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Pires, Ana, Greenshields Watson, Alexander, Jones, Emma, Smart, Kathryn, Lauder, Sarah N., Somerville, Michelle, Milutinovic, Stefan, Kendrick, Howard, Hindley, James P., French, Rhiannon, Smalley, Matthew J., Watkins, William John, Andrews, Robert, Godkin, Andrew and Gallimore, Awen
2020.
Immune remodelling of the extracellular matrix drives loss of cancer stem cells and tumor rejection.
Cancer Immunology Research
8
(12)
, 1520 - 1531.
10.1158/2326-6066.CIR-20-0070
Item availability restricted. |
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Hughes, Ellyn, Lauder, Sarah N., Smart, Kathryn, Bloom, Anja, Scott, Jake, Jones, Emma, Somerville, Michelle, Browne, Molly, Blainey, Andrew, Godkin, Andrew, Ager, Ann and Gallimore, Awen 2020. Primary breast tumours but not lung metastases induce protective anti-tumour immune responses after Treg-depletion. Cancer Immunology, Immunotherapy 69 , 2063 - 2073. 10.1007/s00262-020-02603-x |
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Milutinovic, Stefan, Abe, Jun, Godkin, Andrew, Stein, Jens V. and Gallimore, Awen
2020.
The dual role of high endothelial venules in cancer progression versus immunity.
Trends in Cancer
10.1016/j.trecan.2020.10.001
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Lauder, Sarah Nicol, Smart, Kathryn, Kersemans, Veerle, Allen, Danny, Scott, Jake, Pires, Ana, Milutinovic, Stefan, Somerville, Michelle, Smart, Sean, Kinchesh, Paul, Lopez-Guadamillas, Elena, Hughes, Ellyn, Jones, Emma, Scurr, Martin, Godkin, Andrew, Friedman, Lori S, Vanhaesebroeck, Bart and Gallimore, Awen
2020.
Enhanced antitumor immunity through sequential targeting of PI3Kδ and LAG3.
Journal for ImmunoTherapy of Cancer
8
(2)
, e000693.
10.1136/jitc-2020-000693
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Greenshields-Watson, Alexander, Attaf, Meriem, MacLachlan, Bruce J., Whalley, Thomas, Rius, Cristina, Wall, Aaron, Lloyd, Angharad, Hughes, Hywel, Strange, Kathryn E., Mason, Georgina H., Schauenburg, Andrea J., Hulin-Curtis, Sarah L., Geary, James, Chen, Yuan, Lauder, Sarah N., Smart, Kathryn, Vijaykrishna, Dhanasekaran, Grau, Miguel L., Shugay, Mikhail, Andrews, Robert, Dolton, Garry, Rizkallah, Pierre J., Gallimore, Awen M., Godkin, Andrew J., Sewell, Andrew J. and Cole, David K.
2020.
CD4 + T cells recognize conserved influenza A epitopes through shared patterns of V-Gene usage and complementary biochemical features.
Cell Reports
32
(2)
, 107885.
10.1016/j.celrep.2020.107885
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Scurr, Martin J., Greenshields-Watson, Alexander, Campbell, Emma, Somerville, Michelle, Chen, Yuan, Hulin-Curtis, Sarah L., Burnell, Stephanie E. A., Davies, James A., Davies, Michael M., Hargest, Rachel, Phillips, Simon, Christian, Adam D., Ashelford, Kevin E., Andrews, Robert, Parker, Alan L., Stanton, Richard J., Gallimore, Awen and Godkin, Andrew
2020.
Cancer antigen discovery is enabled by RNA-sequencing of highly purified malignant and non-malignant cells.
Clinical Cancer Research
10.1158/1078-0432.CCR-19-3087
Item availability restricted. |
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MacLachlan, Bruce J., Dolton, Garry, Papakyriakou, Athanasios, Greenshields-Watson, Alexander, Mason, Georgina H., Schauenburg, Andrea, Besneux, Matthieu, Szomolay, Barbara, Elliott, Tim, Sewell, Andrew K., Gallimore, Awen, Rizkallah, Pierre, Cole, David K. and Godkin, Andrew
2019.
Human leukocyte antigen (HLA) class II peptide flanking residues tune the immunogenicity of a human tumor-derived epitope.
Journal of Biological Chemistry
294
(52)
, pp. 20246-20258.
10.1074/jbc.RA119.009437
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Appanna, Gautham D, Pembroke, Thomas P I, Miners, Kelly L, Price, David A, Gallimore, Awen M, Ladell, Kristin and Godkin, Andrew J
2019.
Rituximab depletion of intrahepatic B cells to control refractory hepatic autoimmune overlap syndrome.
QJM: An International Journal of Medicine
112
(10)
, pp. 793-795.
