bruyere, Helene, Westwell, Andrew and Jones, Arwyn Tomos 2010. Tuning the pH sensitivities of orthoester based compounds for drug delivery applications by simple chemical modification. Bioorganic & Medicinal Chemistry Letters 20 (7) , pp. 2200-2203. 10.1016/j.bmcl.2010.02.035

Jones, Arwyn Tomos 2010. Uptake and intracellular dynamics of proteins internalized by cell-penetrating peptides. In: Weissig, Volkmar and D'Souza, Gerard G. M. eds. Organelle-Specific Pharmaceutical Nanotechnology, Hoboken, NJ.: John Wiley & Sons, pp. 263-288. (10.1002/9780470875780.ch15)

Watkins, Catherine Louise, Brennan, Paul, Fegan, Christopher Daniel, Takayama, Kentaro, Nakase, Ikuhiko, Futaki, Shiroh and Jones, Arwyn Tomos 2009. Cellular uptake, distribution and cytotoxicity of the hydrophobic cell penetrating peptide sequence PFVYLI linked to the proapoptotic domain peptide PAD. Journal of Controlled Release 140 (3) , pp. 237-244. 10.1016/j.jconrel.2009.04.028

Hughes, Mary Louise, John, David Neale and Jones, Arwyn Tomos 2009. Information provided with dispensed medicines: What role does language choice play? A perspective from Wales [Abstract]. International Journal of Pharmacy Practice 17 (S2) , B44-B45. 10.1211/096176709789037128

Hughes, Mary Louise, John, David Neale, Jones, Arwyn Tomos, Jones, Elen and Wilkins, Megan Lowri 2009. Language issues in the community pharmacy: a perspective from Wales. International Journal of Pharmacy Practice 17 (3) , pp. 157-163. 10.1211/ijpp.17.03.0006

Hughes, Mary Louise, John, David Neale and Jones, Arwyn Tomos 2009. Medicines use reviews and language choice. International Journal of Pharmacy Practice 17 (s1) , A41. 10.1211/096176709787640689

Watkins, Catherine Louise, Schmaljohann, Dirk, Futaki, Shiroh and Jones, Arwyn Tomos 2009. Low concentration thresholds of plasma membranes for rapid energy-independent translocation of a cell-penetrating peptide. Biochemical Journal 420 (2) , pp. 179-189. 10.1042/BJ20090042

Jin, J. and Jones, Arwyn Tomos 2009. The pH sensitive probe 5-(and-6)-carboxyl seminaphthorhodafluor is a substrate for the multidrug resistance-related protein MRP1. International Journal of Cancer 124 (1) , pp. 233-238. 10.1002/ijc.23892

Kosuge, Michie., Takeuchi, Toshihide, Nakase, Ikuhiko, Jones, Arwyn and Futaki, Shiroh 2008. Cellular internalization and distribution of arginine-rich peptides as a function of extracellular peptide concentration, serum, and plasma membrane associated proteoglycans. Bioconjugate Chemistry 19 (3) , pp. 656-664. 10.1021/bc700289w

Jin, J., Pastrello, D., Penning, N. A. and Jones, Arwyn Tomos 2008. Clustering of endocytic organelles in parental and drug-resistant myeloid leukaemia cell lines lacking centrosomally organised microtubule arrays. The International Journal of Biochemistry & Cell Biology 40 (10) , pp. 2240-2252. 10.1016/j.bioce1.2008.03.004

Jones, Arwyn Tomos 2008. Gateways and tools for drug delivery: Endocytic pathways and the cellular dynamics of cell penetrating peptides. International Journal of Pharmaceutics 354 (1-2) , pp. 34-38. 10.1016/j.ijpharm.2007.10.046

Hughes, Mary Louise, John, David Neale and Jones, Arwyn Tomos 2008. The role of the Welsh language in community pharmacy service provision in Wales. London: Pharmacy Practice Research Trust.

McGuigan, Christopher, Pathirana, Ranjith N., Migliore, Marco, Adak, Rina, Luoni, Giovanna maria, Jones, Arwyn Tomos, Díez-Torrubia, Alberto, Camarasa, Maria-Jose, Velázquez, Sonsoles, Henson, Geoffrey, Verbeken, Erik, Sienaer, Rebecca, Naesens, Lieve, Snoeck, Robert, Andrei, Graciela and Balzarini, Jan 2007. Preclinical development of bicyclic nucleoside analogues as potent and selective inhibitors of varicella zoster virus. Journal of Antimicrobial Chemotherapy 60 (6) , pp. 1316-1330. 10.1093/jac/dkm376

