Browse by Current Cardiff authors

Milutinovic, Stefan, Abe, Jun, Godkin, Andrew, Stein, Jens V. and Gallimore, Awen 2021. The dual role of high endothelial venules in cancer progression versus immunity. Trends in Cancer 7 (3) , pp. 214-225. 10.1016/j.trecan.2020.10.001

Teijeira Crespo, Alicia, Burnell, Stephanie, Capitani, Lorenzo, Bayliss, Rebecca, Moses, Elise, Mason, Georgina H., Davies, James A., Godkin, Andrew J., Gallimore, Awen M. and Parker, Alan L. 2021. Pouring petrol on the flames: using oncolytic virotherapies to enhance tumour immunogenicity. Immunology 10.1111/imm.13323 Item availability restricted.

Pires, Ana, Greenshields Watson, Alexander, Jones, Emma, Smart, Kathryn, Lauder, Sarah N., Somerville, Michelle, Milutinovic, Stefan, Kendrick, Howard, Hindley, James P., French, Rhiannon, Smalley, Matthew J., Watkins, William John, Andrews, Robert, Godkin, Andrew and Gallimore, Awen 2020. Immune remodelling of the extracellular matrix drives loss of cancer stem cells and tumor rejection. Cancer Immunology Research 8 (12) , 1520 - 1531. 10.1158/2326-6066.CIR-20-0070 Item availability restricted.

Hughes, Ellyn, Lauder, Sarah N., Smart, Kathryn, Bloom, Anja, Scott, Jake, Jones, Emma, Somerville, Michelle, Browne, Molly, Blainey, Andrew, Godkin, Andrew, Ager, Ann and Gallimore, Awen 2020. Primary breast tumours but not lung metastases induce protective anti-tumour immune responses after Treg-depletion. Cancer Immunology, Immunotherapy 69 , 2063 - 2073. 10.1007/s00262-020-02603-x

Lauder, Sarah Nicol, Smart, Kathryn, Kersemans, Veerle, Allen, Danny, Scott, Jake, Pires, Ana, Milutinovic, Stefan, Somerville, Michelle, Smart, Sean, Kinchesh, Paul, Lopez-Guadamillas, Elena, Hughes, Ellyn, Jones, Emma, Scurr, Martin, Godkin, Andrew, Friedman, Lori S, Vanhaesebroeck, Bart and Gallimore, Awen 2020. Enhanced antitumor immunity through sequential targeting of PI3Kδ and LAG3. Journal for ImmunoTherapy of Cancer 8 (2) , e000693. 10.1136/jitc-2020-000693

Greenshields-Watson, Alexander, Attaf, Meriem, MacLachlan, Bruce J., Whalley, Thomas, Rius, Cristina, Wall, Aaron, Lloyd, Angharad, Hughes, Hywel, Strange, Kathryn E., Mason, Georgina H., Schauenburg, Andrea J., Hulin-Curtis, Sarah L., Geary, James, Chen, Yuan, Lauder, Sarah N., Smart, Kathryn, Vijaykrishna, Dhanasekaran, Grau, Miguel L., Shugay, Mikhail, Andrews, Robert, Dolton, Garry, Rizkallah, Pierre J., Gallimore, Awen M., Godkin, Andrew J., Sewell, Andrew J. and Cole, David K. 2020. CD4 + T cells recognize conserved influenza A epitopes through shared patterns of V-Gene usage and complementary biochemical features. Cell Reports 32 (2) , 107885. 10.1016/j.celrep.2020.107885

Godkin, Andrew and Humphreys, Ian R. 2020. Elevated interleukin‐6, interleukin‐10 and neutrophil : lymphocyte ratio as identifiers of severe coronavirus disease 2019 [Editorial]. Immunology 160 (3) , pp. 221-222. 10.1111/imm.13225

Scurr, Martin J., Greenshields-Watson, Alexander, Campbell, Emma, Somerville, Michelle, Chen, Yuan, Hulin-Curtis, Sarah L., Burnell, Stephanie E. A., Davies, James A., Davies, Michael M., Hargest, Rachel, Phillips, Simon, Christian, Adam D., Ashelford, Kevin E., Andrews, Robert, Parker, Alan L., Stanton, Richard J., Gallimore, Awen and Godkin, Andrew 2020. Cancer antigen discovery is enabled by RNA-sequencing of highly purified malignant and non-malignant cells. Clinical Cancer Research 10.1158/1078-0432.CCR-19-3087

Bagaev, Dmitry V, Vroomans, Renske M A, Samir, Jerome, Stervbo, Ulrik, Rius, Cristina, Dolton, Garry, Greenshields Watson, Alexander, Attaf, Meriem, Egorov, Evgeny S, Zvyagin, Ivan V, Babel, Nina, Cole, David K, Godkin, Andrew J, Sewell, Andrew K, Kesmir, Can, Chudakov, Dmitriy M, Luciani, Fabio and Shugay, Mikhail 2020. VDJdb in 2019: database extension, new analysis infrastructure and a T-cell receptor motif compendium. Nucleic Acids Research 48 (D1) , D1057-D1062. 10.1093/nar/gkz874

MacLachlan, Bruce J., Dolton, Garry, Papakyriakou, Athanasios, Greenshields-Watson, Alexander, Mason, Georgina H., Schauenburg, Andrea, Besneux, Matthieu, Szomolay, Barbara, Elliott, Tim, Sewell, Andrew K., Gallimore, Awen, Rizkallah, Pierre, Cole, David K. and Godkin, Andrew 2019. Human leukocyte antigen (HLA) class II peptide flanking residues tune the immunogenicity of a human tumor-derived epitope. Journal of Biological Chemistry 294 (52) , pp. 20246-20258. 10.1074/jbc.RA119.009437

