Browse by Current Cardiff authors

Rosas, Marcela, Slatter, David A., Obaji, Samya G., Webber, Jason P., Alvarez-Jarreta, Jorge, Thomas, Christopher P., Aldrovandi, Maceler, Tyrrell, Victoria J., Jenkins, Peter V., O'Donnell, Valerie B. and Collins, Peter W. 2020. The procoagulant activity of tissue factor expressed on fibroblasts is increased by tissue factor-negative extracellular vesicles. PLoS ONE 15 (10) , e0240189. 10.1371/journal.pone.0240189

Ipseiz, Natacha, Pickering, Robert J., Rosas, Marcela, Tyrrell, Victoria J., Davies, Luke C., Orr, Selinda J., Czubala, Magdalena A., Fathalla, Dina, Robertson, Avril A. B., Bryant, Clare E., O'Donnell, Valerie and Taylor, Philip R. 2020. Tissue‐resident macrophages actively suppress IL‐1beta release via a reactive prostanoid/IL‐10 pathway. EMBO Journal 39 (14) , e103454. 10.15252/embj.2019103454

Meckelmann, Sven W., Hawksworth, Jade I., White, Daniel, Andrews, Robert, Rodrigues, Patricia, O'Connor, Anne, Alvarez-Jarreta, Jorge, Tyrrell, Victoria J., Hinz, Christine, Zhou, You, Williams, Julie, Aldrovandi, Maceler, Watkins, William J., Engler, Adam J., Lo Sardo, Valentina, Slatter, David A., Allen, Stuart M., Acharya, Jay, Mitchell, Jacquie, Cooper, Jackie, Aoki, Junken, Kano, Kuniyuki, Humphries, Steve E. and O'Donnell, Valerie B. 2020. Metabolic dysregulation of the lysophospholipid/autotaxin axis in the chromosome 9p21 gene SNP rs10757274. Circulation: Genomic and Precision Medicine 13 (3) , pp. 149-164. 10.1161/CIRCGEN.119.002806

O'Donnell, Valerie B, Thomas, David, Stanton, Richard, Maillard, Jean-Yves, Murphy, Robert C, Jones, Simon A, Humphreys, Ian, Wakelam, Michael J O, Fegan, Christopher, Wise, Matt P, Bosch, Albert and Sattar, Syed A. 2020. Potential role of oral rinses targeting the viral lipid envelope in SARS-CoV-2 infection. Function 1 (1) , zqaa002. 10.1093/function/zqaa002

O'Donnell, Valerie, Thomas, David, Stanton, Richard, Maillard, Jean-Yves, Murphy, Robert C, Jones, Simon, Wakelam, MJO, Fegan, Christopher, Wise, Matthew, Bosch, Albert and Sattar, Syed 2020. Potential role of oral rinses targeting the viral lipid envelope in SARS-CoV-2 infection. Function 1 (1) 10.1093/function/zqaa002

Doll, Sebastian, Freitas, Florencio Porto, Shah, Ron, Aldrovandi, Maceler, da Silva, Milene Costa, Ingold, Irina, Grocin, Andrea Goya, Xavier da Silva, Thamara Nishida, Panzilius, Elena, Scheel, Christina H., Mourão, André, Buday, Katalin, Sato, Mami, Wanninger, Jonas, Vignane, Thibaut, Mohana, Vaishnavi, Rehberg, Markus, Flatley, Andrew, Schepers, Aloys, Kurz, Andreas, White, Daniel, Sauer, Markus, Sattler, Michael, Tate, Edward William, Schmitz, Werner, Schulze, Almut, O'Donnell, Valerie, Proneth, Bettina, Popowicz, Grzegorz M., Pratt, Derek A., Angeli, José Pedro Friedmann and Conrad, Marcus 2019. FSP1 is a glutathione-independent ferroptosis suppressor. Nature 575 , pp. 693-698. 10.1038/s41586-019-1707-0

Gallagher, Hayley, Williams, Jessica O., Ferekidis, Nele, Ismail, Alaa, Chan, Yee-Hung, Michael, Daryn R., Guschina, Irina A., Tyrrell, Victoria J., O'Donnell, Valerie B., Harwood, John L., Khozin-Goldberg, Inna, Boussiba, Sammy and Ramji, Dipak P. 2019. Dihimo-γ-linolenic acid inhibits several key cellular processes associated with atherosclerosis. BBA - Molecular Basis of Disease 1865 (9) , pp. 2538-2550. 10.1016/j.bbadis.2019.06.011

Hinz, Christine, Liggi, Sonia, Mocciaro, Gabriele, Jung, Stephanie M., Induruwa, Isuru, Pereira, Milton C.D.A., Bryant, Clare E., Meckelmann, Sven W., O'Donnell, Valerie B., Farndale, Richard W., Fjeldsted, John C. and Griffin, Julian L. 2019. A comprehensive UHPLC ion mobility QTOF method for profiling and quantification of eicosanoids, other oxylipins and fatty acids. Analytical Chemistry 91 (13) , pp. 8025-8035. 10.1021/acs.analchem.8b04615

Kornilov, Andrei, Kennedy, Paul D., Aldrovandi, MacEler, Watson, Andrew J. A., Hinz, Christine, Harless, Bryan, Colombo, Joseph, Maxey, Kirk M., Tyrrell, Victoria J., Simon, Matthew, Aggarwal, Varinder K., Boeglin, William E., Brash, Alan R., Murphy, Robert C. and O'Donnell, Valerie B. 2019. Revising the structure of a new eicosanoid from human platelets to 8,9-11,12-diepoxy-13- hydroxy-eicosadienoic acid. Journal of Biological Chemistry 294 , pp. 9225-9238. 10.1074/jbc.RA119.008915