Jones, Arwyn Tomos 2007. Enclocytic pathways: gateways for intracellular drug delivery [Abstract]. Journal of Pharmacy and Pharmacology 59 (S1) , A72. 10.1211/002235707781850023

Fretz, Marjan M., Penning, Neal Aart, Al-Taei, Saly, Futaki, Shiroh, Takeuchi, Toshihide, Nakase, Ikuhiko, Storm, Gert and Jones, Arwyn Tomos 2007. Temperature-, concentration- and cholesterol-dependent translocation of L- and D-octa-arginine across the plasma and nuclear membrane of CD34+ leukaemia cells. Biochemical Journal 403 (2) , pp. 335-342. 10.1042/BJ20061808

Futaki, S., Nakase, I., Taclokoro, A., Takeuchi, T. and Jones, Arwyn Tomos 2007. Arginine-rich peptides and their internalization mechanisms. Biochemical Society Transactions 35 (4) , pp. 784-787.

Greco, F., Vicent, M. J., Gee, S., Jones, Arwyn Tomos, Gee, Julia Margaret Wendy, Nicholson, Robert Ian and Duncan, Ruth 2007. Investigating the mechanism of enhanced cytotoxicity of HPMA copolymer-Dox-AGM in breast cancer cells. Journal of Controlled Release 117 (1) , pp. 28-39. 10.1016/j.jconrel.2006.10.012

Jones, Arwyn Tomos 2007. Macropinocytosis: searching for an endocytic identity and role in the uptake of cell penetrating peptides. Journal of Cellular and Molecular Medicine 11 (4) , pp. 670-684. 10.1111/j.1582-4934.2007.00062.x

Maiti, K. K., Lee, W. S., Takeuchi, T., Watkins, Catherine Louise, Fretz, M., Kim, D. C., Futaki, S., Jones, Arwyn Tomos, Kim, K. T. and Chung, S. K. 2007. Guanidine-containing molecular transporters: Sorbitol-based transporters show high intracellular selectivity toward mitochondria. Angewandte Chemie International Edition 46 (31) , pp. 5880-5884. 10.1002/anie.200701346

Manunta, M., Izzo, L., Duncan, Ruth and Jones, Arwyn Tomos 2007. Establishment of subcellular fractionation techniques to monitor the intracellular fate of polymer therapeutics II. Identification of endosomal and lysosomal compartments in HepG2 cells combining single-step subcellular fractionation with fluorescent imaging. Journal of Drug Targeting 15 (1) , pp. 37-50. 10.1080/10611860601010330

Peeters, L., Jones, Arwyn Tomos, Demeester, J., De Smedt, S. and Sanders, N. 2007. Post-PEGylated lipoplexes are promising vehicles for gene delivery in RPE cells. Human Gene Therapy 18 (10) , pp. 1046-1047.

Peeters, L., Sanders, N. N., Jones, Arwyn Tomos, Demeester, J. and De Smedt, S. C. 2007. Post-pegylated lipoplexes are promising vehicles for gene delivery in RPE cells. Journal of Controlled Release 121 (3) , pp. 208-217. 10.1016/j.jconrel.2007.05.033

Seib, F. P., Jones, Arwyn Tomos and Duncan, Ruth 2007. Comparison of the endocytic properties of linear and branched PEIs, and cationic PAMAM dendrimers in B16f10 melanoma cells. Journal of Controlled Release 117 (3) , pp. 291-300. 10.1016/j.jconrel.2006.10.020

Berna, Manuela, Dalzoppo, Daniele, Pasut, Gianfranco, Manunta, Maria, Izzo, Lorella, Jones, Arwyn, Duncan, Ruth and Veronese, Francesco M. 2006. Novel monodisperse PEG-dendrons as new tools for targeted drug delivery: Synthesis, characterisation and cellular uptake. Biomacromolecules 7 (1) , pp. 146-153. 10.1021/bm050480s

Al-Taei, Saly, Penning, Neal Aart, Simpson, Jeremy C., Futaki, Shiroh, Takeuchi, Toshihide, Nakase, Ikuhiko and Jones, Arwyn Tomos 2006. Intracellular traffic and fate of protein transduction domains HIV-1 TAT peptide and octaarginine. Implications for their utilization as drug delivery vectors. Bioconjugate Chemistry 17 (1) , pp. 90-100. 10.1021/bc050274h

Seib, Friedrich Philipp, Jones, Arwyn Tomos and Duncan, Ruth 2006. Establishment of subcellular fractionation techniques to monitor the intracellular fate of polymer therapeutics I. Differential centrifugation fractionation B16F10 cells and use to study the intracellular fate of HPMA copolymer-doxorubicin. Journal of drug targeting 14 (6) , pp. 375-390. 10.1080/10611860600833955

