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Pires, Ana, Greenshields Watson, Alexander, Jones, Emma, Smart, Kathryn, Lauder, Sarah N., Somerville, Michelle, Milutinovic, Stefan, Kendrick, Howard, Hindley, James P., French, Rhiannon, Smalley, Matthew J., Watkins, William John, Andrews, Robert, Godkin, Andrew and Gallimore, Awen
2020.
Immune remodelling of the extracellular matrix drives loss of cancer stem cells and tumor rejection.
Cancer Immunology Research
8
(12)
, 1520 - 1531.
10.1158/2326-6066.CIR-20-0070
Item availability restricted. |
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Hughes, Ellyn, Lauder, Sarah N., Smart, Kathryn, Bloom, Anja, Scott, Jake, Jones, Emma, Somerville, Michelle, Browne, Molly, Blainey, Andrew, Godkin, Andrew, Ager, Ann and Gallimore, Awen 2020. Primary breast tumours but not lung metastases induce protective anti-tumour immune responses after Treg-depletion. Cancer Immunology, Immunotherapy 69 , 2063 - 2073. 10.1007/s00262-020-02603-x |
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Milutinovic, Stefan, Abe, Jun, Godkin, Andrew, Stein, Jens V. and Gallimore, Awen
2020.
The dual role of high endothelial venules in cancer progression versus immunity.
Trends in Cancer
10.1016/j.trecan.2020.10.001
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Lauder, Sarah Nicol, Smart, Kathryn, Kersemans, Veerle, Allen, Danny, Scott, Jake, Pires, Ana, Milutinovic, Stefan, Somerville, Michelle, Smart, Sean, Kinchesh, Paul, Lopez-Guadamillas, Elena, Hughes, Ellyn, Jones, Emma, Scurr, Martin, Godkin, Andrew, Friedman, Lori S, Vanhaesebroeck, Bart and Gallimore, Awen
2020.
Enhanced antitumor immunity through sequential targeting of PI3Kδ and LAG3.
Journal for ImmunoTherapy of Cancer
8
(2)
, e000693.
10.1136/jitc-2020-000693
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Greenshields-Watson, Alexander, Attaf, Meriem, MacLachlan, Bruce J., Whalley, Thomas, Rius, Cristina, Wall, Aaron, Lloyd, Angharad, Hughes, Hywel, Strange, Kathryn E., Mason, Georgina H., Schauenburg, Andrea J., Hulin-Curtis, Sarah L., Geary, James, Chen, Yuan, Lauder, Sarah N., Smart, Kathryn, Vijaykrishna, Dhanasekaran, Grau, Miguel L., Shugay, Mikhail, Andrews, Robert, Dolton, Garry, Rizkallah, Pierre J., Gallimore, Awen M., Godkin, Andrew J., Sewell, Andrew J. and Cole, David K.
2020.
CD4 + T cells recognize conserved influenza A epitopes through shared patterns of V-Gene usage and complementary biochemical features.
Cell Reports
32
(2)
, 107885.
10.1016/j.celrep.2020.107885
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Godkin, Andrew and Humphreys, Ian R. 2020. Elevated interleukin‐6, interleukin‐10 and neutrophil : lymphocyte ratio as identifiers of severe coronavirus disease 2019. Immunology 160 (3) , pp. 221-222. 10.1111/imm.13225 |
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Scurr, Martin J., Greenshields-Watson, Alexander, Campbell, Emma, Somerville, Michelle, Chen, Yuan, Hulin-Curtis, Sarah L., Burnell, Stephanie E. A., Davies, James A., Davies, Michael M., Hargest, Rachel, Phillips, Simon, Christian, Adam D., Ashelford, Kevin E., Andrews, Robert, Parker, Alan L., Stanton, Richard J., Gallimore, Awen and Godkin, Andrew
2020.
Cancer antigen discovery is enabled by RNA-sequencing of highly purified malignant and non-malignant cells.
Clinical Cancer Research
10.1158/1078-0432.CCR-19-3087
Item availability restricted. |
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Bagaev, Dmitry V, Vroomans, Renske M A, Samir, Jerome, Stervbo, Ulrik, Rius, Cristina, Dolton, Garry, Greenshields Watson, Alexander, Attaf, Meriem, Egorov, Evgeny S, Zvyagin, Ivan V, Babel, Nina, Cole, David K, Godkin, Andrew J, Sewell, Andrew K, Kesmir, Can, Chudakov, Dmitriy M, Luciani, Fabio and Shugay, Mikhail
2020.
VDJdb in 2019: database extension, new analysis infrastructure and a T-cell receptor motif compendium.
Nucleic Acids Research
48
(D1)
, D1057-D1062.
10.1093/nar/gkz874
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MacLachlan, Bruce J., Dolton, Garry, Papakyriakou, Athanasios, Greenshields-Watson, Alexander, Mason, Georgina H., Schauenburg, Andrea, Besneux, Matthieu, Szomolay, Barbara, Elliott, Tim, Sewell, Andrew K., Gallimore, Awen, Rizkallah, Pierre, Cole, David K. and Godkin, Andrew
2019.
Human leukocyte antigen (HLA) class II peptide flanking residues tune the immunogenicity of a human tumor-derived epitope.
Journal of Biological Chemistry
294
(52)
, pp. 20246-20258.
10.1074/jbc.RA119.009437
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Appanna, Gautham D, Pembroke, Thomas P I, Miners, Kelly L, Price, David A, Gallimore, Awen M, Ladell, Kristin and Godkin, Andrew J
2019.
