Browse by Current Cardiff authors

Milutinovic, Stefan, Abe, Jun, Godkin, Andrew, Stein, Jens V. and Gallimore, Awen 2021. The dual role of high endothelial venules in cancer progression versus immunity. Trends in Cancer 7 (3) , pp. 214-225. 10.1016/j.trecan.2020.10.001

Teijeira Crespo, Alicia, Burnell, Stephanie, Capitani, Lorenzo, Bayliss, Rebecca, Moses, Elise, Mason, Georgina H., Davies, James A., Godkin, Andrew J., Gallimore, Awen M. and Parker, Alan L. 2021. Pouring petrol on the flames: using oncolytic virotherapies to enhance tumour immunogenicity. Immunology 10.1111/imm.13323 Item availability restricted.

Pires, Ana, Greenshields Watson, Alexander, Jones, Emma, Smart, Kathryn, Lauder, Sarah N., Somerville, Michelle, Milutinovic, Stefan, Kendrick, Howard, Hindley, James P., French, Rhiannon, Smalley, Matthew J., Watkins, William John, Andrews, Robert, Godkin, Andrew and Gallimore, Awen 2020. Immune remodelling of the extracellular matrix drives loss of cancer stem cells and tumor rejection. Cancer Immunology Research 8 (12) , 1520 - 1531. 10.1158/2326-6066.CIR-20-0070 Item availability restricted.

Hughes, Ellyn, Lauder, Sarah N., Smart, Kathryn, Bloom, Anja, Scott, Jake, Jones, Emma, Somerville, Michelle, Browne, Molly, Blainey, Andrew, Godkin, Andrew, Ager, Ann and Gallimore, Awen 2020. Primary breast tumours but not lung metastases induce protective anti-tumour immune responses after Treg-depletion. Cancer Immunology, Immunotherapy 69 , 2063 - 2073. 10.1007/s00262-020-02603-x

Lauder, Sarah Nicol, Smart, Kathryn, Kersemans, Veerle, Allen, Danny, Scott, Jake, Pires, Ana, Milutinovic, Stefan, Somerville, Michelle, Smart, Sean, Kinchesh, Paul, Lopez-Guadamillas, Elena, Hughes, Ellyn, Jones, Emma, Scurr, Martin, Godkin, Andrew, Friedman, Lori S, Vanhaesebroeck, Bart and Gallimore, Awen 2020. Enhanced antitumor immunity through sequential targeting of PI3Kδ and LAG3. Journal for ImmunoTherapy of Cancer 8 (2) , e000693. 10.1136/jitc-2020-000693

Greenshields-Watson, Alexander, Attaf, Meriem, MacLachlan, Bruce J., Whalley, Thomas, Rius, Cristina, Wall, Aaron, Lloyd, Angharad, Hughes, Hywel, Strange, Kathryn E., Mason, Georgina H., Schauenburg, Andrea J., Hulin-Curtis, Sarah L., Geary, James, Chen, Yuan, Lauder, Sarah N., Smart, Kathryn, Vijaykrishna, Dhanasekaran, Grau, Miguel L., Shugay, Mikhail, Andrews, Robert, Dolton, Garry, Rizkallah, Pierre J., Gallimore, Awen M., Godkin, Andrew J., Sewell, Andrew J. and Cole, David K. 2020. CD4 + T cells recognize conserved influenza A epitopes through shared patterns of V-Gene usage and complementary biochemical features. Cell Reports 32 (2) , 107885. 10.1016/j.celrep.2020.107885

Scurr, Martin J., Greenshields-Watson, Alexander, Campbell, Emma, Somerville, Michelle, Chen, Yuan, Hulin-Curtis, Sarah L., Burnell, Stephanie E. A., Davies, James A., Davies, Michael M., Hargest, Rachel, Phillips, Simon, Christian, Adam D., Ashelford, Kevin E., Andrews, Robert, Parker, Alan L., Stanton, Richard J., Gallimore, Awen and Godkin, Andrew 2020. Cancer antigen discovery is enabled by RNA-sequencing of highly purified malignant and non-malignant cells. Clinical Cancer Research 10.1158/1078-0432.CCR-19-3087

MacLachlan, Bruce J., Dolton, Garry, Papakyriakou, Athanasios, Greenshields-Watson, Alexander, Mason, Georgina H., Schauenburg, Andrea, Besneux, Matthieu, Szomolay, Barbara, Elliott, Tim, Sewell, Andrew K., Gallimore, Awen, Rizkallah, Pierre, Cole, David K. and Godkin, Andrew 2019. Human leukocyte antigen (HLA) class II peptide flanking residues tune the immunogenicity of a human tumor-derived epitope. Journal of Biological Chemistry 294 (52) , pp. 20246-20258. 10.1074/jbc.RA119.009437

Appanna, Gautham D, Pembroke, Thomas P I, Miners, Kelly L, Price, David A, Gallimore, Awen M, Ladell, Kristin and Godkin, Andrew J 2019. Rituximab depletion of intrahepatic B cells to control refractory hepatic autoimmune overlap syndrome. QJM: An International Journal of Medicine 112 (10) , pp. 793-795. 10.1093/qjmed/hcz161

