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Flower, Michael, Lomeikaite, Vilija, Holmans, Peter, Jones, Lesley, Tabrizi, Sarah J. and Monckton, Darren G.
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Reply: The repeat variant in MSH3 is not a genetic modifier for spinocerebellar ataxia type 3 and Friedreich’s ataxia.
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Donaldson, Jasmine, Powell, Sophie, Rickards, Nadia, Holmans, Peter and Jones, Lesley 2020. What is the pathogenic CAG expansion length in Huntington’s disease? Journal of Huntington's Disease |
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Baker, Emily, Sims, Rebecca, Leonenko, Ganna, Frizzati, Aura, Harwood, Janet, Grozeva, Detelina, Morgan, Kevin, Passmore, Peter, Holmes, Clives, Powell, John, Brayne, Carol, Gill, Michael, Mead, Simon, Bossu, Paola, Spalletta, Gianfranco, Goate, Alison, Crunchaga, Carlos, Maier, Wolfgang, Heun, Reinhard, Jessen, Frank, Peters, Oliver, Dichgans, Martin, Frolich, Lutz, Ramirez, Alfredo, Jones, Lesley, Hardy, John, Ivanov, Dobril, Hill, Matthew, Holmans, Peter, Allen, Nicholas, Morgan, Paul, Seshadri, Sudha, Schellenberg, Gerard, Amouvel, Philippe, Williams, Julie and Escott-Price, Valentina
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Flowers, Michael, Lomeilkaite, Vilila, Ciosi, Marc, Morales, Fernando, Lo, Kitty, Hensman Moss, Davina, Jones, Lesley, Holmans, Peter, Monckton, Darren and Tabrizi, Sarah
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Massey, Thomas and Jones, Lesley 2018. The central role of DNA damage and repair in CAG repeat diseases. Disease Models & Mechanisms 11 (1) , dmm031930. 10.1242/dmm.031930 |
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Escott-Price, Valentina and Jones, Lesley 2017. Genomic profiling and diagnostic biomarkers in Alzheimer's disease. The Lancet Neurology 16 (8) , pp. 582-583. 10.1016/S1474-4422(17)30202-8 |
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Holmans, Peter Alan, Escott-Price, Valentina, Jones, Lesley, Sharma, Manu, Vedernikov, Alexey, Buchel, Finja, Sadd, Mohamad, Bras, Jose M., Bettella, Francesco, Nicolaou, Nayia, Simón-Sánchez, Javier, Mittag, Florian, Gibbs, J. Raphael, Schulte, Claudia, Durr, Alexandra, Guerreiro, Rita, Hernandez, Dena, Brice, Alexis, Stefánsson, Hreinn, Majamaa, Kari, Gasser, Thomas, Heutink, Peter, Wood, Nicholas W., Martinez, Maria, Singleton, Andrew B., Nalls, Michael A., Hardy, John, Morris, Huw Rees and Williams, Nigel Melville 2013. A pathway-based analysis provides additional support for an immune-related genetic susceptibility to Parkinson's disease. Human Molecular Genetics 22 (5) , pp. 1039-1049. 10.1093/hmg/dds492 |
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Taylor, D. M., Moser, R., Regulier, E., Breuillaud, L., Dixon, M., Beesen, A. A., Elliston, Linda Anne, Silva Santos, M. d. F., Kim, J., Jones, Lesley, Goldstein, D. R., Ferrante, R. J. and Luthi-Carter, R. 2013. MAP Kinase Phosphatase 1 (MKP-1/DUSP1) is neuroprotective in Huntington's Disease via additive effects of JNK and p38 inhibition. Journal of Neuroscience 33 (6) , pp. 2313-2325. 10.1523/JNEUROSCI.4965-11.2013 |
