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Online Research @ Cardiff

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Number of items: 47.

Wilson, Nicholas, Steadman, Robert, Muller, Ilaria, Draman, Mohd, Rees, D. Aled, Taylor, Peter, Dayan, Colin M., Ludgate, Marian and Zhang, Lei 2019. Role of Hyaluronan in Human Adipogenesis: Evidence from in-Vitro and in-Vivo Studies. International Journal of Molecular Sciences 20 (11) , 2675. 10.3390/ijms20112675

Midgley, Adam, Oltean, Sebastian, Hascall, Vincent, Woods, Emma, Steadman, Robert, Phillips, Aled and Meran, Soma 2017. Nuclear hyaluronidase 2 drives alternative splicing of CD44 pre-mRNA to determine profibrotic or antifibrotic cell phenotype. Science Signaling 10 (506) , eaao1822. 10.1126/scisignal.aao1822

Dally, Jordanna, Khan, Jabur S., Voisey, Alexander, Charalambous, Chrisandrea, John, Hannah L., Woods, Emma L., Steadman, Robert, Moseley, Ryan and Midgley, Adam C. 2017. Hepatocyte growth factor mediates enhanced wound healing responses and resistance to transforming growth factor-β1-driven myofibroblast differentiation in oral mucosal fibroblasts. International Journal of Molecular Sciences 18 , 1843. 10.3390/ijms18091843

Martin, John, Midgley, Adam Christopher, Meran, Soma, Woods, Emma, Bowen, Timothy, Phillips, Aled Owain and Steadman, Robert 2016. Tumour necrosis factor-stimulated gene (TSG)-6-mediated interactions with the inter-alpha-inhibitor heavy chain 5 facilitate TGF beta1-dependent fibroblast to myofibroblast differentiation. Journal of Biological Chemistry 291 (26) , pp. 13789-13801. 10.1074/jbc.M115.670521

Midgley, Adam Christopher, Morris, Nathanael Glyn, Phillips, Aled Owain and Steadman, Robert 2016. 17{beta}-estradiol ameliorates age-associated loss of ﬁbroblast function by attenuating IFN-{gamma}/STAT1-dependent miR-7 upregulation. Aging Cell 15 (3) , pp. 531-541. 10.1111/acel.12462

Midgley, Adam Christopher, Druggal, Lucy, Jenkins, Robert, Hascall, Vincent, Steadman, Robert, Phillips, Aled Owain and Meran, Soma 2015. Hyaluronan regulates bone morphogenetic protein-7-dependent prevention and reversal of myofibroblast phenotype. The Journal of Biological Chemistry 129 , pp. 11218-11234. 10.1074/jbc.M114.625939

Webber, Jason P., Spary, Lisa Kate, Sanders, Andrew James, Chowdhury, Ruhena, Jiang, Wen, Steadman, Robert, Wymant, Jennifer, Jones, Arwyn Tomos, Kynaston, Howard, Mason, Malcolm David, Tabi, Zsuzsanna and Clayton, Aled 2015. Differentiation of tumour-promoting stromal myofibroblasts by cancer exosomes. Oncogene 34 , pp. 290-302. 10.1038/onc.2013.560

Midgley, Adam, Bowen, Timothy, Phillips, Aled and Steadman, Robert 2014. MicroRNA-7 inhibition rescues age-associated loss of epidermal growth factor receptor and hyaluronan-dependent differentiation in fibroblasts. Aging Cell 13 (2) , pp. 235-244. 10.1111/acel.12167

Meran, Soma, Martin, John, Luo, Dong Dong, Steadman, Robert and Phillips, Aled Owain 2013. Interleukin-1β induces hyaluronan and CD44-dependent cell protrusions that facilitate fibroblast-monocyte binding. American Journal of Pathology 182 (6) , pp. 2223-2240. 10.1016/j.ajpath.2013.02.038