Allen-Redpath, Keith, Aldrovandi, Maceler, Lauder, Sarah N., Gketsopoulou, Anastasia, Tyrrell, Victoria J., Slatter, David A., Andrews, Robert, Watkins, W. John, Atkinson, Georgia, McNeill, Eileen, Gilfedder, Anna, Protty, Majd, Burston, James, Johnson, Sam R. C., Rodrigues, Patricia R. S., Jones, Dylan O., Lee, Regent, Handa, Ashok, Channon, Keith, Obaji, Samya, Alvarez-Jarreta, Jorge, Krönke, Gerhard, Ackermann, Jochen, Jenkins, P. Vince, Collins, Peter W. and O'Donnell, Valerie B. 2019. Phospholipid membranes drive abdominal aortic aneurysm development through stimulating coagulation factor activity. Proceedings of the National Academy of Sciences 116 (16) , pp. 8038-8047. 10.1073/pnas.1814409116

Evans, Robert J, Pline, Katherine, Loynes, Catherine A., Needs, Sarah, Aldrovandi, Maceler, Tiefenback, Jens, Bielska, Ewa, Rubino, Rachel E., Nicol, Christopher J., May, Robin C., Krause, Henry M., O'Donnell, Valerie B., Renshaw, Stephen A. and Johnstone, Simon A. 2019. 15-keto-prostaglandin E₂ activates host peroxisome proliferator-activated receptor gamma (PPAR-γ) to promote Cryptococcus neoformans growth during infection. PLoS Pathogens 15 (3) , e1007597. 10.1371/journal.ppat.1007597

O'Donnell, V, Aldrovandi, M, Murphy, R C and Kronke, G 2019. Enzymatically-oxidized phospholipids assume center-stage as essential regulators of innate immunity and cell death. Science Signaling 12 (574) , eaau2293. 10.1126/scisignal.aau2293

O'Donnell, Valerie, Dennis, Edward A, Wakelam, Michael J O and Subramaniam, Shankar 2019. LIPID MAP: Serving the next generation of lipid researchers with tools, resources, data and training. Science Signaling 12 (563) , eaaw2964. 10.1126/scisignal.aaw2964

Vliet, Albert van der, Dick, Tobias P., Aust, Steve D., Koppenol, Willem H., Ursini, Fulvio, Kettle, Antony J., Beckman, Joseph S., O'Donnell, Valerie, Darley-Usmar, Victor, Lancaster, Jack, Hogg, Neil, Davies, Kelvin J.A., Forman, Henry Jay and Janssen-Heininger, Yvonne M.W. 2018. Rust never sleeps: the continuing story of the Iron Bolt. Free Radical Biology and Medicine 124 , pp. 353-357. 10.1016/j.freeradbiomed.2018.06.017

Fahy, Eoin, Alvarez-Jarreta, Jorge, Brasher, Christopher, Nguyen, An, Hawksworth, Jade, Rodrigues, Patricia, Meckelmann, Sven, Allen, Stuart and O'Donnell, Valerie 2018. LipidFinder on LIPID MAPS: peak filtering, MS searching and statistical analysis for lipidomics. Bioinformatics 35 (4) , pp. 685-687. 10.1093/bioinformatics/bty679

O'Donnell, Valerie, Rossjohn, Jamie and Wakelam, M. J. O. 2018. Phospholipid signaling in innate immune cells. The Journal of Clinical Investigation 128 (7) , pp. 2670-2679. 10.1172/JCI97944

Freeman, Bruce A., O'Donnell, Valerie B. and Schopfer, Francisco J. 2018. The discovery of nitro-fatty acids as products of metabolic and inflammatory reactions and mediators of adaptive cell signaling. Nitric Oxide: Biology and Chemistry 77 , pp. 106-111. 10.1016/j.niox.2018.05.002

Slatter, David A., Percy, Charles L., Allen-Redpath, Keith, Gajsiewicz, Joshua M., Brooks, Nick J., Clayton, Aled, Tyrrell, Victoria J., Rosas, Marcela, Lauder, Sarah N., Watson, Andrew, Dul, Maria, Garcia-Diaz, Yoel, Aldrovandi, MacEler, Heurich-Sevcenco, Meike, Hall, Judith, Morrissey, James H., Lacroix-Desmazes, Sebastien, Delignat, Sandrine, Jenkins, P. Vincent, Collins, Peter W. and O'Donnell, Valerie B. 2018. Enzymatically-oxidized phospholipids restore thrombin generation in coagulation factor deficiencies. JCI Insight 3 (6) , e98459. 10.1172/jci.insight.98459

Walker, Jaqui, Hutchison, Pippa, Ge, Junbo, Zhao, Dong, Wang, Yongjun, Rothwell, Peter M, Gaziano, J Michael, Chan, Andrew, Burn, John, Chia, John, Langley, Ruth, O'Donnell, Valerie Bridget, Rocca, Bianca and Hawkey, Chris 2018. Aspirin: 120 years of innovation. A report from the 2017 Scientific Conference of the International Aspirin Foundation, 14 September 2017, Charité, Berlin. ecancermedicalscience 12 , 813. 10.3332/ecancer.2018.813

Aldrovandi, Maceler, Banthiya, Swathi, Meckelmann, Sven, Zhou, You, Heydeck, Dagmar, O'Donnell, Valerie B. and Kuhn, Hartmut 2018. Specific oxygenation of plasma membrane phospholipids by Pseudomonas aeruginosa lipoxygenase induces structural and functional alterations in mammalian cells. Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids 1863 (2) , pp. 152-164. 10.1016/j.bbalip.2017.11.005