Appanna, Gautham D, Pembroke, Thomas P I, Miners, Kelly L, Price, David A, Gallimore, Awen M, Ladell, Kristin and Godkin, Andrew J 2019. Rituximab depletion of intrahepatic B cells to control refractory hepatic autoimmune overlap syndrome. QJM: An International Journal of Medicine 112 (10) , pp. 793-795. 10.1093/qjmed/hcz161

Madura, Florian, Rizkallah, Pierre J., Legut, Mateusz, Holland, Christopher J., Fuller, Anna, Bulek, Anna, Schauenburg, Andrea J., Trimby, Andrew, Hopkins, Jade R., Wells, Stephen A., Godkin, Andrew, Miles, John J., Sami, Malkit, Li, Yi, Liddy, Nathaniel, Jakobsen, Bent K., Loveridge, E. Joel, Cole, David K. and Sewell, Andrew K. 2019. TCR-induced alteration of primary MHC peptide anchor residue. European Journal of Immunology 49 (7) , pp. 1052-1066. 10.1002/eji.201948085

Thomson, Amanda, Smart, Kathryn, Somerville, Michelle S., Lauder, Sarah N., Appanna, Gautham, Horwood, James, Lawrence-Sunder, Raj, Srivastava, Brijesh, Durai, Dhamaraj, Scurr, Martin J., Keita, Asa V., Gallimore, Awen M. and Godkin, Andrew 2019. The Ussing chamber system for measuring intestinal permeability in health and disease. BMC Gastroenterology 19 , 98. 10.1186/s12876-019-1002-4

Besneux, Matthieu, Greenshields Watson, Alexander, Scurr, Martin, MacLachlan, Bruce J., Christian, Adam, Davies, Michael M., Hargest, Rachel, Phillips, Simon, Godkin, Andrew and Gallimore, Awen 2019. The nature of the human T cell response to the cancer antigen 5T4 is determined by the balance of regulatory and inflammatory T cells of the same antigen-specificity: implications for vaccine design. Cancer Immunology, Immunotherapy 68 , pp. 247-256. 10.1007/s00262-018-2266-1

Hughes, Ellyn, Scurr, Martin, Campbell, Emma, Jones, Emma, Godkin, Andrew and Gallimore, Awen 2018. T‐cell modulation by cyclophosphamide for tumour therapy. Immunology 154 (1) , pp. 62-68. 10.1111/imm.12913

Holland, Christopher J., MacLachlan, Bruce J., Bianchi, Valentina, Hesketh, Sophie J., Morgan, Richard, Vickery, Owen, Bulek, Anna M., Fuller, Anna, Godkin, Andrew, Sewell, Andrew K., Rizkallah, Pierre J., Wells, Stephen and Cole, David K. 2018. In silico and structural analyses demonstrate that intrinsic protein motions guide T cell receptor complementarity determining region loop flexibility. Frontiers in Immunology 9 , 674. 10.3389/fimmu.2018.00674

Colbeck, Emily J., Jones, Emma, Hindley, James P., Smart, Kathryn, Schulz, Ralph, Browne, Molly, Cutting, Scott, Williams, Anwen, Parry, Lee, Godkin, Andrew, Ware, Carl F., Ager, Ann and Gallimore, Awen 2017. Treg depletion licenses T cell-driven HEV neogenesis and promotes tumor destruction. Cancer Immunology Research 5 (11) , pp. 1005-1015. 10.1158/2326-6066.CIR-17-0131

Scurr, Martin, Pembroke, Tom, Bloom, Anja, Roberts, David, Thomson, Amanda, Smart, Kathryn, Bridgeman, Hayley, Adams, Richard, Brewster, Alison, Jones, Robert, Gwynne, Sarah, Blount, Daniel, Harrop, Richard, Wright, Melissa, Hills, Robert, Gallimore, Awen and Godkin, Andrew 2017. Effect of modified vaccinia Ankara–5T4 and low-dose cyclophosphamide on antitumor immunity in metastatic colorectal cancer: A randomized clinical trial. JAMA Oncology 3 (10) , e172579. 10.1001/jamaoncol.2017.2579

Scurr, Martin J, Pembroke, Tom, Bloom, Anja, Roberts, David J, Thomson, Amanda, Smart, Kathryn, Bridgeman, Hayley, Adams, Richard A, Brewster, Alison E, Jones, Robert, Gwynne, Sarah, Blount, Daniel, Harrop, Richard, Hills, Robert, Gallimore, Awen and Godkin, Andrew 2017. Low-dose cyclophosphamide induces anti-tumor T-cell responses which associate with survival in metastatic colorectal cancer. Clinical Cancer Research , clincanres.0895.2017. 10.1158/1078-0432.CCR-17-0895

Godkin, Andrew and Smith, Katherine 2017. Chronic infections with viruses or parasites: breaking bad to make good. Immunology 150 (4) , pp. 389-396. 10.1111/imm.12703

Scurr, Martin, Pembroke, Tom, Adams, Richard, Blount, Daniel, Brewster, Alison, Gwynne, Sarah, Harrop, Richard, Jones, Robert, Hills, Robert, Gallimore, Awen and Godkin, Andrew 2017. MVA-5T4 immunotherapy and low-dose cyclophosphamide for advanced colorectal cancer (TaCTiCC): An open-label, randomized phase I/II trial. Journal of Clinical Oncology 35 (7) , p. 154. 10.1200/JCO.2017.35.7_suppl.154

