ORCA
Online Research @ Cardiff
Browse by Current Cardiff authors
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Number of items: 59.
Muha, Villo, Williamson, Ritchie, Hills, Rachel, McNeilly, Alison D., McWilliams, Thomas G., Alonso, Jana, Schimpl, Marianne, Leney, Aneika C., Heck, Albert J. R., Sutherland, Calum, Read, Kevin D., McCrimmon, Rory J., Brooks, Simon P. and van Aalten, Daan M. F.
2019.
Loss of CRMP2 O-GlcNAcylation leads to reduced novel object recognition performance in mice.
Open Biology
9
(11)
, 190192.
10.1098/rsob.190192
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Fjodorova, Marija, Louessard, Morgane, Li, Zongze, De La Fuente, Daniel, Dyke, Emma, Brooks, Simon, Perrier, Anselme and Li, Meng
2019.
CTIP2-regulated reduction in PKA-dependent DARPP32 phosphorylation in human medium spiny neurons:
implications for Huntington’s disease.
Stem Cell Reports
13
(3-6)
, pp. 448-457.
10.1016/j.stemcr.2019.07.015
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| McWilliams, Thomas, Barini, Erica, Pohjolan-Pirhonen, Risto, Brooks, Simon, Singh, Francois, Burel, Sophie, Balk, Kristin, Kumar, Atul, Montava-Garriga, Lambert, Prescott, Alan, Hassoun, Sidi, Mouton-Liger, Francois, Ball, Graeme, Hills, Rachel, Knebel, Axel, Ulusoy, Ayse, Di Monte, Donato, Tamjar, Jevgenia, Antico, Odetta, Fears, Kyle, Smith, Laura, Brambilla, Riccardo, Palin, Eino, Valori, Miko, Eerola-Rautio, Johanna, Tienari, Pentti, Corti, Olga, Dunnett, Stephen, Ganley, Ian, Suomalainen, Anu and Muqit, Miratul 2018. Phosphorylation of Parkin at Serine65 is essential for its activation in vivo. Open Biology 8 , 180108. 10.1098/rsob.180108 |
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| Harrison, David, Roberton, Victoria, Vinh, Ngoc-Nga, Brooks, Simon, Dunnett, Stephen and Rosser, Anne 2018. The effect of tissue preparation and donor age on striatal graft morphology in the mouse. Cell Transplantation 27 (2) , pp. 230-244. 10.1177/0963689717744788 |
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McWilliams, Thomas G., Prescott, Alan R., Montava-Garriga, Lambert, Ball, Graeme, Singh, Francois, Barini, Erica, Muqit, Miratul M. K., Brooks, Simon P. and Ganley, Ian G.
2018.
Basal mitophagy occurs independently of PINK1 in mouse tissues of high metabolic demand.
Cell Metabolism
27
(2)
, 439-449.e5.
10.1016/j.cmet.2017.12.008
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| Bragg, Robert M., Coffey, Sydney R., Weston, Rory M., Ament, Seth A., Cantle, Jeffrey P., Minnig, Shawn, Funk, Cory C., Shuttleworth, Dominic D., Woods, Emily L., Sullivan, Bonnie R., Jones, Lindsey, Glickenhaus, Anne, Anderson, John S., Anderson, Michael D., Dunnett, Stephen Bruce, Wheeler, Vanessa C., MacDonald, Marcy E., Brooks, Simon P., Price, Nathan D. and Carroll, Jeffrey B. 2017. Motivational, proteostatic and transcriptional deficits precede synapse loss, gliosis and neurodegeneration in the B6.HttQ111/+ model of Huntington's disease. Scientific Reports 7 , 41570. 10.1038/srep41570 |
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| Yhnell, Emma, Lelos, Mariah Jillian, Dunnett, Stephen Bruce and Brooks, Simon Philip 2016. L30 Cognitive training improves disease symptoms in a mouse model of huntington's disease. Journal of Neurology, Neurosurgery & Psychiatry 87 (Supp 1) , A100-A101. 10.1136/jnnp-2016-314597.285 |
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Yhnell, Emma, Dunnett, Stephen Bruce and Brooks, Simon Philip
2016.
A longitudinal motor characterisation of the HdhQ111 mouse model of Huntington's Disease.
Journal of Huntington's Disease
5
(2)
, pp. 149-161.