Gallimore, Awen, Quezada, Sergio A. and Roychoudhuri, Rahul 2019. Regulatory T cells in cancer: where are we now? Immunology 157 (3) , pp. 187-189. 10.1111/imm.13088

Thomson, Amanda, Smart, Kathryn, Somerville, Michelle S., Lauder, Sarah N., Appanna, Gautham, Horwood, James, Lawrence-Sunder, Raj, Srivastava, Brijesh, Durai, Dhamaraj, Scurr, Martin J., Keita, Asa V., Gallimore, Awen M. and Godkin, Andrew 2019. The Ussing chamber system for measuring intestinal permeability in health and disease. BMC Gastroenterology 19 , 98. 10.1186/s12876-019-1002-4

Watson, H. Angharad, Durairaj, Ruban R.P., Ohme, Julia, Alatsatianos, Markella, Almutairi, Hanan, Mohammed, Rebar N., Vigar, Miriam, Reed, Sophie G., Paisey, Stephen J., Marshall, Christopher, Gallimore, Awen and Ager, Ann 2019. L-selectin enhanced T cells improve the efficacy of cancer immunotherapy. Frontiers in Immunology 10 , 1321. 10.3389/fimmu.2019.01321

Besneux, Matthieu, Greenshields Watson, Alexander, Scurr, Martin, MacLachlan, Bruce J., Christian, Adam, Davies, Michael M., Hargest, Rachel, Phillips, Simon, Godkin, Andrew and Gallimore, Awen 2019. The nature of the human T cell response to the cancer antigen 5T4 is determined by the balance of regulatory and inflammatory T cells of the same antigen-specificity: implications for vaccine design. Cancer Immunology, Immunotherapy 68 , pp. 247-256. 10.1007/s00262-018-2266-1

Jones, Emma, Gallimore, Awen and Ager, Ann 2018. Defining high endothelial venules and tertiary lymphoid structures in cancer. Tertiary Lymphoid Structures. Methods in Molecular Biology, Vol. 1845. Methods in Molecular Biology, Humana Press, pp. 99-118. (10.1007/978-1-4939-8709-2_7)

May, Stephanie, Owen, Heather, Phesse, Toby J., Greenow, Kristy R., Jones, Gareth-Rhys, Blackwood, Adam, Cook, Peter C., Towers, Christopher, Gallimore, Awen M., Williams, Geraint T., Sturzl, Michael, Britzen-Laurent, Nathalie, Sansom, Owen J., MacDonald, Andrew S., Bird, Adrian P., Clarke, Alan R. and Parry, Lee 2018. Mbd2 enables tumourigenesis within the intestine while preventing tumour-promoting inflammation. Journal of Pathology 245 (3) , pp. 270-282. 10.1002/path.5074

Hill, David, Yu, Liang, Gao, Hugh, Balic, Jesse J., West, Alison, Oshima, Hiroko, McLeod, Louise, Oshima, Masanobu, Gallimore, Awen M., D'Costa, Kimberley, Bhathal, Prithi S., Sievert, William, Ferrero, Richard L., Jenkins, Brendan J. and Jones, Gareth W. 2018. Hyperactive gp130/STAT3-driven gastric tumourigenesis promotes submucosal tertiary lymphoid structure development. International Journal of Cancer 143 (1) , pp. 167-178. 10.1002/ijc.31298

Hughes, Ellyn, Scurr, Martin, Campbell, Emma, Jones, Emma, Godkin, Andrew and Gallimore, Awen 2018. T‐cell modulation by cyclophosphamide for tumour therapy. Immunology 154 (1) , pp. 62-68. 10.1111/imm.12913

Miles, John J., Tan, Mai Ping, Dolton, Garry, Edwards, Emily S. J., Galloway, Sarah A. E., Laugel, Bruno, Clement, Mathew, Makinde, Julia, Ladell, Kristin, Matthews, Katherine K., Watkins, Thomas S., Tungatt, Katie, Wong, Yide, Lee, Han Siean, Clark, Richard J., Pentier, Johanne M., Attaf, Meriem, Lissina, Anya, Ager, Ann, Gallimore, Awen, Rizkallah, Pierre J., Gras, Stephanie, Rossjohn, Jamie, Burrows, Scott R., Cole, David K., Price, David A. and Sewell, Andrew K. 2018. Peptide mimic for influenza vaccination using nonnatural combinatorial chemistry. Journal of Clinical Investigation 128 (4) , pp. 1569-1580. 10.1172/JCI91512

Colbeck, Emily Jayne, Ager, Ann, Gallimore, Awen and Jones, Gareth Wyn 2017. Tertiary lymphoid structures in cancer: drivers of antitumor immunity, immunosuppression, or bystander sentinels in disease? Frontiers in Immunology 8 , 1830. 10.3389/fimmu.2017.01830