Clement, Mathew, Marsden, Morgan, Stacey, Maria, Abdul-Karim, Juneid, Gimeno Brias, Silvia, Costa Bento, Diana Filipa, Scurr, Martin, Weaver, Casey, Carlesso, Gianluca, Clare, Simon, Jones, Simon, Godkin, Andrew, Ghazal, Peter, Jones, Gareth W. and Humphreys, Ian 2016. Cytomegalovirus-specific IL-10-producing CD4+ T cells are governed by type-I IFN-induced IL-27 and promote virus persistence. Plos Pathogens 12 (12) , e1006050. 10.1371/journal.ppat.1006050

Jönsson, Peter, Southcombe, Jennifer H., Santos, Ana Mafalda, Huo, Jiandong, Fernandes, Ricardo A., McColl, James, Lever, Melissa, Evans, Edward J., Hudson, Alexander, Chang, Veronica T., Hanke, Tomá?, Godkin, Andrew, Dunne, Paul D., Horrocks, Mathew H., Palayret, Matthieu, Screaton, Gavin R., Petersen, Jan, Rossjohn, Jamie, Fugger, Lars, Dushek, Omer, Xu, Xiao-Ning, Davis, Simon J. and Klenerman, David 2016. Remarkably low affinity of CD4/peptide-major histocompatibility complex class II protein interactions. Proceedings of the National Academy of Sciences of the United States of America 113 (20) , pp. 5682-5687. 10.1073/pnas.1513918113

Holland, Christopher J., Dolton, Garry M., Scurr, Martin, Ladell, Kristin, Schauenburg, Andrea J., Miners, Kelly, Madura, Florian, Sewell, Andrew K., Price, David A., Cole, David K. and Godkin, Andrew J. 2015. Enhanced detection of antigen-specific CD4+ T cells using altered peptide flanking residue peptide-MHC class II multimers. Journal of Immunology 195 (12) , pp. 5827-5836. 10.4049/jimmunol.1402787

Santegoets, Saskia J. A. M., Dijkgraaf, Eveline M., Battaglia, Alessandra, Beckhove, Philipp, Britten, Cedrik M., Gallimore, Awen, Godkin, Andrew James, Gouttefangeas, Cecile, de Gruijl, Tanja D., Koenen, Hans J. P. M., Scheffold, Alexander, Shevach, Ethan M., Staats, Janet, Taskén, Kjetil, Whiteside, Theresa L., Kroep, Judith R., Welters, Marij J. P. and van der Burg, Sjoerd H. 2015. Monitoring regulatory T cells in clinical samples: consensus on an essential marker set and gating strategy for regulatory T cell analysis by flow cytometry. Cancer Immunology, Immunotherapy 64 (10) , pp. 1271-1286. 10.1007/s00262-015-1729-x

Dolton, Garry Michael, Tungatt, Katie, Lloyd, Angharad, Bianchi, Valentina, Theaker, Sarah M., Trimby, Andrew R., Holland, Christopher J., Donia, Marco, Godkin, Andrew James, Cole, David, Straten, Per Thor, Peakman, Mark, Svane, Inge Marie and Sewell, Andrew K. 2015. More tricks with tetramers: a practical guide to staining T cells with peptide-MHC multimers. Immunology 146 (1) , pp. 11-22. 10.1111/imm.12499

Colbeck, Emily, Hindley, James P., Smart, Kathryn, Jones, Emma, Bloom, Anja, Bridgeman, Hayley, McPherson, Rhoanne C., Turner, Darryl G., Ladell, Kristin Ingrid, Price, David, O'Connor, Richard A., Anderton, Stephen M., Godkin, Andrew James and Gallimore, Awen Myfanwy 2015. Eliminating roles for T-bet and IL-2 but revealing superior activation and proliferation as mechanisms underpinning dominance of regulatory T cells in tumors. Oncotarget 6 (28) , pp. 24649-24659. 10.18632/oncotarget.5584

Pembroke, Tom, Gallimore, Awen Myfanwy and Godkin, Andrew James 2015. Tracking the kinetics of intrahepatic immune responses by repeated fine needle aspiration of the liver. Journal of Immunological Methods 424 , pp. 131-135. 10.1016/j.jim.2015.04.011

Ondondo, Beatrice, Colbeck, Emily, Jones, Emma, Smart, Kathryn, Lauder, Sarah Nicol, Hindley, James Philip, Godkin, Andrew James, Moser, Bernhard, Ager, Ann and Gallimore, Awen Myfanwy 2015. A distinct chemokine axis does not account for enrichment of Foxp3+ CD4+T cells in carcinogen-induced fibrosarcomas. Immunology 145 (1) , pp. 94-104. 10.1111/imm.12430

Scurr, Martin J., Brown, Clare M., Costa Bento, Diana F., Betts, Gareth J., Rees, Brian I., Hills, Robert K., Gallimore, Awen and Godkin, Andrew 2015. Assessing the prognostic value of preoperative carcinoembryonic antigen-specific T-cell responses in colorectal cancer. JNCI: Journal of the National Cancer Institute 107 (4) , djv001. 10.1093/jnci/djv001

Costa Bento, Diana Filipa, Jones, Emma, Junaid, Syed, Tull, Justyna, Williams, Geraint Trefor, Godkin, Andrew James, Ager, Ann and Gallimore, Awen Myfanwy 2015. High endothelial venules are rare in colorectal cancers but accumulate in extra-tumoral areas with disease progression. OncoImmunology 4 (3) , pp. 653-660. 10.4161/2162402X.2014.974374

Madura, Florian, Rizkallah, Pierre, Holland, Christopher J., Fuller, Anna, Bulek, Anna Marta, Godkin, Andrew James, Schauenburg, Andrea J., Cole, David K. and Sewell, Andrew K. 2015. Structural basis for ineffective T-cell responses to MHC anchor residue-improved 'heteroclitic' peptides. European Journal of Immunology 45 (2) , pp. 584-591. 10.1002/eji.201445114