Rituximab depletion of intrahepatic B cells to control refractory hepatic autoimmune overlap syndrome.
QJM: An International Journal of Medicine
112
(10)
, pp. 793-795.
10.1093/qjmed/hcz161
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Madura, Florian, Rizkallah, Pierre J., Legut, Mateusz, Holland, Christopher J., Fuller, Anna, Bulek, Anna, Schauenburg, Andrea J., Trimby, Andrew, Hopkins, Jade R., Wells, Stephen A., Godkin, Andrew, Miles, John J., Sami, Malkit, Li, Yi, Liddy, Nathaniel, Jakobsen, Bent K., Loveridge, E. Joel, Cole, David K. and Sewell, Andrew K.
2019.
TCR-induced alteration of primary MHC peptide anchor residue.
European Journal of Immunology
49
(7)
, pp. 1052-1066.
10.1002/eji.201948085
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Thomson, Amanda, Smart, Kathryn, Somerville, Michelle S., Lauder, Sarah N., Appanna, Gautham, Horwood, James, Lawrence-Sunder, Raj, Srivastava, Brijesh, Durai, Dhamaraj, Scurr, Martin J., Keita, Asa V., Gallimore, Awen M. and Godkin, Andrew
2019.
The Ussing chamber system for measuring intestinal permeability in health and disease.
BMC Gastroenterology
19
, 98.
10.1186/s12876-019-1002-4
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Besneux, Matthieu, Greenshields Watson, Alexander, Scurr, Martin, MacLachlan, Bruce, Christian, Adam, Davies, Michael, Hargest, Rachel, Phillips, Simon, Godkin, Andrew and Gallimore, Awen
2019.
The nature of the human T cell response to the cancer antigen 5T4 is determined by the balance of regulatory and inflammatory T cells of the same antigen-specificity: implications for vaccine design.
Cancer Immunology, Immunotherapy
68
, pp. 247-256.
10.1007/s00262-018-2266-1
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Hughes, Ellyn, Scurr, Martin, Campbell, Emma, Jones, Emma, Godkin, Andrew and Gallimore, Awen
2018.
T‐cell modulation by cyclophosphamide for tumour therapy.
Immunology
154
(1)
, pp. 62-68.
10.1111/imm.12913
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Holland, Christopher J., MacLachlan, Bruce J., Bianchi, Valentina, Hesketh, Sophie J., Morgan, Richard, Vickery, Owen, Bulek, Anna M., Fuller, Anna, Godkin, Andrew, Sewell, Andrew K., Rizkallah, Pierre J., Wells, Stephen and Cole, David K. 2018. In silico and structural analyses demonstrate that intrinsic protein motions guide T cell receptor complementarity determining region loop flexibility. Frontiers in Immunology 9 , 674. 10.3389/fimmu.2018.00674 |
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Colbeck, Emily J., Jones, Emma, Hindley, James P., Smart, Kathryn, Schulz, Ralph, Browne, Molly, Cutting, Scott, Williams, Anwen, Parry, Lee, Godkin, Andrew, Ware, Carl F., Ager, Ann and Gallimore, Awen
2017.
Treg depletion licenses T cell-driven HEV neogenesis and promotes tumor destruction.
Cancer Immunology Research
5
(11)
, pp. 1005-1015.
10.1158/2326-6066.CIR-17-0131
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Scurr, Martin, Pembroke, Tom, Bloom, Anja, Roberts, David, Thomson, Amanda, Smart, Kathryn, Bridgeman, Hayley, Adams, Richard, Brewster, Alison, Jones, Robert, Gwynne, Sarah, Blount, Daniel, Harrop, Richard, Wright, Melissa, Hills, Robert, Gallimore, Awen and Godkin, Andrew
2017.
Effect of modified vaccinia Ankara–5T4 and low-dose cyclophosphamide on antitumor immunity in metastatic colorectal cancer: A randomized clinical trial.
JAMA Oncology
3
(10)
, e172579.
10.1001/jamaoncol.2017.2579
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Scurr, Martin J, Pembroke, Tom, Bloom, Anja, Roberts, David J, Thomson, Amanda, Smart, Kathryn, Bridgeman, Hayley, Adams, Richard A, Brewster, Alison E, Jones, Robert, Gwynne, Sarah, Blount, Daniel, Harrop, Richard, Hills, Robert, Gallimore, Awen and Godkin, Andrew 2017. Low-dose cyclophosphamide induces anti-tumor T-cell responses which associate with survival in metastatic colorectal cancer. Clinical Cancer Research , clincanres.0895.2017. 10.1158/1078-0432.CCR-17-0895 |
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Godkin, Andrew and Smith, Katherine 2017. Chronic infections with viruses or parasites: breaking bad to make good. Immunology 150 (4) , pp. 389-396. 10.1111/imm.12703 |
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Scurr, Martin, Pembroke, Tom, Adams, Richard, Blount, Daniel, Brewster, Alison, Gwynne, Sarah, Harrop, Richard, Jones, Robert, Hills, Robert, Gallimore, Awen and Godkin, Andrew
2017.
MVA-5T4 immunotherapy and low-dose cyclophosphamide for advanced colorectal cancer (TaCTiCC): An open-label, randomized phase I/II trial.
Journal of Clinical Oncology
35
(7)
, p. 154.
10.1200/JCO.2017.35.7_suppl.154
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Clement, Mathew, Marsden, Morgan, Stacey, Maria, Abdul-Karim, Juneid, Gimeno Brias, Silvia, Costa Bento, Diana Filipa, Scurr, Martin, Weaver, Casey, Carlesso, Gianluca, Clare, Simon, Jones, Simon, Godkin, Andrew, Ghazal, Peter, Jones, Gareth W. and Humphreys, Ian
2016.