Colbeck, Emily J., Jones, Emma, Hindley, James P., Smart, Kathryn, Schulz, Ralph, Browne, Molly, Cutting, Scott, Williams, Anwen, Parry, Lee, Godkin, Andrew, Ware, Carl F., Ager, Ann and Gallimore, Awen 2017. Treg depletion licenses T cell-driven HEV neogenesis and promotes tumor destruction. Cancer Immunology Research 5 (11) , pp. 1005-1015. 10.1158/2326-6066.CIR-17-0131

Scurr, Martin, Pembroke, Tom, Bloom, Anja, Roberts, David, Thomson, Amanda, Smart, Kathryn, Bridgeman, Hayley, Adams, Richard, Brewster, Alison, Jones, Robert, Gwynne, Sarah, Blount, Daniel, Harrop, Richard, Wright, Melissa, Hills, Robert, Gallimore, Awen and Godkin, Andrew 2017. Effect of modified vaccinia Ankara–5T4 and low-dose cyclophosphamide on antitumor immunity in metastatic colorectal cancer: A randomized clinical trial. JAMA Oncology 3 (10) , e172579. 10.1001/jamaoncol.2017.2579

Scurr, Martin J, Pembroke, Tom, Bloom, Anja, Roberts, David J, Thomson, Amanda, Smart, Kathryn, Bridgeman, Hayley, Adams, Richard A, Brewster, Alison E, Jones, Robert, Gwynne, Sarah, Blount, Daniel, Harrop, Richard, Hills, Robert, Gallimore, Awen and Godkin, Andrew 2017. Low-dose cyclophosphamide induces anti-tumor T-cell responses which associate with survival in metastatic colorectal cancer. Clinical Cancer Research , clincanres.0895.2017. 10.1158/1078-0432.CCR-17-0895

Chen, Hung-Chang, Joalland, Noémie, Bridgeman, John S, Alchami, Fouad S, Jarry, Ulrich, Khan, Mohd Wajid A, Piggott, Luke, Shanneik, Yasmin, Li, Jianqiang, Herold, Marco J, Herrmann, Thomas, Price, David A., Gallimore, Awen M., Clarkson, Richard W., Scotet, Emmanuel, Moser, Bernhard and Eberl, Matthias 2017. Synergistic targeting of breast cancer stem-like cells by human γδ T cells and CD8+ T cells. Immunology and Cell Biology 95 (7) , pp. 620-629. 10.1038/icb.2017.21

Scurr, Martin, Pembroke, Tom, Adams, Richard, Blount, Daniel, Brewster, Alison, Gwynne, Sarah, Harrop, Richard, Jones, Robert, Hills, Robert, Gallimore, Awen and Godkin, Andrew 2017. MVA-5T4 immunotherapy and low-dose cyclophosphamide for advanced colorectal cancer (TaCTiCC): An open-label, randomized phase I/II trial. Journal of Clinical Oncology 35 (7) , p. 154. 10.1200/JCO.2017.35.7_suppl.154

Hughes, E., Bloom, A., Paisey, Stephen James, Smart, K., Ager, A. and Gallimore, Awen Myfanwy 2016. Treating metastatic disease through manipulation of regulatory T cells. European Journal of Immunology 46 , p. 578. 10.1002/eji.201670200

Colbeck, Emily, Hindley, James P., Smart, Kathryn, Jones, Emma, Bloom, Anja, Bridgeman, Hayley, McPherson, Rhoanne C., Turner, Darryl G., Ladell, Kristin Ingrid, Price, David, O'Connor, Richard A., Anderton, Stephen M., Godkin, Andrew James and Gallimore, Awen Myfanwy 2015. Eliminating roles for T-bet and IL-2 but revealing superior activation and proliferation as mechanisms underpinning dominance of regulatory T cells in tumors. Oncotarget 6 (28) , pp. 24649-24659. 10.18632/oncotarget.5584

Pembroke, Tom, Gallimore, Awen Myfanwy and Godkin, Andrew James 2015. Tracking the kinetics of intrahepatic immune responses by repeated fine needle aspiration of the liver. Journal of Immunological Methods 424 , pp. 131-135. 10.1016/j.jim.2015.04.011

Ondondo, Beatrice, Colbeck, Emily, Jones, Emma, Smart, Kathryn, Lauder, Sarah Nicol, Hindley, James Philip, Godkin, Andrew James, Moser, Bernhard, Ager, Ann and Gallimore, Awen Myfanwy 2015. A distinct chemokine axis does not account for enrichment of Foxp3+ CD4+T cells in carcinogen-induced fibrosarcomas. Immunology 145 (1) , pp. 94-104. 10.1111/imm.12430

Scurr, Martin J., Brown, Clare M., Costa Bento, Diana F., Betts, Gareth J., Rees, Brian I., Hills, Robert K., Gallimore, Awen and Godkin, Andrew 2015. Assessing the prognostic value of preoperative carcinoembryonic antigen-specific T-cell responses in colorectal cancer. JNCI: Journal of the National Cancer Institute 107 (4) , djv001. 10.1093/jnci/djv001