O'Donnell, Valerie B. 2018. Gus Born: scientific reflections of later years, inspiring the next generation of blood researchers. Platelets 29 (8) , pp. 763-765. 10.1080/09537104.2018.1534948

Zhao, Jingmin, Minami, Yoshinori, Etling, Emily, Coleman, John M., Lauder, Sarah, Tyrrell, Victoria, Aldrovandi, Maceler, O'Donnell, Valerie Bridget, Claesson, Hans-Erik, Kagan, Valerian and Wenzel, Sally 2017. Preferential Generation of 15-HETE-PE Induced by IL-13 Regulates Goblet Cell Differentiation in Human Airway Epithelial Cells. American Journal of Respiratory Cell and Molecular Biology 57 (6) 10.1165/rcmb.2017-0031OC

Lauder, Sarah N., Allen-Redpath, Keith, Slatter, David A., Aldrovandi, Maceler, O'Connor, Anne, Farewell, Daniel, Percy, Charles L., Molhoek, Jessica E., Rannikko, Sirpa, Tyrrell, Victoria J., Ferla, Salvatore, Milne, Ginger L., Poole, Alastair W., Thomas, Christopher P., Obaji, Samya, Taylor, Philip R., Jones, Simon A., deGroot, Philip G., Urbanus, Rolf T., Horkko, Sohvi, Uderhardt, Stefan, Ackermann, Jochen, Jenkins, P. Vince, Brancale, Andrea, Kronke, Gerhard, Collins, Peter W. and O'Donnell, Valerie B. 2017. Networks of enzymatically oxidized membrane lipids support calcium-dependent coagulation factor binding to maintain hemostasis. Science Signaling 10 (507) , eaan2787. 10.1126/scisignal.aan2787

Lue, H-W, Podolak, J, Kolahi, K, Cheng, L, Rao, S, Garg, D, Xue, C-H, Rantala, J, Tyner, J, Thornburg, K, Martinez-Acevedo, A, Liu, J-J, Amling, C, Truillet, C, Evans, M, O'Donnell, Valerie, Nomura, D, Drake, J, Ritz, A and Thomas, G 2017. Metabolic reprogramming ensures cancer cell survival despite oncogenic signaling blockade. Genes and Development 31 , pp. 2067-2084. 10.1101/gad.305292.117

Uderhardt, Stefan, Ackermann, Jochen, Fillep, Tobias, Hammond, Victoria J., Willeit, Johann, Santer, Peter, Mayr, Manuel, Biburger, Markus, Miller, Meike, Zellner, Katie R., Stark, Konstantin, Zarbock, Alexander, Rossaint, Jan, Schubert, Irene, Mielenz, Dirk, Diete, Barbara, Raaz-Schrauder, Dorette, Ay, Cihan, Gremmel, Thomas, Thaler, Johannes, Heim, Christian, Herrmann, Martin, Collins, Peter W., Schabbauer, Gernot, Mackman, Nigel, Voehringer, David, Nadler, Jerry L., Lee, James J., Massberg, Steffen, Rauh, Manfred, Kiechl, Stefan, Schett, Georg, O'Donnell, Valerie B. and Krönke, Gerhard 2017. Enzymatic lipid oxidation by eosinophils propagates coagulation, hemostasis and thrombotic disease. Journal of Experimental Medicine 214 (7) , pp. 2121-2138. 10.1084/jem.20161070

O'Donnell, Valerie B. and Murphy, Robert C. 2017. Directing eicosanoid esterification into phospholipids. Journal of Lipid Research 58 (5) , pp. 837-839. 10.1194/jlr.C075986

O'Connor, Anne, Brasher, Christopher, Slatter, David, Meckelmann, Sven, Hawksworth, Jade, Allen, Stuart and O'Donnell, Valerie 2017. LipidFinder: a computational workflow for discovery of lipids identifies eicosanoid-phosphoinositides in platelets. JCI Insight 2 (7) , e91634. 10.1172/jci.insight.91634

Aldrovandi, MacEler, Hinz, Christine, Lauder, Sarah N, Podmore, Helen, Hornshaw, Martin, Slatter, David A, Tyrrell, Victoria J, Clark, Stephen R, Marnett, Lawrence J., Collins, Peter W, Murphy, Robert C and O'Donnell, Valerie B 2017. DioxolaneA3-phosphatidylethanolamines are generated by human platelets and stimulate neutrophil integrin expression. Redox Biology 11 , pp. 663-672. 10.1016/j.redox.2017.01.001

Lauder, Sarah N., Tyrrell, Victoria J., Allen-Redpath, Keith, Aldrovandi, MacEler, Gray, David, Collins, Peter, Jones, Simon A., Taylor, Philip R. and O'Donnell, Valerie 2017. Myeloid 12/15-LOX regulates B cell numbers and innate immune antibody levels in vivo. Wellcome Open Research 2 (1) 10.12688/wellcomeopenres.10308.1

Liao, Chia-Te, Rosas, Marcela, Davies, Luke C., Giles, Peter J., Tyrrell, Victoria J., O'Donnell, Valerie B., Topley, Nicholas, Humphreys, Ian R., Fraser, Donald J., Jones, Simon A. and Taylor, Philip R. 2016. IL-10 differentially controls the infiltration of inflammatory macrophages and antigen-presenting cells during inflammation. European Journal of Immunology 46 (9) , pp. 2222-2232. 10.1002/eji.201646528

