Browse by Current Cardiff authors

Ciosi, Marc, Maxwell, Alastair, Cumming, Sarah, Hensman Moss, Davina, Alshammari, Asma, Flower, Michael, Durr, Alexandra, Leavitt, Blair, Roos, Raymund, Holmans, Peter, Jones, Lesley, Langbehn, Douglas, Kwak, Seung, Tabrizi, Sarah and Monckton, Darren 2019. A genetic association study of glutamine-encoding DNA sequence structures, somatic CAG expansion, and DNA repair gene variants, with Huntington disease clinical outcomes. EBioMedicine 10.1016/j.ebiom.2019.09.020

Lee, Jong-Min, Correia, Kevin, Loupe, Jacob, Kim, Kyung, Barker, Douglas, Hong, Eun Pyo, Chao, Michael, Long, Jeffery, Lucente, Diane, Vonsattel, Jean, Pinto, Richardo, Ehiana, Ramos, Mysore, Jayalakshmi, Gillis, Tammy, Wheeler, Vanessa, MacDonald, Marcy, Gusella, James, McAllister, Branduff, Massey, Thomas, Medway, Christopher, Stone, Timothy, Hall, Lynsey, Jones, Lesley, Holmans, Peter, Kwark, Seung, Ehrhardt, Anka, Sampaio, Cristina, Ciosi, Marc, Maxwell, Alastair, Chatzi, Afroditi, Monckton, Darren, Orth, Michael, Landwehrmeyer, Bernhard and Paulsen, Jane 2019. CAG repeat not polyglutamine length determines timing of Huntington’s disease onset. Cell 178 (4) , 887-900.e14. 10.1016/j.cell.2019.06.036

Baker, Emily, Sims, Rebecca, Leonenko, Ganna, Frizzati, Aura, Harwood, Janet, Grozena, Detelina, Morgan, Kevin, Passmore, Peter, Holmes, Clives, Powell, John, Brayne, Carol, Gill, Michael, Mead, Simon, Bossu, Paola, Spalletta, Gianfranco, Goate, Alison, Crunchaga, Carlos, Maier, Wolfgang, Heun, Reinhard, Jessen, Frank, Peters, Oliver, Dichgans, Martin, Frolich, Lutz, Ramirez, Alfredo, Jones, Lesley, Hardy, John, Ivanov, Dobril, Hill, Matthew, Holmans, Peter, Allen, Nicholas, Morgan, Paul, Seshadri, Sudha, Schellenberg, Gerard, Amouvel, Philippe, Williams, Julie and Escott-Price, Valentina 2019. Gene-based analysis in HRC imputed genome wide association data identifies three novel genes for Alzheimer’s disease. PLoS ONE 14 (7) , e0218111. 10.1371/journal.pone.0218111

Flowers, Michael, Lomeilkaite, Vilila, Ciosi, Marc, Morales, Fernando, Lo, Kitty, Hensman Moss, Davina, Jones, Lesley, Holmans, Peter, Monckton, Darren and Tabrizi, Sarah 2019. MSH3 modifies somatic instability and disease severity in Huntington’s and myotonic dystrophy type 1. Brain 142 (7) , pp. 1876-1886. 10.1093/brain/awz115

Kunkle, Brian W., Grenier-Boley, Benjamin, Sims, Rebecca, Bis, Joshua C., Damotte, Vincent, Naj, Adam C., Boland, Anne, Vronskaya, Maria, van der Lee, Sven J., Amlie-Wolf, Alexandre, Bellenguez, Céline, Frizatti, Aura, Chouraki, Vincent, Martin, Eden R., Sleegers, Kristel, Badarinarayan, Nandini, Jakobsdottir, Johanna, Hamilton-Nelson, Kara L., Moreno-Grau, Sonia, Olaso, Robert, Raybould, Rachel, Chen, Yuning, Kuzma, Amanda B., Hiltunen, Mikko, Morgan, Taniesha, Ahmad, Shahzad, Vardarajan, Badri N., Epelbaum, Jacques, Hoffmann, Per, Boada, Merce, Beecham, Gary W., Garnier, Jean-Guillaume, Harold, Denise, Fitzpatrick, Annette L., Valladares, Otto, Moutet, Marie-Laure, Gerrish, Amy, Smith, Albert V., Qu, Liming, Bacq, Delphine, Denning, Nicola, Jian, Xueqiu, Zhao, Yi, Del Zompo, Maria, Fox, Nick C., Choi, Seung-Hoan, Mateo, Ignacio, Hughes, Joseph T., Adams, Hieab H., Malamon, John, Sanchez-Garcia, Florentino, Patel, Yogen, Brody, Jennifer A., Dombroski, Beth A., Naranjo, Maria Candida Deniz, Daniilidou, Makrina, Eiriksdottir, Gudny, Mukherjee, Shubhabrata, Wallon, David, Uphill, James, Aspelund, Thor, Cantwell, Laura B., Garzia, Fabienne, Galimberti, Daniela, Hofer, Edith, Butkiewicz, Mariusz, Fin, Bertrand, Scarpini, Elio, Sarnowski, Chloe, Bush, Will S., Meslage, Stéphane, Kornhuber, Johannes, White, Charles C., Song, Yuenjoo, Barber, Robert C., Engelborghs, Sebastiaan, Sordon, Sabrina, Voijnovic, Dina, Adams, Perrie M., Vandenberghe, Rik, Mayhaus, Manuel, Cupples, L. Adrienne, Albert, Marilyn S., De Deyn, Peter P., Gu, Wei, Himali, Jayanadra J., Beekly, Duane, Squassina, Alessio, Hartmann, Annette M., Orellana, Adelina, Blacker, Deborah, Rodriguez-Rodriguez, Eloy, Lovestone, Simon, Garcia, Melissa E., Doody, Rachelle S., Munoz-Fernadez, Carmen, Sussams, Rebecca, Lin, Honghuang, Fairchild, Thomas J., Benito, Yolanda A., Holmes, Clive, Karamuji-omi, Hata, Frosch, Matthew P., Thonberg, Hakan, Maier, Wolfgang, Roschupkin, Gena, Ghetti, Bernardino, Giedraitis, Vilmantas, Kawalia, Amit, Li, Shuo, Huebinger, Ryan M., Kilander, Lena, Moebus, Susanne, Hernández, Isabel, Kamboh, M. Ilyas, Brundin, RoseMarie, Turton, James, Yang, Qiong, Katz, Mindy J., Concari, Letizia, Lord, Jenny, Beiser, Alexa S., Keene, C. Dirk, Helisalmi, Seppo, Kloszewska, Iwona, Kukull, Walter A., Koivisto, Anne Maria, Lynch, Aoibhinn, Tarraga, Lluís, Larson, Eric B., Haapasalo, Annakaisa, Lawlor, Brian, Mosley, Thomas H., Lipton, Richard B., Solfrizzi, Vincenzo, Gill, Michael, Longstreth, W. T., Montine, Thomas J., Frisardi, Vincenza, Diez-Fairen, Monica, Rivadeneira, Fernando, Petersen, Ronald C., Deramecourt, Vincent, Alvarez, Ignacio, Salani, Francesca, Ciaramella, Antonio, Boerwinkle, Eric, Reiman, Eric M., Fievet, Nathalie, Rotter, Jerome I., Reisch, Joan S., Hanon, Olivier, Cupidi, Chiara, Andre Uitterlinden, A. G., Royall, Donald R., Dufouil, Carole, Maletta, Raffaele Giovanni, de Rojas, Itziar, Sano, Mary, Brice, Alexis, Cecchetti, Roberta, George-Hyslop, Peter St, Ritchie, Karen, Tsolaki, Magda, Tsuang, Debby W., Dubois, Bruno, Craig, David, Wu, Chuang-Kuo, Soininen, Hilkka, Avramidou, Despoina, Albin, Roger L., Fratiglioni, Laura, Germanou, Antonia, Apostolova, Liana G., Keller, Lina, Koutroumani, Maria, Arnold, Steven E., Panza, Francesco, Gkatzima, Olymbia, Asthana, Sanjay, Hannequin, Didier, Whitehead, Patrice, Atwood, Craig S., Caffarra, Paolo, Hampel, Harald, Quintela, Inés, Carracedo, Ángel, Lannfelt, Lars, Rubinsztein, David C., Barnes, Lisa L., Pasquier, Florence, Frölich, Lutz, Barral, Sandra, McGuinness, Bernadette, Beach, Thomas G., Johnston, Janet A., Becker, James T., Passmore, Peter, Bigio, Eileen H., Schott, Jonathan M., Bird, Thomas D., Warren, Jason D., Boeve, Bradley F., Lupton, Michelle K., Bowen, James D., Proitsi, Petra, Boxer, Adam, Powell, John F., Burke, James R., Kauwe, John S. K., Burns, Jeffrey M., Mancuso, Michelangelo, Buxbaum, Joseph D., Bonuccelli, Ubaldo, Cairns, Nigel J., McQuillin, Andrew, Cao, Chuanhai, Livingston, Gill, Carlson, Chris S., Bass, Nicholas J., Carlsson, Cynthia M., Hardy, John, Carney, Regina M., Bras, Jose, Carrasquillo, Minerva M., Guerreiro, Rita, Allen, Mariet, Chui, Helena C., Fisher, Elizabeth, Masullo, Carlo, Crocco, Elizabeth A., DeCarli, Charles, Bisceglio, Gina, Dick, Malcolm, Ma, Li, Duara, Ranjan, Graff-Radford, Neill R., Evans, Denis A., Hodges, Angela, Faber, Kelley M., Scherer, Martin, Fallon, Kenneth B., Riemenschneider, Matthias, Fardo, David W., Heun, Reinhard, Farlow, Martin R., Kölsch, Heike, Ferris, Steven, Leber, Markus, Foroud, Tatiana M., Heuser, Isabella, Galasko, Douglas R., Giegling, Ina, Gearing, Marla, Hüll, Michael, Geschwind, Daniel H., Gilbert, John R., Morris, John, Green, Robert C., Mayo, Kevin, Growdon, John H., Feulner, Thomas, Hamilton, Ronald L., Harrell, Lindy E., Drichel, Dmitriy, Honig, Lawrence S., Cushion, Thomas D., Huentelman, Matthew J., Hollingworth, Paul, Hulette, Christine M., Hyman, Bradley T., Marshall, Rachel, Jarvik, Gail P., Meggy, Alun, Abner, Erin, Menzies, Georgina E., Jin, Lee-Way, Leonenko, Ganna, Real, Luis M., Jun, Gyungah R., Baldwin, Clinton T., Grozeva, Detelina, Karydas, Anna, Russo, Giancarlo, Kaye, Jeffrey A., Kim, Ronald, Jessen, Frank, Kowall, Neil W., Vellas, Bruno, Kramer, Joel H., Vardy, Emma, LaFerla, Frank M., Jöckel, Karl-Heinz, Lah, James J., Dichgans, Martin, Leverenz, James B., Mann, David, Levey, Allan I., Pickering-Brown, Stuart, Lieberman, Andrew P., Klopp, Norman, Lunetta, Kathryn L., Wichmann, H-Erich, Lyketsos, Constantine G., Morgan, Kevin, Marson, Daniel C., Brown, Kristelle, Martiniuk, Frank, Medway, Christopher, Mash, Deborah C., Nöthen, Markus M., Masliah, Eliezer, Hooper, Nigel M., McCormick, Wayne C., Daniele, Antonio, McCurry, Susan M., Bayer, Antony, McDavid, Andrew N., Gallacher, John, McKee, Ann C., van den Bussche, Hendrik, Mesulam, Marsel, Brayne, Carol, Miller, Bruce L., Riedel-Heller, Steffi, Miller, Carol A., Miller, Joshua W., Al-Chalabi, Ammar, Morris, John C., Shaw, Christopher E., Myers, Amanda J., Wiltfang, Jens, O'Bryant, Sid, Olichney, John M., Alvarez, Victoria, Parisi, Joseph E., Singleton, Andrew B., Paulson, Henry L., Collinge, John, Perry, William R., Mead, Simon, Peskind, Elaine, Cribbs, David H., Rossor, Martin, Pierce, Aimee, Ryan, Natalie S., Poon, Wayne W., Nacmias, Benedetta, Potter, Huntington, Sorbi, Sandro, Quinn, Joseph F., Sacchinelli, Eleonora, Raj, Ashok, Spalletta, Gianfranco, Raskind, Murray, Caltagirone, Carlo, Bossù, Paola, Orfei, Maria Donata, Reisberg, Barry, Clarke, Robert, Reitz, Christiane, Smith, A David, Ringman, John M., Warden, Donald, Roberson, Erik D., Wilcock, Gordon, Rogaeva, Ekaterina, Bruni, Amalia Cecilia, Rosen, Howard J., Gallo, Maura, Rosenberg, Roger N., Ben-Shlomo, Yoav, Sager, Mark A., Mecocci, Patrizia, Saykin, Andrew J., Pastor, Pau, Cuccaro, Michael L., Vance, Jeffery M., Schneider, Julie A., Schneider, Lori S., Slifer, Susan, Seeley, William W., Smith, Amanda G., Sonnen, Joshua A., Spina, Salvatore, Stern, Robert A., Swerdlow, Russell H., Tang, Mitchell, Tanzi, Rudolph E., Trojanowski, John Q., Troncoso, Juan C., Van Deerlin, Vivianna M., Van Eldik, Linda J., Vinters, Harry V., Vonsattel, Jean Paul, Weintraub, Sandra, Welsh-Bohmer, Kathleen A., Wilhelmsen, Kirk C., Williamson, Jennifer, Wingo, Thomas S., Woltjer, Randall L., Wright, Clinton B., Yu, Chang-En, Yu, Lei, Saba, Yasaman, Pilotto, Alberto, Bullido, Maria J., Peters, Oliver, Crane, Paul K., Bennett, David, Bosco, Paola, Coto, Eliecer, Boccardi, Virginia, De Jager, Phil L., Lleo, Alberto, Warner, Nick, Lopez, Oscar L., Ingelsson, Martin, Deloukas, Panagiotis, Cruchaga, Carlos, Graff, Caroline, Gwilliam, Rhian, Fornage, Myriam, Goate, Alison M., Sanchez-Juan, Pascual, Kehoe, Patrick G., Amin, Najaf, Ertekin-Taner, Nilifur, Berr, Claudine, Debette, Stéphanie, Love, Seth, Launer, Lenore J., Younkin, Steven G., Dartigues, Jean-Francois, Corcoran, Chris, Ikram, M. Arfan, Dickson, Dennis W., Nicolas, Gael, Campion, Dominique, Tschanz, JoAnn, Schmidt, Helena, Hakonarson, Hakon, Clarimon, Jordi, Munger, Ron, Schmidt, Reinhold, Farrer, Lindsay A., Van Broeckhoven, Christine, O'Donovan, Michael C, DeStefano, Anita L., Jones, Lesley, Haines, Jonathan L., Deleuze, Jean-Francois, Owen, Michael J, Gudnason, Vilmundur, Mayeux, Richard, Escott-Price, Valentina, Psaty, Bruce M., Ramirez, Alfredo, Wang, Li-San, Ruiz, Agustin, van Duijn, Cornelia M., Holmans, Peter, Seshadri, Sudha, Williams, Julie, Amouyel, Phillippe, Schellenberg, Gerard D., Lambert, Jean-Charles and Pericak-Vance, Margaret A. 2019. Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nature Genetics 51 (3) , pp. 414-430. 10.1038/s41588-019-0358-2

