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Number of items: 55.

Valle-Encinas, Eider and Dale, Trevor C. 2020. Wnt ligand and receptor patterning in the liver. Current Opinion in Cell Biology 62 , pp. 17-25. 10.1016/j.ceb.2019.07.014
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Young, Rodrigo M., Ewan, Kenneth B., Ferrer, Veronica P., Allende, Miguel L., Godovac-Zimmermann, Jasminka, Dale, Trevor C. and Wilson, Stephen W. 2019. Developmentally regulated Tcf7l2 splice variants mediate transcriptional repressor functions during eye formation. eLife 8 , e51447. 10.7554/eLife.51447

Pope, I., Masia, F., Bradley, J., Ewan, K., Karuna, A., Payne, L., Guschina, I., Harwood, J., Swann, K., Dale, T., Watson, P., Langbein, W. and Borri, P. 2018. Coherent Raman Scattering microscopy: technology developments and biological applications. Presented at: 20th International Conference on Transparent Optical Networks (ICTON), Bucharest, Romania, 1-5 Jul 2018. 20th International Conference on Transparent Optical Networks (ICTON). IEEE, 10.1109/ICTON.2018.8473706

Dietrich, Laura, Rathmer, Bernd, Ewan, Kenneth, Bange, Tanja, Stefan, Heinrichs, Dale, Trevor Clive, Dennis, Schade and Grossmann, Tom N. 2017. Cell permeable stapled peptide inhibitor of Wnt signaling that targets β-catenin protein‒protein interactions. Cell Chemical Biology 24 (8) , pp. 958-968. 10.1016/j.chembiol.2017.06.013

Carotenuto, Pietro, Fassan, Matteo, Pandolfo, Rosantony, Lampis, Andrea, Vicentini, Caterina, Cascione, Luciano, Paulus-Hock, Viola, Boulter, Luke, Guest, Rachel, Quagliata, Luca, Hahne, Jens Claus, Ridgway, Rachel, Jamieson, Tam, Athineos, Dimitris, Veronese, Angelo, Visone, Rosa, Murgia, Claudio, Ferrari, Giulia, Guzzardo, Vincenza, Evans, Thomas Ronald Jeffry, MacLeod, Martin, Feng, Gui Ji, Dale, Trevor Clive, Negrini, Massimo, Forbes, Stuart J, Terracciano, Luigi, Scarpa, Aldo, Patel, Tushar, Valeri, Nicola, Workman, Paul, Sansom, Owen and Braconi, Chiara 2017. Wnt signalling modulates transcribed-ultraconserved regions in hepatobiliary cancers. Gut 66 (7) , pp. 1268-1277. 10.1136/gutjnl-2016-312278

Kay, Sophie K., Harrington, Heather A., Shepherd, Sarah, Brennan, Keith, Dale, Trevor, Osborne, James M., Gavaghan, David J. and Byrne, Helen M. 2017. The role of the Hes1 crosstalk hub in Notch-Wnt interactions of the intestinal crypt. PLoS Computational Biology 13 (2) , e1005400. 10.1371/journal.pcbi.1005400

Clarke, Paul A., Ortiz-Ruiz, Maria-Jesus, TePoele, Robert, Adeniji-Popoola, Olajumoke, Box, Gary, Court, Will, Czasch, Stefanie, El Bawab, Samer, Esdar, Christina, Ewan, Ken, Gowan, Sharon, De Haven Brandon, Alexis, Hewitt, Phllip, Hobbs, Stephen M., Kaufmann, Wolfgang, Mallinger, Aurélie, Raynaud, Florence, Roe, Toby, Rohdich, Felix, Schiemann, Kai, Simon, Stephanie, Schneider, Richard, Valenti, Melanie, Weigt, Stefan, Blagg, Julian, Blaukat, Andree, Dale, Trevor C., Eccles, Suzanne A., Hecht, Stefan, Urbahns, Klaus, Workman, Paul and Wienke, Dirk 2016. Assessing the mechanism and therapeutic potential of modulators of the human Mediator complex-associated protein kinases. eLife 5 , e20722. 10.7554/eLife.20722