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Hollingworth, Paul, Sweet, R., Sims, Rebecca, Harold, Denise, Russo, Giancarlo, Abraham, Richard Alun, Stretton, Alexandra, Denning, Nicola, Gerrish, Amy, Chapman, Jade Alice, Ivanov, Dobril, Escott-Price, Valentina, Lovestone, S., Priotsi, P., Lupton, M., Brayne, C., Gill, M., Lawlor, B., Lynch, A., Craig, D., McGuinness, B., Johnston, J., Holmes, C., Livingston, G., Bass, N. J., Gurling, H., McQuillin, A., Holmans, Peter Alan, Jones, Lesley, Devlin, B., Klei, L., Barmada, M. M., Demirci, F. Y., DeKosky, S. T., Lopez, O. L., Passmore, P., Owen, Michael John, O'Donovan, Michael Conlon, Mayeux, R., Kamboh, M. I. and Williams, Julie 2012. Genome-wide association study of Alzheimer's disease with psychotic symptoms. Molecular Psychiatry 17 (12) , pp. 1316-1327. 10.1038/mp.2011.125 |
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Deschepper, Mia Pieter, Hoogendoorn, Bastiaan, Brooks, Simon Philip, Dunnett, Stephen Bruce and Jones, Lesley 2012. Proteomic changes in the brains of Huntington's disease mouse models reflect pathology and implicate mitochondrial changes. Brain Research Bulletin 88 (2-3) , pp. 210-222. 10.1016/j.brainresbull.2011.01.012 |
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Brooks, Simon Philip, Higgs, Gemma, Jones, Lesley and Dunnett, Stephen Bruce 2012. Longitudinal analysis of the behavioural phenotype in HdhQ92 Huntington's disease knock-in mice. Brain Research Bulletin 88 (2-3) , pp. 148-155. 10.1016/j.brainresbull.2010.05.003 |
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Brooks, Simon Philip, Higgs, Gemma, Jones, Lesley and Dunnett, Stephen Bruce 2012. Longitudinal analysis of the behavioural phenotype in Hdh(CAG)150 Huntington's disease knock-in mice. Brain Research Bulletin 88 (2-3) , pp. 182-188. 10.1016/j.brainresbull.2010.05.004 |
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Bayram-Weston, Zubeyde, Torres, Eduardo Miguel, Jones, Lesley, Dunnett, Stephen Bruce and Brooks, Simon Philip 2012. Light and electron microscopic characterization of the evolution of cellular pathology in the Hdh((CAG)150) Huntington's disease knock-in mouse. Brain Research Bulletin 88 (2-3) , pp. 189-198. 10.1016/j.brainresbull.2011.03.014 |
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Brooks, Simon Philip, Higgs, Gemma, Janghra, Nari, Jones, Lesley and Dunnett, Stephen Bruce 2012. Longitudinal analysis of the behavioural phenotype in YAC128 (C57BL/6J) Huntington's disease transgenic mice. Brain Research Bulletin 88 (2-3) , pp. 113-120. 10.1016/j.brainresbull.2010.05.005 |
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Brooks, Simon Philip, Janghra, Nari, Workman, Victoria Louise, Bayram-Weston, Zubeyde, Jones, Lesley and Dunnett, Stephen Bruce 2012. Longitudinal analysis of the behavioural phenotype in R6/1 (C57BL/6J) Huntington's disease transgenic mice. Brain Research Bulletin 88 (2-3) , pp. 94-103. 10.1016/j.brainresbull.2011.01.010 |
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Trueman, Rebecca C., Dunnett, Stephen Bruce, Jones, Lesley and Brooks, Simon Philip 2012. Five choice serial reaction time performance in the HdhQ92 mouse model of Huntington's disease. Brain Research Bulletin 88 (2-3) , pp. 163-170. 10.1016/j.brainresbull.2011.10.019 |