10.3233/JHD-160191
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| Brooks, Simon Philip 2016. Foreword. Journal of Neuroscience Methods 265 , pp. 1-2. 10.1016/j.jneumeth.2016.01.011 |
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| Yhnell, Emma, Dunnett, Stephen Bruce and Brooks, Simon Philip 2016. The utilisation of operant delayed matching and non-matching to position for probing cognitive flexibility and working memory in mouse models of Huntington's disease. Journal of Neuroscience Methods 265 , pp. 72-80. 10.1016/j.jneumeth.2015.08.022 |
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| Bayram-Weston, Zubeyde, Olsen, Elliott, Harrison, David, Dunnett, Stephen Bruce and Brooks, Simon 2016. Optimising Golgi-Cox staining for use with perfusion-fixed brain tissue validated in the zQ175 mouse model of Huntington's disease. Journal of Neuroscience Methods 265 , pp. 81-88. 10.1016/j.jneumeth.2015.09.033 |
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| Yhnell, Emma, Lelos, Mariah Jillian, Dunnett, Stephen Bruce and Brooks, Simon Philip 2016. Cognitive training modifies disease symptoms in a mouse model of Huntington's disease. Experimental Neurology 282 , pp. 19-26. 10.1016/j.expneurol.2016.05.008 |
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| Bayram-Weston, Zubeyde, Stone, Timothy C., Giles, Peter James, Elliston, Linda Anne, Janghra, Narinder, Higgs, Gemma, Holmans, Peter Alan, Dunnett, Stephen Bruce, Brooks, Simon Philip and Jones, Lesley 2015. Similar striatal gene expression profiles in the striatum of the YAC128 and HdhQ150 mouse models of Huntington's disease are not reflected in mutant Huntingtin inclusion prevalence. BMC Genomics 16 , -. 10.1186/s12864-015-2251-4 |
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Bowles, Kathryn R., Brooks, Simon P., Dunnett, Stephen Bruce and Jones, Lesley
2015.
Huntingtin subcellular localisation is regulated by Kinase signalling activity in the StHdhQ111 model of HD.
PLoS ONE
10
(12)
, e0144864.
10.1371/journal.pone.0144864
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| Steventon, Jessica, Harrison, David John, Trueman, Rebecca C., Rosser, Anne Elizabeth, Jones, Derek K. and Brooks, Simon Philip 2015. In Vivo MRI evidence that neuropathology is attenuated by cognitive enrichment in the Yac128 Huntington's Disease mouse model. Journal of Huntington's Disease 4 (2) , pp. 149-160. 10.3233/JHD-150147 |
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| Brooks, Simon Philip and Dunnett, Stephen Bruce 2015. Mouse models of Huntington's disease. Behavioral Neurobiology of Huntington's Disease and Parkinson's Disease, Current Topics in Behavioral Neurosciences, vol. 22. Berlin: Springer, pp. 101-133. (10.1007/7854_2013_256) |
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| Yhnell, Emma, Dunnett, Stephen Bruce and Brooks, Simon Philip 2014. C04 A longitudinal behavioural characterisation of the HDHQ111 mouse model of Huntington's Disease. Journal of Neurology, Neurosurgery & Psychiatry 85 (Supp 1) , A26. 10.1136/jnnp-2014-309032.77 |
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| Hughes, Alis, Mort, Matthew Edwin, Elliston, Linda Anne, Thomas, Rhian M., Brooks, Simon Philip, Dunnett, Stephen Bruce and Jones, Lesley 2014. Identification of novel alternative splicing events in the Huntingtin gene and assessment of the functional consequences using structural protein homology modelling. Journal of Molecular Biology 426 (7) , pp. 1428-1438. 10.1016/j.jmb.2013.12.028 |
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Yhnell, Emma, Dunnett, Stephen B. and Brooks, Simon P.
2014.
The development of operant delayed matching to position for Huntington's disease mouse models.
Presented at: 12th meeting of the International Society for Neural Transplantation and Restoration,
, vol. 3.
Lippincott, Williams & Wilkins,
p. 163.