Goold, Robert, Flower, Michael, Moss, Davina Hensman, Medway, Christopher, Wood-Kaczmar, Alison, Andre, Ralph, Farshim, Pamela, Bates, Gill P, Holmans, Peter, Jones, Lesley and Tabrizi, Sarah J 2019. FAN1 modifies Huntington's disease progression by stabilising the expanded HTT CAG repeat. Human Molecular Genetics 28 (4) , pp. 650-661. 10.1093/hmg/ddy375

Benn, Caroline, Davis, John, Dawson, Lee, Dawson, Gerry, Evans, Alison, Fox, Nick, Gallacher, John, Hutton, Mike, Isaac, John, Jones, Declan, Jones, Lesley, Libri, Vincenzo, Lovestone, Simon, Mauricio, Rui, Moody, Catherine, Noble, Wendy, Perry, Hugh, Pickett, James, Reynolds, David, Ritche, Craig, Rohrer, John, Routledge, Carol, Rowe, James, Snyder, Heather, Spires-Jones, Tara, Swartz, Jina, Truyen, Luc and Whiting, Paul 2019. Tackling gaps in developing life-changing treatments for dementia. Alzheimer's & Dementia: Translational Research & Clinical Interventions 5 , pp. 241-253. 10.1016/j.trci.2019.05.001

McNulty, Paul, Pilcher, Richard, Ramesh, Raviram, Necuiniate, Renata, Hughes, Alis, Farewell, Daniel, Holmans, Peter and Jones, Lesley 2018. Reduced cancer incidence in Huntington's disease: analysis in the Registry study. Journal of Huntington's Disease 7 (3) , pp. 209-222. 10.3233/JHD-170263

Carboni, Lucia, Marchetti, Luca, Lauria, Mario, Gass, Peter, Vollmayr, Barbara, Redfern, Amanda, Jones, Lesley, Razzoli, Maria, Malki, Karim, Begni, Veronica, Riva, Marco A., Domenici, Enrico, Caberlotto, Laura and Mathé, Aleksander A. 2018. Cross-species evidence from human and rat brain transcriptome for growth factor signaling pathway dysregulation in major depression. Neuropsychopharmacology 43 , pp. 2134-2145. 10.1038/s41386-018-0117-6

Massey, Thomas, McAllister, Branduff and Jones, Lesley 2018. Methods for assessing DNA repair and repeat expansion in Huntington's Disease. Methods in Molecular Biology 1780 , pp. 483-495. 10.1007/978-1-4939-7825-0_22

Chao, Michael J., Kim, Kyung-Hee, Shin, Jun Wan, Lucente, Diane, Wheeler, Vanessa C., Li, Hong, Roach, Jared C., Hood, Leroy, Wexler, Nancy S., Jardim, Laura B., Holmans, Peter, Jones, Lesley, Orth, Michael, Kwak, Seung, MacDonald, Marcy E., Gusella, James F. and Lee, Jong-Min 2018. Population-specific genetic modification of Huntington's disease in Venezuela. PLoS Genetics 14 (5) , e1007274. 10.1371/journal.pgen.1007274

Massey, Thomas and Jones, Lesley 2018. The central role of DNA damage and repair in CAG repeat diseases. Disease Models & Mechanisms 11 (1) , dmm031930. 10.1242/dmm.031930

Lee, Jong-Min, Chao, Michael J., Harold, Denise, Abu Elneel, Kawther, Gillis, Tammy, Holmans, Peter, Jones, Lesley, Orth, Michael, Myers, Richard H., Kwak, Seung, Wheeler, Vanessa C, MacDonald, Marcy E. and Gusella, James F. 2017. A modifier of Huntington's disease onset at the MLH1 locus. Human Molecular Genetics 26 (19) , pp. 3859-3867. 10.1093/hmg/ddx286

Holmans, Peter A., Massey, Thomas H. and Jones, Lesley 2017. Genetic modifiers of Mendelian disease: Huntington's disease and the trinucleotide repeat disorders. Human Molecular Genetics 26 (R2) , R83-R90. 10.1093/hmg/ddx261

Sims, Rebecca, van der Lee, Sven J, Naj, Adam C, Badarinarayan, Nandini, Morgan, Taniesha, Denning, Nicola, Majounie, Elisa, O'Donovan, Michael, Owen, Michael, Jones, Lesley, Escott-Price, Valentina, Holmans, Peter and Williams, Julie 2017. Rare coding variants in PLCG2, ABI3 and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nature Genetics 49 , pp. 1373-1384. 10.1038/ng.3916

Chao, Michael J., Gillis, Tammy, Atwal, Ranjit S., Srinidhi Mysore, Jayalakshmi, Arjomand, Jamshid, Harold, Denise, Holmans, Peter Alan, Jones, Lesley, Orth, Michael, Myers, Richard H., Kwak, Seung, Wheeler, Vanessa C., MacDonald, Marcy E., Gusella, James F. and Lee, Jong-Min 2017. Haplotype-based stratification of Huntington's disease. European Journal of Human Genetics 25 , pp. 1202-1209. 10.1038/ejhg.2017.125