10.1093/qjmed/hcz161
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Gallimore, Awen, Quezada, Sergio A. and Roychoudhuri, Rahul 2019. Regulatory T cells in cancer: where are we now? Immunology 157 (3) , pp. 187-189. 10.1111/imm.13088 |
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Thomson, Amanda, Smart, Kathryn, Somerville, Michelle S., Lauder, Sarah N., Appanna, Gautham, Horwood, James, Lawrence-Sunder, Raj, Srivastava, Brijesh, Durai, Dhamaraj, Scurr, Martin J., Keita, Asa V., Gallimore, Awen M. and Godkin, Andrew
2019.
The Ussing chamber system for measuring intestinal permeability in health and disease.
BMC Gastroenterology
19
, 98.
10.1186/s12876-019-1002-4
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Watson, H. Angharad, Durairaj, Ruban R.P., Ohme, Julia, Alatsatianos, Markella, Almutairi, Hanan, Mohammed, Rebar N., Vigar, Miriam, Reed, Sophie G., Paisey, Stephen J., Marshall, Christopher, Gallimore, Awen and Ager, Ann
2019.
L-selectin enhanced T cells improve the efficacy of cancer immunotherapy.
Frontiers in Immunology
10
, 1321.
10.3389/fimmu.2019.01321
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Besneux, Matthieu, Greenshields Watson, Alexander, Scurr, Martin, MacLachlan, Bruce J., Christian, Adam, Davies, Michael M., Hargest, Rachel, Phillips, Simon, Godkin, Andrew and Gallimore, Awen
2019.
The nature of the human T cell response to the cancer antigen 5T4 is determined by the balance of regulatory and inflammatory T cells of the same antigen-specificity: implications for vaccine design.
Cancer Immunology, Immunotherapy
68
, pp. 247-256.
10.1007/s00262-018-2266-1
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Jones, Emma, Gallimore, Awen and Ager, Ann 2018. Defining high endothelial venules and tertiary lymphoid structures in cancer. Tertiary Lymphoid Structures. Methods in Molecular Biology, Vol. 1845. Methods in Molecular Biology, Humana Press, pp. 99-118. (10.1007/978-1-4939-8709-2_7) |
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May, Stephanie, Owen, Heather, Phesse, Toby J., Greenow, Kristy R., Jones, Gareth-Rhys, Blackwood, Adam, Cook, Peter C., Towers, Christopher, Gallimore, Awen M., Williams, Geraint T., Sturzl, Michael, Britzen-Laurent, Nathalie, Sansom, Owen J., MacDonald, Andrew S., Bird, Adrian P., Clarke, Alan R. and Parry, Lee
2018.
Mbd2 enables tumourigenesis within the intestine while preventing tumour-promoting inflammation.
Journal of Pathology
245
(3)
, pp. 270-282.
10.1002/path.5074
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Hill, David, Yu, Liang, Gao, Hugh, Balic, Jesse J., West, Alison, Oshima, Hiroko, McLeod, Louise, Oshima, Masanobu, Gallimore, Awen M., D'Costa, Kimberley, Bhathal, Prithi S., Sievert, William, Ferrero, Richard L., Jenkins, Brendan J. and Jones, Gareth W. 2018. Hyperactive gp130/STAT3-driven gastric tumourigenesis promotes submucosal tertiary lymphoid structure development. International Journal of Cancer 143 (1) , pp. 167-178. 10.1002/ijc.31298 |
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Hughes, Ellyn, Scurr, Martin, Campbell, Emma, Jones, Emma, Godkin, Andrew and Gallimore, Awen
2018.
T‐cell modulation by cyclophosphamide for tumour therapy.
Immunology
154
(1)
, pp. 62-68.
10.1111/imm.12913
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Miles, John J., Tan, Mai Ping, Dolton, Garry, Edwards, Emily S. J., Galloway, Sarah A. E., Laugel, Bruno, Clement, Mathew, Makinde, Julia, Ladell, Kristin, Matthews, Katherine K., Watkins, Thomas S., Tungatt, Katie, Wong, Yide, Lee, Han Siean, Clark, Richard J., Pentier, Johanne M., Attaf, Meriem, Lissina, Anya, Ager, Ann, Gallimore, Awen, Rizkallah, Pierre J., Gras, Stephanie, Rossjohn, Jamie, Burrows, Scott R., Cole, David K., Price, David A. and Sewell, Andrew K.
2018.
Peptide mimic for influenza vaccination using nonnatural combinatorial chemistry.
Journal of Clinical Investigation
128
(4)
, pp. 1569-1580.
10.1172/JCI91512
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Colbeck, Emily Jayne, Ager, Ann, Gallimore, Awen and Jones, Gareth Wyn 2017. Tertiary lymphoid structures in cancer: drivers of antitumor immunity, immunosuppression, or bystander sentinels in disease? Frontiers in Immunology 8 , 1830. 10.3389/fimmu.2017.01830 |
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Colbeck, Emily J., Jones, Emma, Hindley, James P., Smart, Kathryn, Schulz, Ralph, Browne, Molly, Cutting, Scott, Williams, Anwen, Parry, Lee, Godkin, Andrew, Ware, Carl F., Ager, Ann and Gallimore, Awen
2017.