Jardé, Thierry, Lloyd-Lewis, Bethan, Thomas, Mairian, Kendrick, Howard, Melchor, Lorenzo, Bougaret, Lauriane, Watson, Peter D., Ewan, Kenneth, Smalley, Matthew J. and Dale, Trevor C. 2016. Wnt and Neuregulin1/ErbB signalling extends 3D culture of hormone responsive mammary organoids. Nature Communications 7 , 13207. 10.1038/ncomms13207

Czodrowski, Paul, Mallinger, Aurélie, Wienke, Dirk, Esdar, Christina, Pöschke, Oliver, Busch, Michael, Rohdich, Felix, Eccles, Suzanne A., Ortiz-Ruiz, Maria-Jesus, Schneider, Richard, Raynaud, Florence I., Clarke, Paul A., Musil, Djordje, Schwarz, Daniel, Dale, Trevor Clive, Urbahns, Klaus, Blagg, Julian and Schiemann, Kai 2016. Structure-based optimization of potent, selective, and orally bioavailable CDK8 inhibitors discovered by high-throughput screening. Journal of Medicinal Chemistry 59 (20) , pp. 9337-9349. 10.1021/acs.jmedchem.6b00597

Mallinger, Aurélie, Schiemann, Kai, Rink, Christian, Stieber, Frank, Calderini, Michel, Crumpler, Simon, Stubbs, Mark, Adeniji-Popoola, Olajumoke, Poeschke, Oliver, Busch, Michael, Czodrowski, Paul, Musil, Djordje, Schwarz, Daniel, Ortiz-Ruiz, Maria-Jesus, Schneider, Richard, Thai, Ching, Valenti, Melanie, de Haven Brandon, Alexis, Burke, Rosemary, Workman, Paul, Dale, Trevor Clive, Wienke, Dirk, Clarke, Paul A., Esdar, Christina, Raynaud, Florence I., Eccles, Suzanne A., Rohdich, Felix and Blagg, Julian 2016. Discovery of potent, selective, and orally bioavailable small-molecule modulators of the mediator complex-associated kinases CDK8 and CDK19. Journal of Medicinal Chemistry 59 (3) , pp. 1078-1101. 10.1021/acs.jmedchem.5b01685

Freeman, Jamie, Smith, David, Latinkic, Branko, Ewan, Ken, Samuel, Lee, Zollo, Massimo, Marino, Natascia, Tyas, Lorraine, Jones, Nick and Dale, Trevor C. 2015. A functional connectome: regulation of Wnt/TCF-dependent transcription by pairs of pathway activators. Molecular Cancer 14 , 206. 10.1186/s12943-015-0475-1

Dale, Trevor, Clarke, Paul A., Esdar, Christina, Waalboer, Dennis, Adeniji-Popoola, Olajumoke, Ortiz-Ruiz, Maria-Jesus, Mallinger, Aurélie, Samant, Rahul S., Czodrowski, Paul, Musil, Djordje, Schwarz, Daniel, Schneider, Klaus, Stubbs, Mark, Ewan, Ken, Fraser, Elizabeth, TePoele, Robert, Court, Will, Box, Gary, Valenti, Melanie, de Haven Brandon, Alexis, Gowan, Sharon, Rohdich, Felix, Raynaud, Florence, Schneider, Richard, Poeschke, Oliver, Blaukat, Andree, Workman, Paul, Schiemann, Kai, Eccles, Suzanne A., Wienke, Dirk and Blagg, Julian 2015. A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease. Nature Chemical Biology 11 , pp. 973-980. 10.1038/nchembio.1952

Rada, Patricia, Rojo, Ana I., Offergeld, Anika, Feng, Gui Jie, Velasco-Martín, Juan P., González-Sancho, José Manuel, Valverde, Ángela M., Dale, Trevor Clive, Regadera, Javier and Cuadrado, Antonio 2015. WNT-3A regulates an Axin1/NRF2 complex that regulates antioxidant metabolism in hepatocytes. Antioxidants & Redox Signaling 22 (7) , pp. 555-571. 10.1089/ars.2014.6040