10.1097/01.wnr.0000443076.61006.22
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| Brooks, Simon Philip and Dunnett, Stephen Bruce 2013. Cognitive deficits in animal models of basal ganglia disorders. Brain Research Bulletin 92 , pp. 29-40. 10.1016/j.brainresbull.2012.04.011 |
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| Peters, Owen Morgan, Shelkovnikova, Tatyana, Tarasova, Tatiana, Springe, Signe, Kukharsky, Michail S., Smith, Gaynor A., Brooks, Simon Philip, Kozin, Sergey A., Kotelevtsev, Yury, Bachurin, Sergey O., Ninkina, Natalia and Buchman, Vladimir L. 2013. Chronic administration of dimebon does not ameliorate amyloid-β pathology in 5xFAD transgenic mice. Journal of Alzheimer's Disease 36 (3) , pp. 589-596. 10.3233/JAD-130071 |
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| Harrison, David John, Busse, Monica, Openshaw, Rebecca, Rosser, Anne Elizabeth, Dunnett, Stephen Bruce and Brooks, Simon Philip 2013. Exercise attenuates neuropathology and has greater benefit on cognitive than motor deficits in the R6/1 Huntington's disease mouse model. Experimental Neurology 248 , pp. 457-469. 10.1016/j.expneurol.2013.07.014 |
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| Dunnett, Stephen Bruce, Fuller, Anna, Rosser, Anne Elizabeth and Brooks, Simon Philip 2012. A novel extended sequence learning task (ESLeT) for rodents: validation and the effects of amphetamine, scopolamine and striatal lesions. Brain Research Bulletin 88 (2-3) , pp. 237-250. 10.1016/j.brainresbull.2010.10.005 |
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| Deschepper, Mia Pieter, Hoogendoorn, Bastiaan, Brooks, Simon Philip, Dunnett, Stephen Bruce and Jones, Lesley 2012. Proteomic changes in the brains of Huntington's disease mouse models reflect pathology and implicate mitochondrial changes. Brain Research Bulletin 88 (2-3) , pp. 210-222. 10.1016/j.brainresbull.2011.01.012 |
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| Dunnett, Stephen Bruce, Heuer, Andreas, Lelos, Mariah Jillian, Brooks, Simon Philip and Rosser, Anne Elizabeth 2012. Bilateral striatal lesions disrupt performance in an operant delayed reinforcement task in rats. Brain Research Bulletin 88 (2-3) , pp. 251-260. 10.1016/j.brainresbull.2011.04.002 |
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| Brooks, Simon Philip, Higgs, Gemma, Jones, Lesley and Dunnett, Stephen Bruce 2012. Longitudinal analysis of the behavioural phenotype in HdhQ92 Huntington's disease knock-in mice. Brain Research Bulletin 88 (2-3) , pp. 148-155. 10.1016/j.brainresbull.2010.05.003 |
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| Brooks, Simon Philip, Higgs, Gemma, Jones, Lesley and Dunnett, Stephen Bruce 2012. Longitudinal analysis of the behavioural phenotype in Hdh(CAG)150 Huntington's disease knock-in mice. Brain Research Bulletin 88 (2-3) , pp. 182-188. 10.1016/j.brainresbull.2010.05.004 |
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| Bayram-Weston, Zubeyde, Torres, Eduardo Miguel, Jones, Lesley, Dunnett, Stephen Bruce and Brooks, Simon Philip 2012. Light and electron microscopic characterization of the evolution of cellular pathology in the Hdh((CAG)150) Huntington's disease knock-in mouse. Brain Research Bulletin 88 (2-3) , pp. 189-198. 10.1016/j.brainresbull.2011.03.014 |
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| Brooks, Simon Philip, Higgs, Gemma, Janghra, Nari, Jones, Lesley and Dunnett, Stephen Bruce 2012. Longitudinal analysis of the behavioural phenotype in YAC128 (C57BL/6J) Huntington's disease transgenic mice. Brain Research Bulletin 88 (2-3) , pp. 113-120. 10.1016/j.brainresbull.2010.05.005 |
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| Brooks, Simon Philip, Janghra, Nari, Workman, Victoria Louise, Bayram-Weston, Zubeyde, Jones, Lesley and Dunnett, Stephen Bruce 2012. Longitudinal analysis of the behavioural phenotype in R6/1 (C57BL/6J) Huntington's disease transgenic mice. Brain Research Bulletin 88 (2-3) , pp. 94-103. 10.1016/j.brainresbull.2011.01.010 |
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| Trueman, Rebecca C., Dunnett, Stephen Bruce, Jones, Lesley and Brooks, Simon Philip 2012. Five choice serial reaction time performance in the HdhQ92 mouse model of Huntington's disease. Brain Research Bulletin 88 (2-3) , pp. 163-170. 10.1016/j.brainresbull.2011.10.019 |