Tungatt, Katie, Bianchi, Valentina, Crowther, Michael D., Powell, Wendy, Schauenburg, Andrea J. A., Trimby, Andrew R., Donia, M., Miles, John James, Holland, Christopher J., Cole, David, Godkin, Andrew James, Peakman, M., Straten, P. T., Svane, I. M., Sewell, Andrew K. and Dolton, Garry Michael 2015. Antibody stabilization of peptide-MHC multimers reveals functional T cells bearing extremely low-affinity TCRs. Journal of Immunology 194 (1) , pp. 463-474. 10.4049/jimmunol.1401785

Dolton, Garry Michael, Lissina, A., Skowera, A., Ladell, Kristin Ingrid, Tungatt, Katie, Jones, Emma, Kronenberg-Versteeg, D., Akpovwa, Hephzibah, Pentier, Johanne, Holland, C. J., Godkin, Andrew James, Cole, David, Neller, M. A., Miles, John James, Price, David, Peakman, M. and Sewell, Andrew K. 2014. Comparison of peptide-major histocompatibility complex tetramers and dextramers for the identification of antigen-specific T cells. Clinical and Experimental Immunology 177 (1) , pp. 47-63. 10.1111/cei.12339

Ondondo, Beatrice, Jones, Emma, Hindley, James, Cutting, Scott, Smart, Kathryn, Bridgeman, Hayley, Matthews, Katherine K., Ladell, Kristin Ingrid, Price, David, Jackson, David G., Godkin, Andrew James, Ager, Ann and Gallimore, Awen Myfanwy 2014. Progression of carcinogen-induced fibrosarcomas is associated with the accumulation of naïve CD4+ T cellsviablood vessels and lymphatics. International Journal of Cancer 134 (9) , pp. 2156-2167. 10.1002/ijc.28556

Scurr, Martin, Bloom, Anja, Pembroke, Thomas, Srinivasan, R., Brown, Clare, Smart, Kathryn, Bridgeman, H., Davies, Michael, Hargest, Rachel, Phillips, Simon, Christian, Adam, Hockey, T., Gallimore, Awen and Godkin, Andrew 2013. Escalating regulation of 5T4-specific IFN- + CD4+ T cells distinguishes colorectal cancer patients from healthy controls and provides a target for in vivo therapy. Cancer Immunology Research 1 (6) , 416. 10.1158/2326-6066.CIR-13-0035

Lauder, Sarah Nicol, Jones, Emma, Smart, Kathryn, Bloom, Anja Constanze, Williams, Anwen Sian, Hindley, James P., Ondondo, Beatrice, Taylor, Philip Russel, Clement, Mathew, Fielding, Ceri Alan, Godkin, Andrew James, Jones, Simon Arnett and Gallimore, Awen Myfanwy 2013. Interleukin-6 limits influenza-induced inflammation and protects against fatal lung pathology. European Journal of Immunology 43 (10) , pp. 2613-2625. 10.1002/eji.201243018

Scurr, Martin John, Ladell, Kristin Ingrid, Besneux, Matthieu, Christian, Adam, Hockey, T., Smart, Kathryn, Bridgeman, Hayley, Hargest, Rachel, Phillips, S., Davies, M., Price, David, Gallimore, Awen Myfanwy and Godkin, Andrew James 2013. Highly prevalent colorectal cancer-infiltrating LAP+ Foxp3- T cells exhibit more potent immunosuppressive activity than Foxp3+ regulatory T cells. Mucosal Immunology n/a 10.1038/mi.2013.62

Ondondo, Beatrice, Jones, Emma, Godkin, Andrew James and Gallimore, Awen Myfanwy 2013. Home sweet home: The tumor microenvironment as a haven for regulatory T cells. Frontiers in Immunology 4 , 197. 10.3389/fimmu.2013.00197

Holland, Christopher J., Cole, David and Godkin, Andrew James 2013. Re-directing CD4+ T cell responses with the flanking residues of MHC class II-bound peptides: The core is not enough. Frontiers in Immunology 4 , 172. 10.3389/fimmu.2013.00172

Pembroke, T., Gallimore, A. and Godkin, A. 2013. Flow cytometry makes all the difference. Journal of Hepatology 59 (4) , pp. 909-910. 10.1016/j.jhep.2013.05.047

Pembroke, Thomas, Christian, Adam, Jones, Emma, Hills, Robert Kerrin, Wang, Edward Chung Yern, Gallimore, Awen Myfanwy and Godkin, Andrew James 2013. The paradox of NKp46+ natural killer cells: drivers of severe hepatitis C virus-induced pathology but in-vivo resistance to interferon treatment. Gut n/a 10.1136/gutjnl-2013-304472

Pembroke, Thomas, Gallimore, Awen and Godkin, Andrew 2013. Rapid innate control of antigen abrogates adaptive immunity. Immunology 138 (4) , pp. 293-297. 10.1111/imm.12048

Gallimore, Awen Myfanwy and Godkin, Andrew James 2013. Epithelial barriers, microbiota, and colorectal cancer. New England Journal of Medicine 368 (3) , pp. 282-284. 10.1056/NEJMcibr1212341

Cole, David, Miles, Kim Michelle, Madura, Florian, Holland, Christopher J., Schauenburg, Andrea J. A., Godkin, Andrew James, Bulek, Anna Marta, Fuller, Anna, Akpovwa, Hephzibah, Pymm, Phillip G., Liddy, N., Sami, M., Li, Y., Rizkallah, Pierre, Jakobsen, B. K. and Sewell, Andrew K. 2013. T-cell Receptor (TCR)-Peptide Specificity Overrides Affinity-enhancing TCR-Major Histocompatibility Complex Interactions. Journal of Biological Chemistry 289 (2) , pp. 628-638. 10.1074/jbc.M113.522110