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Bayram-Weston, Zubeyde, Jones, Lesley, Dunnett, Stephen Bruce and Brooks, Simon Philip 2012. Light and electron microscopic characterization of the evolution of cellular pathology in YAC128 Huntington's disease transgenic mice. Brain Research Bulletin 88 (2-3) , pp. 137-147. 10.1016/j.brainresbull.2011.05.005 |
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Bayram-Weston, Zubeyde, Jones, Lesley, Dunnett, Stephen Bruce and Brooks, Simon Philip 2012. Light and electron microscopic characterization of the evolution of cellular pathology in the R6/1 Huntington's disease transgenic mice. Brain Research Bulletin 88 (2-3) , pp. 104-112. 10.1016/j.brainresbull.2011.07.009 |
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Trueman, Rebecca C., Jones, Lesley, Dunnett, Stephen Bruce and Brooks, Simon Philip 2012. Early onset deficits on the delayed alternation task in the HdhQ92 knock-in mouse model of Huntington's disease. Brain Research Bulletin 88 (2-3) , pp. 156-162. 10.1016/j.brainresbull.2011.03.012 |
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Bayram-Weston, Zubeyde, Jones, Lesley, Dunnett, Stephen Bruce and Brooks, Simon Philip 2012. Light and electron microscopic characterization of the evolution of cellular pathology in HdhQ92 Huntington's disease knock-in mice. Brain Research Bulletin 88 (2-3) , pp. 171-181. 10.1016/j.brainresbull.2011.03.013 |
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Brooks, Simon Philip, Janghra, Narinder, Higgs, Gemma V., Bayram-Weston, Zubeyde, Heuer, Andreas, Jones, Lesley and Dunnett, Stephen Bruce 2012. Selective cognitive impairment in the YAC128 Huntington's disease mouse. Brain Research Bulletin 88 (2-3) , pp. 121-129. 10.1016/j.brainresbull.2011.05.010 |
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Fielding, Steven A., Brooks, Simon Philip, Klein, Alexander, Bayram-Weston, Zubeyde, Jones, Lesley and Dunnett, Stephen Bruce 2012. Profiles of motor and cognitive impairment in the transgenic rat model of Huntington's disease. Brain Research Bulletin 88 (2-3) , pp. 223-236. 10.1016/j.brainresbull.2011.09.011 |
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Brooks, Simon Philip, Jones, Lesley and Dunnett, Stephen Bruce 2012. Comparative analysis of pathology and behavioural phenotypes in mouse models of Huntington's disease. Brain Research Bulletin 88 (2-3) , pp. 81-93. 10.1016/j.brainresbull.2011.10.002 |
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Brooks, Simon Philip, Jones, Lesley and Dunnett, Stephen Bruce 2012. Longitudinal analyses of operant performance on the serial implicit learning task (SILT) in the YAC128 Huntington's disease mouse line. Brain Research Bulletin 88 (2-3) , pp. 130-136. 10.1016/j.brainresbull.2011.06.008 |
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Bowles, Kathryn R., Brooks, Simon Philip, Dunnett, Stephen Bruce and Jones, Lesley 2012. Gene expression and behaviour in mouse models of HD. Brain Research Bulletin 88 (2-3) , pp. 276-284. 10.1016/j.brainresbull.2011.07.021 |