Treg depletion licenses T cell-driven HEV neogenesis and promotes tumor destruction.
Cancer Immunology Research
5
(11)
, pp. 1005-1015.
10.1158/2326-6066.CIR-17-0131
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Scurr, Martin, Pembroke, Tom, Bloom, Anja, Roberts, David, Thomson, Amanda, Smart, Kathryn, Bridgeman, Hayley, Adams, Richard, Brewster, Alison, Jones, Robert, Gwynne, Sarah, Blount, Daniel, Harrop, Richard, Wright, Melissa, Hills, Robert, Gallimore, Awen and Godkin, Andrew
2017.
Effect of modified vaccinia Ankara–5T4 and low-dose cyclophosphamide on antitumor immunity in metastatic colorectal cancer: A randomized clinical trial.
JAMA Oncology
3
(10)
, e172579.
10.1001/jamaoncol.2017.2579
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Scurr, Martin J, Pembroke, Tom, Bloom, Anja, Roberts, David J, Thomson, Amanda, Smart, Kathryn, Bridgeman, Hayley, Adams, Richard A, Brewster, Alison E, Jones, Robert, Gwynne, Sarah, Blount, Daniel, Harrop, Richard, Hills, Robert, Gallimore, Awen and Godkin, Andrew 2017. Low-dose cyclophosphamide induces anti-tumor T-cell responses which associate with survival in metastatic colorectal cancer. Clinical Cancer Research , clincanres.0895.2017. 10.1158/1078-0432.CCR-17-0895 |
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Chen, Hung-Chang, Joalland, Noémie, Bridgeman, John S, Alchami, Fouad S, Jarry, Ulrich, Khan, Mohd Wajid A, Piggott, Luke, Shanneik, Yasmin, Li, Jianqiang, Herold, Marco J, Herrmann, Thomas, Price, David A., Gallimore, Awen M., Clarkson, Richard W., Scotet, Emmanuel, Moser, Bernhard and Eberl, Matthias 2017. Synergistic targeting of breast cancer stem-like cells by human γδ T cells and CD8+ T cells. Immunology and Cell Biology 95 (7) , pp. 620-629. 10.1038/icb.2017.21 |
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Scurr, Martin, Pembroke, Tom, Adams, Richard, Blount, Daniel, Brewster, Alison, Gwynne, Sarah, Harrop, Richard, Jones, Robert, Hills, Robert, Gallimore, Awen and Godkin, Andrew
2017.
MVA-5T4 immunotherapy and low-dose cyclophosphamide for advanced colorectal cancer (TaCTiCC): An open-label, randomized phase I/II trial.
Journal of Clinical Oncology
35
(7)
, p. 154.
10.1200/JCO.2017.35.7_suppl.154
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Hughes, E., Bloom, A., Paisey, Stephen James, Smart, K., Ager, A. and Gallimore, Awen Myfanwy 2016. Treating metastatic disease through manipulation of regulatory T cells. European Journal of Immunology 46 , p. 578. 10.1002/eji.201670200 |
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Colbeck, Emily, Hindley, James P., Smart, Kathryn, Jones, Emma, Bloom, Anja, Bridgeman, Hayley, McPherson, Rhoanne C., Turner, Darryl G., Ladell, Kristin Ingrid, Price, David, O'Connor, Richard A., Anderton, Stephen M., Godkin, Andrew James and Gallimore, Awen Myfanwy 2015. Eliminating roles for T-bet and IL-2 but revealing superior activation and proliferation as mechanisms underpinning dominance of regulatory T cells in tumors. Oncotarget 6 (28) , pp. 24649-24659. 10.18632/oncotarget.5584 |
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Pembroke, Tom, Gallimore, Awen Myfanwy and Godkin, Andrew James 2015. Tracking the kinetics of intrahepatic immune responses by repeated fine needle aspiration of the liver. Journal of Immunological Methods 424 , pp. 131-135. 10.1016/j.jim.2015.04.011 |
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Ondondo, Beatrice, Colbeck, Emily, Jones, Emma, Smart, Kathryn, Lauder, Sarah Nicol, Hindley, James Philip, Godkin, Andrew James, Moser, Bernhard, Ager, Ann and Gallimore, Awen Myfanwy 2015. A distinct chemokine axis does not account for enrichment of Foxp3+ CD4+T cells in carcinogen-induced fibrosarcomas. Immunology 145 (1) , pp. 94-104. 10.1111/imm.12430 |
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Scurr, Martin J., Brown, Clare M., Costa Bento, Diana F., Betts, Gareth J., Rees, Brian I., Hills, Robert K., Gallimore, Awen and Godkin, Andrew
2015.
Assessing the prognostic value of preoperative carcinoembryonic antigen-specific T-cell responses in colorectal cancer.