Escott-Price, Valentina and Jones, Lesley 2017. Genomic profiling and diagnostic biomarkers in Alzheimer's disease. The Lancet Neurology 16 (8) , pp. 582-583. 10.1016/S1474-4422(17)30202-8

Hensman Moss, Davina J., Flower, Michael D., Lo, Kitty K., Miller, James R. C., van Ommen, Gert-Jan B., 't Hoen, Peter A. C., Stone, Timothy C., Guinee, Amelia, Langbehn, Douglas R., Jones, Lesley, Plagnol, Vincent, van Roon-Mom, Willeke M. C., Holmans, Peter and Tabrizi, Sarah J. 2017. Huntington's disease blood and brain show a common gene expression pattern and share an immune signature with Alzheimer's disease. Scientific Reports 7 , -. 10.1038/srep44849

Bowles, Kathryn R., Stone, Timothy C., Holmans, Peter Alan, Allen, Nicholas Denby, Dunnett, Stephen Bruce and Jones, Lesley 2017. SMAD transcription factors are altered in cell models of HD and regulate HTT expression. Cellular Signalling 31 , pp. 1-14. 10.1016/j.cellsig.2016.12.005

Morgan, Angharad, Touchard, Samuel, O'Hagan, Caroline, Sims, Rebecca, Majounie, Elisa, Escott-Price, Valentina, Jones, Lesley, Williams, Julie and Morgan, Bryan 2017. The correlation between inflammatory biomarkers and polygenic risk score in Alzheimer's Disease. Journal of Alzheimer's Disease 56 (1) , pp. 25-36. 10.3233/JAD-160889

Jones, Lesley, Houlden, Henry and Tabrizi, Sarah J. 2017. DNA repair in the trinucleotide repeat disorders. The Lancet Neurology 16 (1) , pp. 88-96. 10.1016/S1474-4422(16)30350-7

Bowles, Kathryn R., Brooks, Simon P., Hughes, Alis, Dunnett, Stephen Bruce and Jones, Lesley 2016. Correction: Huntingtin Subcellular localisation is regulated by kinase signalling activity in the StHdhQ111 model of HD. PLoS ONE 11 (10) , e0165069. 10.1371/journal.pone.0165069

Precious, Sophie Victoria, Kelly, Claire M., Reddington, A. E., Vinh, Ngoc-Nga, Stickland, Rachael, Pekarik, V., Scherf, C., Jeyasingham, R., Glasbey, James, Holeiter, M., Jones, Lesley, Taylor, Michael Victor and Rosser, Anne Elizabeth 2016. FoxP1 marks medium spiny neurons from precursors to maturity and is required for their differentiation. Experimental Neurology 282 , pp. 9-18. 10.1016/j.expneurol.2016.05.002

Thomas, Rhian, Henson, Alexander, Gerrish, Amy, Jones, Lesley, Williams, Julie and Kidd, Emma Jane 2016. Decreasing the expression of PICALM reduces endocytosis and the activity of β-secretase: implications for Alzheimer's disease. BMC Neuroscience 17 , 50. 10.1186/s12868-016-0288-1

Miller, James RC, Lo, Kitty K, Andre, Ralph, Moss, Davina J Hensman, Träger, Ulrike, Stone, Timothy C., Jones, Lesley, Holmans, Peter, Plagnol, Vincent and Tabrizi, Sarah J 2016. RNA-Seq of Huntington's Disease patient myeloid cells reveals innate transcriptional dysregulation associated with proinflammatory pathway activation. Human Molecular Genetics 25 (14) , pp. 2893-2904. 10.1093/hmg/ddw142

Bettencourt, Conceicao, Hensman-Moss, Davina J., Flower, Michael, Wiethoff, Sarah, Brice, Alexis, Goizet, Cyril, Stevanin, Giovanni, Koutis, Georgios, Karadima, Georgia, Panos, Marios, Yescas-Gomez, Petra, Garcia-Velazquez, Lizbeth Esmeralda, Alonso-Vilatela, Maria Elisa, Lima, Manuela, Raposo, Mafalda, Traynor, Bryan, Sweeney, Mary, Wood, Nicholas, Guinti, Paola, Holmans, Peter Alan, Durr, Alexandra, Houlden, Henry, Tabrizi, Sarah J. and Jones, Lesley 2016. DNA repair pathways underlie a common genetic mechanism modulating onset in polyglutamine diseases. Annals of Neurology 79 (6) , pp. 983-990. 10.1002/ana.24656

Bayram-Weston, Zubeyde, Jones, Lesley, Dunnett, Stephen Bruce and Brooks, Simon Philip 2016. Comparison of mHTT antibodies in Huntington's disease mouse models reveal specific binding profiles and steady-state ubiquitin levels with disease development. PloS One 10.1371/journal.pone.0155834

Keum, Jae Whan, Shin, Aram, Gillis, Tammy, Mysore, Jayalakshmi Srinidhi, Elneel, Kawther Abu, Lucente, Diane, Hadzi, Tiffany, Holmans, Peter Alan, Jones, Lesley, Orth, Michael, Kwak, Seung, MacDonald, Marcy, Gusella, James F. and Lee, Jong-Min 2016. The HTT CAG expansion mutation determines age at death but not disease duration in Huntington’s Disease. American Journal of Human Genetics 98 (2) , pp. 287-298. 10.1016/j.ajhg.2015.12.018

Keum, Jae Whan, Shin, Aram, Gillis, Tammy, Mysore, Jayalakshmi Srinidhi, Abu Elneel, Kawther, Lucente, Diane, Hadzi, Tiffany, Holmans, Peter, Jones, Lesley, Orth, Michael, Kwak, Seung, MacDonald, Marcy E., Gusella, James F. and Lee, Jong-Min 2016. The HTT CAG-Expansion mutation determines age at death but not disease duration in Huntington disease. The American Journal of Human Genetics 98 (2) , pp. 287-298. 10.1016/j.ajhg.2015.12.018

Bayram-Weston, Zubeyde, Stone, Timothy C., Giles, Peter James, Elliston, Linda Anne, Janghra, Narinder, Higgs, Gemma, Holmans, Peter Alan, Dunnett, Stephen Bruce, Brooks, Simon Philip and Jones, Lesley 2015. Similar striatal gene expression profiles in the striatum of the YAC128 and HdhQ150 mouse models of Huntington's disease are not reflected in mutant Huntingtin inclusion prevalence. BMC Genomics 16 , -. 10.1186/s12864-015-2251-4

Bowles, Kathryn R., Brooks, Simon P., Dunnett, Stephen Bruce and Jones, Lesley 2015. Huntingtin subcellular localisation is regulated by Kinase signalling activity in the StHdhQ111 model of HD. PLoS ONE 10 (12) , e0144864. 10.1371/journal.pone.0144864

Escott-Price, Valentina, Sims, Rebecca, Bannister, Christian, Harold, Denise, Vronskaya, Maria, Majounie, Elisa, Badarinarayan, Nandini, Morgan, Kevin, Passmore, Peter, Holmes, Clive, Powell, John, Brayne, Carol, Gill, Michael, Mead, Simon, Goate, Alison, Cruchaga, Carlos, Lambert, Jean-Charles, van Duijn, Cornelia, Maier, Wolfgang, Ramirez, Alfredo, Holmans, Peter Alan, Jones, Lesley, Hardy, John, Seshadri, Sudha, Schellenberg, Gerard D., Amouyel, Philippe and Williams, Julie 2015. Common polygenic variation enhances risk prediction for Alzheimer's disease. Brain 138 (12) , pp. 3673-3684. 10.1093/brain/awv268

Lee, J. M., Wheeler, V. C., Chao, M. J., Vonsattel, P., Pinto, R. M., Lucente, D., Abu-Elmeel, K., Ramos, E. M., Mysore, J. S., Gillis, T., MacDonald, M. E., Gusella, J. F., Harold, Denise, Stone, Timothy C., Escott-Price, Valentina, Han, Jun, Vedernikov, Alexey, Holmans, Peter Alan, Jones, Lesley, Kwak, S., Mahmoudi, M., Orth, M., Landwehmeyer, G. B., Paulsen, J. S., Dorsey, R., Shoulson, I. and Myers, R. H. 2015. Identification of Genetic Factors that Modify Clinical Onset of Huntington's Disease. Cell 162 (3) , pp. 516-26. 10.1016/j.cell.2015.07.003

Mort, Matthew Edwin, Carlisle, Francesca, Waite, Adrian, Elliston, Lyn, Allen, Nicholas Denby, Jones, Lesley and Hughes, Alis 2015. Huntingtin exists as multiple splice forms in human brain. Journal of Huntington's Disease 4 (2) , pp. 161-171. 10.3233/JHD-150151

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Brooks, Simon Philip, Higgs, Gemma, Jones, Lesley and Dunnett, Stephen Bruce 2012. Longitudinal analysis of the behavioural phenotype in Hdh(CAG)150 Huntington's disease knock-in mice. Brain Research Bulletin 88 (2-3) , pp. 182-188. 10.1016/j.brainresbull.2010.05.004

Bayram-Weston, Zubeyde, Torres, Eduardo Miguel, Jones, Lesley, Dunnett, Stephen Bruce and Brooks, Simon Philip 2012. Light and electron microscopic characterization of the evolution of cellular pathology in the Hdh((CAG)150) Huntington's disease knock-in mouse. Brain Research Bulletin 88 (2-3) , pp. 189-198. 10.1016/j.brainresbull.2011.03.014

Brooks, Simon Philip, Higgs, Gemma, Janghra, Nari, Jones, Lesley and Dunnett, Stephen Bruce 2012. Longitudinal analysis of the behavioural phenotype in YAC128 (C57BL/6J) Huntington's disease transgenic mice. Brain Research Bulletin 88 (2-3) , pp. 113-120. 10.1016/j.brainresbull.2010.05.005

Brooks, Simon Philip, Janghra, Nari, Workman, Victoria Louise, Bayram-Weston, Zubeyde, Jones, Lesley and Dunnett, Stephen Bruce 2012. Longitudinal analysis of the behavioural phenotype in R6/1 (C57BL/6J) Huntington's disease transgenic mice. Brain Research Bulletin 88 (2-3) , pp. 94-103. 10.1016/j.brainresbull.2011.01.010