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Giles, Peter James, Elliston, Linda Anne, Higgs, Gemma, Brooks, Simon Philip, Dunnett, Stephen Bruce and Jones, Lesley 2012. Longitudinal analysis of gene expression and behaviour in the HdhQ150 mouse model of Huntington's disease. Brain Research Bulletin 88 (2-3) , pp. 199-209. 10.1016/j.brainresbull.2011.10.001 |
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Richards, Alexander, Jones, Lesley, Escott-Price, Valentina, Kirov, George, Gejman, P. V., Levinson, D. F., Sanders, A. R., Molecular Genetics of Schizophrenia Collaboration (MGS), , International Schizophrenia Consortium (ISC), , Purcell, S., Visscher, P. M., Craddock, Nicholas John, Owen, Michael John, Holmans, Peter Alan and O'Donovan, Michael Conlon 2012. Schizophrenia susceptibility alleles are enriched for alleles that affect gene expression in adult human brain. Molecular Psychiatry 17 (2) , pp. 193-201. 10.1038/mp.2011.11 |
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Gerrish, Amy, Russo, Giancarlo, Richards, Alexander, Escott-Price, Valentina, Ivanov, Dobril, Harold, Denise, Sims, Rebecca, Abraham, Richard Alun, Hollingworth, Paul, Chapman, Jade Alice, Hamshere, Marian Lindsay, Pahwa, Jaspreet Singh, Dowzell, Kimberley Frances, Williams, Amy, Denning, Nicola, Thomas, Charlene, Stretton, Alexandra, Morgan, Angharad Rhys, Lovestone, Simon, Powell, John, Proitsi, Petroula, Lupton, Michelle K., Brayne, Carol, Rubinsztein, David C., Gill, Michael, Lawlor, Brian, Lynch, Aoibhinn, Morgan, Kevin, Brown, Kristelle S., Passmore, Peter A., Craig, David, McGuinness, Bernadette, Todd, Stephen, Johnston, Janet A., Holmes, Clive, Mann, David, Smith, A. David, Love, Seth, Kehoe, Patrick G., Hardy, John, Mead, Simon, Fox, Nick, Rossor, Martin, Collinge, John, Maier, Wolfgang, Jessen, Frank, Kölsch, Heike, Heun, Reinhard, Schürmann, Britta, van den Bussche, Hendrik, Heuser, Isabella, Kornhuber, Johannes, Wiltfang, Jens, Dichgans, Martin, Frölich, Lutz, Hampel, Harald, Hüll, Michael, Rujescu, Dan, Goate, Alison M., Kauwe, John S. K., Cruchaga, Carlos, Nowotny, Petra, Morris, John C., Mayo, Kevin, Livingston, Gill, Bass, Nicholas J., Gurling, Hugh, McQuillin, Andrew, Gwilliam, Rhian, Deloukas, Panagiotis, Davies, Gail, Harris, Sarah E., Starr, John M., Deary, Ian J., Al-Chalabi, Ammar, Shaw, Christopher E., Tsolaki, Magda, Singleton, Andrew B., Guerreiro, Rita, Mühleisen, Thomas W., Nöthen, Markus M., Moebus, Susanne, Jöckel, Karl-Heinz, Klopp, Norman, Wichmann, H-Erich, Carrasquillo, Minerva M, Pankratz, V. Shane, Younkin, Steven G., Jones, Lesley, Holmans, Peter Alan, O'Donovan, Michael Conlon, Owen, Michael John and Williams, Julie 2012. The role of variation at AβPP, PSEN1, PSEN2, and MAPT in late onset Alzheimer's Disease. Journal of Alzheimer's Disease 28 (2) , pp. 377-387. 10.3233/JAD-2011-110824 |
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Hughes, Alis, Rosser, Anne Elizabeth and Jones, Lesley 2012. E06 Family history curation in Huntington's disease: a survey of the data so far. Journal of Neurology, Neurosurgery & Psychiatry 83 (Suppl) , A21-A21. 10.1136/jnnp-2012-303524.65 |
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Bayram-Weston, Zubeyde, Jones, Lesley, Dunnett, Stephen Bruce and Brooks, Simon P. 2012. B08 Differential sensitivity of aggregate markers in HdhQ150 and YAC128 HD mouse models. Journal of Neurology, Neurosurgery & Psychiatry 83 (Suppl) , A8-A8. 10.1136/jnnp-2012-303524.24 |