JNCI: Journal of the National Cancer Institute
107
(4)
, djv001.
10.1093/jnci/djv001
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Costa Bento, Diana Filipa, Jones, Emma, Junaid, Syed, Tull, Justyna, Williams, Geraint Trefor, Godkin, Andrew James, Ager, Ann and Gallimore, Awen Myfanwy 2015. High endothelial venules are rare in colorectal cancers but accumulate in extra-tumoral areas with disease progression. OncoImmunology 4 (3) , pp. 653-660. 10.4161/2162402X.2014.974374 |
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Ford, Catriona A., Petrova, Sofia, Pound, John D., Voss, Jorine J.L.P., Melville, Lynsey, Paterson, Margaret, Farnworth, Sarah L., Gallimore, Awen Myfanwy, Cuff, Simone, Wheadon, Helen, Dobbin, Edwina, Ogden, Carol Anne, Dumitriu, Ingrid E., Dunbar, Donald R., Murray, Paul G., Ruckerl, Dominik, Allen, Judith E., Hume, David A., van Rooijen, Nico, Goodlad, John R., Freeman, Tom C. and Gregory, Christopher D. 2015. Oncogenic properties of apoptotic tumor cells in aggressive B cell lymphoma. Current Biology 25 (5) , pp. 577-588. 10.1016/j.cub.2014.12.059 |
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Stack, Gabrielle, Jones, Emma, Marsden, Morgan, Stacey, Maria A., Snelgrove, Robert J., Lacaze, Paul, Jacques, Laura C., Cuff, Simone, Stanton, Richard J., Gallimore, Awen M., Hussell, Tracy, Wilkinson, Gavin W. G., Ghazal, Peter, Taylor, Philip R. and Humphreys, Ian R.
2015.
CD200 receptor restriction of myeloid cell responses antagonizes antiviral immunity and facilitates cytomegalovirus persistence within mucosal tissue.
PLoS Pathogens
11
(2)
, e1004641.
10.1371/journal.ppat.1004641
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Ondondo, Beatrice, Jones, Emma, Hindley, James, Cutting, Scott, Smart, Kathryn, Bridgeman, Hayley, Matthews, Katherine K., Ladell, Kristin Ingrid, Price, David, Jackson, David G., Godkin, Andrew James, Ager, Ann and Gallimore, Awen Myfanwy 2014. Progression of carcinogen-induced fibrosarcomas is associated with the accumulation of naïve CD4+ T cellsviablood vessels and lymphatics. International Journal of Cancer 134 (9) , pp. 2156-2167. 10.1002/ijc.28556 |
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Stacey, Maria A., Marsden, Morgan, Pham N., Tu Anh, Clare, Simon, Dolton, Garry, Stack, Gabrielle, Jones, Emma, Klenerman, Paul, Gallimore, Awen M., Taylor, Philip R., Snelgrove, Robert J., Lawley, Trevor D., Dougan, Gordon, Benedict, Chris A., Jones, Simon A., Wilkinson, Gavin W. G. and Humphreys, Ian R.
2014.
Neutrophils recruited by IL-22 in peripheral tissues function as TRAIL-dependent antiviral effectors against MCMV.
Cell Host and Microbe
15
(4)
, pp. 471-483.
10.1016/j.chom.2014.03.003
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Scurr, Martin, Bloom, Anja, Pembroke, Thomas, Srinivasan, R., Brown, Clare, Smart, Kathryn, Bridgeman, H., Davies, Michael, Hargest, Rachel, Phillips, Simon, Christian, Adam, Hockey, T., Gallimore, Awen and Godkin, Andrew 2013. Escalating regulation of 5T4-specific IFN- + CD4+ T cells distinguishes colorectal cancer patients from healthy controls and provides a target for in vivo therapy. Cancer Immunology Research 1 (6) , 416. 10.1158/2326-6066.CIR-13-0035 |
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Lauder, Sarah Nicol, Jones, Emma, Smart, Kathryn, Bloom, Anja Constanze, Williams, Anwen Sian, Hindley, James P., Ondondo, Beatrice, Taylor, Philip Russel, Clement, Mathew, Fielding, Ceri Alan, Godkin, Andrew James, Jones, Simon Arnett and Gallimore, Awen Myfanwy 2013. Interleukin-6 limits influenza-induced inflammation and protects against fatal lung pathology. European Journal of Immunology 43 (10) , pp. 2613-2625. 10.1002/eji.201243018 |
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Scurr, Martin John, Ladell, Kristin Ingrid, Besneux, Matthieu, Christian, Adam, Hockey, T., Smart, Kathryn, Bridgeman, Hayley, Hargest, Rachel, Phillips, S., Davies, M., Price, David, Gallimore, Awen Myfanwy and Godkin, Andrew James 2013. Highly prevalent colorectal cancer-infiltrating LAP+ Foxp3- T cells exhibit more potent immunosuppressive activity than Foxp3+ regulatory T cells. Mucosal Immunology n/a 10.1038/mi.2013.62 |
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Ondondo, Beatrice, Jones, Emma, Godkin, Andrew James and Gallimore, Awen Myfanwy 2013. Home sweet home: The tumor microenvironment as a haven for regulatory T cells. Frontiers in Immunology 4 , 197. 10.3389/fimmu.2013.00197 |