Trueman, Rebecca C., Dunnett, Stephen Bruce, Jones, Lesley and Brooks, Simon Philip 2012. Five choice serial reaction time performance in the HdhQ92 mouse model of Huntington's disease. Brain Research Bulletin 88 (2-3) , pp. 163-170. 10.1016/j.brainresbull.2011.10.019

Bayram-Weston, Zubeyde, Jones, Lesley, Dunnett, Stephen Bruce and Brooks, Simon Philip 2012. Light and electron microscopic characterization of the evolution of cellular pathology in YAC128 Huntington's disease transgenic mice. Brain Research Bulletin 88 (2-3) , pp. 137-147. 10.1016/j.brainresbull.2011.05.005

Bayram-Weston, Zubeyde, Jones, Lesley, Dunnett, Stephen Bruce and Brooks, Simon Philip 2012. Light and electron microscopic characterization of the evolution of cellular pathology in the R6/1 Huntington's disease transgenic mice. Brain Research Bulletin 88 (2-3) , pp. 104-112. 10.1016/j.brainresbull.2011.07.009

Trueman, Rebecca C., Jones, Lesley, Dunnett, Stephen Bruce and Brooks, Simon Philip 2012. Early onset deficits on the delayed alternation task in the HdhQ92 knock-in mouse model of Huntington's disease. Brain Research Bulletin 88 (2-3) , pp. 156-162. 10.1016/j.brainresbull.2011.03.012

Bayram-Weston, Zubeyde, Jones, Lesley, Dunnett, Stephen Bruce and Brooks, Simon Philip 2012. Light and electron microscopic characterization of the evolution of cellular pathology in HdhQ92 Huntington's disease knock-in mice. Brain Research Bulletin 88 (2-3) , pp. 171-181. 10.1016/j.brainresbull.2011.03.013

Brooks, Simon Philip, Janghra, Narinder, Higgs, Gemma V., Bayram-Weston, Zubeyde, Heuer, Andreas, Jones, Lesley and Dunnett, Stephen Bruce 2012. Selective cognitive impairment in the YAC128 Huntington's disease mouse. Brain Research Bulletin 88 (2-3) , pp. 121-129. 10.1016/j.brainresbull.2011.05.010

Fielding, Steven A., Brooks, Simon Philip, Klein, Alexander, Bayram-Weston, Zubeyde, Jones, Lesley and Dunnett, Stephen Bruce 2012. Profiles of motor and cognitive impairment in the transgenic rat model of Huntington's disease. Brain Research Bulletin 88 (2-3) , pp. 223-236. 10.1016/j.brainresbull.2011.09.011

Brooks, Simon Philip, Jones, Lesley and Dunnett, Stephen Bruce 2012. Comparative analysis of pathology and behavioural phenotypes in mouse models of Huntington's disease. Brain Research Bulletin 88 (2-3) , pp. 81-93. 10.1016/j.brainresbull.2011.10.002

Brooks, Simon Philip, Jones, Lesley and Dunnett, Stephen Bruce 2012. Longitudinal analyses of operant performance on the serial implicit learning task (SILT) in the YAC128 Huntington's disease mouse line. Brain Research Bulletin 88 (2-3) , pp. 130-136. 10.1016/j.brainresbull.2011.06.008

Bowles, Kathryn R., Brooks, Simon Philip, Dunnett, Stephen Bruce and Jones, Lesley 2012. Gene expression and behaviour in mouse models of HD. Brain Research Bulletin 88 (2-3) , pp. 276-284. 10.1016/j.brainresbull.2011.07.021

Giles, Peter James, Elliston, Linda Anne, Higgs, Gemma, Brooks, Simon Philip, Dunnett, Stephen Bruce and Jones, Lesley 2012. Longitudinal analysis of gene expression and behaviour in the HdhQ150 mouse model of Huntington's disease. Brain Research Bulletin 88 (2-3) , pp. 199-209. 10.1016/j.brainresbull.2011.10.001

Richards, Alexander, Jones, Lesley, Escott-Price, Valentina, Kirov, George, Gejman, P. V., Levinson, D. F., Sanders, A. R., Molecular Genetics of Schizophrenia Collaboration (MGS), , International Schizophrenia Consortium (ISC), , Purcell, S., Visscher, P. M., Craddock, Nicholas John, Owen, Michael John, Holmans, Peter Alan and O'Donovan, Michael Conlon 2012. Schizophrenia susceptibility alleles are enriched for alleles that affect gene expression in adult human brain. Molecular Psychiatry 17 (2) , pp. 193-201. 10.1038/mp.2011.11

Gerrish, Amy, Russo, Giancarlo, Richards, Alexander, Escott-Price, Valentina, Ivanov, Dobril, Harold, Denise, Sims, Rebecca, Abraham, Richard Alun, Hollingworth, Paul, Chapman, Jade Alice, Hamshere, Marian Lindsay, Pahwa, Jaspreet Singh, Dowzell, Kimberley Frances, Williams, Amy, Denning, Nicola, Thomas, Charlene, Stretton, Alexandra, Morgan, Angharad Rhys, Lovestone, Simon, Powell, John, Proitsi, Petroula, Lupton, Michelle K., Brayne, Carol, Rubinsztein, David C., Gill, Michael, Lawlor, Brian, Lynch, Aoibhinn, Morgan, Kevin, Brown, Kristelle S., Passmore, Peter A., Craig, David, McGuinness, Bernadette, Todd, Stephen, Johnston, Janet A., Holmes, Clive, Mann, David, Smith, A. David, Love, Seth, Kehoe, Patrick G., Hardy, John, Mead, Simon, Fox, Nick, Rossor, Martin, Collinge, John, Maier, Wolfgang, Jessen, Frank, Kölsch, Heike, Heun, Reinhard, Schürmann, Britta, van den Bussche, Hendrik, Heuser, Isabella, Kornhuber, Johannes, Wiltfang, Jens, Dichgans, Martin, Frölich, Lutz, Hampel, Harald, Hüll, Michael, Rujescu, Dan, Goate, Alison M., Kauwe, John S. K., Cruchaga, Carlos, Nowotny, Petra, Morris, John C., Mayo, Kevin, Livingston, Gill, Bass, Nicholas J., Gurling, Hugh, McQuillin, Andrew, Gwilliam, Rhian, Deloukas, Panagiotis, Davies, Gail, Harris, Sarah E., Starr, John M., Deary, Ian J., Al-Chalabi, Ammar, Shaw, Christopher E., Tsolaki, Magda, Singleton, Andrew B., Guerreiro, Rita, Mühleisen, Thomas W., Nöthen, Markus M., Moebus, Susanne, Jöckel, Karl-Heinz, Klopp, Norman, Wichmann, H-Erich, Carrasquillo, Minerva M, Pankratz, V. Shane, Younkin, Steven G., Jones, Lesley, Holmans, Peter Alan, O'Donovan, Michael Conlon, Owen, Michael John and Williams, Julie 2012. The role of variation at AβPP, PSEN1, PSEN2, and MAPT in late onset Alzheimer's Disease. Journal of Alzheimer's Disease 28 (2) , pp. 377-387. 10.3233/JAD-2011-110824

Hughes, Alis, Rosser, Anne Elizabeth and Jones, Lesley 2012. E06 Family history curation in Huntington's disease: a survey of the data so far. Journal of Neurology, Neurosurgery & Psychiatry 83 (Suppl) , A21-A21. 10.1136/jnnp-2012-303524.65

Bayram-Weston, Zubeyde, Jones, Lesley, Dunnett, Stephen Bruce and Brooks, Simon P. 2012. B08 Differential sensitivity of aggregate markers in HdhQ150 and YAC128 HD mouse models. Journal of Neurology, Neurosurgery & Psychiatry 83 (Suppl) , A8-A8. 10.1136/jnnp-2012-303524.24

Feyeux, M., Bourgois-Rocha, F., Redfern, Amanda Jane, Giles, Peter James, Lefort, N., Aubert, S., Bonnefond, C., Buiga, A., Ruiz, M., Deglon, N., Jones, Lesley, Peschanski, M., Allen, Nicholas Denby and Perrier, A. L. 2012. Early transcriptional changes linked to naturally occurring Huntington's disease mutations in neural derivatives of human embryonic stem cells. Human Molecular Genetics 21 (17) , pp. 3883-3895. 10.1093/hmg/dds216