Humphreys, Ian R., Clement, Mathew, Marsden, Morgan, Ladell, Kristin Ingrid, McLaren, James Edward, Smart, Kathryn, Hindley, James Philip, Bridgeman, Hayley, van den Berg, Hugo A., Price, David, Ager, Ann, Wooldridge, Linda, Godkin, Andrew James and Gallimore, Awen Myfanwy 2012. Avidity of influenza-specific memory CD8+T-cell populations decays over time compromising antiviral immunity. European Journal of Immunology 42 (12) , pp. 3235-3242. 10.1002/eji.201242575

Hindley, James Phillip, Jones, Emma, Smart, Kathryn, Bridgeman, Hayley, Lauder, Sarah Nicol, Ondondo, Beatrice Omusiro, Cutting, Scott, Ladell, Kristin Ingrid, Wynn, Katherine Kay, Withers, David, Price, David, Ager, Ann, Godkin, Andrew James and Gallimore, Awen Myfanwy 2012. T-cell trafficking facilitated by high endothelial venules is required for tumor control after regulatory T cell depletion. Cancer Research 72 (21) , pp. 5473-5482. 10.1158/0008-5472.CAN-12-1912

Holland, Christopher J., Rizkallah, Pierre, Vollers, Sabrina, Calvo-Calle, J. Mauricio, Madura, Florian, Fuller, Anna, Sewell, Andrew K., Stern, Lawrence J., Godkin, Andrew James and Cole, David 2012. Minimal conformational plasticity enables TCR cross-reactivity to different MHC class II heterodimers. Scientific Reports 2 , 629. 10.1038/srep00629

Scurr, Martin John, Gallimore, Awen Myfanwy and Godkin, Andrew James 2012. T cell subsets and colorectal cancer: discerning the good from the bad. Cellular Immunology 279 (1) , pp. 21-24. 10.1016/j.cellimm.2012.08.004

Pembroke, Thomas, Rees, Ian W., Gallagher, Kathleen, Jones, Emma, Mizen, Paul Edward, Navruzov, Timur, Freedman, Andrew Robert, Fielding, Ceri Alan, Humphreys, Ian R., Wang, Edward Chung Yern, Gallimore, Awen Myfanwy and Godkin, Andrew James 2012. Rapid early innate control of hepatitis C virus during IFN-α treatment compromises adaptive CD4+T-cell immunity. European Journal of Immunology 42 (9) , pp. 2383-2394. 10.1002/eji.201142072

Pembroke, Thomas, Wang, Edward Chung Yern, Gallimore, Awen Myfanwy and Godkin, Andrew James 2012. PMO-174 Intrahepatic natural killer cell phenotyping and functional analysis by fine needle aspiration in chronic HCV infection. Gut 61 (S2) , A144-A145. 10.1136/gutjnl-2012-302514b.174

Scurr, Martin John, Gallimore, Awen Myfanwy and Godkin, Andrew James 2012. PMO-088 A large proportion of colorectal tumour-infiltrating CD4+ T cells are suppressive irrespective of FOXP3 expression. Gut 61 (S2) , A109. 10.1136/gutjnl-2012-302514b.88

Cole, David, Gallagher, Kathleen, Lemercier, Brigitte, Holland, Christopher J., Junaid, Sayed, Hindley, James Phillip, Wynn, Katherine Kay, Gostick, Emma, Sewell, Andrew K., Gallimore, Awen Myfanwy, Ladell, Kristin Ingrid, Price, David, Gougeon, Marie-Lise and Godkin, Andrew James 2012. Modification of the carboxy-terminal flanking region of a universal influenza epitope alters CD4+ T-cell repertoire selection. Nature Communications 3 , 665. 10.1038/ncomms1665

Betts, Gareth James, Jones, Emma, Junaid, Syed, El-Shanawany, Tariq, Scurr, Martin John, Mizen, Paul Edward, Kumar, Mayur, Jones, Sion, Rees, Brian Idris, Williams, Geraint Trefor, Gallimore, Awen Myfanwy and Godkin, Andrew James 2012. Suppression of tumour-specific CD4+ T cells by regulatory T cells is associated with progression of human colorectal cancer. Gut 61 (8) , pp. 1163-1171. 10.1136/gutjnl-2011-300970

Clement, Mathew, Ladell, Kristin Ingrid, Ekeruche, Julia, Miles, John James, Edwards, Emily, Dolton, Garry Michael, Williams, Tamsin, Schauenburg, Andrea J. A., Cole, David, Lauder, Sarah Nicol, Gallimore, Awen Myfanwy, Godkin, Andrew James, Burrows, Scott R., Price, David, Sewell, Andrew K. and Wooldridge, Linda 2011. Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining. The Journal of Immunology 187 (2) , pp. 654-663. 10.4049/jimmunol.1003941

Lauder, Sarah Nicol, Taylor, Philip Russel, Clark, Stephen Robert, Evans, Rhys Lloyd, Hindley, James Phillip, Smart, Kathryn, Leach, Heather, Kidd, Emma Jane, Broadley, Kenneth John, Jones, Simon Arnett, Wise, Matthew Peter, Godkin, Andrew James, O'Donnell, Valerie Bridget and Gallimore, Awen Myfanwy 2011. Paracetamol reduces influenza-induced immunopathology in a mouse model of infection without compromising virus clearance or the generation of protective immunity. Thorax 66 (5) , pp. 368-374. 10.1136/thx.2010.150318