Heurich-Sevcenco, M., Preston, R.J.S., O'Donnell, V. B., Morgan, B. P. and Collins, P. W. 2016. Thrombomodulin enhances complement regulation through strong affinity interactions with factor H and C3b-Factor H complex. Thrombosis Research 145 , pp. 84-92. 10.1016/j.thromres.2016.07.017

Stokes, C. A., Kaur, R., Edwards, M R, Mondhe, Madhav, Robinson, D., Prestwich, E. C., Hume, R. D., Marshall, C. A., Perrie, Y., O'Donnell, Valerie Bridget, Harwood, John L., Sabroe, I. and Parker, L. C. 2016. Human rhinovirus-induced inflammatory responses are inhibited by phosphatidylserine containing liposomes. Mucosal Immunology 9 (5) , pp. 1303-1316. 10.1038/mi.2015.137

Chiba, Takahito, Thomas, Christopher P., Calcutt, M. Wade, Boeglin, William E., O'Donnell, Valerie B. and Brash, Alan R. 2016. The precise structures and stereochemistry of trihydroxy-linoleates esterified in human and porcine epidermis and their significance in skin barrier function: Implication of an epoxide hydrolase in the transformations of linoleate. Journal of Biological Chemistry 291 (28) , pp. 14540-14544. 10.1074/jbc.M115.711267

Bascoul-Colombo, Cécile, Guschina, Irina A., Maskrey, Benjamin H., Good, Mark, O'Donnell, Valerie B. and Harwood, John L. 2016. Dietary DHA supplementation causes selective changes in phospholipids from different brain regions in both wild type mice and the Tg2576 mouse model of Alzheimer's disease. Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids 1861 (6) , pp. 524-537. 10.1016/j.bbalip.2016.03.005

Hinz, Christine, Aldrovandi, Maceler, Uhlson, Charis, Marnett, Lawrence J., Longhurst, Hilary J., Warner, Timothy D., Alam, Saydul, Slatter, David A., Lauder, Sarah N., Allen-Redpath, Keith, Collins, Peter W., Thomas, Christopher P. and O'Donnell, Valerie B. 2016. Human platelets utilize cycloxygenase-1 to generate dioxolane A3, a neutrophil activating eicosanoid. Journal of Biological Chemistry 291 (26) , pp. 13448-13464. 10.1074/jbc.M115.700609

Slatter, David, Aldrovandi, MacEler, O'Connor, Anne, Allen, Stuart M., Brasher, Christopher J., Murphy, Robert C., Mecklemann, Sven, Ravi, Saranya, Darley-Usmar, Victor and O'Donnell, Valerie B. 2016. Mapping the human platelet lipidome reveals cytosolic phospholipase A2 as a regulator of mitochondrial bioenergetics during activation. Cell Metabolism 23 (5) , pp. 930-944. 10.1016/j.cmet.2016.04.001

Jones, Victoria, Birrell, Mark, Maher, Sarah, Griffiths, Mark, Grace, Megan, O'Donnell, Valerie Bridget, Clark, Stephen Robert and Belisi, Maria 2016. Role of Ep2 and Ep4 receptors in airway microvascular leak induced by prostaglandin E2. British Journal of Pharmacology 173 (6) , pp. 992-1004. 10.1111/bph.13400

Freeman, Phillip, Moschonas, Konstantinos, Hinz, Christine, O'Donnell, Valerie Bridget, Kinnaird, Tim D., James, Philip E. and Anderson, Richard A. 2015. Changes in platelet function independent of pharmacotherapy following coronary intervention in non-ST-elevation myocardial infarction patients. Atherosclerosis 243 (1) , pp. 320-327. 10.1016/j.atherosclerosis.2015.09.024

McCully, Michelle L., Collins, Paul J., Hughes, Timothy R., Thomas, Christopher P., Billen, Jaak, O'Donnell, Valerie B. and Moser, Bernhard 2015. Skin metabolites define a new paradigm in the localization of skin tropic memory T cells. Journal of Immunology 195 (1) , pp. 96-104. 10.4049/jimmunol.1402961

Percy, Charles L., Hartmann, Rudolf, Jones, Rhidian M., Balachandran, Subramaniam, Mehta, Dheeraj, Dockal, Michael, Scheiflinger, Friedrich, O'Donnell, Valerie Bridget, Hall, Judith Elizabeth and Collins, Peter William 2015. Correcting thrombin generation ex vivo using different haemostatic agents following cardiac surgery requiring the use of cardiopulmonary bypass. Blood Coagulation and Fibrinolysis 26 (4) , pp. 357-367. 10.1097/MBC.0000000000000243

Ravi, Saranya, Chacko, Balu, Sawada, Hirotaka, Kramer, Philip A., Johnson, Michelle S., Benavides, Gloria A., O'Donnell, Valerie Bridget, Marques, Marisa B. and Darley-Usmar, Victor M. 2015. Metabolic plasticity in resting and thrombin activated platelets. PLoS ONE 10 (4) , e0123597. 10.1371/journal.pone.0123597

Morgan, Alwena H., Hammond, Victoria J., Sakoh-Nakatogawa, Machiko, Ohsumi, Yoshinori, Thomas, Christopher P., Blanchet, Fabien, Piguet, Vincent, Kiselyov, Kirill and O'Donnell, Valerie Bridget 2015. A novel role for 12/15-lipoxygenase in regulating autophagy. Redox Biology 4 , pp. 40-47. 10.1016/j.redox.2014.11.005