Mallinger, Aurélie, Crumpler, Simon, Pichowicz, Mark, Waalboer, Dennis, Stubbs, Mark, Adeniji-Popoola, Olajumoke, Wood, Bozena, Smith, Elizabeth, Thai, Ching, Henley, Alan T., Georgi, Katrin, Court, William, Hobbs, Steve, Box, Gary, Ortiz-Ruiz, Maria-Jesus, Valenti, Melanie, De Haven Brandon, Alexis, TePoele, Robert, Leuthner, Birgitta, Workman, Paul, Aherne, Wynne, Poeschke, Oliver, Dale, Trevor Clive, Wienke, Dirk, Esdar, Christina, Rohdich, Felix, Raynaud, Florence, Clarke, Paul A., Eccles, Suzanne A., Stieber, Frank, Schiemann, Kai and Blagg, Julian 2015. Discovery of potent, orally bioavailable, small-molecule inhibitors of WNT signaling from a cell-based pathway screen. Journal of Medicinal Chemistry 58 (4) , pp. 1717-1735. 10.1021/jm501436m

Carotenuto, M., De Antonellis, P., Liguori, L., Benvenuto, G., Magliulo, D., Alonzi, A., Turino, C., Attanasio, C., Damiani, V., Bello, A. M., Vitiello, F., Pasquinelli, R., Terracciano, L., Federico, A., Fusco, A., Freeman, Jamie, Dale, Trevor Clive, Decraene, C., Chiappetta, G., Piantedosi, F., Calabrese, C. and Zollo, M. 2014. H-Prune through GSK-3β interaction sustains canonical WNT/β-catenin signaling enhancing cancer progression in NSCLC. Oncotarget 5 (14) , pp. 5736-5749. 10.18632/oncotarget.2169

Rudge, Felicity and Dale, Trevor Clive 2014. Therapeutic targeting of the Wnt signaling network. In: Hoppler, Stefan P. and Moon, Randall T. eds. Wnt Signaling in Development and Disease: Molecular Mechanisms and Biological Functions, John Wiley & Sons, pp. 421-443.

de Groot, Reinoud E. A., Ganji, Ranjani S., Bernatik, Ondrej, Lloyd-Lewis, Bethan, Seipel, Katja, Šedova, Katerina, Zdrahal, Zbynek, Dhople, Vishnu M., Dale, Trevor C., Korswagen, Hendrik C. and Bryja, Vitezslav 2014. Huwe1-mediated ubiquitylation of dishevelled defines a negative feedback loop in the Wnt signaling pathway. Science Signaling 7 (317) , ra26. 10.1126/scisignal.2004985

Jarde, Thierry, Evans, Rebecca Jane, McQuillan, Karina, Parry, Lee, Feng, Gui Jie, Alvares, B., Clarke, Alan Richard and Dale, Trevor Clive 2013. In vivo and in vitro models for the therapeutic targeting of Wnt signaling using a Tet-OΔN89β-catenin system. Oncogene 32 (7) , pp. 883-893. 10.1038/onc.2012.103

Lloyd-Lewis, Bethan, Fletcher, Alexander G., Dale, Trevor Clive and Byrne, Helen M. 2013. Toward a quantitative understanding of the Wnt/β-catenin pathway through simulation and experiment. Wiley Interdisciplinary Reviews: Systems Biology and Medicine 5 (4) , pp. 391-407. 10.1002/wsbm.1221

Feng, Gui Jie, Cotta, Welwyn, Wei, Xiao-Qing, Poetz, Oliver, Evans, Rebecca Jane, Jardé, Thierry, Reed, Karen Ruth, Meniel, Valerie, Williams, Geraint Trefor, Clarke, Alan Richard and Dale, Trevor Clive 2012. Conditional disruption of Axin1 leads to development of liver tumors in mice. Gastroenterology 143 (6) , pp. 1650-1659. 10.1053/j.gastro.2012.08.047

Shorning, Boris, Jarde, Thierry, McCarthy, Afshan, Ashworth, Alan, de Leng, Wendy W. J., Offerhaus, George Johan A., Resta, Nicoletta, Dale, Trevor Clive and Clarke, Alan Richard 2012. Intestinal renin-angiotensin system is stimulated after deletion of Lkb1. Gut 61 (2) , pp. 202-213. 10.1136/gutjnl-2011-300046