Costa Bento, Diana Filipa, Jones, Emma, Junaid, Syed, Tull, Justyna, Williams, Geraint Trefor, Godkin, Andrew James, Ager, Ann and Gallimore, Awen Myfanwy 2015. High endothelial venules are rare in colorectal cancers but accumulate in extra-tumoral areas with disease progression. OncoImmunology 4 (3) , pp. 653-660. 10.4161/2162402X.2014.974374

Ford, Catriona A., Petrova, Sofia, Pound, John D., Voss, Jorine J.L.P., Melville, Lynsey, Paterson, Margaret, Farnworth, Sarah L., Gallimore, Awen Myfanwy, Cuff, Simone, Wheadon, Helen, Dobbin, Edwina, Ogden, Carol Anne, Dumitriu, Ingrid E., Dunbar, Donald R., Murray, Paul G., Ruckerl, Dominik, Allen, Judith E., Hume, David A., van Rooijen, Nico, Goodlad, John R., Freeman, Tom C. and Gregory, Christopher D. 2015. Oncogenic properties of apoptotic tumor cells in aggressive B cell lymphoma. Current Biology 25 (5) , pp. 577-588. 10.1016/j.cub.2014.12.059

Stack, Gabrielle, Jones, Emma, Marsden, Morgan, Stacey, Maria A., Snelgrove, Robert J., Lacaze, Paul, Jacques, Laura C., Cuff, Simone, Stanton, Richard J., Gallimore, Awen M., Hussell, Tracy, Wilkinson, Gavin W. G., Ghazal, Peter, Taylor, Philip R. and Humphreys, Ian R. 2015. CD200 receptor restriction of myeloid cell responses antagonizes antiviral immunity and facilitates cytomegalovirus persistence within mucosal tissue. PLoS Pathogens 11 (2) , e1004641. 10.1371/journal.ppat.1004641

Ondondo, Beatrice, Jones, Emma, Hindley, James, Cutting, Scott, Smart, Kathryn, Bridgeman, Hayley, Matthews, Katherine K., Ladell, Kristin Ingrid, Price, David, Jackson, David G., Godkin, Andrew James, Ager, Ann and Gallimore, Awen Myfanwy 2014. Progression of carcinogen-induced fibrosarcomas is associated with the accumulation of naïve CD4+ T cellsviablood vessels and lymphatics. International Journal of Cancer 134 (9) , pp. 2156-2167. 10.1002/ijc.28556

Stacey, Maria A., Marsden, Morgan, Pham N., Tu Anh, Clare, Simon, Dolton, Garry, Stack, Gabrielle, Jones, Emma, Klenerman, Paul, Gallimore, Awen M., Taylor, Philip R., Snelgrove, Robert J., Lawley, Trevor D., Dougan, Gordon, Benedict, Chris A., Jones, Simon A., Wilkinson, Gavin W. G. and Humphreys, Ian R. 2014. Neutrophils recruited by IL-22 in peripheral tissues function as TRAIL-dependent antiviral effectors against MCMV. Cell Host and Microbe 15 (4) , pp. 471-483. 10.1016/j.chom.2014.03.003

Scurr, Martin, Bloom, Anja, Pembroke, Thomas, Srinivasan, R., Brown, Clare, Smart, Kathryn, Bridgeman, H., Davies, Michael, Hargest, Rachel, Phillips, Simon, Christian, Adam, Hockey, T., Gallimore, Awen and Godkin, Andrew 2013. Escalating regulation of 5T4-specific IFN- + CD4+ T cells distinguishes colorectal cancer patients from healthy controls and provides a target for in vivo therapy. Cancer Immunology Research 1 (6) , 416. 10.1158/2326-6066.CIR-13-0035

Lauder, Sarah Nicol, Jones, Emma, Smart, Kathryn, Bloom, Anja Constanze, Williams, Anwen Sian, Hindley, James P., Ondondo, Beatrice, Taylor, Philip Russel, Clement, Mathew, Fielding, Ceri Alan, Godkin, Andrew James, Jones, Simon Arnett and Gallimore, Awen Myfanwy 2013. Interleukin-6 limits influenza-induced inflammation and protects against fatal lung pathology. European Journal of Immunology 43 (10) , pp. 2613-2625. 10.1002/eji.201243018

Scurr, Martin John, Ladell, Kristin Ingrid, Besneux, Matthieu, Christian, Adam, Hockey, T., Smart, Kathryn, Bridgeman, Hayley, Hargest, Rachel, Phillips, S., Davies, M., Price, David, Gallimore, Awen Myfanwy and Godkin, Andrew James 2013. Highly prevalent colorectal cancer-infiltrating LAP+ Foxp3- T cells exhibit more potent immunosuppressive activity than Foxp3+ regulatory T cells. Mucosal Immunology n/a 10.1038/mi.2013.62

Ondondo, Beatrice, Jones, Emma, Godkin, Andrew James and Gallimore, Awen Myfanwy 2013. Home sweet home: The tumor microenvironment as a haven for regulatory T cells. Frontiers in Immunology 4 , 197. 10.3389/fimmu.2013.00197