Hindley, James Philip, Ferreira, Cristina, Jones, Emma, Lauder, Sarah Nicol, Ladell, Kristin, Wynn, Katherine, Betts, Gareth James, Singh, Yogesh, Price, David, Godkin, Andrew James, Dyson, Julian and Gallimore, Awen Myfanwy 2011. Analysis of the T-cell receptor repertoires of tumor-infiltrating conventional and regulatory T cells reveals no evidence for conversion in carcinogen-induced tumors. Cancer Research 71 (3) , pp. 736-746. 10.1158/0008-5472.CAN-10-1797

Godkin, Andrew James and Gallimore, Awen Myfanwy 2011. Setting the threshold for extra-thymic differentiation of Foxp3+ Tregs: TGF-β-dependent and T-cell autonomous. European Journal of Immunology 41 (5) , pp. 1218-1220. 10.1002/eji.201141576

Lauder, Sarah Nicol, Smart, Kathryn, Ondondo, B., Fielding, Ceri Alan, Godkin, Andrew James, Jones, Simon Arnett and Gallimore, Awen Myfanwy 2010. A critical role for interleukin-6 in limiting influenza-induced pathology and generating heterosubtypic immunity [Abstract]. Immunology 131 (S1) , p. 186. 10.1111/j.1365-2567.2010.03390.x

Turner, Jeff, Godkin, Andrew James, Neville, Peter, Kingham, Jerry and Ch'ng, Chin Lye 2010. Clinical characteristics of hepatitis E in a "Non-Endemic" population. Journal of Medical Virology 82 (11) , pp. 1899-1902. 10.1002/jmv.21905

Richards, Hannah Catharine, Williams, Anwen Sian, Jones, Emma, Hindley, James Phillip, Godkin, Andrew James, Simon, Anna Katharina and Gallimore, Awen Myfanwy 2010. Novel role of regulatory T cells in limiting early neutrophil responses in skin. Immunology 131 (4) , pp. 583-592. 10.1111/j.1365-2567.2010.03333.x

Gallagher, Kathleen M. E., Lauder, Sarah Nicol, Rees, Ian W., Gallimore, Awen Myfanwy and Godkin, Andrew James 2009. Type I interferon (IFNα) acts directly on human memory CD4+ T cells altering their response to antigen. The Journal of Immunology 183 (5) , pp. 2915-2920. 10.4049/jimmunol.0801607

Wise, Matthew Peter, Frost, Paul John, Hingston, Christopher D. and Godkin, Andrew James 2009. Latent viral infections in critically ill patients. Critical care (London, England) 13 (3) , 410. 10.1186/cc7902

Baalasubramanian, Sivasankar, Longhi, M. Paula, Gallagher, Kathleen M. E., Betts, Gareth J., Morgan, Bryan Paul, Godkin, Andrew James and Gallimore, Awen Myfanwy 2009. CD59 blockade enhances antigen-specific CD4+ T cell responses in humans: a new target for cancer immunotherapy? The Journal of Immunology 182 (9) , pp. 5203-5207. 10.4049/jimmunol.0804243

Lissina, Anna, Ladell, Kristin Ingrid, Skowera, Ania, Clement, Mathew, Edwards, Emily, Seggewiss, Ruth, van den Berg, Hugo A., Gostick, Emma, Gallagher, Kathleen, Jones, Emma, Melenhorst, J. Joseph, Godkin, Andrew James, Peakman, Mark, Price, David, Sewell, Andrew K. and Wooldridge, Linda 2009. Protein kinase inhibitors substantially improve the physical detection of T-cells with peptide-MHC tetramers. Journal of Immunological Methods 340 (1) , pp. 11-24. 10.1016/j.jim.2008.09.014

Longhi, Maria Paula, Wright, Kate Louise, Lauder, Sarah Nicol, Nowell, Mari Ann, Jones, Gareth Wyn, Godkin, Andrew James, Jones, Simon Arnett and Gallimore, Awen Myfanwy 2008. Interleukin-6 is crucial for recall of influenza-specific memory cd4+ t cells. PLoS Pathogens 4 (2) , e1000006. 10.1371/journal.ppat.1000006

Godkin, Andrew James, Ng, Wan Fai, Gallagher, Kathleen M., Betts, Gareth J., Thomas, Howard C. and Lechler, Robert I. 2008. Expansion of hepatitis C-specific CD4+CD25+ regulatory T cells after viral clearance: a mechanism to limit collateral damage? Journal of Allergy and Clinical Immunology 121 (5) , pp. 1277-1284. 10.1016/j.jaci.2008.01.070

Owen, P. J. D., Baghomian, A., Lazarus, L. H. and Godkin, Andrew James 2007. Lesson of the week - An unusual cause of jaundice. BMJ 335 (7623) , pp. 773-774. 10.1136/hmj.39247.452141.BE

Boulter, Jonathan M., Schmitz, Nicole, Sewell, Andrew K., Godkin, Andrew James, Bachmann, Martin F. and Gallimore, Awen Myfanwy 2007. Potent T cell agonism mediated by a very rapid TCR/pMHC interaction. European Journal of Immunology 37 (3) , pp. 798-806. 10.1002/eji.200636743

Simon, Anna Katharina, Jones, Emma, Richards, Hannah, Wright, Kate Louise, Betts, Gareth James, Godkin, Andrew James, Screaton, Gavin and Gallimore, Awen Myfanwy 2007. Regulatory T cells inhibit Fas ligand induced innate and adaptive tumour immunity. European Journal of Immunology 37 (3) , pp. 758-767. 10.1002/eji.200636593

Betts, G., Twohig, Jason Peter, Van den Broek, M., Sierro, S., Godkin, Andrew James and Gallimore, Awen Myfanwy 2007. The impact of regulatory T cells on carcinogen-induced sarcogenesis. British Journal of Cancer 96 (12) , pp. 1849-1854. 10.1038/sj.bjc.6603824