Hollingworth, Paul, Harold, Denise, Sims, Rebecca, Gerrish, Amy, Lambert, Jean-Charles, Carrasquillo, Minerva M., Abraham, Richard Alun, Hamshere, Marian Lindsay, Pahwa, Jaspreet Singh, Escott-Price, Valentina, Dowzell, Kimberley Frances, Denning, Nicola, Stretton, Alexandra, Thomas, Charlene, Richards, Alexander, Ivanov, Dobril, Widdowson, Caroline Susan, Chapman, Jade Alice, Lovestone, Simon, Powell, John, Proitsi, Petroula, Lupton, Michelle K., Brayne, Carol, Rubinsztein, David C., Gill, Michael, Lawlor, Brian, Lynch, Aoibhinn, Brown, Kristelle S., Passmore, Peter A., Craig, David, McGuinness, Bernadette, Todd, Stephen, Holmes, Clive, Mann, David, Smith, A David, Beaumont, Helen, Warden, Donald, Wilcock, Gordon, Love, Seth, Kehoe, Patrick G., Hooper, Nigel M., Vardy, Emma R. L. C., Hardy, John, Mead, Simon, Fox, Nick C, Rossor, Martin, Collinge, John, Maier, Wolfgang, Jessen, Frank, Rüther, Eckart, Schürmann, Britta, Heun, Reiner, Kölsch, Heike, van den Bussche, Hendrik, Heuser, Isabella, Kornhuber, Johannes, Wiltfang, Jens, Dichgans, Martin, Frölich, Lutz, Hampel, Harald, Gallacher, John Edward, Hüll, Michael, Rujescu, Dan, Giegling, Ina, Goate, Alison M., Kauwe, John S. K., Cruchaga, Carlos, Nowotny, Petra, Morris, John C., Mayo, Kevin, Sleegers, Kristel, Bettens, Karolien, Engelborghs, Sebastiaan, De Deyn, Peter P, Van Broeckhoven, Christine, Livingston, Gill, Bass, Nicholas J., Gurling, Hugh, McQuillin, Andrew, Gwilliam, Rhian, Deloukas, Panagiotis, Al-Chalabi, Ammar, Shaw, Christopher E., Tsolaki, Magda, Singleton, Andrew B., Guerreiro, Rita, Mühleisen, Thomas W., Nöthen, Markus M., Moebus, Susanne, Jöckel, Karl-Heinz, Klopp, Norman, Wichmann, H-Erich, Pankratz, V. Shane, Sando, Sigrid B., Aasly, Jan O., Barcikowska, Maria, Wszolek, Zbigniew K., Dickson, Dennis W., Graff-Radford, Neill R., Petersen, Ronald C., van Duijn, Cornelia M., Breteler, Monique M. B., Ikram, M. Arfan, DeStefano, Anita L., Fitzpatrick, Annette L., Lopez, Oscar, Launer, Lenore J., Seshadri, Sudha, Berr, Claudine, Campion, Dominique, Epelbaum, Jacques, Dartigues, Jean-François, Tzourio, Christophe, Alpérovitch, Annick, Lathrop, Mark, Feulner, Thomas M., Friedrich, Patricia, Riehle, Caterina, Krawczak, Michael, Schreiber, Stefan, Mayhaus, Manuel, Nicolhaus, S., Wagenpfeil, Stefan, Steinberg, Stacy, Stefansson, Hreinn, Stefansson, Kari, Snædal, Jon, Björnsson, Sigurbjörn, Jonsson, Palmi V., Chouraki, Vincent, Genier-Boley, Benjamin, Hiltunen, Mikko, Soininen, Hilkka, Combarros, Onofre, Zelenika, Diana, Delepine, Marc, Bullido, Maria J., Pasquier, Florence, Mateo, Ignacio, Frank-Garcia, Ana, Porcellini, Elisa, Hanon, Olivier, Coto, Eliecer, Alvarez, Victoria, Bosco, Paolo, Siciliano, Gabriele, Mancuso, Michelangelo, Panza, Francesco, Solfrizzi, Vincenzo, Nacmias, Benedetta, Sorbi, Sandro, Bossù, Paola, Piccardi, Paola, Arosio, Beatrice, Annoni, Giorgio, Seripa, Davide, Pilotto, Alberto, Scarpini, Elio, Galimberti, Daniela, Brice, Alexis, Hannequin, Didier, Licastro, Federico, Jones, Lesley, Holmans, Peter Alan, Jonsson, Thorlakur, Riemenschneider, Matthias, Morgan, Kevin, Younkin, Steven G., Owen, Michael John, O'Donovan, Michael Conlon, Amouyel, Philippe and Williams, Julie 2011. Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nature Genetics 43 (5) , pp. 429-435. 10.1038/ng.803

Jones, Lesley and Hughes, Alis 2011. Pathogenic mechanisms in Huntington's Disease. International Review of Neurobiology 98 , pp. 373-418. 10.1016/B978-0-12-381328-2.00015-8

Sims, Rebecca, Dwyer, Sarah Lynne, Harold, Denise, Gerrish, Amy, Hollingworth, Paul, Chapman, Jade Alice, Denning, Nicola, Abraham, Richard Alun, Ivanov, Dobril, Pahwa, Jaspreet Singh, Escott-Price, Valentina, Dowzell, Kimberley Frances, Thomas, Charlene, Stretton, Alexandra, Lovestone, Simon, Powell, John, Proitsi, Petroula, Lupton, Michelle K., Brayne, Carol, Rubinsztein, David C., Gill, Michael, Lawlor, Brian, Lynch, Aoibhinn, Morgan, Kevin, Brown, Kristelle S., Passmore, Peter A., Craig, David, McGuiness, Bernadette, Todd, Stephen, Johnston, Janet A., Holmes, Clive, Mann, David, Smith, A. David, Love, Seth, Kehoe, Patrick G., Hardy, John, Mead, Simon, Fox, Nick, Rossor, Martin, Collinge, John, Livingston, Gill, Bass, Nicholas J., Gurling, Hugh, McQuillin, Andrew, Jones, Lesley, Holmans, Peter Alan, O'Donovan, Michael Conlon, Owen, Michael John and Williams, Julie 2011. No evidence that extended tracts of homozygosity are associated with Alzheimer's disease. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 156 (7) , pp. 764-771. 10.1002/ajmg.b.31216

Hughes, Alis and Jones, Lesley 2011. Huntingtin localisation studies - a technical review. Plos Currents 3 , RRN1211. 10.1371/currents.RRN1211

Jones, Lesley, Holmans, Peter Alan, Hamshere, Marian Lindsay, Harold, Denise, Escott-Price, Valentina, Ivanov, Dobril, Pocklington, Andrew, Abraham, Richard Alun, Hollingworth, Paul, Sims, Rebecca, Gerrish, Amy, Pahwa, Jaspreet Singh, Denning, Nicola, Stretton, Alexandra, Morgan, Angharad Rhys, Lovestone, Simon, Powell, John, Proitsi, Petroula, Lupton, Michelle K., Brayne, Carol, Rubinsztein, David C., Gill, Michael, Lawlor, Brian, Lynch, Aoibhinn, Morgan, Kevin, Brown, Kristelle S., Passmore, Peter A., Craig, David, McGuinness, Bernadette, Todd, Stephen, Holmes, Clive, Mann, David, Smith, A. David, Love, Seth, Kehoe, Patrick G., Mead, Simon, Fox, Nick, Rossor, Martin, Collinge, John, Maier, Wolfgang, Jessen, Frank, Schürmann, Britta, Heun, Reinhard, Kölsch, Heike, van den Bussche, Hendrik, Heuser, Isabella, Peters, Oliver, Kornhuber, Johannes, Wiltfang, Jens, Dichgans, Martin, Frölich, Lutz, Hampel, Harald, Hüll, Michael, Rujescu, Dan, Goate, Alison M., Kauwe, John S. K., Cruchaga, Carlos, Nowotny, Petra, Mayo, Kevin, Morris, John C., Livingston, Gill, Bass, Nicholas J., Gurling, Hugh, McQuillin, Andrew, Gwilliam, Rhian, Deloukas, Panos, Al-Chalabi, Ammar, Shaw, Christopher E., Singleton, Andrew B., Guerreiro, Rita, Mühleisen, Thomas W., Nöthen, Markus M., Moebus, Susanne, Jöckel, Karl-Heinz, Klopp, Norman, Wichmann, H.-Erich, Rüther, Eckhard, Carrasquillo, Minerva M., Pankratz, V. Shane, Younkin, Steven G., Hardy, John, O'Donovan, Michael Conlon, Williams, Julie and Owen, Michael John 2010. Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease. PLoS ONE 5 (11) , e13950. 10.1371/journal.pone.0013950

Craddock, Nicholas John, Jones, Lesley, Jones, Ian Richard, Kirov, George, Green, Elaine Karen, Grozeva, Detelina Valentinova, Escott-Price, Valentina, Nikolov, Ivan, Hamshere, Marian Lindsay, Vukcevic, D., Caesar, S., Gordon-Smith, Katherine, Fraser, Christine, Russell, E., Norton, Nadine, Breen, G., St Clair, D., Collier, D. A., Young, A. H., Ferrier, I. N., Farmer, A, McGuffin, P., Holmans, Peter Alan, Donnelly, Peter, Owen, Michael John and O'Donovan, Michael Conlon 2010. Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype [Corrigendum]. Molecular Psychiatry 15 (11) , p. 1121. 10.1038/mp.2010.62

Brooks, Simon Philip, Jones, Lesley and Dunnett, Stephen Bruce 2010. Frontostriatal pathology in the (C57BL/6J) YAC128 mouse uncovered by the operant delayed alternation task [Meeting abstract]. Journal of Neurology, Neurosurgery and Psychiatry 81 (1) , A9-A10. 10.1136/jnnp.2010.222570.29

Hughes, Alis, Ersoy, N., Elliston, Linda Anne and Jones, Lesley 2010. Protein localisation studies: Where is Huntingtin hiding? [Meeting abstract]. Journal of Neurology, Neurosurgery and Psychiatry 81 (1) , A1. 10.1136/jnnp.2010.222570.3

Hollingworth, Paul, Harold, Denise, Jones, Lesley, Owen, Michael John and Williams, Julie 2010. Alzheimer's disease genetics: current knowledge and future challenges. International Journal of Geriatric Psychiatry 26 (8) , pp. 793-802. 10.1002/gps.2628

Jones, Lesley, Harold, Denise and Williams, Julie 2010. Genetic evidence for the involvement of lipid metabolism in Alzheimer's disease. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1801 (8) , pp. 754-761. 10.1016/j.bbalip.2010.04.005

Trueman, Rebecca C., Brooks, Simon Philip, Jones, Lesley and Dunnett, Stephen Bruce 2009. Rule learning, visuospatial function and motor performance in the Hdh(Q92) knock-in mouse model of Huntington's disease. Behavioural Brain Research 203 (2) , pp. 215-222. 10.1016/j.bbr.2009.05.006

Wood, Ian C., Gray, Nicola K. and Jones, Lesley 2009. Gene expression in neuronal disease. Biochemical Society Transactions 37 (6) , pp. 1261-1262. 10.1042/BST0371261

Packer, Amy N., Xing, Yi, Harper, Scott Q., Jones, Lesley and Davidson, Beverley L. 2008. The bifunctional microRNA miR-9/miR-9* regulates REST and CoREST and is downregulated in Huntington's disease. Journal of Neuroscience 28 (53) , pp. 14341-14346. 10.1523/JNEUROSCI.2390-08.2008

Hodges, Angela Kaye, Hughes, Gareth, Brooks, Simon Philip, Elliston, Linda Anne, Holmans, Peter Alan, Dunnett, Stephen Bruce and Jones, Lesley 2008. Brain gene expression correlates with changes in behavior in the R6/1 mouse model of Huntington's disease. Genes, Brain and Behavior 7 (3) , pp. 288-299. 10.1111/j.1601-183X.2007.00350.x

Trueman, Rebecca C., Brooks, Simon Philip, Jones, Lesley and Dunnett, Stephen Bruce 2008. Time course of choice reaction time deficits in the Hdh Q92/Q92 knock-in mouse model of Huntington's disease. Behavioural Brain Research 189 (2) , pp. 317-334. 10.1016/j.bbr.2008.01.020