Pembroke, T., Gallimore, A. and Godkin, A. 2013. Flow cytometry makes all the difference. Journal of Hepatology 59 (4) , pp. 909-910. 10.1016/j.jhep.2013.05.047

Pembroke, Thomas, Christian, Adam, Jones, Emma, Hills, Robert Kerrin, Wang, Edward Chung Yern, Gallimore, Awen Myfanwy and Godkin, Andrew James 2013. The paradox of NKp46+ natural killer cells: drivers of severe hepatitis C virus-induced pathology but in-vivo resistance to interferon treatment. Gut n/a 10.1136/gutjnl-2013-304472

Pembroke, Thomas, Gallimore, Awen and Godkin, Andrew 2013. Rapid innate control of antigen abrogates adaptive immunity. Immunology 138 (4) , pp. 293-297. 10.1111/imm.12048

Gallimore, Awen Myfanwy and Godkin, Andrew James 2013. Epithelial barriers, microbiota, and colorectal cancer. New England Journal of Medicine 368 (3) , pp. 282-284. 10.1056/NEJMcibr1212341

Humphreys, Ian R., Clement, Mathew, Marsden, Morgan, Ladell, Kristin Ingrid, McLaren, James Edward, Smart, Kathryn, Hindley, James Philip, Bridgeman, Hayley, van den Berg, Hugo A., Price, David, Ager, Ann, Wooldridge, Linda, Godkin, Andrew James and Gallimore, Awen Myfanwy 2012. Avidity of influenza-specific memory CD8+T-cell populations decays over time compromising antiviral immunity. European Journal of Immunology 42 (12) , pp. 3235-3242. 10.1002/eji.201242575

Hindley, James Phillip, Jones, Emma, Smart, Kathryn, Bridgeman, Hayley, Lauder, Sarah Nicol, Ondondo, Beatrice Omusiro, Cutting, Scott, Ladell, Kristin Ingrid, Wynn, Katherine Kay, Withers, David, Price, David, Ager, Ann, Godkin, Andrew James and Gallimore, Awen Myfanwy 2012. T-cell trafficking facilitated by high endothelial venules is required for tumor control after regulatory T cell depletion. Cancer Research 72 (21) , pp. 5473-5482. 10.1158/0008-5472.CAN-12-1912

Scurr, Martin John, Gallimore, Awen Myfanwy and Godkin, Andrew James 2012. T cell subsets and colorectal cancer: discerning the good from the bad. Cellular Immunology 279 (1) , pp. 21-24. 10.1016/j.cellimm.2012.08.004

Pembroke, Thomas, Rees, Ian W., Gallagher, Kathleen, Jones, Emma, Mizen, Paul Edward, Navruzov, Timur, Freedman, Andrew Robert, Fielding, Ceri Alan, Humphreys, Ian R., Wang, Edward Chung Yern, Gallimore, Awen Myfanwy and Godkin, Andrew James 2012. Rapid early innate control of hepatitis C virus during IFN-α treatment compromises adaptive CD4+T-cell immunity. European Journal of Immunology 42 (9) , pp. 2383-2394. 10.1002/eji.201142072

Twohig, Jason Peter, Marsden, Morgan, Cuff, Simone, Ferdinand, John R., Gallimore, Awen Myfanwy, Perks, William Victor, Al-Shamkhani, Aymen, Humphreys, Ian R. and Wang, Edward Chung Yern 2012. The death receptor 3/TL1A pathway is essential for efficient development of antiviral CD4+ and CD8+ T-cell immunity. The FASEB Journal 26 (8) , pp. 3575-3586. 10.1096/fj.11-200618

Kempshall, Emma, Thebault, Simon, Morgan, Bryan Paul, Harris, Claire Louise and Gallimore, Awen Myfanwy 2012. Complement-induced protection: an explanation for the limitations of cell-based tumour immunotherapies. Immunology and Cell Biology 90 (9) , pp. 869-871. 10.1038/icb.2012.30

Pembroke, Thomas, Wang, Edward Chung Yern, Gallimore, Awen Myfanwy and Godkin, Andrew James 2012. PMO-174 Intrahepatic natural killer cell phenotyping and functional analysis by fine needle aspiration in chronic HCV infection. Gut 61 (S2) , A144-A145. 10.1136/gutjnl-2012-302514b.174

Scurr, Martin John, Gallimore, Awen Myfanwy and Godkin, Andrew James 2012. PMO-088 A large proportion of colorectal tumour-infiltrating CD4+ T cells are suppressive irrespective of FOXP3 expression. Gut 61 (S2) , A109. 10.1136/gutjnl-2012-302514b.88

Cole, David, Gallagher, Kathleen, Lemercier, Brigitte, Holland, Christopher J., Junaid, Sayed, Hindley, James Phillip, Wynn, Katherine Kay, Gostick, Emma, Sewell, Andrew K., Gallimore, Awen Myfanwy, Ladell, Kristin Ingrid, Price, David, Gougeon, Marie-Lise and Godkin, Andrew James 2012. Modification of the carboxy-terminal flanking region of a universal influenza epitope alters CD4+ T-cell repertoire selection. Nature Communications 3 , 665. 10.1038/ncomms1665