Lewis, Gemma, Wise, Matthew Peter, Poynton, Christopher H. and Godkin, Andrew James 2007. A case of persistent anemia and alcohol abuse. Nature Clinical Practice Gastroenterology & Hepatology 4 (9) , pp. 521-526. 10.1038/ncpgasthep0922

Owen, Penelope Judith Dawn, Baghomian, Aram, Lazarus, John Henry and Godkin, Andrew James 2007. An unusual cause of jaundice. British Medical Journal (BMJ) 335 (7623) , p. 773. 10.1136/bmj.39247.452141.BE

Betts, Gareth James, Godkin, Andrew James and Gallimore, Awen Myfanwy 2007. Reply: forkhead box P3-positive regulatory T cells in immune surveillance and cancer. British Journal of Cancer 97 , pp. 1017-1018. 10.1038/sj.bjc.6603940

Gallimore, Awen Myfanwy and Godkin, Andrew James 2007. Regulatory T cells and tumour immunity - observations in mice and men. Immunology 123 (2) , pp. 157-163. 10.1111/j.1365-2567.2007.02748.x

Godkin, Andrew James, Clarke, Sarah Louise, Betts, Gareth James and Wright, Kate Louise 2006. CD4CD25FOXP3 Regulatory T Cells Suppress Anti-Tumor Immune Responses in Patients with Colorectal Cancer. PLoS ONE 1 (1) , e129. 10.1371/journal.pone.0000129

Wise, Matthew Peter, Gallimore, Awen Myfanwy and Godkin, Andrew James 2006. T-Cell costimulation [Letter]. New England Journal of Medicine 355 (24) , pp. 2594-2595. 10.1056/NEJMc062767

Betts, Gareth James, Clarke, Sarah Louise, Richards, Hannah E., Godkin, Andrew James and Gallimore, Awen Myfanwy 2006. Regulating the immune response to tumours. Advanced Drug Delivery Reviews 58 (8) , pp. 948-961. 10.1016/j.addr.2006.05.006

Clarke, S. L., Betts, G. J., Wright, K. L., El-Shanawany, Tariq, Plant, A., Gallimore, Awen Myfanwy and Godkin, Andrew James 2005. Analysis of CD4(+)CD25(hi) cells in peripheral blood and lymph nodes of patients with colorectal cancer. Immunology 116 (1) , p. 37. 10.1111/j.1365-2567.2005.02287.x

Godkin, Andrew James, Openshaw, P. and Thomas, H. C. 2005. Immune tolerance to hepatitis C virus acquired during engraftment of bone marrow transplant. Journal of Viral Hepatitis 12 (6) , pp. 604-608. 10.1111/j.1365-2893.2005.00627.x

Godkin, Andrew James, Hill, A. V. and Davenport, M. 2005. Molecular analysis of HLA class II associations with hepatitis B virus clearance and vaccine nonresponsiveness. Hepatology 41 (6) , pp. 1383-1390. 10.1002/hep.20716

Harcourt, G. C., Lucas, M., Godkin, Andrew James, Kantzanou, M., Phillips, R. E. and Klenerman, P. 2003. Evidence for lack of cross-genotype protection of CD4+ T cell responses during chronic hepatitis C virus infection. Clinical and Experimental Immunology 131 (1) , pp. 122-129. 10.1046/j.1365-2249.2003.02033.x

Godkin, Andrew James, Thomas, H. C. and Openshaw, P. J. 2002. Evolution of epitope-specific memory CD4+ T cells after clearance of Hepatitis C virus. The Journal of Immunology 169 (4) , pp. 2210-2214. 10.4049/jimmunol.169.4.2210

Godkin, Andrew James, Thomas, Howard C. and Openshaw, Peter J. 2002. Evolution of epitope-specific memory CD4(+) T cells after clearance of hepatitis C virus. Journal of immunology 169 (4) , pp. 2210-2214.

Godkin, Andrew James, Ng, W. F., Thomas, H. and Lechler, R. 2002. A population of CD25+CD4+regulatory cells that recognise hepatitis C virus antigens can be identified following clearance of infection. Gastroenterology 122 (4) , A676-A676.

Godkin, Andrew James, Openshaw, P. and Thomas, H. 2002. Characterisation of epitope-specific functionally distinct CD4+memory cell populations after clearance of hepatitis C virus (HCV). Gastroenterology 122 (4) , A640-A640.

Popat, S., Bevan, S., Braegger, C. P., Busch, A., O'Donoghue, D., Falth-Magnusson, K., Godkin, Andrew James, Hogberg, L., Holmes, G., Hosie, K. B., Howdle, P. D., Jenkins, H., Jewell, D., Johnston, S., Kennedy, N. P., Kumar, P., Logan, R. F. A., Love, A. H. G., Marsh, N. M., Mulder, C. J., Sjoberg, K., Stenhammer, L., Walker-Smith, J. and Houslton, R. S. 2002. Genome screening of coeliac disease [Letter]. Journal of Medical Genetics 39 (5) , pp. 328-331. 10.1136/jmg.39.5.328

Godkin, Andrew James, Willis, A., Smith, K. J. and Hill, A. V. S. 2001. Naturally processed HLA class II peptides reveal highly conserved immunogenic flanking region sequence preferences that reflect antigen processing rather than peptide-MHC interactions. Journal of Immunology 166 (11) , pp. 6720-6727.

Godkin, Andrew James, Jeanguet, N., Thursz, M., Openshaw, P. and Thomas, H. 2001. Characterization of novel HLA-DR11-restricted HCV epitopes reveals both qualitative and quantitative differences in HCV-specific CD4+ T cell responses in chronically infected and non-viremic patients. European Journal of Immunology 31 (5) , pp. 1438-1446.