Jarde, Thierry and Dale, Trevor Clive 2012. Wnt signalling in murine postnatal mammary gland development. Acta Physiologica 204 (1) , pp. 118-127. 10.1111/j.1748-1716.2011.02283.x

Braun, Sebastian, Humphreys, Christine and Dale, Trevor Clive 2012. Evolutionary routes from a prebiotic ANA-world. Communicative & Integrative Biology 5 (2) , pp. 199-202. 10.4161/cib.18892

Braun, Sebastian, Humphreys, Christine, Fraser, Elizabeth, Brancale, Andrea, Bochtler, Matthias and Dale, Trevor Clive 2011. Amyloid-Associated Nucleic Acid Hybridisation. PLoS ONE 6 (5) , e19125. 10.1371/journal.pone.0019125

Perrins, Richard D., Orchard, Craig B., Zavodszky, Maria, Kasry, Amal, Nikolaev, Nikolay, Harwood, Adrian John, Borri, Paola and Dale, Trevor Clive 2011. Doing more with less: a method for low total mass, affinity measurement using variable-length nanotethers. Analytical Chemistry 83 (23) , pp. 8900-8905. 10.1021/ac2012569

Ewan, Kenneth Burnside Ramsay, Pajak, Bozena, Stubbs, M., Todd, H., Barbeau, O., Quevedo, C., Botfield, H., Young, R., Ruddle, R., Samuel, L., Battersby, Alysia Agnes, Raynaud, F., Allen, Nicholas Denby, Wilson, Samuel, Latinkic, Branko, Workman, P., McDonald, E., Blagg, J., Aherne, W. and Dale, Trevor Clive 2010. A useful approach to identify novel small-molecule inhibitors of Wnt-dependent transcription. Cancer Research 70 (14) , pp. 5963-5973. 10.1158/0008-5472.CAN-10-1028

Wolkenhauer, Olaf, Auffray, Charles, Baltrusch, Simone, Blüthgen, Nils, Byrne, Helen, Cascante, Marta, Ciliberto, Andrea, Dale, Trevor Clive, Drasdo, Dirk, Fell, David, Ferrell, James Jr. E., Gallahan, Daniel, Gatenby, Robert, Günther, Ulrich, Harms, Brian D., Herzel, Hanspeter, Junghanss, Christian, Kunz, Manfred, van Leeuwen, Ingeborg, Lenormand, Philippe, Levi, Francis, Linnebacher, Michael, Lowengrub, John, Maini, Philip K., Malik, Arif, Rateitschak, Katja, Sansom, Owen, Schäfer, Reinhold, Schürrle, Karsten, Sers, Christine, Schnell, Santiago, Shibata, Darryl, Tyson, John, Vera, Julio, White, Michael, Zhivotovsky, Boris and Jaster, Robert 2010. Systems biologists seek fuller integration of systems biology approaches in new cancer research programs. Cancer Research 70 (1) , pp. 12-13. 10.1158/0008-5472.CAN-09-2676

Kasry, Amal, Borri, Paola, Davies, Philip Rosser, Harwood, Adrian John, Thomas, Nick, Lofas, Stefan and Dale, Trevor Clive 2009. Comparison of methods for generating planar DNA-modified surfaces for hybridization studies. ACS Applied Materials & Interfaces 1 (8) , pp. 1793-1798. 10.1021/am9003073

Kadri, Hachemi, Dale, Trevor Clive, Ewan, Kenneth Burnside Ramsay and Westwell, Andrew 2008. The design, synthesis and antitumour evaluation of novel small molecule inhibitors of the Dishevelled PDZ domain [Poster Presentation/Abstract]. EJC Supplements 6 (12) , p. 137. 10.1016/S1359-6349(08)72370-X

Freeman, Jamie, Zollo, M. and Dale, Trevor Clive 2008. Investigating h-Prune activation of Wnt signalling in breast cancer. Breast Cancer Research 10 (s2) , p. 10. 10.1186/bcr1899

Phesse, Toby, Parry, Lee, Reed, Karen Ruth, Ewan, Kenneth Burnside Ramsay, Dale, Trevor Clive, Sansom, Owen J. and Clarke, Alan Richard 2008. Deficiency of Mbd2 attenuates Wnt induced tumourigenesis via deregulation of a novel Wnt inhibitor, Lect.2. Molecular and Cellular Biology 28 (19) , pp. 6094-6103. 10.1128/MCB.00539-08

Ewan, Kenneth Burnside Ramsay and Dale, Trevor Clive 2008. The potential for targeting oncogenic WNT/beta-catenin signaling in therapy. Current Drug Targets 9 (7) , pp. 532-547. 10.2174/138945008784911787

University College Cardiff Consultants, Ltd. 2008. Method of measuring the affinity of biomolecules. EP1949104A2. [Patent].