Betts, Gareth James, Jones, Emma, Junaid, Syed, El-Shanawany, Tariq, Scurr, Martin John, Mizen, Paul Edward, Kumar, Mayur, Jones, Sion, Rees, Brian Idris, Williams, Geraint Trefor, Gallimore, Awen Myfanwy and Godkin, Andrew James 2012. Suppression of tumour-specific CD4+ T cells by regulatory T cells is associated with progression of human colorectal cancer. Gut 61 (8) , pp. 1163-1171. 10.1136/gutjnl-2011-300970

Clement, Mathew, Ladell, Kristin Ingrid, Ekeruche, Julia, Miles, John James, Edwards, Emily, Dolton, Garry Michael, Williams, Tamsin, Schauenburg, Andrea J. A., Cole, David, Lauder, Sarah Nicol, Gallimore, Awen Myfanwy, Godkin, Andrew James, Burrows, Scott R., Price, David, Sewell, Andrew K. and Wooldridge, Linda 2011. Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining. The Journal of Immunology 187 (2) , pp. 654-663. 10.4049/jimmunol.1003941

Lauder, Sarah Nicol, Taylor, Philip Russel, Clark, Stephen Robert, Evans, Rhys Lloyd, Hindley, James Phillip, Smart, Kathryn, Leach, Heather, Kidd, Emma Jane, Broadley, Kenneth John, Jones, Simon Arnett, Wise, Matthew Peter, Godkin, Andrew James, O'Donnell, Valerie Bridget and Gallimore, Awen Myfanwy 2011. Paracetamol reduces influenza-induced immunopathology in a mouse model of infection without compromising virus clearance or the generation of protective immunity. Thorax 66 (5) , pp. 368-374. 10.1136/thx.2010.150318

Hindley, James Philip, Ferreira, Cristina, Jones, Emma, Lauder, Sarah Nicol, Ladell, Kristin, Wynn, Katherine, Betts, Gareth James, Singh, Yogesh, Price, David, Godkin, Andrew James, Dyson, Julian and Gallimore, Awen Myfanwy 2011. Analysis of the T-cell receptor repertoires of tumor-infiltrating conventional and regulatory T cells reveals no evidence for conversion in carcinogen-induced tumors. Cancer Research 71 (3) , pp. 736-746. 10.1158/0008-5472.CAN-10-1797

Ruge, Fiona, Glavini, Aikaterini, Gallimore, Awen Myfanwy, Richards, Hannah E., Thomas, Christopher P., O'Donnell, Valerie Bridget, Philpott, Michael P. and Porter, Rebecca 2011. Delineating immune-mediated mechanisms underlying hair follicle destruction in the mouse mutant defolliculated. Journal of Investigative Dermatology 131 (3) , pp. 572-579. 10.1038/jid.2010.379

Godkin, Andrew James and Gallimore, Awen Myfanwy 2011. Setting the threshold for extra-thymic differentiation of Foxp3+ Tregs: TGF-β-dependent and T-cell autonomous. European Journal of Immunology 41 (5) , pp. 1218-1220. 10.1002/eji.201141576

Lauder, Sarah Nicol, Smart, Kathryn, Ondondo, B., Fielding, Ceri Alan, Godkin, Andrew James, Jones, Simon Arnett and Gallimore, Awen Myfanwy 2010. A critical role for interleukin-6 in limiting influenza-induced pathology and generating heterosubtypic immunity [Abstract]. Immunology 131 (S1) , p. 186. 10.1111/j.1365-2567.2010.03390.x

Cuff, Simone, Dolton, Garry Michael, Matthews, Reginald James and Gallimore, Awen Myfanwy 2010. Antigen specificity determines the pro- or antitumoral nature of CD8+ T cells. The Journal of Immunology 184 (2) , pp. 607-614. 10.4049/jimmunol.0804089

Richards, Hannah Catharine, Williams, Anwen Sian, Jones, Emma, Hindley, James Phillip, Godkin, Andrew James, Simon, Anna Katharina and Gallimore, Awen Myfanwy 2010. Novel role of regulatory T cells in limiting early neutrophil responses in skin. Immunology 131 (4) , pp. 583-592. 10.1111/j.1365-2567.2010.03333.x

Gallagher, Kathleen M. E., Lauder, Sarah Nicol, Rees, Ian W., Gallimore, Awen Myfanwy and Godkin, Andrew James 2009. Type I interferon (IFNα) acts directly on human memory CD4+ T cells altering their response to antigen. The Journal of Immunology 183 (5) , pp. 2915-2920. 10.4049/jimmunol.0801607

Baalasubramanian, Sivasankar, Longhi, M. Paula, Gallagher, Kathleen M. E., Betts, Gareth J., Morgan, Bryan Paul, Godkin, Andrew James and Gallimore, Awen Myfanwy 2009. CD59 blockade enhances antigen-specific CD4+ T cell responses in humans: a new target for cancer immunotherapy? The Journal of Immunology 182 (9) , pp. 5203-5207. 10.4049/jimmunol.0804243