Friedmann Angeli, Jose Pedro, Schneider, Manuela, Proneth, Bettina, Tyurina, Yulia Y., Tyurin, Vladimir A., Hammond, Victoria J., Herbach, Nadja, Aichler, Michaela, Walch, Axel, Eggenhofer, Elke, Basavarajappa, Devaraj, Rådmark, Olof, Kobayashi, Sho, Seibt, Tobias, Beck, Heike, Neff, Frauke, Esposito, Irene, Wanke, Rüdiger, Förster, Heidi, Yefremova, Olena, Heinrichmeyer, Marc, Bornkamm, Georg W., Geissler, Edward K., Thomas, Stephen B., Stockwell, Brent R., O'Donnell, Valerie B., Kagan, Valerian E., Schick, Joel A. and Conrad, Marcus 2014. Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nature Cell Biology 16 , pp. 1180-1194. 10.1038/ncb3064

Mathie, S. A., Dixon, K. L., Walker, S. A., Tyrell, Victoria Jayne, Mondhe, M., O'Donnell, Valerie Bridget, Gregory, L. G. and Lloyd, C. M. 2014. Alveolar macrophages are sentinels of murine pulmonary homeostasis following inhaled antigen challenge. Allergy 70 (1) , pp. 80-89. 10.1111/all.12536

Rosas, Marcela, Davies, Luke, Giles, Peter, Liao, Chia-Te, Kharfan, Bashar, Stone, Timothy, O'Donnell, Valerie, Fraser, Donald, Jones, Simon and Taylor, Philip Russel 2014. The transcription factor Gata6 links tissue macrophage phenotype and proliferative renewal. Science 344 (6184) , pp. 645-648. 10.1126/science.1251414

Fielding, Ceri A., Jones, Gareth W., McLoughlin, Rachel M., McLeod, Louise, Hammond, Victoria J., Uceda, Javier, Williams, Anwen S., Lambie, Mark, Foster, Thomas L., Liao, Chia-Te, Rice, Christopher M., Greenhill, Claire J., Colmont, Chantal S., Hams, Emily, Coles, Barbara, Kift-Morgan, Ann, Newton, Zarabeth, Craig, Katherine J., Williams, John D., Williams, Geraint T., Davies, Simon J., Humphreys, Ian R., O'Donnell, Valerie B., Taylor, Philip R., Jenkins, Brendan J., Topley, Nicholas and Jones, Simon A. 2014. Interleukin-6 signaling drives fibrosis in unresolved inflammation. Immunity 40 (1) , pp. 40-50. 10.1016/j.immuni.2013.10.022

O'Donnell, Valerie, Murphy, Robert C. and Watson, Steve P. 2014. Platelet lipidomics: modern day perspective on lipid discovery and characterization in platelets. Circulation Research 114 (7) , pp. 1185-1203. 10.1161/CIRCRESAHA.114.301597

Thomas, Christopher P., Clark, Stephen Robert, Hammond, Victoria Jayne, Aldrovandi, Maceler, Collins, Peter William and O'Donnell, Valerie Bridget 2014. Identification and quantification of aminophospholipid molecular species on the surface of apoptotic and activated cells. Nature Protocols 9 (1) , pp. 51-63. 10.1038/nprot.2013.163

Aldrovandi, Maceler, Hammond, Victoria Jayne, Podmore, Helen, Hornshaw, Martin, Clark, Stephen Robert, Marnett, Lawrence J., Slatter, David, Murphy, Robert C., Collins, Peter William and O'Donnell, Valerie Bridget 2013. Human platelets generate phospholipid-esterified prostaglandins via cyclooxygenase-1 that are inhibited by low dose aspirin supplementation. Journal of Lipid Research 54 (11) , pp. 3085-3097. 10.1194/jlr.M041533

Pauling, J. D., O'Donnell, Valerie Bridget and Mchugh, N. J. 2013. The contribution of platelets to the pathogenesis of Raynaud's phenomenon and systemic sclerosis. Platelets 24 (7) , pp. 503-515. 10.3109/09537104.2012.719090

Bonilla, L., O'Donnell, Valerie Bridget, Clark, Stephen Robert, Rubbo, H. and Trostchansky, A. 2013. Regulation of protein kinase C by nitroarachidonic acid: impact on human platelet activation. Archives of Biochemistry and Biophysics 533 (1-2) , pp. 55-61. 10.1016/j.abb.2013.03.001

Clark, Stephen Robert, Thomas, Christopher P., Hammond, Victoria Jayne, Aldrovandi, Maceler, Wilkinson, Gavin William Grahame, Hart, Keith William, Murphy, Robert C., Collins, Peter William and O'Donnell, Valerie Bridget 2013. Characterization of platelet aminophospholipid externalization reveals fatty acids as molecular determinants that regulate coagulation. Proceedings of the National Academy of Sciences of the United States of America 110 (15) , pp. 5875-5880. 10.1073/pnas.1222419110

Moideen, Abdul Nazeer, Evans, Laura, Osgood, Louise Emma, Williams, Anwen Sian, Jones, Simon Arnett, Thomas, Christopher P., O'Donnell, Valerie Bridget and Nowell, Mari Ann 2013. Characterization of enzymes involved in nicotinamide adenine dinucleotide biosynthesis in rheumatoid arthritis synovium and cytokine-stimulated synovial fibroblasts [Abstracts]. Rhuematology 52 (s1) , pp. 138-139.