Bray, Nicholas John, Holmans, Peter Alan, van den Bree, Marianne Bernadette, Jones, Lesley, Elliston, Linda Anne, Hughes, Gareth, Richards, Alexander, Williams, Nigel Melville, Craddock, Nicholas John, Owen, Michael John and O'Donovan, Michael Conlon 2008. Cis- and trans- loci influence expression of the schizophrenia susceptibility gene DTNBP1. Human Molecular Genetics 17 (8) , pp. 1169-1174. 10.1093/hmg/ddn006

Richards, Alexander L., Holmans, Peter Alan, O'Donovan, Michael Conlon, Owen, Michael John and Jones, Lesley 2008. A comparison of four clustering methods for brain expression microarray data. BMC Bioinformatics 9 , 490. 10.1186/1471-2105-9-490

Li, Y., Grupe, A., Rowland, C., Holmans, Peter Alan, Segurado, Ricardo, Abraham, Richard Alun, Jones, Lesley, Catanese, J., Ross, D., Mayo, K., Martinez, M., Hollingworth, Paul, Goate, A., Cairns, N. J., Racette, B. A., Perlmutter, J. S., O'Donovan, Michael Conlon, Morris, J. C., Brayne, C., Rubinsztein, D. C., Lovestone, S., Thal, L. J., Owen, Michael John and Williams, Julie 2008. Evidence that common variation in NEDD9 is associated with susceptibility to late-onset Alzheimer's and Parkinson's disease. Human Molecular Genetics 17 (5) , pp. 759-767. 10.1093/hmg/ddm348

Strand, A. D., Baquet, Z. C., Aragaki, A. K., Holmans, Peter Alan, Yang, L., Cleren, C., Beal, M. F., Jones, Lesley, Kooperberg, C., Olson, J. M. and Jones, K. R. 2007. Expression profiling of Huntington's disease models suggests that brain-derived neurotrophic factor depletion plays a major role in striatal degeneration. Journal of Neuroscience 27 (43) , pp. 11758-11768. 10.1523/JNEUROSCI.2461-07.2007

Morgan, A.R., Turic, Darko, Jehu, Luke, Hamilton, G., Hollingworth, Paul, Escott-Price, Valentina, Jones, Lesley, Lovestone, S., Brayne, C., Rubinsztein, D.C., Lawlor, B., Gill, M., O'Donovan, Michael Conlon, Owen, Michael John and Williams, Julie 2007. Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 144B (6) , pp. 762-770. 10.1002/ajmg.b.30509

Harold, Denise, Jehu, Luke, Turic, Darko, Hollingworth, Paul, Moore, P., Summerhayes, P., Escott-Price, Valentina, Foy, C., Archer, N., Hamilton, B.A., Lovestone, S., Powell, J., Brayne, C., Rubinsztein, D.C., Jones, Lesley, O'Donovan, Michael Conlon, Owen, Michael John and Williams, Julie 2007. Interaction between theADAM12 andSH3MD1 genes may confer susceptibility to late-onset Alzheimer's disease. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 144B (4) , pp. 448-452. 10.1002/ajmg.b.30456

Kuhn, Alexandre, Goldstein, Darlene R., Hodges, Angela Kaye, Strand, Andrew D., Sengstag, Thierry, Kooperberg, Charles, Becanovic, Christina, Pouladi, Mahmud A., Sathasivam, Kirupa, Cha, Jang-Ho J., Hannon, Anthony J., Hayden, Michael R., Leavitt, Blair A., Dunnett, Stephen Bruce, Ferrante, Robert J., Albin, Roger, Shelbourne, Peggy, Delorenzi, Mauro, Augood, Sarah J., Faull, Richard L. M., Olson, James M., Bates, Gillian P., Jones, Lesley and Luthi-Carter, Ruth 2007. Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage. Human Molecular Genetics 16 (15) , pp. 1845-1861. 10.1093/hmg/ddm133

Strand, Andrew D., Aragaki, Aaron K., Baquet, Zachary C., Hodges, Angela, Cunningham, Philip, Holmans, Peter Alan, Jones, Kevin R., Jones, Lesley, Kooperberg, Charles and Olson, James M. 2007. Conservation of regional gene expression in mouse and human brain. PLOS Genetics 3 (4) , e59. 10.1371/journal.pgen.0030059

Trueman, Rebecca C., Brooks, Simon Philip, Jones, Lesley and Dunnett, Stephen Bruce 2007. The operant serial implicit learning task reveals early onset motor learning deficits in the HdhQ92 knock-in mouse model of Huntington's disease. European Journal of Neuroscience 25 (2) , pp. 551-558. 10.1111/j.1460-9568.2007.05307.x

Bray, Nicholas John, Holmans, Peter Alan, van Den Bree, Marianne Bernadette, Williams, Nigel Melville, Jones, Lesley, Craddock, Nicholas John, Owen, Michael John and O'Donovan, Michael Conlon 2006. Cis- and trans-acting loci influence expression of DTNBP1, a susceptibility gene for schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 141B (7) , pp. 723-724.

Georgieva, Lyudmila, Escott-Price, Valentina, Peirce, Timothy Rowan, Norton, Nadine, Bray, Nicholas John, Jones, Lesley, Holmans, Peter Alan, Macgregor, Stuart, Zammit, Stanley, Wilkinson, Jennifer Camilla, Williams, Hywel John, Nikolov, Ivan, Williams, Nigel Melville, Ivanov, Dobril, Davis, Kenneth L., Haroutunian, Vahram, Buxbaum, Joseph D., Craddock, Nicholas John, Kirov, George, Owen, Michael John and O'Donovan, Michael Conlon 2006. Convergent evidence that oligodendrocyte lineage transcription factor 2 (OLIG2) and interacting genes influence susceptibility to schizophrenia. Proceedings of the National Academy of Sciences of the United States of America (PNAS) ISSN 1091-6490 103 (33) , pp. 12469-12474. 10.1073/pnas.0603029103

Brooks, Simon, Betteridge, H., Trueman, R.C., Jones, Lesley and Dunnett, S.B. 2006. Selective extra-dimensional set shifting deficit in a knock-in mouse model of Huntington's disease. Brain Research Bulletin 69 (4) , pp. 452-7. 10.1016/j.brainresbull.2006.02.011

Jones, Lesley, Goldstein, Darlene R., Hughes, Gareth, Strand, Andrew D., Collin, Francois, Dunnett, Stephen Bruce, Kooperberg, Charles, Aragaki, Aaron, Olson, James M., Augood, Sarah J., Faull, Richard LM, Luthi-Carter, Ruth, Escott-Price, Valentina and Hodges, Angela K. 2006. Assessment of the relationship between pre-chip and post-chip quality measures for Affymetrix GeneChip expression data. BioMed Central Bioinformatics 7 (1) , 211. 10.1186/1471-2105-7-211

Hodges, Angela Kaye, Strand, Andrew D., Aragaki, Aaron K., Kuhn, Alexandre, Sengstag, Thierry, Hughes, Gareth, Elliston, Linda Anne, Hartog, Catherine, Goldstein, Darlene R., Thu, Doris, Hollingsworth, Zane R., Collin, Francois, Synek, Beth, Holmans, Peter Alan, Young, Anne B., Wexler, Nancy S., Delorenzi, Mauro, Kooperberg, Charles, Augood, Sarah J., Faull, Richard L. M., Olson, James M., Jones, Lesley and Luthi-Carter, Ruth 2006. Regional and cellular gene expression changes in human Huntington's disease brain. Human Molecular Genetics 15 (6) , pp. 965-977. 10.1093/hmg/ddl013

Harold, Denise, Macgregor, S., Patterson, C. E., Hollingworth, P., Moore, P., Owen, Michael John, Williams, Julie, O'Donovan, Michael Conlon, Passmore, P., McIlroy, S. and Jones, Lesley 2006. A single nucleotide polymorphism in CHAT influences response to acetylcholinesterase inhibitors in Alzheimer's disease. Pharmacogenetics and genomics 16 (2) , pp. 75-77.

Grupe, Andrew, Li, Yonghong, Rowland, Charles, Nowotny, Petra, Hinrichs, Anthony L., Smemo, Scott, Kauwe, John S. K., Maxwell, Taylor J., Cherny, Sara, Doil, Lisa, Tacey, Kristina, Luchene, Ryan van, Myers, Amanda, Wavrant-De Vrièze, Fabienne, Kaleem, Mona, Hollingworth, Paul, Jehu, Luke, Foy, Catherine, Archer, Nicola, Hamilton, Gillian, Holmans, Peter Alan, Morris, Chris M., Catanese, Joseph, Sninsky, John, White, Thomas J., Powell, John, Hardy, John, O'Donovan, Michael Conlon, Lovestone, Simon, Jones, Lesley, Morris, John C., Thal, Leon, Owen, Michael John, Williams, Julie and Goate, Alison 2006. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. The American Journal of Human Genetics 78 (1) , pp. 78-88.

Hodges, A., Strand, A. D., Aragaki, A. K., Sengstag, T., Hughes, G., Elliston, Linda Anne, Hartog, C., Goldstein, D. R., Thu, D., Hollingsworth, Z. R., Collin, F., Synek, B., Holmans, Peter Alan, Young, A. B., Wexler, N. S., Delorenzi, M., Kooperberg, C., Augood, S. J., Faull, R. L. M., Olson, J. M., Luthi-Carter, R. and Jones, Lesley 2005. Regional specificity of transcriptional changes in early grade Huntington's disease brain. Journal of Neurology, Neurosurgery and Psychiatry 76 , A16-A16.

Brooks, Simon P., Higgs, G., Trueman, R. C., Dunnett, Stephen Bruce, Cheng, P., Redfern, A. R. and Jones, Lesley 2005. Longitudinal behavioural characterisation of the Q92 mouse line. Journal of Neurology, Neurosurgery and Psychiatry 76 , A48-A48.

Hughes, G. P., Brooks, Simon P., Hodges, A. H., Holmans, Peter Alan, Thomas, J. M., Goldstein, D., Dunnett, Stephen Bruce and Jones, Lesley 2005. Integrating behaviour and brain gene expression in Huntington's disease transgenic mouse models. Journal of Neurology, Neurosurgery and Psychiatry 76 , A41-A41.

Jones, Lesley, Elliston, Linda Anne, Caswell, R. and Ersoy, N. 2005. Mutant huntingtin represses transcription from the thyroid hormone receptor. Journal of Neurology, Neurosurgery and Psychiatry 76 , A17-A17.