Jones, Gareth Wyn, Stumhofer, J. S., Newton, Zarabeth, Gallimore, Awen Myfanwy, Ernst, M., Topley, Nicholas, Williams, Anwen Sian, Hunter, Catherine, Jenkins, Brian J., Wang, Edward Chung Yern and Jones, Simon Arnett 2008. TL1A/TNFSF15 promotes a STAT1-mediated suppression of IL-17-secreting T-helper cells [Abstract]. Immunology 125 (s1) , p. 62. 10.1111/j.1365-2567.2008.02974.x

Morton, Jonathan, Coles, Barbara, Wright, Kate Louise, Gallimore, Awen Myfanwy, Morrow, Jason D., Terry, Erin S., Anning, Peter, Morgan, Bryan Paul, Dioszeghy, Vincent, Kuhn, Hartmut, Chaitidis, Pavlos, Hobbs, Adrian J., Jones, Simon Arnett and O'Donnell, Valerie Bridget 2008. Circulating neutrophils maintain physiological blood pressure by suppressing bacteria and IFN -dependent iNOS expression in the vasculature of healthy mice. Blood 111 (10) , pp. 5187-5194. 10.1182/blood-2007-10-117283

Longhi, Maria Paula, Wright, Kate Louise, Lauder, Sarah Nicol, Nowell, Mari Ann, Jones, Gareth Wyn, Godkin, Andrew James, Jones, Simon Arnett and Gallimore, Awen Myfanwy 2008. Interleukin-6 is crucial for recall of influenza-specific memory cd4+ t cells. PLoS Pathogens 4 (2) , e1000006. 10.1371/journal.ppat.1000006

Richards, Hannah Catharine, Longhi, Maria Paula, Wright, Kate Louise, Gallimore, Awen Myfanwy and Ager, Ann 2008. CD62L (L-Selectin) down-regulation does not affect memory T cell distribution but failure to shed compromises anti-viral immunity. Journal of Immunology 180 (1) , pp. 198-206.

Gallimore, Awen Myfanwy and Simon, A. K. 2008. Positive and negative influences of regulatory T cells on tumour immunity. Oncogene 27 (45) , pp. 5886-5893. 10.1038/onc.2008.269

Boulter, Jonathan M., Schmitz, Nicole, Sewell, Andrew K., Godkin, Andrew James, Bachmann, Martin F. and Gallimore, Awen Myfanwy 2007. Potent T cell agonism mediated by a very rapid TCR/pMHC interaction. European Journal of Immunology 37 (3) , pp. 798-806. 10.1002/eji.200636743

Simon, Anna Katharina, Jones, Emma, Richards, Hannah, Wright, Kate Louise, Betts, Gareth James, Godkin, Andrew James, Screaton, Gavin and Gallimore, Awen Myfanwy 2007. Regulatory T cells inhibit Fas ligand induced innate and adaptive tumour immunity. European Journal of Immunology 37 (3) , pp. 758-767. 10.1002/eji.200636593

Betts, G., Twohig, Jason Peter, Van den Broek, M., Sierro, S., Godkin, Andrew James and Gallimore, Awen Myfanwy 2007. The impact of regulatory T cells on carcinogen-induced sarcogenesis. British Journal of Cancer 96 (12) , pp. 1849-1854. 10.1038/sj.bjc.6603824

Betts, Gareth James, Godkin, Andrew James and Gallimore, Awen Myfanwy 2007. Reply: forkhead box P3-positive regulatory T cells in immune surveillance and cancer. British Journal of Cancer 97 , pp. 1017-1018. 10.1038/sj.bjc.6603940

Gallimore, Awen Myfanwy and Godkin, Andrew James 2007. Regulatory T cells and tumour immunity - observations in mice and men. Immunology 123 (2) , pp. 157-163. 10.1111/j.1365-2567.2007.02748.x

Wise, Matthew Peter, Gallimore, Awen Myfanwy and Godkin, Andrew James 2006. T-Cell costimulation [Letter]. New England Journal of Medicine 355 (24) , pp. 2594-2595. 10.1056/NEJMc062767

Betts, Gareth James, Clarke, Sarah Louise, Richards, Hannah E., Godkin, Andrew James and Gallimore, Awen Myfanwy 2006. Regulating the immune response to tumours. Advanced Drug Delivery Reviews 58 (8) , pp. 948-961. 10.1016/j.addr.2006.05.006

Longhi, M. Paula, Baalasubramanian, Sivasankar, Omidvar, Nader, Morgan, Bryan Paul and Gallimore, Awen Myfanwy 2005. Cutting edge: murine CD59a modulates antiviral CD4+ T cell activity in a complement-independent manner. Journal of Immunology 175 (11) , pp. 7098-7102.