Cytomegalovirus-specific IL-10-producing CD4+ T cells are governed by type-I IFN-induced IL-27 and promote virus persistence.
Plos Pathogens
12
(12)
, e1006050.
10.1371/journal.ppat.1006050
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Jönsson, Peter, Southcombe, Jennifer H., Santos, Ana Mafalda, Huo, Jiandong, Fernandes, Ricardo A., McColl, James, Lever, Melissa, Evans, Edward J., Hudson, Alexander, Chang, Veronica T., Hanke, Tomá?, Godkin, Andrew, Dunne, Paul D., Horrocks, Mathew H., Palayret, Matthieu, Screaton, Gavin R., Petersen, Jan, Rossjohn, Jamie, Fugger, Lars, Dushek, Omer, Xu, Xiao-Ning, Davis, Simon J. and Klenerman, David
2016.
Remarkably low affinity of CD4/peptide-major histocompatibility complex class II protein interactions.
Proceedings of the National Academy of Sciences of the United States of America
113
(20)
, pp. 5682-5687.
10.1073/pnas.1513918113
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Holland, Christopher J., Dolton, Garry M., Scurr, Martin, Ladell, Kristin, Schauenburg, Andrea J., Miners, Kelly, Madura, Florian, Sewell, Andrew K., Price, David A., Cole, David K. and Godkin, Andrew J.
2015.
Enhanced detection of antigen-specific CD4+ T cells using altered peptide flanking residue peptide-MHC class II multimers.
Journal of Immunology
195
(12)
, pp. 5827-5836.
10.4049/jimmunol.1402787
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Santegoets, Saskia J. A. M., Dijkgraaf, Eveline M., Battaglia, Alessandra, Beckhove, Philipp, Britten, Cedrik M., Gallimore, Awen, Godkin, Andrew James, Gouttefangeas, Cecile, de Gruijl, Tanja D., Koenen, Hans J. P. M., Scheffold, Alexander, Shevach, Ethan M., Staats, Janet, Taskén, Kjetil, Whiteside, Theresa L., Kroep, Judith R., Welters, Marij J. P. and van der Burg, Sjoerd H.
2015.
Monitoring regulatory T cells in clinical samples: consensus on an essential marker set and gating strategy for regulatory T cell analysis by flow cytometry.
Cancer Immunology, Immunotherapy
64
(10)
, pp. 1271-1286.
10.1007/s00262-015-1729-x
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Dolton, Garry Michael, Tungatt, Katie, Lloyd, Angharad, Bianchi, Valentina, Theaker, Sarah M., Trimby, Andrew R., Holland, Christopher J., Donia, Marco, Godkin, Andrew James, Cole, David, Straten, Per Thor, Peakman, Mark, Svane, Inge Marie and Sewell, Andrew K. 2015. More tricks with tetramers: a practical guide to staining T cells with peptide-MHC multimers. Immunology 146 (1) , pp. 11-22. 10.1111/imm.12499 |
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Colbeck, Emily, Hindley, James P., Smart, Kathryn, Jones, Emma, Bloom, Anja, Bridgeman, Hayley, McPherson, Rhoanne C., Turner, Darryl G., Ladell, Kristin Ingrid, Price, David, O'Connor, Richard A., Anderton, Stephen M., Godkin, Andrew James and Gallimore, Awen Myfanwy 2015. Eliminating roles for T-bet and IL-2 but revealing superior activation and proliferation as mechanisms underpinning dominance of regulatory T cells in tumors. Oncotarget 6 (28) , pp. 24649-24659. 10.18632/oncotarget.5584 |
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Pembroke, Tom, Gallimore, Awen Myfanwy and Godkin, Andrew James 2015. Tracking the kinetics of intrahepatic immune responses by repeated fine needle aspiration of the liver. Journal of Immunological Methods 424 , pp. 131-135. 10.1016/j.jim.2015.04.011 |
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Ondondo, Beatrice, Colbeck, Emily, Jones, Emma, Smart, Kathryn, Lauder, Sarah Nicol, Hindley, James Philip, Godkin, Andrew James, Moser, Bernhard, Ager, Ann and Gallimore, Awen Myfanwy 2015. A distinct chemokine axis does not account for enrichment of Foxp3+ CD4+T cells in carcinogen-induced fibrosarcomas. Immunology 145 (1) , pp. 94-104. 10.1111/imm.12430 |
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Scurr, Martin J., Brown, Clare M., Costa Bento, Diana F., Betts, Gareth J., Rees, Brian I., Hills, Robert K., Gallimore, Awen and Godkin, Andrew
2015.
Assessing the prognostic value of preoperative carcinoembryonic antigen-specific T-cell responses in colorectal cancer.
JNCI: Journal of the National Cancer Institute
107
(4)
, djv001.
10.1093/jnci/djv001
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Costa Bento, Diana Filipa, Jones, Emma, Junaid, Syed, Tull, Justyna, Williams, Geraint Trefor, Godkin, Andrew James, Ager, Ann and Gallimore, Awen Myfanwy 2015. High endothelial venules are rare in colorectal cancers but accumulate in extra-tumoral areas with disease progression. OncoImmunology 4 (3) , pp. 653-660. 10.4161/2162402X.2014.974374 |
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Madura, Florian, Rizkallah, Pierre, Holland, Christopher J., Fuller, Anna, Bulek, Anna Marta, Godkin, Andrew James, Schauenburg, Andrea J., Cole, David K. and Sewell, Andrew K.