Redfern, A., Hughes, G., McGuffin, P., Aitchison, K., Vollmayr, B., Gass, P., O'Donovan, Michael Conlon, Craddock, Nicholas John and Jones, Lesley 2005. Global gene expression profiling in the hippocampus and frontal cortex of Escitalopram-treated Learned Helplessness rats. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 138B (1) , p. 107.

Brooks, S. P., Pask, T., Jones, Lesley and Dunnett, Stephen Bruce 2005. Behavioural profiles of inbred mouse strains used as transgenic backgrounds. II: cognitive tests. Genes, Brain and Behavior 4 (5) , pp. 307-317. 10.1111/j.1601-183X.2004.00109.x

Holmans, Peter Alan, Hamshere, Marian Lindsay, Hollingworth, P., Rice, Frances, Tunstall, N., Jones, S., Moore, P., Wavrant DeVrieze, F., Myers, A., Crook, R., Compton, D., Marshall, H., Meyer, D., Shears, S., Booth, J., Ramic, D., Williams, Nigel Melville, Norton, N., Abraham, R., Kehoe, P., Williams, H., Rudrasingham, V., O'Donovan, Michael Conlon, Jones, Lesley, Hardy, J., Goate, A., Lovestone, S., Owen, Michael John and Williams, Julie 2005. Genome screen for loci influencing age at onset and rate of decline in late onset Alzheimer's disease. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 135B (1) , pp. 24-32. 10.1002/ajmg.b.30114

Morton, A. Jennifer, Hunt, Mark J., Hodges, Angela Kaye, Lewis, Paul David, Redfern, Amanda Jane, Dunnett, Stephen Bruce and Jones, Lesley 2005. A combination drug therapy improves cognition and reverses gene expression changes in a mouse model of Huntington's disease. European Journal of Neuroscience 21 (4) , pp. 855-870. 10.1111/j.1460-9568.2005.03895.x

Hughes, Alis, Errington, Rachel Jane, Fricker-Gates, Rosemary and Jones, Lesley 2004. Endophilin A3 forms filamentous structures that colocalise with microtubules but not with actin filaments. Molecular Brain Research 128 (2) , pp. 182-192. 10.1016/j.molbrainres.2004.06.016

Brooks, S. P., Pask, T., Jones, Lesley and Dunnett, S. B. 2004. Behavioural profiles of inbred mouse strains used as transgenic backgrounds. I: motor tests. Genes, Brain and Behavior 3 (4) , pp. 206-215. 10.1111/j.1601-183X.2004.00072.x

Myers, Amanda J., Marshall, Helen, Holmans, Peter Alan, Compton, Danielle, Crook, Richard J.P., Mander, Adrian P., Nowotny, Petra, Smemo, Scott, Dunstan, Melanie, Jehu, Luke, Wang, Jen C., Hamshere, Marian Lindsay, Morris, John C., Norton, Joanne, Chakraventy, Sumi, Tunstall, Nigel, Lovestone, Simon, Petersen, Ronald, O'Donovan, Michael Conlon, Jones, Lesley, Williams, Julie, Owen, Michael John, Hardy, John and Goate, Alison 2004. Variation in the urokinase-plasminogen activator gene does not explain the chromosome 10 linkage signal for late onset AD. American Journal of Medical Genetics 124B (1) , pp. 29-37. 10.1002/ajmg.b.20036

Busby, Victoria, Goossens, Steven, Nowotny, Petra, Hamilton, Gillian, Smemo, Scott, Harold, Denise, Turic, Dragana, Jehu, Luke, Myers, Amanda, Womick, Meredith, Woo, Daniel, Compton, Danielle, Doil, Lisa M., Tacey, Kristina M., Lau, Kit F., Al-Saraj, Safa, Killick, Richard, Pickering-Brown, Stuart, Moore, Pamela, Hollingworth, Paul, Archer, Nicola, Foy, Catherine, Walter, Sarah, Lovestone, Simon, O'Donovan, Michael Conlon, Owen, Michael John, Jones, Lesley, Williams, Julie and Holmans, Peter Alan 2004. Alpha-T-Catenin Is Expressed in Human Brain and Interacts With the Wnt Signaling Pathway But Is Not Responsible for Linkage to Chromosome 10 in Alzheimer's Disease. Neuromolecular Medicine 5 (2) , pp. 133-146. 10.1385/NMM:5:2:133

Harold, Denise, Peirce, Timothy, Escott-Price, Valentina, Lovestone, Simon, Powell, John, Foy, Catherine, Archer, Nicola, Walter, Sarah, Edmonson, Amanda, McIlroy, Stephen, Craig, David, Passmore, Peter A., Goate, Alison, Hardy, John, O'Donovan, Michael Conlon, Williams, Julie, Liddell, Malcolm, Owen, Michael John, Jones, Lesley, Myers, Amanda, Jones, Susan, Hollingworth, Paul and Moore, Pamela 2003. Sequence variation in the CHAT locus shows no association with late-onset Alzheimer's disease. Human Genetics 113 (3) , pp. 258-267. 10.1007/s00439-003-0960-2

Reid, Suzanne J., Rees, Mark I., van Roon-Mom, Willeke M.C., Jones, Lesley, MacDonald, Marcy E., Sutherland, Greg, During, Matthew J., Faull, Richard L.M., Owen, Michael John, Dragunow, Mike and Snell, Russell G. 2003. Molecular investigation of TBP allele length:. Neurobiology of Disease 13 (1) , pp. 37-45. 10.1016/S0969-9961(03)00014-7

von Horsten, S., Schmitt, I., Nguyen, H. P., Holzmann, C., Schmidt, T., Walther, T., Bader, M., Pabst, R., Kobbe, P., Krotova, J., Stiller, D., Kask, A., Vaarmann, A., Rathke-Hartlieb, S., Schulz, J. B., Grasshoff, U., Bauer, I., Vieira-Saecker, A. M. M., Paul, M., Jones, Lesley, Lindenberg, K. S., Landwehrmeyer, B., Bauer, A., Li, X.-J. and Riess, O. 2003. Transgenic rat model of Huntington's disease. Human Molecular Genetics 12 (6) , pp. 617-624. 10.1093/hmg/ddg075

Jones, Lesley, Gane, A. M., Herbert, D., Willey, D. L., Rutter, A. J., Kille, P., Dancer, J. E. and Harwood, J. L. 2003. beta-Ketoacyl-acyl carrier protein synthase III from pea (Pisum sativum L.): properties, inhibition by a novel thiolactomycin analogue and isolation of a cDNA clone encoding the enzyme. Planta 216 (5) , pp. 752-761.

van Roon-Mom, Willeke M.C, Reid, Suzanne J, Jones, Lesley, MacDonald, Marcy E, Faull, Richard L.M and Snell, Russell G 2002. Insoluble TATA-binding protein accumulation in Huntington's disease cortex. Molecular Brain Research 109 (1-2) , pp. 1-10. 10.1016/S0169-328X(02)00450-3

Duce, James, Hartog, Cathy, Elliston, Linda Anne, Neal, James W., Nicholson, Louise F. B. and Jones, Lesley 2002. Transcriptional dysregulation in Huntington's disease. American Journal of Human Genetics 69 (4) , p. 545. 10.1007/978-1-4615-0715-4_49

Myers, Amanda, Wavrant De-Vrieze, Fabienne, Holmans, Peter Alan, Hamshere, Marian Lindsay, Crook, Richard, Compton, Danielle, Marshall, Helen, Meyer, David, Shears, Shantia, Booth, Jeremy, Ramic, Dzanan, Knowles, Heather, Morris, John C., Williams, Nigel Melville, Norton, Nadine, Abraham, Richard, Kehoe, Pat, Williams, Hywel, Rudrasingham, Varuni, Rice, Frances, Giles, Peter, Tunstall, Nigel, Jones, Lesley, Lovestone, Simon, Williams, Julie, Owen, Michael John, Hardy, John and Goate, Alison 2002. Full genome screen for Alzheimer disease: Stage II analysis. American Journal Of Medical Genetics Part A 114 (2) , pp. 235-244. 10.1002/ajmg.10183

Jones, Lesley 2002. The cell biology of Huntington's disease. In: Bates, G., Harper, P. S. and Jones, Aileen Lesley eds. Huntington's Disease (3rd ed.), Oxford Monographs on Medical Genetics, vol. 45. Oxford: Oxford University Press, pp. 348-386.

Abraham, Richard, Myers, Amanda, Wavrant-DeVrieze, Fabienne, Hamshere, Marian Lindsay, Thomas, Hollie Victoria, Marshall, Helen, Compton, Danielle, Spurlock, Gillian, Turic, Dragana, Hoogendoorn, Bastiaan, Kwon, Jennifer M., Petersen, Ronald C., Tangalos, Eric, Norton, Joanne, Morris, John C., Bullock, Roger, Liolitsa, Danae, Lovestone, Simon, Hardy, John, Goate, Alison, O'Donovan, Michael Conlon, Williams, Julie, Owen, Michael John and Jones, Lesley 2001. Substantial linkage disequilibrium across the insulin-degrading enzyme locus but no association with late-onset Alzheimer's disease. Human Genetics 109 (6) , pp. 646-652. 10.1007/s00439-001-0614-1

Harper, Peter, Evans, R, Elliston, Linda, Ironside, J. W., Jones, Lesley and Lazarou, L. 2001. Huntington's disease intermediate allele and new variant CJD. American Journal of Human Genetics 69 (4) , p. 547.

Reid, S. J., Rees, M. I., van Roon-Mom, W. M. C., Jones, Lesley, McDonald, M. E., Sutherland, G. T., Owen, Michael John, Dragunow, M. and Snell, R. G. 2001. Expression and population studies of the TATA-box binding protein polyglutamine region at normal and expanded lengths. American Journal of Human Genetics 69 (4) , p. 424.

Jones, Lesley, Duce, J., Elliston, Linda and Harper, Peter 2001. The involvement of transcriptional repressor proteins in Huntington's disease. Journal of Medical Genetics 38 (Suppl1) , S65-S65.