Aldrovandi, Maceler and O'Donnell, Valerie Bridget 2013. Oxidized PLs and vascular inflammation. Current Atherosclerosis Reports 15 (5) , pp. 1989-1996. 10.1007/s11883-013-0323-y

Hammond, Victoria Jayne, Morgan, Alwena H., Lauder, Sarah Nicol, Thomas, Christopher P., Brown, Sarah, Freeman, Bruce A., Lloyd, Clare M., Davies, Jane, Bush, Andrew, Levonen, Anna-Liisa, Kansanen, Emilia, Villacorta, Luis, Chen, Y. Eugene, Porter, Ned, Garcia-Diaz, Yoel M., Schopfer, Francisco J. and O'Donnell, Valerie Bridget 2012. Novel keto-phospholipids are generated by monocytes and macrophages, detected in cystic fibrosis, and activate peroxisome proliferator-activated receptor-γ. Journal of Biological Chemistry 287 (50) , pp. 41651-41666. 10.1074/jbc.M112.405407

Hammond, Victoria Jayne and O'Donnell, Valerie Bridget 2012. Esterified eicosanoids: generation, characterization and function. Biochimica et Biophysica Acta - Biomembranes 1818 (10) , pp. 2403-2412. 10.1016/j.bbamem.2011.12.013

Reynolds, Sophie Leanne, Williams, Anwen Sian, Williams, H., Smale, Shaun, Stephenson, Hayden J., Amos, Nick, George, S. J., O'Donnell, Valerie Bridget and Lang, Derek 2012. Contractile, but not endothelial, dysfunction in early inflammatory arthritis: a possible role for matrix metalloproteinase-9. British Journal of Pharmacology 167 (3) , pp. 505-514. 10.1111/j.1476-5381.2012.01988.x

O'Donnell, Valerie Bridget and Murphy, Robert C. 2012. New families of bioactive oxidized phospholipids generated by immune cells: Identification and signaling actions. Blood 120 (10) , pp. 1985-1992. 10.1182/blood-2012-04-402826

Thomas, Christopher P. and O'Donnell, Valerie Bridget 2012. Oxidized phospholipid signaling in immune cells. Current Opinion in Pharmacology 12 (4) , pp. 471-477. 10.1016/j.coph.2012.02.013

Taylor, Philip Russel, Heydeck, Dagmar, Jones, Gareth Wyn, Kronke, Gerhard, Funk, Colin D., Knapper, Steven, Adams, Deborah, Kuhn, Hartmut and O'Donnell, Valerie Bridget 2012. Development of myeloproliferative disease in 12/15-lipoxygenase deficiency [Letter]. Blood 119 (25) , pp. 6173-6174. 10.1182/blood-2012-02-410928

O'Donnell, Valerie Bridget 2011. Mass spectrometry analysis of oxidized phosphatidylcholine and phosphatidylethanolamine. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids 1811 (11) , pp. 818-826. 10.1016/j.bbalip.2011.07.018

Lauder, Sarah Nicol, Taylor, Philip Russel, Clark, Stephen Robert, Evans, Rhys Lloyd, Hindley, James Phillip, Smart, Kathryn, Leach, Heather, Kidd, Emma Jane, Broadley, Kenneth John, Jones, Simon Arnett, Wise, Matthew Peter, Godkin, Andrew James, O'Donnell, Valerie Bridget and Gallimore, Awen Myfanwy 2011. Paracetamol reduces influenza-induced immunopathology in a mouse model of infection without compromising virus clearance or the generation of protective immunity. Thorax 66 (5) , pp. 368-374. 10.1136/thx.2010.150318

Guschina, Irina, Millership, Steven, O'Donnell, Valerie Bridget, Ninkina, Natalia, Harwood, John and Buchman, Vladimir L. 2011. Lipid classes and fatty acid patterns are altered in the brain of γ-synuclein null mutant mice. Lipids 46 (2) , pp. 121-130. 10.1007/s11745-010-3486-0

Ruge, Fiona, Glavini, Aikaterini, Gallimore, Awen Myfanwy, Richards, Hannah E., Thomas, Christopher P., O'Donnell, Valerie Bridget, Philpott, Michael P. and Porter, Rebecca 2011. Delineating immune-mediated mechanisms underlying hair follicle destruction in the mouse mutant defolliculated. Journal of Investigative Dermatology 131 (3) , pp. 572-579. 10.1038/jid.2010.379

Zhao, Jinming, O'Donnell, Valerie Bridget, Balzar, Silvana, St. Croix, Claudette M., Trudeau, John B. and Wenzel, Sally E. 2011. 15-Lipoxygenase 1 interacts with phosphatidylethanolamine-binding protein to regulate MAPK signaling in human airway epithelial cells. Proceedings of the National Academy of Sciences of the United States of America 108 (34) , pp. 14246-14251. 10.1073/pnas.1018075108

Trostchansky, A., Bonilla, L., Thomas, Christopher P., O'Donnell, Valerie Bridget, Marnett, L. J., Radi, R. and Rubbo, H. 2011. Nitroarachidonic Acid, a Novel Peroxidase Inhibitor of Prostaglandin Endoperoxide H Synthases 1 and 2. Journal of Biological Chemistry 286 (15) , pp. 12891-12900. 10.1074/jbc.M110.154518

Clark, Stephen Robert, Guy, Christopher J., Scurr, Martin J., Taylor, Philip Russel, Kift-Morgan, Ann Patricia, Hammond, Victoria Jayne, Thomas, Christopher P., Coles, Barbara, Roberts, Gareth Wyn, Eberl, Matthias, Jones, Simon Arnett, Topley, Nicholas, Kotecha, Sailesh and O'Donnell, Valerie Bridget 2011. Esterified eicosanoids are acutely generated by 5-lipoxygenase in primary human neutrophils and in human and murine infection. Blood 117 (6) , pp. 2033-2043. 10.1182/blood-2010-04-278887