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Pembroke, T., Gallimore, A. and Godkin, A. 2013. Flow cytometry makes all the difference. Journal of Hepatology 59 (4) , pp. 909-910. 10.1016/j.jhep.2013.05.047 |
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Pembroke, Thomas, Gallimore, Awen and Godkin, Andrew 2013. Rapid innate control of antigen abrogates adaptive immunity. Immunology 138 (4) , pp. 293-297. 10.1111/imm.12048 |
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Gallimore, Awen Myfanwy and Godkin, Andrew James 2013. Epithelial barriers, microbiota, and colorectal cancer. New England Journal of Medicine 368 (3) , pp. 282-284. 10.1056/NEJMcibr1212341 |
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Humphreys, Ian R., Clement, Mathew, Marsden, Morgan, Ladell, Kristin Ingrid, McLaren, James Edward, Smart, Kathryn, Hindley, James Philip, Bridgeman, Hayley, van den Berg, Hugo A., Price, David, Ager, Ann, Wooldridge, Linda, Godkin, Andrew James and Gallimore, Awen Myfanwy 2012. Avidity of influenza-specific memory CD8+T-cell populations decays over time compromising antiviral immunity. European Journal of Immunology 42 (12) , pp. 3235-3242. 10.1002/eji.201242575 |
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Hindley, James Phillip, Jones, Emma, Smart, Kathryn, Bridgeman, Hayley, Lauder, Sarah Nicol, Ondondo, Beatrice Omusiro, Cutting, Scott, Ladell, Kristin Ingrid, Wynn, Katherine Kay, Withers, David, Price, David, Ager, Ann, Godkin, Andrew James and Gallimore, Awen Myfanwy 2012. T-cell trafficking facilitated by high endothelial venules is required for tumor control after regulatory T cell depletion. Cancer Research 72 (21) , pp. 5473-5482. 10.1158/0008-5472.CAN-12-1912 |
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Scurr, Martin John, Gallimore, Awen Myfanwy and Godkin, Andrew James 2012. T cell subsets and colorectal cancer: discerning the good from the bad. Cellular Immunology 279 (1) , pp. 21-24. 10.1016/j.cellimm.2012.08.004 |
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Pembroke, Thomas, Rees, Ian W., Gallagher, Kathleen, Jones, Emma, Mizen, Paul Edward, Navruzov, Timur, Freedman, Andrew Robert, Fielding, Ceri Alan, Humphreys, Ian R., Wang, Edward Chung Yern, Gallimore, Awen Myfanwy and Godkin, Andrew James 2012. Rapid early innate control of hepatitis C virus during IFN-α treatment compromises adaptive CD4+T-cell immunity. European Journal of Immunology 42 (9) , pp. 2383-2394. 10.1002/eji.201142072 |
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Twohig, Jason Peter, Marsden, Morgan, Cuff, Simone, Ferdinand, John R., Gallimore, Awen Myfanwy, Perks, William Victor, Al-Shamkhani, Aymen, Humphreys, Ian R. and Wang, Edward Chung Yern 2012. The death receptor 3/TL1A pathway is essential for efficient development of antiviral CD4+ and CD8+ T-cell immunity. The FASEB Journal 26 (8) , pp. 3575-3586. 10.1096/fj.11-200618 |
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Kempshall, Emma, Thebault, Simon, Morgan, Bryan Paul, Harris, Claire Louise and Gallimore, Awen Myfanwy 2012. Complement-induced protection: an explanation for the limitations of cell-based tumour immunotherapies. Immunology and Cell Biology 90 (9) , pp. 869-871. 10.1038/icb.2012.30 |
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Cole, David, Gallagher, Kathleen, Lemercier, Brigitte, Holland, Christopher J., Junaid, Sayed, Hindley, James Phillip, Wynn, Katherine Kay, Gostick, Emma, Sewell, Andrew K., Gallimore, Awen Myfanwy, Ladell, Kristin Ingrid, Price, David, Gougeon, Marie-Lise and Godkin, Andrew James 2012. Modification of the carboxy-terminal flanking region of a universal influenza epitope alters CD4+ T-cell repertoire selection. Nature Communications 3 , 665. 10.1038/ncomms1665 |
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Betts, Gareth James, Jones, Emma, Junaid, Syed, El-Shanawany, Tariq, Scurr, Martin John, Mizen, Paul Edward, Kumar, Mayur, Jones, Sion, Rees, Brian Idris, Williams, Geraint Trefor, Gallimore, Awen Myfanwy and Godkin, Andrew James 2012. Suppression of tumour-specific CD4+ T cells by regulatory T cells is associated with progression of human colorectal cancer. Gut 61 (8) , pp. 1163-1171. 10.1136/gutjnl-2011-300970 |