2015.
Structural basis for ineffective T-cell responses to MHC anchor residue-improved 'heteroclitic' peptides.
European Journal of Immunology
45
(2)
, pp. 584-591.
10.1002/eji.201445114
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Tungatt, Katie, Bianchi, Valentina, Crowther, Michael D., Powell, Wendy, Schauenburg, Andrea J. A., Trimby, Andrew R., Donia, M., Miles, John James, Holland, Christopher J., Cole, David, Godkin, Andrew James, Peakman, M., Straten, P. T., Svane, I. M., Sewell, Andrew K. and Dolton, Garry Michael 2015. Antibody stabilization of peptide-MHC multimers reveals functional T cells bearing extremely low-affinity TCRs. Journal of Immunology 194 (1) , pp. 463-474. 10.4049/jimmunol.1401785 |
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Dolton, Garry Michael, Lissina, A., Skowera, A., Ladell, Kristin Ingrid, Tungatt, Katie, Jones, Emma, Kronenberg-Versteeg, D., Akpovwa, Hephzibah, Pentier, Johanne, Holland, C. J., Godkin, Andrew James, Cole, David, Neller, M. A., Miles, John James, Price, David, Peakman, M. and Sewell, Andrew K. 2014. Comparison of peptide-major histocompatibility complex tetramers and dextramers for the identification of antigen-specific T cells. Clinical and Experimental Immunology 177 (1) , pp. 47-63. 10.1111/cei.12339 |
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Ondondo, Beatrice, Jones, Emma, Hindley, James, Cutting, Scott, Smart, Kathryn, Bridgeman, Hayley, Matthews, Katherine K., Ladell, Kristin Ingrid, Price, David, Jackson, David G., Godkin, Andrew James, Ager, Ann and Gallimore, Awen Myfanwy 2014. Progression of carcinogen-induced fibrosarcomas is associated with the accumulation of naïve CD4+ T cellsviablood vessels and lymphatics. International Journal of Cancer 134 (9) , pp. 2156-2167. 10.1002/ijc.28556 |
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Scurr, Martin, Bloom, Anja, Pembroke, Thomas, Srinivasan, R., Brown, Clare, Smart, Kathryn, Bridgeman, H., Davies, Michael, Hargest, Rachel, Phillips, Simon, Christian, Adam, Hockey, T., Gallimore, Awen and Godkin, Andrew 2013. Escalating regulation of 5T4-specific IFN- + CD4+ T cells distinguishes colorectal cancer patients from healthy controls and provides a target for in vivo therapy. Cancer Immunology Research 1 (6) , 416. 10.1158/2326-6066.CIR-13-0035 |
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Lauder, Sarah Nicol, Jones, Emma, Smart, Kathryn, Bloom, Anja Constanze, Williams, Anwen Sian, Hindley, James P., Ondondo, Beatrice, Taylor, Philip Russel, Clement, Mathew, Fielding, Ceri Alan, Godkin, Andrew James, Jones, Simon Arnett and Gallimore, Awen Myfanwy 2013. Interleukin-6 limits influenza-induced inflammation and protects against fatal lung pathology. European Journal of Immunology 43 (10) , pp. 2613-2625. 10.1002/eji.201243018 |
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Scurr, Martin John, Ladell, Kristin Ingrid, Besneux, Matthieu, Christian, Adam, Hockey, T., Smart, Kathryn, Bridgeman, Hayley, Hargest, Rachel, Phillips, S., Davies, M., Price, David, Gallimore, Awen Myfanwy and Godkin, Andrew James 2013. Highly prevalent colorectal cancer-infiltrating LAP+ Foxp3- T cells exhibit more potent immunosuppressive activity than Foxp3+ regulatory T cells. Mucosal Immunology n/a 10.1038/mi.2013.62 |
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Ondondo, Beatrice, Jones, Emma, Godkin, Andrew James and Gallimore, Awen Myfanwy 2013. Home sweet home: The tumor microenvironment as a haven for regulatory T cells. Frontiers in Immunology 4 , 197. 10.3389/fimmu.2013.00197 |
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Holland, Christopher J., Cole, David and Godkin, Andrew James 2013. Re-directing CD4+ T cell responses with the flanking residues of MHC class II-bound peptides: The core is not enough. Frontiers in Immunology 4 , 172. 10.3389/fimmu.2013.00172 |
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Pembroke, T., Gallimore, A. and Godkin, A. 2013. Flow cytometry makes all the difference. Journal of Hepatology 59 (4) , pp. 909-910. 10.1016/j.jhep.2013.05.047 |
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Pembroke, Thomas, Gallimore, Awen and Godkin, Andrew 2013. Rapid innate control of antigen abrogates adaptive immunity. Immunology 138 (4) , pp. 293-297. 10.1111/imm.12048 |
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Gallimore, Awen Myfanwy and Godkin, Andrew James 2013. Epithelial barriers, microbiota, and colorectal cancer. New England Journal of Medicine 368 (3) , pp. 282-284. 10.1056/NEJMcibr1212341 |
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Cole, David, Miles, Kim Michelle, Madura, Florian, Holland, Christopher J., Schauenburg, Andrea J. A., Godkin, Andrew James, Bulek, Anna Marta, Fuller, Anna, Akpovwa, Hephzibah, Pymm, Phillip G., Liddy, N., Sami, M., Li, Y., Rizkallah, Pierre, Jakobsen, B. K. and Sewell, Andrew K. 2013. T-cell Receptor (TCR)-Peptide Specificity Overrides Affinity-enhancing TCR-Major Histocompatibility Complex Interactions. Journal of Biological Chemistry 289 (2) , pp. 628-638. 10.1074/jbc.M113.522110 |