Myers, A., Holmans, Peter Alan, Marshall, H., Kwon, J., Meyer, D., Ramic, D., Shears, S., Booth, J., DeVrieze, F. W., Crook, R., Hamshere, Marian Lindsay, Abraham, R., Tunstall, N., Rice, Frances, Carty, S., Lillystone, S., Kehoe, P., Rudrasingham, V., Jones, Lesley, Lovestone, S., Perez-Tur, J., Williams, Julie, Owen, Michael John, Hardy, J. and Goate, A. M. 2000. Susceptibility locus for Alzheimer's disease on chromosome 10. Science 290 (5500) , pp. 2304-2305. 10.1126/science.290.5500.2304

Jones, Lesley, Herbert, D., Rutter, A. J., Dancer, J. E. and Harwood, J. L. 2000. Novel inhibitors of the condensing enzymes of the type II fatty acid synthase of pea (Pisum sativum). Biochemical Journal 347 (1) , pp. 205-209. 10.1042/bj3470205

Boutell, J. M., Thomas, P., Neal, J. W., Weston, V. J., Duce, J., Harper, P. S. and Jones, Lesley 1999. Aberrant interactions of transcriptional repressor proteins with the Huntington's disease gene product, huntingtin. Human Molecular Genetics 8 (9) , pp. 1647-1655. 10.1093/hmg/8.9.1647

Jones, Lesley 1999. The localization and interactions of huntingtin. Philosophical Transactions of the Royal Society of London Series B - Biological Sciences 354 (1386) , pp. 1021-1027. 10.1098/rstb.1999.0454

Wilkinson, F. L., Nguyen, T. M., Manilal, S. B., Thomas, P., Neal, J. W., Harper, P. S., Jones, Lesley and Morris, G. E. 1999. Localization of rabbit huntingtin using a new panel of monoclonal antibodies. Molecular Brain Research 69 (1) , pp. 10-20. 10.1016/S0169-328X(99)00097-2

Sieradzan, K. A., Mechan, A. O., Jones, Lesley, Wanker, E. E., Nukina, N. and Mann, D. M. 1999. Huntington's disease intranuclear inclusions contain truncated, ubiquitinated huntingtin protein. Experimental Neurology 156 (1) , pp. 92-99. 10.1006/exnr.1998.7005

Kehoe, P., Krawczak, M., Harper, P. S., Owen, Michael John and Jones, Lesley 1999. Age of onset in Huntington disease: sex specific influence of apolipoprotein E genotype and normal CAG repeat length. Journal of Medical Genetics 36 (2) , pp. 108-111. 10.1136/jmg.36.2.108

Thomas, P., Wilkinson, F., Nguyen, T. M., Harper, P. S., Neal, J. W., Morris, G. E. and Jones, Lesley 1998. Full length huntingtin is not detected in intranuclear inclusions in Huntington's disease brain. Biochemical Society Transactions 26 (3) , S243. 10.1042/bst026s243

Singhrao, S. K., Thomas, P., Wood, D. J., MacMillan, J. C., Neal, J. W., Harper, P. S. and Jones, Lesley 1998. Huntingtin protein colocalizes with lesions of neurodegenerative diseases: An investigation in Huntington's, Alzheimer's, and Pick's diseases. Experimental Neurology 150 (2) , pp. 213-222. 10.1006/exnr.1998.6778

Boutell, J. M., Wood, J. D., Harper, P. S. and Jones, Lesley 1998. Huntingtin interacts with cystathionine beta-synthase. Human Molecular Genetics 7 (3) , pp. 371-378. 10.1093/hmg/7.3.371

Jones, Lesley, Middle, F., Guy, Carol, Spurlock, G., Cairns, N. J., McGuffin, P., Craddock, Nicholas John, Owen, Michael John and O'Donovan, Michael Conlon 1997. No evidence for expanded polyglutamine sequences in bipolar disorder and schizophrenia. Molecular Psychiatry 2 (6) , pp. 478-482. 10.1038/sj.mp.4000297

Boutell, J. M., Krusche, L. A., Harper, P. S. and Jones, Lesley 1997. Generation of clones with varying trinucleotide repeat sires using intrinsic instability in E-coli. American Journal of Human Genetics 61 (4) , A404-A404.

Singhrao, S. K., Thomas, P., Wood, J. D., Harper, P. S., Neal, J. W. and Jones, Lesley 1997. Huntingtin is associated with intracellular neuropathology in Huntington's, Alzheimer's and Pick's disease. American Journal of Human Genetics 61 (4) , A321-A321.

Jones, Lesley, Boutell, J. M., Wood, J. D. and Harper, P. S. 1997. Two proteins which interact with the N-terminus of huntingtin. American Journal of Human Genetics 61 (4) , A311-A311.

Jones, Lesley, Wood, J. D. and Harper, P. S. 1997. Huntington disease: advances in molecular and cell biology. Journal of Inherited Metabolic Disease 20 (2) , pp. 125-138. 10.1023/A:1005340302695

Wood, J. D., MacMillan, J. C., Harper, P. S., Lowenstein, P. R. and Jones, Lesley 1996. Partial characterisation of murine huntingtin and apparent variations in the subcellular localisation of huntingtin in human, mouse and rat brain. Human Molecular Genetics 5 (4) , pp. 481-487. 10.1093/hmg/5.4.481

Wood, J., MacMillan, J. C., Thomas, P., Lowenstein, P. R., Harper, P. S. and Jones, Lesley 1995. Characterising the Huntington's disease gene product. Biochemical Society Transactions 23 (4) , 595S. 10.1042/bst023595s

MacMillan, J. C., Thomas, P., Wood, J., Jones, Lesley, Harper, P. S. and Lowenstein, P. R. 1995. Light microscopic analysis of the distribution of the Huntington disease protein in murine brain. American Journal of Human Genetics 57 (4) , p. 1823.

Wood, J., MacMillan, J. C., Harper, P. S. and Jones, Lesley 1995. Subcellular-distribution and characterization of the Huntingtons-Disease gene-product in human and mouse brain. American Journal of Human Genetics 57 (4) , p. 1473.

Jones, Lesley, Dancer, Jane E. and Harwood, John L. 1995. Effect of thiolactomycin on fatty acid synthesis in peas. Phytochemistry 39 (3) , p. 511. 10.1016/0031-9422(95)00033-4

Jones, Lesley, Dancer, J. E. and Harwood, J. L. 1994. The effect of thiolactomycin analogues on fatty acid synthesis in peas (Pisum sativum cv. Onward). Biochemical Society Transactions 22 (3) , 258S. 10.1042/bst022258s

Jones, Lesley, Lloyd, D and Harwood, J L 1993. Rapid induction of microsomal delta12(w 6)-desaturase activity in chilledAcanthamoeba castellanii. Biochemical Journal 296 (1) , pp. 183-188. 10.1042/bj2960183

Jones, Lesley and Harwood, John L. 1993. Lipids and lipid metabolism in the marine alga Enteromorpha intestinalis. Phytochemistry 34 (4) , pp. 969-972. 10.1016/S0031-9422(00)90695-2

Jones, Lesley and Harwood, J. 1993. Lipid-metabolism in the brown marine-algae fucus-vesiculosus and ascophyllum-nodosum. Journal of Experimental Botany 44 (264) , pp. 1203-1210. 10.1093/jxb/44.7.1203

Jones, Lesley, Kille, Peter, Dancer, Jane E. and Harwood, John L. 1993. The cloning and overexpression ofE coliacyl carrier protein (ACP). Biochemical Society Transactions 21 (2) , 202S-202S. 10.1042/bst021202s

Jones, Lesley, Kille, Peter, Dancer, J. E. and Harwood, J. L. 1993. The cloning and overexpression of escherichia-coli acyl carrier protein. Grasas Y Aceites 44 (2) , pp. 116-117.

Jones, Lesley, Hann, A C, Harwood, J L and Lloyd, D 1993. Temperature-induced membrane-lipid adaptation inAcanthamoeba castellanii. Biochemical Journal 290 (1) , pp. 273-278. 10.1042/bj2900273

Jones, Lesley and Harwood, John L. 1992. Lipid composition of the brown algae fucus vesiculosus and Ascophyllum nodosum. Phytochemistry 31 (10) , pp. 3397-3403. 10.1016/0031-9422(92)83693-S

Jones, Lesley, Harwood, John L. and Lloyd, David 1992. Induction of delta12-desaturase activity during temperature adaptation in Acanthamoeba castellanii. Biochemical Society Transactions 20 (2) , 170S-170S. 10.1042/bst020170s

Jones, Lesley, Pruitt, Nancy L., Lloyd, David and Harwood, John L. 1991. Temperature-induced Changes in the Synthesis of Unsaturated Fatty Acids byAcanthamoeba castellanii. The Journal of Protozoology 38 (6) , pp. 532-536. 10.1111/j.1550-7408.1991.tb06076.x

Jones, Lesley, Lloyd, D., Hann, A. C. and Harwood, J. L. 1991. Lipid changes in individual membranes of Acanthamoeba castellanii during temperature adaptation. Biochemical Society Transactions 19 (3) , 318S-318S. 10.1042/bst019318s

Jones, Lesley, Pruitt, Nancy L., Lloyd, David and Harwood, John L. 1990. Effect of growth temperature on fatty acid biosynthesis in Acanthamoeba castellanii. Biochemical Society Transactions 18 (4) , p. 627. 10.1042/bst0180627

Harwood, John L. and Jones, Lesley 1989. Lipid Metabolism in Algae. Advances in Botanical Research 16 , pp. 1-53. 10.1016/S0065-2296(08)60238-4

Pettitt, T.R., Jones, Lesley and Harwood, J.L. 1989. Lipids of the marine red algae, chondrus-crispus and polysiphonia-lanosa. Phytochemistry 28 (2) , pp. 399-405.

Pettitt, Trevor R., Jones, Lesley and Harwood, John L. 1989. Lipid metabolism in the red marine algae Chondrus crispus and Polysiphonia lanosa as modified by temperature. Phytochemistry 28 (8) , pp. 2053-2058. 10.1016/S0031-9422(00)97919-6

Jones, Lesley and Harwood, J.L. 1988. Effects of heavy-metals on lipid-metabolism in marine-algae. Biochemical Society Transactions 16 (3) , pp. 275-276.

Jones, Lesley and Harwood, John L. 1987. Comparative aspects of lipid metabolism in marine algae. Biochemical Society Transactions 15 (3) , p. 482. 10.1042/bst0150482