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Clement, Mathew, Ladell, Kristin Ingrid, Ekeruche, Julia, Miles, John James, Edwards, Emily, Dolton, Garry Michael, Williams, Tamsin, Schauenburg, Andrea J. A., Cole, David, Lauder, Sarah Nicol, Gallimore, Awen Myfanwy, Godkin, Andrew James, Burrows, Scott R., Price, David, Sewell, Andrew K. and Wooldridge, Linda 2011. Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining. The Journal of Immunology 187 (2) , pp. 654-663. 10.4049/jimmunol.1003941 |
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Lauder, Sarah Nicol, Taylor, Philip Russel, Clark, Stephen Robert, Evans, Rhys Lloyd, Hindley, James Phillip, Smart, Kathryn, Leach, Heather, Kidd, Emma Jane, Broadley, Kenneth John, Jones, Simon Arnett, Wise, Matthew Peter, Godkin, Andrew James, O'Donnell, Valerie Bridget and Gallimore, Awen Myfanwy 2011. Paracetamol reduces influenza-induced immunopathology in a mouse model of infection without compromising virus clearance or the generation of protective immunity. Thorax 66 (5) , pp. 368-374. 10.1136/thx.2010.150318 |
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Hindley, James Philip, Ferreira, Cristina, Jones, Emma, Lauder, Sarah Nicol, Ladell, Kristin, Wynn, Katherine, Betts, Gareth James, Singh, Yogesh, Price, David, Godkin, Andrew James, Dyson, Julian and Gallimore, Awen Myfanwy 2011. Analysis of the T-cell receptor repertoires of tumor-infiltrating conventional and regulatory T cells reveals no evidence for conversion in carcinogen-induced tumors. Cancer Research 71 (3) , pp. 736-746. 10.1158/0008-5472.CAN-10-1797 |
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Ruge, Fiona, Glavini, Aikaterini, Gallimore, Awen Myfanwy, Richards, Hannah E., Thomas, Christopher P., O'Donnell, Valerie Bridget, Philpott, Michael P. and Porter, Rebecca 2011. Delineating immune-mediated mechanisms underlying hair follicle destruction in the mouse mutant defolliculated. Journal of Investigative Dermatology 131 (3) , pp. 572-579. 10.1038/jid.2010.379 |
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Godkin, Andrew James and Gallimore, Awen Myfanwy 2011. Setting the threshold for extra-thymic differentiation of Foxp3+ Tregs: TGF-β-dependent and T-cell autonomous. European Journal of Immunology 41 (5) , pp. 1218-1220. 10.1002/eji.201141576 |
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Cuff, Simone, Dolton, Garry Michael, Matthews, Reginald James and Gallimore, Awen Myfanwy 2010. Antigen specificity determines the pro- or antitumoral nature of CD8+ T cells. The Journal of Immunology 184 (2) , pp. 607-614. 10.4049/jimmunol.0804089 |
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Richards, Hannah Catharine, Williams, Anwen Sian, Jones, Emma, Hindley, James Phillip, Godkin, Andrew James, Simon, Anna Katharina and Gallimore, Awen Myfanwy 2010. Novel role of regulatory T cells in limiting early neutrophil responses in skin. Immunology 131 (4) , pp. 583-592. 10.1111/j.1365-2567.2010.03333.x |
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Gallagher, Kathleen M. E., Lauder, Sarah Nicol, Rees, Ian W., Gallimore, Awen Myfanwy and Godkin, Andrew James 2009. Type I interferon (IFNα) acts directly on human memory CD4+ T cells altering their response to antigen. The Journal of Immunology 183 (5) , pp. 2915-2920. 10.4049/jimmunol.0801607 |
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Baalasubramanian, Sivasankar, Longhi, M. Paula, Gallagher, Kathleen M. E., Betts, Gareth J., Morgan, Bryan Paul, Godkin, Andrew James and Gallimore, Awen Myfanwy 2009. CD59 blockade enhances antigen-specific CD4+ T cell responses in humans: a new target for cancer immunotherapy? The Journal of Immunology 182 (9) , pp. 5203-5207. 10.4049/jimmunol.0804243 |
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Jones, Gareth Wyn, Stumhofer, J. S., Newton, Zarabeth, Gallimore, Awen Myfanwy, Ernst, M., Topley, Nicholas, Williams, Anwen Sian, Hunter, Catherine, Jenkins, Brian J., Wang, Edward Chung Yern and Jones, Simon Arnett 2008. TL1A/TNFSF15 promotes a STAT1-mediated suppression of IL-17-secreting T-helper cells [Abstract]. Immunology 125 (s1) , p. 62. 10.1111/j.1365-2567.2008.02974.x |