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Humphreys, Ian R., Clement, Mathew, Marsden, Morgan, Ladell, Kristin Ingrid, McLaren, James Edward, Smart, Kathryn, Hindley, James Philip, Bridgeman, Hayley, van den Berg, Hugo A., Price, David, Ager, Ann, Wooldridge, Linda, Godkin, Andrew James and Gallimore, Awen Myfanwy 2012. Avidity of influenza-specific memory CD8+T-cell populations decays over time compromising antiviral immunity. European Journal of Immunology 42 (12) , pp. 3235-3242. 10.1002/eji.201242575 |
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Hindley, James Phillip, Jones, Emma, Smart, Kathryn, Bridgeman, Hayley, Lauder, Sarah Nicol, Ondondo, Beatrice Omusiro, Cutting, Scott, Ladell, Kristin Ingrid, Wynn, Katherine Kay, Withers, David, Price, David, Ager, Ann, Godkin, Andrew James and Gallimore, Awen Myfanwy 2012. T-cell trafficking facilitated by high endothelial venules is required for tumor control after regulatory T cell depletion. Cancer Research 72 (21) , pp. 5473-5482. 10.1158/0008-5472.CAN-12-1912 |
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Holland, Christopher J., Rizkallah, Pierre, Vollers, Sabrina, Calvo-Calle, J. Mauricio, Madura, Florian, Fuller, Anna, Sewell, Andrew K., Stern, Lawrence J., Godkin, Andrew James and Cole, David 2012. Minimal conformational plasticity enables TCR cross-reactivity to different MHC class II heterodimers. Scientific Reports 2 , 629. 10.1038/srep00629 |
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Scurr, Martin John, Gallimore, Awen Myfanwy and Godkin, Andrew James 2012. T cell subsets and colorectal cancer: discerning the good from the bad. Cellular Immunology 279 (1) , pp. 21-24. 10.1016/j.cellimm.2012.08.004 |
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Pembroke, Thomas, Rees, Ian W., Gallagher, Kathleen, Jones, Emma, Mizen, Paul Edward, Navruzov, Timur, Freedman, Andrew Robert, Fielding, Ceri Alan, Humphreys, Ian R., Wang, Edward Chung Yern, Gallimore, Awen Myfanwy and Godkin, Andrew James 2012. Rapid early innate control of hepatitis C virus during IFN-α treatment compromises adaptive CD4+T-cell immunity. European Journal of Immunology 42 (9) , pp. 2383-2394. 10.1002/eji.201142072 |
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Cole, David, Gallagher, Kathleen, Lemercier, Brigitte, Holland, Christopher J., Junaid, Sayed, Hindley, James Phillip, Wynn, Katherine Kay, Gostick, Emma, Sewell, Andrew K., Gallimore, Awen Myfanwy, Ladell, Kristin Ingrid, Price, David, Gougeon, Marie-Lise and Godkin, Andrew James 2012. Modification of the carboxy-terminal flanking region of a universal influenza epitope alters CD4+ T-cell repertoire selection. Nature Communications 3 , 665. 10.1038/ncomms1665 |
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Betts, Gareth James, Jones, Emma, Junaid, Syed, El-Shanawany, Tariq, Scurr, Martin John, Mizen, Paul Edward, Kumar, Mayur, Jones, Sion, Rees, Brian Idris, Williams, Geraint Trefor, Gallimore, Awen Myfanwy and Godkin, Andrew James 2012. Suppression of tumour-specific CD4+ T cells by regulatory T cells is associated with progression of human colorectal cancer. Gut 61 (8) , pp. 1163-1171. 10.1136/gutjnl-2011-300970 |
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Clement, Mathew, Ladell, Kristin Ingrid, Ekeruche, Julia, Miles, John James, Edwards, Emily, Dolton, Garry Michael, Williams, Tamsin, Schauenburg, Andrea J. A., Cole, David, Lauder, Sarah Nicol, Gallimore, Awen Myfanwy, Godkin, Andrew James, Burrows, Scott R., Price, David, Sewell, Andrew K. and Wooldridge, Linda 2011. Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining. The Journal of Immunology 187 (2) , pp. 654-663. 10.4049/jimmunol.1003941 |
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Lauder, Sarah Nicol, Taylor, Philip Russel, Clark, Stephen Robert, Evans, Rhys Lloyd, Hindley, James Phillip, Smart, Kathryn, Leach, Heather, Kidd, Emma Jane, Broadley, Kenneth John, Jones, Simon Arnett, Wise, Matthew Peter, Godkin, Andrew James, O'Donnell, Valerie Bridget and Gallimore, Awen Myfanwy 2011. Paracetamol reduces influenza-induced immunopathology in a mouse model of infection without compromising virus clearance or the generation of protective immunity. Thorax 66 (5) , pp. 368-374. 10.1136/thx.2010.150318 |
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Hindley, James Philip, Ferreira, Cristina, Jones, Emma, Lauder, Sarah Nicol, Ladell, Kristin, Wynn, Katherine, Betts, Gareth James, Singh, Yogesh, Price, David, Godkin, Andrew James, Dyson, Julian and Gallimore, Awen Myfanwy 2011. Analysis of the T-cell receptor repertoires of tumor-infiltrating conventional and regulatory T cells reveals no evidence for conversion in carcinogen-induced tumors. Cancer Research 71 (3) , pp. 736-746. 10.1158/0008-5472.CAN-10-1797 |
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Godkin, Andrew James and Gallimore, Awen Myfanwy 2011. Setting the threshold for extra-thymic differentiation of Foxp3+ Tregs: TGF-β-dependent and T-cell autonomous. European Journal of Immunology 41 (5) , pp. 1218-1220. 10.1002/eji.201141576 |