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| Bayram-Weston, Zubeyde, Jones, Lesley, Dunnett, Stephen Bruce and Brooks, Simon Philip 2012. Light and electron microscopic characterization of the evolution of cellular pathology in YAC128 Huntington's disease transgenic mice. Brain Research Bulletin 88 (2-3) , pp. 137-147. 10.1016/j.brainresbull.2011.05.005 |
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| Bayram-Weston, Zubeyde, Jones, Lesley, Dunnett, Stephen Bruce and Brooks, Simon Philip 2012. Light and electron microscopic characterization of the evolution of cellular pathology in the R6/1 Huntington's disease transgenic mice. Brain Research Bulletin 88 (2-3) , pp. 104-112. 10.1016/j.brainresbull.2011.07.009 |
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| Trueman, Rebecca C., Jones, Lesley, Dunnett, Stephen Bruce and Brooks, Simon Philip 2012. Early onset deficits on the delayed alternation task in the HdhQ92 knock-in mouse model of Huntington's disease. Brain Research Bulletin 88 (2-3) , pp. 156-162. 10.1016/j.brainresbull.2011.03.012 |
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| Bayram-Weston, Zubeyde, Jones, Lesley, Dunnett, Stephen Bruce and Brooks, Simon Philip 2012. Light and electron microscopic characterization of the evolution of cellular pathology in HdhQ92 Huntington's disease knock-in mice. Brain Research Bulletin 88 (2-3) , pp. 171-181. 10.1016/j.brainresbull.2011.03.013 |
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| Trueman, Rebecca C., Dunnett, Stephen Bruce and Brooks, Simon Philip 2012. Operant-based instrumental learning for analysis of genetically modified models of Huntington's disease. Brain Research Bulletin 88 (2-3) , pp. 261-275. 10.1016/j.brainresbull.2011.03.015 |
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| Brooks, Simon Philip, Janghra, Narinder, Higgs, Gemma V., Bayram-Weston, Zubeyde, Heuer, Andreas, Jones, Lesley and Dunnett, Stephen Bruce 2012. Selective cognitive impairment in the YAC128 Huntington's disease mouse. Brain Research Bulletin 88 (2-3) , pp. 121-129. 10.1016/j.brainresbull.2011.05.010 |
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| Brooks, Simon Philip, Jones, Lesley and Dunnett, Stephen Bruce 2012. Longitudinal analyses of operant performance on the serial implicit learning task (SILT) in the YAC128 Huntington's disease mouse line. Brain Research Bulletin 88 (2-3) , pp. 130-136. 10.1016/j.brainresbull.2011.06.008 |
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| Fielding, Steven A., Brooks, Simon Philip, Klein, Alexander, Bayram-Weston, Zubeyde, Jones, Lesley and Dunnett, Stephen Bruce 2012. Profiles of motor and cognitive impairment in the transgenic rat model of Huntington's disease. Brain Research Bulletin 88 (2-3) , pp. 223-236. 10.1016/j.brainresbull.2011.09.011 |
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| Brooks, Simon Philip, Jones, Lesley and Dunnett, Stephen Bruce 2012. Comparative analysis of pathology and behavioural phenotypes in mouse models of Huntington's disease. Brain Research Bulletin 88 (2-3) , pp. 81-93. 10.1016/j.brainresbull.2011.10.002 |
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| Bowles, Kathryn R., Brooks, Simon Philip, Dunnett, Stephen Bruce and Jones, Lesley 2012. Gene expression and behaviour in mouse models of HD. Brain Research Bulletin 88 (2-3) , pp. 276-284. 10.1016/j.brainresbull.2011.07.021 |
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| Giles, Peter James, Elliston, Linda Anne, Higgs, Gemma, Brooks, Simon Philip, Dunnett, Stephen Bruce and Jones, Lesley 2012. Longitudinal analysis of gene expression and behaviour in the HdhQ150 mouse model of Huntington's disease. Brain Research Bulletin 88 (2-3) , pp. 199-209. 10.1016/j.brainresbull.2011.10.001 |
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| Bayram-Weston, Zubeyde, Jones, Lesley, Dunnett, Stephen Bruce and Brooks, Simon P. 2012. B08 Differential sensitivity of aggregate markers in HdhQ150 and YAC128 HD mouse models. Journal of Neurology, Neurosurgery & Psychiatry 83 (Suppl) , A8-A8. 10.1136/jnnp-2012-303524.24 |
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| Busse, Monica, Khalil, Hanan, Quinn, Lori, Brooks, Simon Philip and Rosser, Anne Elizabeth 2012. Practice, progress and future directions for physical therapies in Huntington's Disease. Journal of Huntington's Disease 1 (2) , pp. 175-185. 10.3233/JHD-120025 |