Clarke, S. L., Betts, G. J., Wright, K. L., El-Shanawany, Tariq, Plant, A., Gallimore, Awen Myfanwy and Godkin, Andrew James 2005. Analysis of CD4(+)CD25(hi) cells in peripheral blood and lymph nodes of patients with colorectal cancer. Immunology 116 (1) , p. 37. 10.1111/j.1365-2567.2005.02287.x

Richards, H. E., Simon, A. K., Jones, E., Williams, Anwen Sian, Screaton, G. R. and Gallimore, Awen Myfanwy 2005. Inhibition of innate immune responses to tumours by CD4+CD25+ regulatory T cells [Abstract]. Immunology 116 (s1) , p. 36. 10.1111/j.1365-2567.2005.02287.x

Jones, Emma, Price, David, Dahm-Vicker, Michaela, Cerundolo, Vincenzo, Klenerman, Paul and Gallimore, Awen 2003. The influence of macrophage inflammatory protein-1alpha on protective immunity mediated by antiviral cytotoxic T cells. Immunology 109 (1) , pp. 68-75. 10.1046/j.1365-2567.2003.01636.x

Simon, Anna Katharina, Gallimore, Awen Myfanwy, Jones, Emma, Sawitzki, Birgit, Cerundolo, Vincenzo and Screaton, Gavin R. 2002. Fas ligand breaks tolerance to self-antigens and induces tumor immunity mediated by antibodies. Cancer Cell 2 (4) , pp. 315-322. 10.1016/S1535-6108(02)00151-4

Golgher, Denise, Jones, Emma, Powrie, Fiona, Elliot, Tim and Gallimore, Awen Myfanwy 2002. CD25+ regulatory cells uncover immune responses to shared tumour rejection antigens. European Journal of Immunology 32 (11) , pp. 3267-3275. 10.1002/1521-4141(200211)32:11<3267::AID-IMMU3267>3.0.CO;2-1

Bachmann, M. F., Gallimore, Awen Myfanwy, Linkert, S., Cerundolo, V., Lanzavecchia, A., Kopf, M. and Viola, A. 1999. Developmental regulation of Lck targeting to the CD8 coreceptor controls signaling in naive and memory T cells. Journal of Experimental Medicine 189 (10) , pp. 1521-1530.

Gallimore, Awen Myfanwy, Hombach, Joachim, Dumrese, Tilman, Rammensee, Hans-Georg, Zinkernagel, Rolf M. and Hengartner, Hans 1998. A protective cytotoxic T cell response to a subdominant epitope is influenced by the stability of the MHC class I/peptide complex and the overall spectrum of viral peptides generated within infected cells. European Journal of Immunology 28 (10) , pp. 3301-3311.

Gallimore, Awen Myfanwy, Hengartner, H. and Zinkernagel, R. 1998. Hierarchies of antigen-specific cytotoxic T-cell responses. Immunological Reviews 164 , pp. 29-36. 10.1111/j.1600-065X.1998.tb01205.x

Gallimore, Awen Myfanwy, Schwarz, K., van den Broek, M., Hengartner, H. and Groettrup, M. 1998. The proteasome inhibitor lactacystin prevents the generation of an endoplasmic reticulum leader-derived T cell epitope. Molecular Immunology 35 (10) , pp. 581-591.

Gallimore, Awen Myfanwy, Dumrese, T., Hengartner, H., Zinkernagel, R. M. and Rammensee, H. G. 1998. Protective immunity does not correlate with the hierarchy of virus-specific cytotoxic T cell responses to naturally processed peptides. Journal of Experimental Medicine 187 (10) , pp. 1647-1657.

Gotch, F., Gallimore, Awen Myfanwy and McMichael, A. 1996. Cytotoxic T cells--protection from disease progression--protection from infection. Immunology Letters 51 (1-2) , pp. 125-128. 10.1016/0165-2478(96)02566-7

Gallimore, Awen Myfanwy, Cranage, M., Cook, N., Almond, N., Bootman, J., Rud, E., Silvera, P., Dennis, M., Corcoran, T. and Stott, J. 1995. Early suppression of SIV replication by CD8+ nef-specific cytotoxic T cells in vaccinated macaques. Natural Medicines 1 (11) , pp. 1167-1173.

Boyson, J. E,, McAdam, S. N., Gallimore, Awen Myfanwy, Golos, T. G., Liu, X., Gotch, F. M., Hughes, A. L. and Watkins, D. I. 1995. The MHC E locus in macaques is polymorphic and is conserved between macaques and humans. Immunogenetics 41 (2-3) , pp. 59-68. 10.1007/BF00182314

Rowland-Jones, S., Sutton, J., Ariyoshi, K., Dong, T., Gotch, F., McAdam, S., Whitby, D., Sabally, S., Gallimore, Awen Myfanwy and Corrah, T. 1995. HIV-specific cytotoxic T-cells in HIV-exposed but uninfected Gambian women. Natural Medicines 1 (1) , pp. 59-64.

Gotch, F., McAdam, S. N., Allsopp, C. E., Gallimore, Awen Myfanwy, Elvin, J., Kieny, M. P., Hill, A. V., McMichael, A. J. and Whittle, H. C. 1993. Cytotoxic T cells in HIV2 seropositive Gambians. Identification of a virus-specific MHC-restricted peptide epitope. The Journal of Immunology 151 (6) , pp. 3361-3369.