Midgley, Adam Christopher, Rogers, Mathew James, Hallett, Maurice Bartlett, Clayton, Aled, Bowen, Timothy, Phillips, Aled Owain and Steadman, Robert 2013. Transforming growth factor-β1 (TGF-β1)-stimulated fibroblast to myofibroblast differentiation Is mediated by hyaluronan (HA)-facilitated epidermal growth factor receptor (EGFR) and CD44 co-localization in lipid rafts. Journal of Biological Chemistry 288 (21) , pp. 14824-14838. 10.1074/jbc.M113.451336

Bommayya, Girish, Meran, Soma, Krupa, Aleksandra, Phillips, Aled Owain and Steadman, Robert 2011. Tumour necrosis factor-stimulated gene (TSG)-6 controls epithelial–mesenchymal transition of proximal tubular epithelial cells. International Journal of Biochemistry & Cell Biology 43 (12) , pp. 1739-1746. 10.1016/j.biocel.2011.08.009

Meran, Soma, Luo, Dong Dong, Simpson, Russell M. L., Martin, John, Wells, Alan, Steadman, Robert and Phillips, Aled Owain 2011. Hyaluronan facilitates transforming growth factor-β1-dependent proliferation via CD44 and epidermal growth factor receptor interaction. Journal of Biological Chemistry 286 (20) , pp. 17618-17630. 10.1074/jbc.M111.226563

Meran, Soma and Steadman, Robert 2011. Fibroblasts and myofibroblasts in renal fibrosis. International Journal of Experimental Pathology 92 (3) , pp. 158-167. 10.1111/j.1365-2613.2011.00764.x

Khammas, Hassan, Bowen, Timothy, Williams, John David, Phillips, Aled Owain, Steadman, Robert and Martin, John 2011. Characterisation of the human ADAM15 promoter. Nephron Experimental Nephrology 118 (2) , e27-e38. 10.1159/000320698

Webber, Jason P., Steadman, Robert, Mason, Malcolm David, Tabi, Zsuzsanna and Clayton, Aled 2010. Cancer exosomes trigger fibroblast to myofibroblast differentiation. Cancer Research 70 (23) , pp. 9621-9630. 10.1158/0008-5472.CAN-10-1722

Simpson, Russell M. L., Wells, Alan, Thomas, David William, Stephens, Philip, Steadman, Robert and Phillips, Aled Owain 2010. Aging fibroblasts resist phenotypic maturation because of impaired hyaluronan-dependent CD44/epidermal growth factor receptor signaling. American Journal of Pathology 176 (3) , pp. 1215-1228. 10.2353/ajpath.2010.090802

Simpson, Russell M. L., Meran, Soma, Thomas, David William, Stephens, Philip, Bowen, Timothy, Steadman, Robert and Phillips, Aled Owain 2009. Age-related changes in pericellular hyaluronan organization leads to impaired dermal fibroblast to myofibroblast differentiation. American Journal of Pathology 175 (5) , pp. 1915-1928. 10.2353/ajpath.2009.090045

Zhang, Lei, Bowen, Timothy, Grennan-Jones, Fiona Antoinette, Paddon, Carol Ann, Giles, Peter James, Webber, Jason P., Steadman, Robert and Ludgate, Marian Elizabeth 2009. Thyrotropin receptor activation increases hyaluronan production in preadipocyte fibroblasts: Contributory role in hyaluronan accumulation in thyroid dysfunction. Journal of Biological Chemistry 284 (39) , pp. 26447-26455. 10.1074/jbc.M109.003616

Webber, Jason P., Jenkins, Robert Hywel, Meran, Soma, Phillips, Aled Owain and Steadman, Robert 2009. Modulation of TGFβ1-dependent myofibroblast differentiation by hyaluronan. American Journal of Pathology 175 (1) , pp. 148-160. 10.2353/ajpath.2009.080837

Webber, Jason P., Meran, Soma, Steadman, Robert and Phillips, Aled Owain 2009. Hyaluronan orchestrates transforming growth factor-β1-dependent maintenance of myofibroblast phenotype. Journal of Biological Chemistry 284 (14) , pp. 9083-9092. 10.1074/jbc.M806989200

Simpson, Russell M.L., Stephens, Philip, Thomas, David, Webber, J. P., Meran, Soma, Steadman, Robert and Phillips, Aled Owain 2009. Age related changes in pericellular hyaluronan leads to impaired dermal fibroblast to myofibroblast differentiation. International Journal of Experimental Pathology 90 (2) , A128-A129.