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Turner, Jeff, Godkin, Andrew James, Neville, Peter, Kingham, Jerry and Ch'ng, Chin Lye 2010. Clinical characteristics of hepatitis E in a "Non-Endemic" population. Journal of Medical Virology 82 (11) , pp. 1899-1902. 10.1002/jmv.21905 |
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Richards, Hannah Catharine, Williams, Anwen Sian, Jones, Emma, Hindley, James Phillip, Godkin, Andrew James, Simon, Anna Katharina and Gallimore, Awen Myfanwy 2010. Novel role of regulatory T cells in limiting early neutrophil responses in skin. Immunology 131 (4) , pp. 583-592. 10.1111/j.1365-2567.2010.03333.x |
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Gallagher, Kathleen M. E., Lauder, Sarah Nicol, Rees, Ian W., Gallimore, Awen Myfanwy and Godkin, Andrew James 2009. Type I interferon (IFNα) acts directly on human memory CD4+ T cells altering their response to antigen. The Journal of Immunology 183 (5) , pp. 2915-2920. 10.4049/jimmunol.0801607 |
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Wise, Matthew Peter, Frost, Paul John, Hingston, Christopher D. and Godkin, Andrew James 2009. Latent viral infections in critically ill patients. Critical care (London, England) 13 (3) , 410. 10.1186/cc7902 |
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Baalasubramanian, Sivasankar, Longhi, M. Paula, Gallagher, Kathleen M. E., Betts, Gareth J., Morgan, Bryan Paul, Godkin, Andrew James and Gallimore, Awen Myfanwy 2009. CD59 blockade enhances antigen-specific CD4+ T cell responses in humans: a new target for cancer immunotherapy? The Journal of Immunology 182 (9) , pp. 5203-5207. 10.4049/jimmunol.0804243 |
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Lissina, Anna, Ladell, Kristin Ingrid, Skowera, Ania, Clement, Mathew, Edwards, Emily, Seggewiss, Ruth, van den Berg, Hugo A., Gostick, Emma, Gallagher, Kathleen, Jones, Emma, Melenhorst, J. Joseph, Godkin, Andrew James, Peakman, Mark, Price, David, Sewell, Andrew K. and Wooldridge, Linda 2009. Protein kinase inhibitors substantially improve the physical detection of T-cells with peptide-MHC tetramers. Journal of Immunological Methods 340 (1) , pp. 11-24. 10.1016/j.jim.2008.09.014 |
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Longhi, Maria Paula, Wright, Kate Louise, Lauder, Sarah Nicol, Nowell, Mari Ann, Jones, Gareth Wyn, Godkin, Andrew James, Jones, Simon Arnett and Gallimore, Awen Myfanwy 2008. Interleukin-6 is crucial for recall of influenza-specific memory cd4+ t cells. PLoS Pathogens 4 (2) , e1000006. 10.1371/journal.ppat.1000006 |
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Godkin, Andrew James, Ng, Wan Fai, Gallagher, Kathleen M., Betts, Gareth J., Thomas, Howard C. and Lechler, Robert I. 2008. Expansion of hepatitis C-specific CD4+CD25+ regulatory T cells after viral clearance: a mechanism to limit collateral damage? Journal of Allergy and Clinical Immunology 121 (5) , pp. 1277-1284. 10.1016/j.jaci.2008.01.070 |
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Owen, P. J. D., Baghomian, A., Lazarus, L. H. and Godkin, Andrew James 2007. Lesson of the week - An unusual cause of jaundice. BMJ 335 (7623) , pp. 773-774. 10.1136/hmj.39247.452141.BE |
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Boulter, Jonathan M., Schmitz, Nicole, Sewell, Andrew K., Godkin, Andrew James, Bachmann, Martin F. and Gallimore, Awen Myfanwy 2007. Potent T cell agonism mediated by a very rapid TCR/pMHC interaction. European Journal of Immunology 37 (3) , pp. 798-806. 10.1002/eji.200636743 |
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Simon, Anna Katharina, Jones, Emma, Richards, Hannah, Wright, Kate Louise, Betts, Gareth James, Godkin, Andrew James, Screaton, Gavin and Gallimore, Awen Myfanwy 2007. Regulatory T cells inhibit Fas ligand induced innate and adaptive tumour immunity. European Journal of Immunology 37 (3) , pp. 758-767. 10.1002/eji.200636593 |
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Betts, G., Twohig, Jason Peter, Van den Broek, M., Sierro, S., Godkin, Andrew James and Gallimore, Awen Myfanwy 2007. The impact of regulatory T cells on carcinogen-induced sarcogenesis. British Journal of Cancer 96 (12) , pp. 1849-1854. 10.1038/sj.bjc.6603824 |
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Lewis, Gemma, Wise, Matthew Peter, Poynton, Christopher H. and Godkin, Andrew James 2007. A case of persistent anemia and alcohol abuse. Nature Clinical Practice Gastroenterology & Hepatology 4 (9) , pp. 521-526. 10.1038/ncpgasthep0922 |
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Owen, Penelope Judith Dawn, Baghomian, Aram, Lazarus, John Henry and Godkin, Andrew James 2007. An unusual cause of jaundice. British Medical Journal (BMJ) 335 (7623) , p. 773. 10.1136/bmj.39247.452141.BE |
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Betts, Gareth James, Godkin, Andrew James and Gallimore, Awen Myfanwy 2007. Reply: forkhead box P3-positive regulatory T cells in immune surveillance and cancer. British Journal of Cancer 97 , pp. 1017-1018. 10.1038/sj.bjc.6603940 |