Oosterveen, Tony, Coudreuse, Damien Y.M., Yang, Pei-Tzu, Fraser, Elizabeth, Bergsma, Joost, Dale, Trevor Clive and Korswagen, Hendrik C. 2007. Two functionally distinct Axin-like proteins regulate canonical Wnt signaling in C. elegans. Developmental Biology 308 (2) , pp. 438-448. 10.1016/j.ydbio.2007.05.043

Forde, Josephine and Dale, Trevor Clive 2007. Glycogen synthase kinase 3: A key regulator of cellular fate. Cellular and Molecular Life Sciences 64 (15) , pp. 1930-1944. 10.1007/s00018-007-7045-7

Dale, Trevor Clive 2006. Protein and nucleic acid together: A mechanism for the emergence of biological selection. Journal of Theoretical Biology 240 (3) , pp. 337-342. 10.1016/j.jtbi.2005.09.027

Dale, Trevor Clive 2006. Kinase cogs go forward and reverse in the Wnt signaling machine. Nature Structural & Molecular Biology 13 (1) , pp. 9-11. 10.1038/nsmb0106-9

Dale, Trevor Clive, Jonker, J.W., Mesman, E. and Schinkel, A.H. 2005. The Breast Cancer Resistance Protein (BCRP/ABCG2) concentrates drugs and carcinogenic xenotoxins into milk. Nature Medicine volume (issue) , pp. 127-129. 10.1038/nm1186

Le Floch, N., Rivat, C., De Wever, O., Bruyneel, E., Mareel, M., Dale, Trevor Clive and Gespach, C. 2005. The proinvasive activity of Wnt-2 is mediated through a noncanonical Wnt pathway coupled to GSK-3 and c-Jun/AP-1 signaling. The FASEB Journal 19 (1) , pp. 144-146. 10.1096/fj.04-2373fje

Jonker, Johan W., Freeman, Jamie, Bolscher, Ellen, Musters, Sandra, Alvi, Azra J., Titley, Ian, Schinkel, Alfred H. and Dale, Trevor Clive 2005. Contribution of the ABC transporters Bcrp1 and Mdr1a/1b to the side population phenotype in mammary gland and bone marrow of mice. Stem Cells 23 (8) , pp. 1059-1065. 10.1634/stemcells.2005-0150

Smalley, Matthew John, Signoret, Nathalie, Robertson, David, Tilley, Alan, Hann, Anthony, Ewan, Kenneth, Ding, Yanning, Paterson, Hugh and Dale, Trevor Clive 2005. Dishevelled (Dvl-2) activates canonical Wnt signalling in the absence of cytoplasmic puncta. Journal of Cell Science 118 (22) , pp. 5279-5289. 10.1242/jcs.02647

Roberts, M. S., Woods, A. J., Dale, Trevor Clive, van der Sluijs, P. and Norman, J. C. 2004. Protein kinase B/Akt acts via glycogen synthase kinase 3 to regulate recycling of αvβ3 and α5β1 integrins. Molecular and Cellular Biology 24 (4) , pp. 1505-1515. 10.1128/MCB.24.4.1505-1515.2004

Ciani, L., Krylova, O., Smalley, Matthew John, Dale, Trevor Clive and Salinas, P. 2004. A divergent canonical WNT-signaling pathway regulates microtubule dynamics: Dishevelled signals locally to stabilize microtubules. Journal of Cell Biology 164 (2) , pp. 243-253. 10.1083/jcb.200309096