Thomas, Christopher P., Morgan, Lloyd T., Maskrey, Ben, Murphy, Robert C., Kuhn, Hartmut, Hazen, Stanley L., Goodall, Alison H., Hamali, Hassan A., Collins, Peter William and O'Donnell, Valerie Bridget 2010. Phospholipid-esterified eicosanoids are generated in agonist-activated human platelets and enhance tissue factor-dependent thrombin generation. Journal of Biological Chemistry 285 (10) , pp. 6891-6903. 10.1074/jbc.M109.078428

Morgan, Alwena Haf, Hammond, Victoria Jayne, Morgan, Lloyd, Thomas, Christopher P., Tallman, Keri A., Garcia-Diaz, Yoel Ruslan, McGuigan, Christopher, Serpi, Michaela, Porter, Ned A., Murphy, Robert C. and O'Donnell, Valerie Bridget 2010. Quantitative assays for esterified oxylipins generated by immune cells. Nature Protocols 5 (12) , pp. 1919-1931. 10.1038/nprot.2010.162

Ivanov, Igor, Heydeck, Dagmar, Hofheinz, Katharina, Roffeis, Jana, O'Donnell, Valerie Bridget, Kuhn, Hartmut and Walther, Matthias 2010. Molecular enzymology of lipoxygenases. Archives of biochemistry and biophysics 503 (2) , pp. 161-174. 10.1016/j.abb.2010.08.016

Morgan, Lloyd T., Thomas, Christopher P., Kühn, Hartmut and O'Donnell, Valerie Bridget 2010. Thrombin-activated human platelets acutely generate oxidized docosahexaenoic-acid-containing phospholipids via 12-lipoxygenase. Biochemical Journal 431 (1) , pp. 141-148. 10.1042/BJ20100415

Tull, Samantha P., Yates, Clara M., Maskrey, Ben, O'Donnell, Valerie Bridget, Madden, Jackie, Grimble, Robert F., Calder, Philip C., Nash, Gerard B. and Rainger, G. Ed. 2009. Omega-3 fatty acids and inflammation: novel interactions reveal a new step in neutrophil recruitment. PLoS Biology 7 (8) , e1000177. 10.1371/journal.pbio.1000177

Rubbo, Homero, Trostchansky, Andrés and O'Donnell, Valerie Bridget 2009. Peroxynitrite-mediated lipid oxidation and nitration: mechanisms and consequences. Archives of Biochemistry and Biophysics 484 (2) , pp. 167-172. 10.1016/j.abb.2008.11.007

Ferreira, Ana M., Ferrari, Mariana I., Trostchansky, Andrés, Batthyany, Carlos, Souza, José M., Alvarez, María N., López, Gloria V., Baker, Paul R. S., Schopfer, Francisco J., O'Donnell, Valerie Bridget, Freeman, Bruce A. and Rubbo, Homero 2009. Macrophage activation induces formation of the anti-inflammatory lipid cholesteryl-nitrolinoleate. Biochemical Journal 417 (1) , pp. 223-234. 10.1042/BJ20080701

Maskrey, B. H., Bermudez-Fajardo, A., Morgan, Alwena Haf, Stewart-Jones, Esther, Dioszeghy, Vincent, Taylor, G. W., Baker, P. R. S., Coles, Barbara, Coffey, Marcus Jonathan, Kuhn, H. and O'Donnell, Valerie Bridget 2009. Activated platelets and monocytes generate four hydroxyphosphatidylethanolamines via lipoxygenase [Addition]. Journal of Biological Chemistry 284 (37) , p. 25460. 10.1074/jbc.A611776200

Morgan, Alwena Haf, Dioszeghy, Vincent, Maskrey, Benjamin, Thomas, Christopher P., Clark, Stephen Robert, Mathie, Sara A., Lloyd, Clare M., Kuhn, Hartmut, Topley, Nicholas, Coles, Barbara, Taylor, Philip Russel, Jones, Simon Arnett and O'Donnell, Valerie Bridget 2009. Phosphatidylethanolamine-esterified eicosanoids in the mouse: tissue localization and inflammation-dependent formation in Th-2 disease. Journal of Biological Chemistry 284 (32) , pp. 21185-21191. 10.1074/jbc.M109.021634

Baker, Paul R. S., Schopfer, Francisco J., O'Donnell, Valerie Bridget and Freeman, Bruce A. 2009. Convergence of nitric oxide and lipid signaling: anti-inflammatory nitro-fatty acids. Free Radical Biology & Medicine 46 (8) , pp. 989-1003. 10.1016/j.freeradbiomed.2008.11.021

Gregory, L. G., Causton, B., Murdoch, J. R., Mathie, S. A., O'Donnell, Valerie Bridget, Thomas, Christopher P., Priest, F. M., Quint, D. J. and Lloyd, C. M. 2009. Inhaled house dust mite induces pulmonary T helper 2 cytokine production. Clinical and Experimental Allergy 39 (10) , pp. 1597-1610. 10.1111/j.1365-2222.2009.03302.x

Zhao, Jinming, Maskrey, Ben, Balzar, Silvana, Chibana, Kazuyuki, Mustovich, Anthony, Hu, Haizhen, Trudeau, John B., O'Donnell, Valerie Bridget and Wenzel, Sally E. 2009. Interleukin-13-induced MUC5AC is regulated by 15-Lipoxygenase 1 pathway in human bronchial epithelial cells. American Journal of Respiratory and Critical Care Medicine 179 (9) , pp. 782-790. 10.1164/rccm.200811-1744OC