Godkin, Andrew James, Thursz, M., Openshaw, P. and Thomas, H. C. 2000. Identification of HLA-DR11-restricted CD4+T cell epitopes derived from hepatitis C virus. Hepatology 32 (4) , 271A-271A.

Godkin, Andrew James, Thompson, Mary and Summerfield, John 2000. Abdominal pain and melaena: an unusual cause. The Lancet 356 (9229) , pp. 562-563. 10.1016/S0140-6736(00)02582-4

Anderson, R. P., Degano, P., Godkin, Andrew James, Jewell, D. P. and Hill, A. V. 2000. In vivo antigen challenge in celiac disease identifies a single transglutaminase-modified peptide as the dominant A-gliadin T-cell epitope. Nature Medicine 6 (3) , pp. 337-342. 10.1038/73200

Bevan, S., Popat, S., Braegger, C. P., Busch, A., O'Donoghue, D., Falth-Magnusson, K., Ferguson, A., Godkin, Andrew James, Hogberg, L., Holmes, G., Hosie, K. B., Howdle, P. D., Jenkins, H., Jewell, D., Johnston, S., Kennedy, N. P., Kerr, G., Kumar, P., Logan, R. F., Love, A. H., Marsh, M., Mulder, C. J., Sjoberg, K., Stenhammer, L., Walker-Smith, J., Marossy, A. M. and Houlston, R. S. 1999. Contribution of the MHC region to the familial risk of coeliac disease. Journal of Medical Genetics 36 (9) , pp. 687-690. 10.1136/jmg.36.9.687

Godkin, Andrew James, Davenport, M. P., Willis, A., Jewell, D. P. and Hill, A. V. 1998. Use of complete eluted peptide sequence data from HLA-DR and -DQ molecules to predict T cell epitopes, and the influence of the nonbinding terminal regions of ligands in epitope selection. The Journal of Immunology 161 (2) , pp. 850-858.

Gallimore, A., Glithero, A., Godkin, Andrew James, Tissot, A. C., Plückthun, A., Elliott, T., Hengartner, H. and Zinkernagel, R. 1998. Induction and exhaustion of lymphocytic choriomeningitis virus-specific cytotoxic T lymphocytes visualized using soluble tetrameric major histocompatibility complex class I-peptide complexes. Journal of Experimental Medicine 187 (9) , pp. 1383-1393.

Godkin, Andrew James and Jewell, Derek 1998. The pathogenesis of celiac disease. Gastroenterology 115 (1) , pp. 206-210. 10.1016/S0016-5085(98)70382-8

Godkin, Andrew James, Tatham, A., Shewry, P., Hill, A. and Jewell, D. 1997. Possible immuno-modulatory activity of gliadin by interference with antigen processing. Gastroenterology 112 (4) , A365-A365.

Godkin, Andrew James, Davenport, M., Hill, A. and Jewell, D. 1997. Binding characteristics of synthetic ligands from A-gliadin to the coeliac disease susceptibility molecules HLA-DQ2/8, and the linked molecules HLA-DR3/4. Gastroenterology 112 (4) , A364-A364.

Davenport, M. P., Godkin, Andrew James, Friede, Thomas, Stevanovic, Stefan, Willis, Anthony C., Hill, Adrian V. S. and Rammensee, Hans-Georg 1997. A distinctive peptide binding motif for HLA-DRB1 * 0407, an HLA-DR4 subtype not associated with rheumatoid arthritis. Immunogenetics 45 (3) , pp. 229-232. 10.1007/s002510050196

Godkin, Andrew James, Friede, T., Davenport, M., Stevanovic, S., Willis, A., Jewell, D., Hill, A. and Rammensee, H. G. 1997. Use of eluted peptide sequence data to identify the binding characteristics of peptides to the insulin-dependent diabetes susceptibility allele HLA-DQ8 (DQ 3.2). International Immunology 9 (6) , pp. 905-911. 10.1093/intimm/9.6.905

Houlston, R. S., Tomlinson, I. P. M., Ford, D., Seal, S., Marossy, A. M., Ferguson, A., Holmes, G. K. T., Hosie, K. B., Howdle, P. D., Jewell, D. P., Godkin, Andrew James, Kerr, G. D., Kumar, P., Logan, R. F. A., Love, A. H. G., Johnston, S., Marsh, M. N., Mitton, S., O'Donoghue, D., Roberts, A., Walker-Smith, J. A. and Stratton, M. F. 1997. Linkage analysis of candidate regions for coeliac disease genes. Human Molecular Genetics 6 (8) , pp. 1335-1339. 10.1093/hmg/6.8.1335

Godkin, Andrew James, Davenport, M., Willis, T., Hill, A. and Jewell, D. P. 1996. Pool sequencing of naturally bound peptides from the HLA class II DQ2 allele and use of this data for T-cell epitope prediction in coeliac disease. Gastroenterology 110 (4) , A326-A326.

Godkin, Andrew James, De Belder, A. J., Villa, L., Wong, A., Beesley, J. E., Kane, S. P. and Martin, J. F. 1996. Expression of nitric oxide synthase in ulcerative colitis. European Journal of Clinical Investigation 26 (10) , pp. 867-872. 10.1111/j.1365-2362.1996.tb02131.x

Godkin, Andrew James, Dinning, W. J. and Anderson, M. G. 1994. Scleritis associated with Coxsackle B type 5 infection [Letter]. Eye 8 (3) , pp. 357-358. 10.1038/eye.1994.76

Godkin, Andrew James, Brookes, R. and Jewell, D. P. Identification of a coeliac disease-specific T cell eptope from A-gliadin. Gastroenterology 116 (4) , A882-A882.