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Morton, Jonathan, Coles, Barbara, Wright, Kate Louise, Gallimore, Awen Myfanwy, Morrow, Jason D., Terry, Erin S., Anning, Peter, Morgan, Bryan Paul, Dioszeghy, Vincent, Kuhn, Hartmut, Chaitidis, Pavlos, Hobbs, Adrian J., Jones, Simon Arnett and O'Donnell, Valerie Bridget 2008. Circulating neutrophils maintain physiological blood pressure by suppressing bacteria and IFN -dependent iNOS expression in the vasculature of healthy mice. Blood 111 (10) , pp. 5187-5194. 10.1182/blood-2007-10-117283 |
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Longhi, Maria Paula, Wright, Kate Louise, Lauder, Sarah Nicol, Nowell, Mari Ann, Jones, Gareth Wyn, Godkin, Andrew James, Jones, Simon Arnett and Gallimore, Awen Myfanwy 2008. Interleukin-6 is crucial for recall of influenza-specific memory cd4+ t cells. PLoS Pathogens 4 (2) , e1000006. 10.1371/journal.ppat.1000006 |
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Richards, Hannah Catharine, Longhi, Maria Paula, Wright, Kate Louise, Gallimore, Awen Myfanwy and Ager, Ann 2008. CD62L (L-Selectin) down-regulation does not affect memory T cell distribution but failure to shed compromises anti-viral immunity. Journal of Immunology 180 (1) , pp. 198-206. |
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Gallimore, Awen Myfanwy and Simon, A. K. 2008. Positive and negative influences of regulatory T cells on tumour immunity. Oncogene 27 (45) , pp. 5886-5893. 10.1038/onc.2008.269 |
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Boulter, Jonathan M., Schmitz, Nicole, Sewell, Andrew K., Godkin, Andrew James, Bachmann, Martin F. and Gallimore, Awen Myfanwy 2007. Potent T cell agonism mediated by a very rapid TCR/pMHC interaction. European Journal of Immunology 37 (3) , pp. 798-806. 10.1002/eji.200636743 |
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Simon, Anna Katharina, Jones, Emma, Richards, Hannah, Wright, Kate Louise, Betts, Gareth James, Godkin, Andrew James, Screaton, Gavin and Gallimore, Awen Myfanwy 2007. Regulatory T cells inhibit Fas ligand induced innate and adaptive tumour immunity. European Journal of Immunology 37 (3) , pp. 758-767. 10.1002/eji.200636593 |
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Betts, G., Twohig, Jason Peter, Van den Broek, M., Sierro, S., Godkin, Andrew James and Gallimore, Awen Myfanwy 2007. The impact of regulatory T cells on carcinogen-induced sarcogenesis. British Journal of Cancer 96 (12) , pp. 1849-1854. 10.1038/sj.bjc.6603824 |
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Betts, Gareth James, Godkin, Andrew James and Gallimore, Awen Myfanwy 2007. Reply: forkhead box P3-positive regulatory T cells in immune surveillance and cancer. British Journal of Cancer 97 , pp. 1017-1018. 10.1038/sj.bjc.6603940 |
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Gallimore, Awen Myfanwy and Godkin, Andrew James 2007. Regulatory T cells and tumour immunity - observations in mice and men. Immunology 123 (2) , pp. 157-163. 10.1111/j.1365-2567.2007.02748.x |
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Wise, Matthew Peter, Gallimore, Awen Myfanwy and Godkin, Andrew James 2006. T-Cell costimulation [Letter]. New England Journal of Medicine 355 (24) , pp. 2594-2595. 10.1056/NEJMc062767 |
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Betts, Gareth James, Clarke, Sarah Louise, Richards, Hannah E., Godkin, Andrew James and Gallimore, Awen Myfanwy 2006. Regulating the immune response to tumours. Advanced Drug Delivery Reviews 58 (8) , pp. 948-961. 10.1016/j.addr.2006.05.006 |
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Longhi, M. Paula, Baalasubramanian, Sivasankar, Omidvar, Nader, Morgan, Bryan Paul and Gallimore, Awen Myfanwy 2005. Cutting edge: murine CD59a modulates antiviral CD4+ T cell activity in a complement-independent manner. Journal of Immunology 175 (11) , pp. 7098-7102. |
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Clarke, S. L., Betts, G. J., Wright, K. L., El-Shanawany, Tariq, Plant, A., Gallimore, Awen Myfanwy and Godkin, Andrew James 2005. Analysis of CD4(+)CD25(hi) cells in peripheral blood and lymph nodes of patients with colorectal cancer. Immunology 116 (1) , p. 37. 10.1111/j.1365-2567.2005.02287.x |
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Richards, H. E., Simon, A. K., Jones, E., Williams, Anwen Sian, Screaton, G. R. and Gallimore, Awen Myfanwy 2005. Inhibition of innate immune responses to tumours by CD4+CD25+ regulatory T cells [Abstract]. Immunology 116 (s1) , p. 36. 10.1111/j.1365-2567.2005.02287.x |