Meran, Soma, Thomas, David William, Stephens, Philip, Enoch, Stuart, Martin, John, Steadman, Robert and Phillips, Aled Owain 2008. Hyaluronan facilitates transforming growth factor-β1-mediated fibroblast proliferation. Journal of Biological Chemistry 283 (10) , pp. 6530-6545. 10.1074/jbc.M704819200

Lewis, Aled G., Steadman, Robert, Manley, Paul, Craig, Kathrine Jane, de la Motte, Carol, Hascall, Vincent and Phillips, Aled Owain 2008. Diabetic nephropathy, inflammation, hyaluronan and interstitial fibrosis. Histology and Histopathology 23 (6) , pp. 731-739.

Meran, Soma, Steadman, Robert, Phillips, Aled Owain, Thomas, David William and Stephens, Philip 2008. Hyaluronan facilitates TGF beta 1 mediated myofibroblastic differentiation [Abstract]. Wound Repair and Regeneration 16 (2) , A12. 10.1111/j.1524-475X.2008.00371.x

Kastner, Sabine, Thomas, Gareth John, Jenkins, Robert Hywel, Davies, Malcolm and Steadman, Robert 2007. Hyaluronan induces the selective accumulation of matrix- and cell-associated proteoglycans by mesangial cells. American Journal of Pathology 171 , pp. 1811-1821. 10.2353/ajpath.2007.070085

Meran, Soma, Thomas, David William, Stephens, Philip, Martin, John, Bowen, Timothy, Phillips, Aled Owain and Steadman, Robert 2007. Involvement of hyaluronan in regulation of fibroblast phenotype. The Journal of Biological Chemistry 282 (35) , pp. 25687-25697. 10.1074/jbc.M700773200

Martin, John, Bowen, Timothy and Steadman, Robert 2006. The pluripotent cytokine pleiotrophin is induced by wounding in human mesangial cells. Kidney International 70 (9) , pp. 1616-1622. 10.1038/sj.ki.5001800

Khera, Tarnjit, Martin, John, Riley, Stephen George, Steadman, Robert and Phillips, Aled Owain 2006. Glucose enhances mesangial cell apoptosis. Laboratory Investigation 86 (6) , pp. 566-577. 10.1038/labinvest.3700418

Jenkins, Robert Hywel, Thomas, Gareth John, Williams, John David and Steadman, Robert 2004. Myofibroblastic differentiation leads to hyaluronan accumulation through reduced hyaluronan turnover. The Journal of Biological Chemistry 279 (40) , pp. 41453-41460. 10.1074/jbc.M401678200

Clayton, Aled, Turkes, Atilla, Dewitt, Sharon, Steadman, Robert, Mason, Malcolm David and Hallett, Maurice Bartlett 2004. Adhesion and signaling by B cell-derived exosomes: the role of integrins. The FASEB Journal 18 , pp. 977-979. 10.1096/fj.03-1094fje

Thomas, Gareth John, Clayton, Aled, Thomas, Janet, Davies, Malcolm and Steadman, Robert 2003. Structural and functional changes in heparan sulfate proteoglycan expression associated with the myofibroblastic phenotype. America Journal of Pathology 162 (3) , pp. 977-989.

Blaber, Robert, Stylianou, Eleni, Clayton, Aled and Steadman, Robert 2003. Selective regulation of ICAM-1 and RANTES gene expression after ICAM-1 ligation on human renal fibroblasts. Journal of the American Society of Nephrology 14 (1) , pp. 116-127. 10.1097/01.ASN.0000040595.35207.62

Martin, John, Eynstone, Lisa V., Davies, Malcolm, Williams, John David and Steadman, Robert 2002. The role of ADAM 15 in glomerular mesangial cell migration. The Journal of Biological Chemistry 277 (37) , pp. 33683-33689. 10.1074/jbc.M200988200

Clayton, Aled, Thomas, Janet, Thomas, Gareth J., Davies, Malcolm and Steadman, Robert 2001. Cell surface heparan sulfate proteoglycans control the response of renal interstitial fibroblasts to fibroblast growth factor-2. Kidney International 59 (6) , pp. 2084-2094. 10.1046/j.1523-1755.2001.00723.x

Martin, John, Eynstone, Lisa V., Davies, Malcolm and Steadman, Robert 2001. Induction of metalloproteinases by glomerular mesangial cells stimulated by proteins of the extracellular matrix. Journal of the American Society of Nephrology 12 (1) , pp. 88-96.