Fretz, Marjan Maria, Jin, Jing, Conibere, Robin John, Penning, Neal Aart, Al-Taei, Saly, Storm, Gert, Futaki, Shiroh, Takeuchi, Toshihide, Nakase, Ikuhiko and Jones, Arwyn Tomos 2006. Effects of Na+/H+ exchanger inhibitors on subcellular localisation of endocytic organelles and intracellular dynamics of protein transduction domains HIV-TAT peptide and octaarginine. Journal of Controlled Release 116 (2) , pp. 247-254. 10.1016/j.jconrel.2006.07.009

Hughes, Mary Louise, John, David Neale, Jones, Arwyn Tomos, Wilkins, M. L. and Jones, E. H. 2005. Patients' views on use of the Welsh language in community pharmacy: an exploratory study. International Journal of Pharmacy Practice 13 (s1) , R93. 10.1211/096176705777341217/pdf

Hughes, Mary Louise, John, David Neale and Jones, Arwyn Tomos 2005. Exploring the role of the Welsh language in community pharmacy: the professionals' views. International Journal of Pharmacy Practice 13 (s1) , R94. 10.1211/096176705777341217/pdf

Watson, Peter Duncan, Jones, Arwyn Tomos and Stephens, David J. 2005. Intracellular trafficking pathways and drug delivery: fluorescence imaging of living and fixed cells. Advanced Drug Delivery Reviews 57 (1) , pp. 43-61. 10.1016/j.addr.2004.05.003

Simpson, Jeremy C. and Jones, Arwyn Tomos 2005. Early endocytic Rabs: functional prediction to functional characterization. In: McIlhinney, Jeff and Hooper, Nigel eds. Biochemical Society Symposia Volume 72: Lipids, Rafts and Traffic, Portland Press, pp. 99-108.

Nakase, Ikuhiko, Niwa, Miki, Takeuchi, Toshihide, Sonomura, Kazuhiro, Ueda, Kunihiro, Simpson, Jeremy C., Jones, Arwyn Tomos, Sugiura, Yukio and Futaki, Shiroh 2004. Cellular uptake of arginine-rich peptides: roles for macropinocytosis and actin rearrangement. Molecular Therapy 10 (6) , pp. 1011-22. 10.1016/j.ymthe.2004.08.010

Simpson, Jeremy C., Griffiths, Gareth, Wessling-Resnick, Marianne, Fransen, Jack A. M., Bennett, Holly and Jones, Arwyn Tomos 2004. A role for the small GTPase Rab21 in the early endocytic pathway. Journal of cell science 117 (26) , pp. 6297-6311. 10.1242/jcs.01560

Jones, Arwyn Tomos, Gumbleton, Mark and Duncan, Ruth 2003. Understanding endocytic pathways and intracellular trafficking: a prerequisite for effective design of advanced drug delivery systems. Advanced Drug Delivery Reviews 55 (11) , pp. 1353-1367. 10.1016/j.addr.2003.07.002

Jones, Arwyn Tomos 2001. Intracellular drug delivery. Workshop teport from the 28th International Symposium on Controlled Release of Bioactive Materials, San Diego, 23-24 June 2001. Traffic 2 (12) , pp. 917-920. 10.1034/j.1600-0854.2001.21207.x

Jones, Arwyn Tomos, Mills, Ian G., Scheidig, Axel J., Alexandrov, Kirill and Clague, Michael J. 1998. Inhibition of endosome fusion by wortmannin persists in the presence of activated rab5. Molecular Biology of the Cell 9 (2) , pp. 323-332. 10.1091/mbc.9.2.323

Jones, Arwyn Tomos and Wessling-Resnick, M. 1998. Inhibition of in vitro endosomal vesicle fusion activity by aminoglycoside antibiotics. Journal of Biological Chemistry 273 (39) , pp. 25301-25309. 10.1074/jbc.273.39.25301

Jones, Arwyn Tomos and Clague, Michael J. 1997. Regulation of early endosome fusion by phospholipase D activity. Biochemical and Biophysical Research Communications 236 (2) , pp. 285-288. 10.1006/bbrc.1997.6962

Gaffet, P., Jones, Arwyn Tomos and Clague, M. J. 1997. Inhibition of calcium-independent mannose 6-phosphate receptor incorporation into trans-Golgi network-derived clathrin-coated vesicles by wortmannin. Journal of Biological Chemistry 272 (39) , pp. 24170-24175. 10.1074/jbc.272.39.24170