Dajani, Rana, Fraser, Elizabeth, Roe, S. Mark, Yeo, Margaret, Good, Valerie M., Thompson, Vivienne, Dale, Trevor Clive and Pearl, Laurence H. 2003. Structural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complex. The EMBO Journal 22 (3) , pp. 494-501. 10.1093/emboj/cdg068

Alvi, Azra J., Clayton, Helen, Joshi, Chirag, Enver, Tariq, Ashworth, Alan, Vivanco, Maria d. M, Dale, Trevor Clive and Smalley, Matthew John 2003. Functional and molecular characterisation of mammary side population cells. Breast Cancer Research 5 (1) , R1-R8. 10.1186/bcr547

Franca-Koh, Jonathan, Yeo, Margaret, Fraser, Elizabeth, Young, Neville and Dale, Trevor Clive 2002. The regulation of glycogen synthase kinase-3 nuclear export by Frat/GBP. Journal of Biological Chemistry , pp. 43844-43848. 10.1074/jbc.M207265200

Fraser, Elizabeth, Young, N., Dajani, R., Franca-Koh, J., Ryves, William Jonathan, Williams, R. S. B., Yeo, M., Webster, M.-T., Richardson, C., Smalley, Matthew John, Pearl, L. H., Harwood, Adrian John and Dale, Trevor Clive 2002. Identification of the Axin and Frat binding region of glycogen synthase kinase-3. Journal of Biological Chemistry 277 (3) , pp. 2176-2185. 10.1074/jbc.M109462200

Ding, Yanning and Dale, Trevor Clive 2002. Wnt signal transduction: kinase cogs in a nano-machine? Trends in Biochemical Sciences 27 (7) , pp. 327-329. 10.1016/S0968-0004(02)02137-0

Dajani, Rana, Fraser, Elizabeth, Roe, S. Mark, Young, Neville, Good, Valerie, Dale, Trevor Clive and Pearl, Laurence H. 2001. Crystal structure of glycogen synthase kinase 3β : structural basis for phosphate-primed substrate specificity and autoinhibition. Cell 105 (6) , pp. 721-732. 10.1016/S0092-8674(01)00374-9

Smalley, Matthew John and Dale, Trevor Clive 2001. Wnt signaling and mammary tumorigenesis. Journal of Mammary Gland Biology and Neoplasia 6 (1) , pp. 37-52.

Heisenberg, C. -P., Houart, Corinne, Take-uchi, Masaya, Rauch, Gerd-Jörg, Young, Neville, Coutinho, Pedro, Masai, Ichiro, Caneparo, Luca, Concha, Miguel L., Geisler, Robert, Dale, Trevor Clive, Wilson, Stephen W. and Stemple, Derek L. 2001. A mutation in the Gsk3-binding domain of zebrafish Masterblind/Axin1 leads to a fate transformation of telencephalon and eyes to diencephalon. Genes & Development 15 (11) , pp. 1427-1434. 10.1101/gad.194301

Sarkar, L., Cobourne, M., Naylor, S., Smalley, Matthew John, Dale, Trevor Clive and Sharpe, P. T. 2000. Wnt/Shh interactions regulate ectodermal boundary formation during mammalian tooth development. Proceedings of the National Academy of Sciences of the United States of America 97 (9) , pp. 4520-4524. 10.1073/pnas.97.9.4520

Webster, M. T., Rozycka, M., Sara, Elizabeth, Davis, E., Smalley, Matthew John, Young, N., Dale, Trevor Clive and Wooster, R. 2000. Sequence variants of the Axin gene in breast, colon, and other cancers: an analysis of mutations that interfere with GSK3 binding. Genes Chromosomes and Cancer 28 (4) , pp. 443-453. 10.1002/1098-2264(200008)28:4<443::AID-GCC10>3.0.CO;2-D

Naylor, S., Smalley, Matthew John, Robertson, D., Gusterson, B. A., Edwards, P. A. and Dale, Trevor Clive 2000. Retroviral expression of Wnt-1 and Wnt-7b produces different effects in mouse mammary epithelium. Journal of Cell Science 113 (12) , pp. 2129-2138.

Smalley, Matthew John and Dale, Trevor Clive 1999. Wnt signalling in mammalian development and cancer. Cancer and Metastasis Reviews 18 (2) , pp. 215-230. 10.1023/A:1006369223282

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