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| Brooks, Simon Philip, Jones, Lesley and Dunnett, Stephen Bruce 2010. Frontostriatal pathology in the (C57BL/6J) YAC128 mouse uncovered by the operant delayed alternation task [Meeting abstract]. Journal of Neurology, Neurosurgery and Psychiatry 81 (1) , A9-A10. 10.1136/jnnp.2010.222570.29 |
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| Twohig, Jason Peter, Roberts, Malcolm I., Gavalda, Nuria, Rees-Taylor, Emma Louise, Giralt, Albert, Adams, Deborah, Brooks, Simon Philip, Bull, Melanie Jane, Calder, Claudia Jane, Cuff, Simone, Yong, Audrey Alice, Alberch, Jordi, Davies, Alun M., Dunnett, Stephen Bruce, Tolkovsky, Aviva M. and Wang, Edward Chung Yern 2010. Age-dependent maintenance of motor controland corticostriatal innervation by death receptor 3. Journal of Neuroscience 30 (10) , pp. 3782-3792. 10.1523/JNEUROSCI.1928-09.2010 |
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| Brooks, Simon Philip, Fielding, Steven A., Döbrössy, Màtè, von Hörsten, Stephan and Dunnett, Stephen Bruce 2009. Subtle but progressive cognitive deficits in the female tgHD hemizygote rat as demonstrated by operant SILT performance. Brain Research Bulletin 79 (5) , pp. 310-315. 10.1016/j.brainresbull.2009.03.003 |
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| Trueman, Rebecca C., Brooks, Simon Philip, Jones, Lesley and Dunnett, Stephen Bruce 2009. Rule learning, visuospatial function and motor performance in the Hdh(Q92) knock-in mouse model of Huntington's disease. Behavioural Brain Research 203 (2) , pp. 215-222. 10.1016/j.bbr.2009.05.006 |
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| Brooks, Simon Philip and Dunnett, Stephen Bruce 2009. Tests to assess motor phenotype in mice: a user's guide. Nature Reviews Neurosciences 10 (7) , pp. 519-529. 10.1038/nrn2652 |
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| Hodges, Angela Kaye, Hughes, Gareth, Brooks, Simon Philip, Elliston, Linda Anne, Holmans, Peter Alan, Dunnett, Stephen Bruce and Jones, Lesley 2008. Brain gene expression correlates with changes in behavior in the R6/1 mouse model of Huntington's disease. Genes, Brain and Behavior 7 (3) , pp. 288-299. 10.1111/j.1601-183X.2007.00350.x |
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| Trueman, Rebecca C., Brooks, Simon Philip, Jones, Lesley and Dunnett, Stephen Bruce 2008. Time course of choice reaction time deficits in the Hdh Q92/Q92 knock-in mouse model of Huntington's disease. Behavioural Brain Research 189 (2) , pp. 317-334. 10.1016/j.bbr.2008.01.020 |
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| Trueman, Rebecca C., Brooks, Simon Philip, Jones, Lesley and Dunnett, Stephen Bruce 2007. The operant serial implicit learning task reveals early onset motor learning deficits in the HdhQ92 knock-in mouse model of Huntington's disease. European Journal of Neuroscience 25 (2) , pp. 551-558. 10.1111/j.1460-9568.2007.05307.x |
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| Brooks, Simon Philip, Trueman, Rebecca C. and Dunnett, Stephen Bruce 2007. Striatal lesions in the mouse disrupt acquisition and retention, but not implicit learning, in the SILT procedural motor learning task. Brain Research 1185 , pp. 179-188. 10.1016/j.brainres.2007.09.017 |
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| Brooks, Simon, Betteridge, H., Trueman, R.C., Jones, Lesley and Dunnett, S.B. 2006. Selective extra-dimensional set shifting deficit in a knock-in mouse model of Huntington's disease. Brain Research Bulletin 69 (4) , pp. 452-7. 10.1016/j.brainresbull.2006.02.011 |
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| Brooks, Simon P., Higgs, G., Trueman, R. C., Dunnett, Stephen Bruce, Cheng, P., Redfern, A. R. and Jones, Lesley 2005. Longitudinal behavioural characterisation of the Q92 mouse line. Journal of Neurology, Neurosurgery and Psychiatry 76 , A48-A48. |
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| Hughes, G. P., Brooks, Simon P., Hodges, A. H., Holmans, Peter Alan, Thomas, J. M., Goldstein, D., Dunnett, Stephen Bruce and Jones, Lesley 2005. Integrating behaviour and brain gene expression in Huntington's disease transgenic mouse models. Journal of Neurology, Neurosurgery and Psychiatry 76 , A41-A41. |
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