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Gallimore, Awen Myfanwy and Godkin, Andrew James 2007. Regulatory T cells and tumour immunity - observations in mice and men. Immunology 123 (2) , pp. 157-163. 10.1111/j.1365-2567.2007.02748.x |
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Godkin, Andrew James, Clarke, Sarah Louise, Betts, Gareth James and Wright, Kate Louise 2006. CD4CD25FOXP3 Regulatory T Cells Suppress Anti-Tumor Immune Responses in Patients with Colorectal Cancer. PLoS ONE 1 (1) , e129. 10.1371/journal.pone.0000129 |
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Wise, Matthew Peter, Gallimore, Awen Myfanwy and Godkin, Andrew James 2006. T-Cell costimulation [Letter]. New England Journal of Medicine 355 (24) , pp. 2594-2595. 10.1056/NEJMc062767 |
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Betts, Gareth James, Clarke, Sarah Louise, Richards, Hannah E., Godkin, Andrew James and Gallimore, Awen Myfanwy 2006. Regulating the immune response to tumours. Advanced Drug Delivery Reviews 58 (8) , pp. 948-961. 10.1016/j.addr.2006.05.006 |
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Clarke, S. L., Betts, G. J., Wright, K. L., El-Shanawany, Tariq, Plant, A., Gallimore, Awen Myfanwy and Godkin, Andrew James 2005. Analysis of CD4(+)CD25(hi) cells in peripheral blood and lymph nodes of patients with colorectal cancer. Immunology 116 (1) , p. 37. 10.1111/j.1365-2567.2005.02287.x |
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Godkin, Andrew James, Openshaw, P. and Thomas, H. C. 2005. Immune tolerance to hepatitis C virus acquired during engraftment of bone marrow transplant. Journal of Viral Hepatitis 12 (6) , pp. 604-608. 10.1111/j.1365-2893.2005.00627.x |
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Godkin, Andrew James, Hill, A. V. and Davenport, M. 2005. Molecular analysis of HLA class II associations with hepatitis B virus clearance and vaccine nonresponsiveness. Hepatology 41 (6) , pp. 1383-1390. 10.1002/hep.20716 |
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Harcourt, G. C., Lucas, M., Godkin, Andrew James, Kantzanou, M., Phillips, R. E. and Klenerman, P. 2003. Evidence for lack of cross-genotype protection of CD4+ T cell responses during chronic hepatitis C virus infection. Clinical and Experimental Immunology 131 (1) , pp. 122-129. 10.1046/j.1365-2249.2003.02033.x |
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Godkin, Andrew James, Thomas, H. C. and Openshaw, P. J. 2002. Evolution of epitope-specific memory CD4+ T cells after clearance of Hepatitis C virus. The Journal of Immunology 169 (4) , pp. 2210-2214. 10.4049/jimmunol.169.4.2210 |
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Godkin, Andrew James, Thomas, Howard C. and Openshaw, Peter J. 2002. Evolution of epitope-specific memory CD4(+) T cells after clearance of hepatitis C virus. Journal of immunology 169 (4) , pp. 2210-2214. |
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Godkin, Andrew James, Ng, W. F., Thomas, H. and Lechler, R. 2002. A population of CD25+CD4+regulatory cells that recognise hepatitis C virus antigens can be identified following clearance of infection. Gastroenterology 122 (4) , A676-A676. |
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Godkin, Andrew James, Openshaw, P. and Thomas, H. 2002. Characterisation of epitope-specific functionally distinct CD4+memory cell populations after clearance of hepatitis C virus (HCV). Gastroenterology 122 (4) , A640-A640. |
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Popat, S., Bevan, S., Braegger, C. P., Busch, A., O'Donoghue, D., Falth-Magnusson, K., Godkin, Andrew James, Hogberg, L., Holmes, G., Hosie, K. B., Howdle, P. D., Jenkins, H., Jewell, D., Johnston, S., Kennedy, N. P., Kumar, P., Logan, R. F. A., Love, A. H. G., Marsh, N. M., Mulder, C. J., Sjoberg, K., Stenhammer, L., Walker-Smith, J. and Houslton, R. S. 2002. Genome screening of coeliac disease [Letter]. Journal of Medical Genetics 39 (5) , pp. 328-331. 10.1136/jmg.39.5.328 |
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Godkin, Andrew James, Willis, A., Smith, K. J. and Hill, A. V. S. 2001. Naturally processed HLA class II peptides reveal highly conserved immunogenic flanking region sequence preferences that reflect antigen processing rather than peptide-MHC interactions. Journal of Immunology 166 (11) , pp. 6720-6727. |
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Godkin, Andrew James, Jeanguet, N., Thursz, M., Openshaw, P. and Thomas, H. 2001. Characterization of novel HLA-DR11-restricted HCV epitopes reveals both qualitative and quantitative differences in HCV-specific CD4+ T cell responses in chronically infected and non-viremic patients. European Journal of Immunology 31 (5) , pp. 1438-1446. |
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Godkin, Andrew James, Thursz, M., Openshaw, P. and Thomas, H. C. 2000. Identification of HLA-DR11-restricted CD4+T cell epitopes derived from hepatitis C virus. Hepatology 32 (4) , 271A-271A. |