Morton, Jonathan, Coles, Barbara, Wright, Kate Louise, Gallimore, Awen Myfanwy, Morrow, Jason D., Terry, Erin S., Anning, Peter, Morgan, Bryan Paul, Dioszeghy, Vincent, Kuhn, Hartmut, Chaitidis, Pavlos, Hobbs, Adrian J., Jones, Simon Arnett and O'Donnell, Valerie Bridget 2008. Circulating neutrophils maintain physiological blood pressure by suppressing bacteria and IFN -dependent iNOS expression in the vasculature of healthy mice. Blood 111 (10) , pp. 5187-5194. 10.1182/blood-2007-10-117283

Dioszeghy, Vincent, Rosas, Marcela, Maskrey, Benjamin H., Colmont, Chantal Sophie, Topley, Nicholas, Chaitidis, Pavlos, Kühn, Hartmut, Jones, Simon Arnett, Taylor, Philip Russel and O'Donnell, Valerie Bridget 2008. 12/15-lipoxygenase regulates the inflammatory response to bacterial products in vivo. The Journal of Immunology 181 (9) , pp. 6514-6524.

Coles, Barbara, Fielding, Ceri Alan, Rose-John, Stefan, Scheller, J., Jones, S. A. and O'Donnell, Valerie Bridget 2007. Classic interleukin-6 receptor signaling and interleukin-6 trans-signaling differentially control angiotensin II-dependent hypertension, cardiac signal transducer and activator of transcription-3 activation, and vascular hypertrophy in vivo. American Journal of Pathology 171 (1) , pp. 315-325. 10.2353/ajpath.2007.061078

Anning, Peter Brian, Coles, Barbara, Morton, Jonathan, Wang, Haibin, Uddin, Jashim, Morrow, Jason D., Dey, Sudhansu K., Marnett, Lawrence J. and O'Donnell, Valerie Bridget 2006. Nitric Oxide deficiency promotes vascular side effects of cyclooxygenase inhibitors. Blood 108 (13) , pp. 4059-4062. 10.1182/blood-2006-02-005330

Williams, Paula Claire, Coffey, Marcus Jonathan, Coles, Barbara, Sanchez, Stephanie, Morrow, Jason D., Cockcroft, John Ronald, Lewis, Malcolm John and O'Donnell, Valerie Bridget 2005. In vivo aspirin supplementation inhibits nitric oxide consumption by human platelets. Blood 106 (8) , pp. 2737-2743. 10.1182/blood-2005-02-0664

Clark, Stephen Robert, Anning, Peter Brian, Coffey, Marcus Jonathan, Roberts, Andrew Glyn, Marnett, Lawrence J. and O'Donnell, Valerie Bridget 2005. Depletion of iNOS-derived nitric oxide by prostaglandin H synthase-2 in inflammation-activated J774.2 macrophages through lipohydroperoxidase turnover. Biochemical Journal 385 (3) , pp. 815-821. 10.1042/BJ20041353

Coffey, Marcus Jonathan, Coles, Barbara, Locke, Matthew, Bermudez-Fajardo, Alexandra, Williams, Paula Claire, Jarvis, Gavin E. and O'Donnell, Valerie Bridget 2004. Interactions of 12-lipoxygenase with phospholipase A2 isoforms following platelet activation through the glycoprotein VI collagen receptor. FEBS Letters 576 (1-2) , pp. 165-168. 10.1016/j.febslet.2004.09.007

Coffey, Marcus Jonathan, Jarvis, Gavin E, Gibbins, Jonathan M., Coles, Barbara, Barrett, Natasha E., Wylie, Oliver R.E. and O'Donnell, Valerie Bridget 2004. Platelet 12-lipoxygenase activation via glycoprotein VI: involvement of multiple signaling pathways in agonist control of H(P)ETE synthesis. Circulation Research 94 (12) , pp. 1598-1605. 10.1161/01.RES.0000132281.78948.65

Clark, Stephen Robert, Coffey, Marcus Jonathan, McLean, Rhona Murray, Collins, Peter William, Lewis, Malcolm John, Cross, Andrew R. and O'Donnell, Valerie Bridget 2002. Characterization of nitric oxide consumption pathways by normal, chronic granulomatous disease and myeloperoxidase-deficient human neutrophils. The Journal of Immunology 169 (10) , pp. 5889-5896.

Coles, Barbara, Bloodsworth, Allison, Clark, Stephen Robert, Lewis, Malcolm John, Cross, Andrew R., Freeman, Bruce A. and O'Donnell, Valerie Bridget 2002. Nitrolinoleate inhibits superoxide generation, degranulation, and integrin expression by human neutrophils: novel antiinflammatory properties of nitric oxide-derived reactive species in vascular cells. Circulation Research 91 (5) , pp. 375-381. 10.1161/01.RES.0000032114.68919.EF

Coffey, Marcus Jonathan, Natarajan, Rama, Chumley, Philip H., Coles, Barbara, Thimmalapura, Pushpa-Rekha, Nowell, Mari Ann, Kühn, Hartmut, Lewis, Malcolm John, Freeman, Bruce A. and O'Donnell, Valerie Bridget 2001. Catalytic consumption of nitric oxide by 12/15- lipoxygenase: inhibition of monocyte soluble guanylate cyclase activation. Proceedings of the National Academy of Sciences of the United States of America (PNAS) ISSN 1091-6490 98 (14) , pp. 8006-8011. 10.1073/pnas.141136098