Clayton, Aled and Steadman, Robert 1999. ICAM-1 interactions in the renal interstitium: a novel activator of fibroblasts during nephritis. Histology and Histopathology 14 (3) , pp. 861-870.

Clayton, Aled, Thomas, Janet, Thomas, Gareth, Davies, Malcolm and Steadman, Robert 1999. Fibroblasts from the cortical interstitium express cell surface heparan sulphate proteoglycans [Abstract]. Kidney International 55 (6) , p. 2588. 10.1046/j.1523-1755.2002.t01-1-00456.x

Evans, R. E., Clayton, Aled, Martin, J., Williams, J. D., Davies, M. and Steadman, Robert 1999. Neutrophil binding stimulates the synthesis, release and activation of MMP 3 and MMP 2 from endothelial cells in vitro [Abstract]. Kidney International 55 (5) , p. 2105. 10.1046/j.1523-1755.1999.00404.x

Clayton, Aled, Evans, Rachel A., Pettit, Elizabeth, Hallett, Maurice, Williams, John David and Steadman, Robert 1998. Cellular activation through the ligation of intercellular adhesion molecule-1. Journal of Cell Science 111 (4) , pp. 443-453.

Evans, R. A., Clayton, Aled, Martin, J., Williams, J. D., Davies, M. and Steadman, Robert 1997. Neutrophil binding stimulates the synthesis, release and activation of MMP 2 from endothelial cells in vitro. Journal of the American Society of Nephrology 8 , A2390-A2390.

Clayton, Aled, Williams, J. D. and Steadman, Robert 1997. The ligation of ICAM-1 on renal cortical fibroblasts initiates the de novo expression of ICAM-1 and VCAM-1. Journal of the American Society of Nephrology 8 , A2385-A2385.

Clayton, Aled, Williams, J. D. and Steadman, Robert 1997. Ligation of ICAM-1 on the surface of renal cortical fibroblasts stimulates de novo expression of ICAM-1 and VCAM-1 [Abstract]. Kidney International 52 (1) , pp. 262-263. 10.1038/ki.1997.329

Clayton, Aled, Steadman, Robert and Williams, John David 1997. Cells isolated from the human cortical interstitium resemble myofibroblasts and bind neutrophils in an ICAM-1--dependent manner. Journal of the American Society of Nephrology 8 (4) , pp. 604-615.

Steadman, Robert, Clayton, Aled, Pettit, J., Hallett, B. and Williams, J. D. 1996. Leukocytes trigger an influx of calcium in renal interstitial fibroblasts through ligation ICAM-1. Journal of the American Society of Nephrology 7 (9) , A2594-A2594.

Clayton, Aled, Steadman, Robert and Williams, J. D. 1995. Human renal cortical fibroblasts (RCF) bind leukocytes in-vitro through a CD18-dependent and VLA(4)-dependent interaction. Journal of the American Society of Nephrology 6 (3) , p. 894.

Steadman, Robert, Topley, Nicholas, Jenner, D. E., Davies, M. and Williams, John David 1988. Type-1 fimbriate escherichia-coli stimulates a unique pattern of de-granulation by human polymorphonuclear leukocytes. Infection and Immunity 56 (4) , pp. 815-822.

Steadman, Robert, Topley, Nicholas, MacKenzie, Ruth Kathryn, Davies, M. and Williams, John David 1988. Scarring potential, fimbrial type-alpha-hemolysin production and human neutrophil (pmn) activation by uropathogenic strains of escherichia-coli [Abstract]. Kidney International 33 (1) , p. 325.

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