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Godkin, Andrew James, Thompson, Mary and Summerfield, John 2000. Abdominal pain and melaena: an unusual cause. The Lancet 356 (9229) , pp. 562-563. 10.1016/S0140-6736(00)02582-4 |
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Anderson, R. P., Degano, P., Godkin, Andrew James, Jewell, D. P. and Hill, A. V. 2000. In vivo antigen challenge in celiac disease identifies a single transglutaminase-modified peptide as the dominant A-gliadin T-cell epitope. Nature Medicine 6 (3) , pp. 337-342. 10.1038/73200 |
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Bevan, S., Popat, S., Braegger, C. P., Busch, A., O'Donoghue, D., Falth-Magnusson, K., Ferguson, A., Godkin, Andrew James, Hogberg, L., Holmes, G., Hosie, K. B., Howdle, P. D., Jenkins, H., Jewell, D., Johnston, S., Kennedy, N. P., Kerr, G., Kumar, P., Logan, R. F., Love, A. H., Marsh, M., Mulder, C. J., Sjoberg, K., Stenhammer, L., Walker-Smith, J., Marossy, A. M. and Houlston, R. S. 1999. Contribution of the MHC region to the familial risk of coeliac disease. Journal of Medical Genetics 36 (9) , pp. 687-690. 10.1136/jmg.36.9.687 |
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Godkin, Andrew James, Davenport, M. P., Willis, A., Jewell, D. P. and Hill, A. V. 1998. Use of complete eluted peptide sequence data from HLA-DR and -DQ molecules to predict T cell epitopes, and the influence of the nonbinding terminal regions of ligands in epitope selection. The Journal of Immunology 161 (2) , pp. 850-858. |
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Gallimore, A., Glithero, A., Godkin, Andrew James, Tissot, A. C., Plückthun, A., Elliott, T., Hengartner, H. and Zinkernagel, R. 1998. Induction and exhaustion of lymphocytic choriomeningitis virus-specific cytotoxic T lymphocytes visualized using soluble tetrameric major histocompatibility complex class I-peptide complexes. Journal of Experimental Medicine 187 (9) , pp. 1383-1393. |
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Godkin, Andrew James and Jewell, Derek 1998. The pathogenesis of celiac disease. Gastroenterology 115 (1) , pp. 206-210. 10.1016/S0016-5085(98)70382-8 |
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Godkin, Andrew James, Tatham, A., Shewry, P., Hill, A. and Jewell, D. 1997. Possible immuno-modulatory activity of gliadin by interference with antigen processing. Gastroenterology 112 (4) , A365-A365. |
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Godkin, Andrew James, Davenport, M., Hill, A. and Jewell, D. 1997. Binding characteristics of synthetic ligands from A-gliadin to the coeliac disease susceptibility molecules HLA-DQ2/8, and the linked molecules HLA-DR3/4. Gastroenterology 112 (4) , A364-A364. |
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Davenport, M. P., Godkin, Andrew James, Friede, Thomas, Stevanovic, Stefan, Willis, Anthony C., Hill, Adrian V. S. and Rammensee, Hans-Georg 1997. A distinctive peptide binding motif for HLA-DRB1 * 0407, an HLA-DR4 subtype not associated with rheumatoid arthritis. Immunogenetics 45 (3) , pp. 229-232. 10.1007/s002510050196 |
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Godkin, Andrew James, Friede, T., Davenport, M., Stevanovic, S., Willis, A., Jewell, D., Hill, A. and Rammensee, H. G. 1997. Use of eluted peptide sequence data to identify the binding characteristics of peptides to the insulin-dependent diabetes susceptibility allele HLA-DQ8 (DQ 3.2). International Immunology 9 (6) , pp. 905-911. 10.1093/intimm/9.6.905 |
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Houlston, R. S., Tomlinson, I. P. M., Ford, D., Seal, S., Marossy, A. M., Ferguson, A., Holmes, G. K. T., Hosie, K. B., Howdle, P. D., Jewell, D. P., Godkin, Andrew James, Kerr, G. D., Kumar, P., Logan, R. F. A., Love, A. H. G., Johnston, S., Marsh, M. N., Mitton, S., O'Donoghue, D., Roberts, A., Walker-Smith, J. A. and Stratton, M. F. 1997. Linkage analysis of candidate regions for coeliac disease genes. Human Molecular Genetics 6 (8) , pp. 1335-1339. 10.1093/hmg/6.8.1335 |
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Godkin, Andrew James, Davenport, M., Willis, T., Hill, A. and Jewell, D. P. 1996. Pool sequencing of naturally bound peptides from the HLA class II DQ2 allele and use of this data for T-cell epitope prediction in coeliac disease. Gastroenterology 110 (4) , A326-A326. |
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Godkin, Andrew James, De Belder, A. J., Villa, L., Wong, A., Beesley, J. E., Kane, S. P. and Martin, J. F. 1996. Expression of nitric oxide synthase in ulcerative colitis. European Journal of Clinical Investigation 26 (10) , pp. 867-872. 10.1111/j.1365-2362.1996.tb02131.x |
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Godkin, Andrew James, Dinning, W. J. and Anderson, M. G. 1994. Scleritis associated with Coxsackle B type 5 infection [Letter]. Eye 8 (3) , pp. 357-358. 10.1038/eye.1994.76 |
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Godkin, Andrew James, Brookes, R. and Jewell, D. P. Identification of a coeliac disease-specific T cell eptope from A-gliadin. Gastroenterology 116 (4) , A882-A882. |
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