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Jones, Emma, Price, David, Dahm-Vicker, Michaela, Cerundolo, Vincenzo, Klenerman, Paul and Gallimore, Awen 2003. The influence of macrophage inflammatory protein-1alpha on protective immunity mediated by antiviral cytotoxic T cells. Immunology 109 (1) , pp. 68-75. 10.1046/j.1365-2567.2003.01636.x |
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Simon, Anna Katharina, Gallimore, Awen Myfanwy, Jones, Emma, Sawitzki, Birgit, Cerundolo, Vincenzo and Screaton, Gavin R. 2002. Fas ligand breaks tolerance to self-antigens and induces tumor immunity mediated by antibodies. Cancer Cell 2 (4) , pp. 315-322. 10.1016/S1535-6108(02)00151-4 |
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Golgher, Denise, Jones, Emma, Powrie, Fiona, Elliot, Tim and Gallimore, Awen Myfanwy 2002. CD25+ regulatory cells uncover immune responses to shared tumour rejection antigens. European Journal of Immunology 32 (11) , pp. 3267-3275. 10.1002/1521-4141(200211)32:11<3267::AID-IMMU3267>3.0.CO;2-1 |
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Bachmann, M. F., Gallimore, Awen Myfanwy, Linkert, S., Cerundolo, V., Lanzavecchia, A., Kopf, M. and Viola, A. 1999. Developmental regulation of Lck targeting to the CD8 coreceptor controls signaling in naive and memory T cells. Journal of Experimental Medicine 189 (10) , pp. 1521-1530. |
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Gallimore, Awen Myfanwy, Hombach, Joachim, Dumrese, Tilman, Rammensee, Hans-Georg, Zinkernagel, Rolf M. and Hengartner, Hans 1998. A protective cytotoxic T cell response to a subdominant epitope is influenced by the stability of the MHC class I/peptide complex and the overall spectrum of viral peptides generated within infected cells. European Journal of Immunology 28 (10) , pp. 3301-3311. |
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Gallimore, Awen Myfanwy, Hengartner, H. and Zinkernagel, R. 1998. Hierarchies of antigen-specific cytotoxic T-cell responses. Immunological Reviews 164 , pp. 29-36. 10.1111/j.1600-065X.1998.tb01205.x |
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Gallimore, Awen Myfanwy, Schwarz, K., van den Broek, M., Hengartner, H. and Groettrup, M. 1998. The proteasome inhibitor lactacystin prevents the generation of an endoplasmic reticulum leader-derived T cell epitope. Molecular Immunology 35 (10) , pp. 581-591. |
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Gallimore, Awen Myfanwy, Dumrese, T., Hengartner, H., Zinkernagel, R. M. and Rammensee, H. G. 1998. Protective immunity does not correlate with the hierarchy of virus-specific cytotoxic T cell responses to naturally processed peptides. Journal of Experimental Medicine 187 (10) , pp. 1647-1657. |
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Gotch, F., Gallimore, Awen Myfanwy and McMichael, A. 1996. Cytotoxic T cells--protection from disease progression--protection from infection. Immunology Letters 51 (1-2) , pp. 125-128. 10.1016/0165-2478(96)02566-7 |
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Gallimore, Awen Myfanwy, Cranage, M., Cook, N., Almond, N., Bootman, J., Rud, E., Silvera, P., Dennis, M., Corcoran, T. and Stott, J. 1995. Early suppression of SIV replication by CD8+ nef-specific cytotoxic T cells in vaccinated macaques. Natural Medicines 1 (11) , pp. 1167-1173. |
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Boyson, J. E,, McAdam, S. N., Gallimore, Awen Myfanwy, Golos, T. G., Liu, X., Gotch, F. M., Hughes, A. L. and Watkins, D. I. 1995. The MHC E locus in macaques is polymorphic and is conserved between macaques and humans. Immunogenetics 41 (2-3) , pp. 59-68. 10.1007/BF00182314 |
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Rowland-Jones, S., Sutton, J., Ariyoshi, K., Dong, T., Gotch, F., McAdam, S., Whitby, D., Sabally, S., Gallimore, Awen Myfanwy and Corrah, T. 1995. HIV-specific cytotoxic T-cells in HIV-exposed but uninfected Gambian women. Natural Medicines 1 (1) , pp. 59-64. |
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Gotch, F., McAdam, S. N., Allsopp, C. E., Gallimore, Awen Myfanwy, Elvin, J., Kieny, M. P., Hill, A. V., McMichael, A. J. and Whittle, H. C. 1993. Cytotoxic T cells in HIV2 seropositive Gambians. Identification of a virus-specific MHC-restricted peptide epitope. The Journal of Immunology 151 (6) , pp. 3361-3369. |
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