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Feyeux, M., Bourgois-Rocha, F., Redfern, Amanda Jane, Giles, Peter James, Lefort, N., Aubert, S., Bonnefond, C., Buiga, A., Ruiz, M., Deglon, N., Jones, Lesley, Peschanski, M., Allen, Nicholas Denby and Perrier, A. L. 2012. Early transcriptional changes linked to naturally occurring Huntington's disease mutations in neural derivatives of human embryonic stem cells. Human Molecular Genetics 21 (17) , pp. 3883-3895. 10.1093/hmg/dds216 |
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Hollingworth, Paul, Harold, Denise, Sims, Rebecca, Gerrish, Amy, Lambert, Jean-Charles, Carrasquillo, Minerva M., Abraham, Richard Alun, Hamshere, Marian Lindsay, Pahwa, Jaspreet Singh, Escott-Price, Valentina, Dowzell, Kimberley Frances, Denning, Nicola, Stretton, Alexandra, Thomas, Charlene, Richards, Alexander, Ivanov, Dobril, Widdowson, Caroline Susan, Chapman, Jade Alice, Lovestone, Simon, Powell, John, Proitsi, Petroula, Lupton, Michelle K., Brayne, Carol, Rubinsztein, David C., Gill, Michael, Lawlor, Brian, Lynch, Aoibhinn, Brown, Kristelle S., Passmore, Peter A., Craig, David, McGuinness, Bernadette, Todd, Stephen, Holmes, Clive, Mann, David, Smith, A David, Beaumont, Helen, Warden, Donald, Wilcock, Gordon, Love, Seth, Kehoe, Patrick G., Hooper, Nigel M., Vardy, Emma R. L. C., Hardy, John, Mead, Simon, Fox, Nick C, Rossor, Martin, Collinge, John, Maier, Wolfgang, Jessen, Frank, Rüther, Eckart, Schürmann, Britta, Heun, Reiner, Kölsch, Heike, van den Bussche, Hendrik, Heuser, Isabella, Kornhuber, Johannes, Wiltfang, Jens, Dichgans, Martin, Frölich, Lutz, Hampel, Harald, Gallacher, John Edward, Hüll, Michael, Rujescu, Dan, Giegling, Ina, Goate, Alison M., Kauwe, John S. K., Cruchaga, Carlos, Nowotny, Petra, Morris, John C., Mayo, Kevin, Sleegers, Kristel, Bettens, Karolien, Engelborghs, Sebastiaan, De Deyn, Peter P, Van Broeckhoven, Christine, Livingston, Gill, Bass, Nicholas J., Gurling, Hugh, McQuillin, Andrew, Gwilliam, Rhian, Deloukas, Panagiotis, Al-Chalabi, Ammar, Shaw, Christopher E., Tsolaki, Magda, Singleton, Andrew B., Guerreiro, Rita, Mühleisen, Thomas W., Nöthen, Markus M., Moebus, Susanne, Jöckel, Karl-Heinz, Klopp, Norman, Wichmann, H-Erich, Pankratz, V. Shane, Sando, Sigrid B., Aasly, Jan O., Barcikowska, Maria, Wszolek, Zbigniew K., Dickson, Dennis W., Graff-Radford, Neill R., Petersen, Ronald C., van Duijn, Cornelia M., Breteler, Monique M. B., Ikram, M. Arfan, DeStefano, Anita L., Fitzpatrick, Annette L., Lopez, Oscar, Launer, Lenore J., Seshadri, Sudha, Berr, Claudine, Campion, Dominique, Epelbaum, Jacques, Dartigues, Jean-François, Tzourio, Christophe, Alpérovitch, Annick, Lathrop, Mark, Feulner, Thomas M., Friedrich, Patricia, Riehle, Caterina, Krawczak, Michael, Schreiber, Stefan, Mayhaus, Manuel, Nicolhaus, S., Wagenpfeil, Stefan, Steinberg, Stacy, Stefansson, Hreinn, Stefansson, Kari, Snædal, Jon, Björnsson, Sigurbjörn, Jonsson, Palmi V., Chouraki, Vincent, Genier-Boley, Benjamin, Hiltunen, Mikko, Soininen, Hilkka, Combarros, Onofre, Zelenika, Diana, Delepine, Marc, Bullido, Maria J., Pasquier, Florence, Mateo, Ignacio, Frank-Garcia, Ana, Porcellini, Elisa, Hanon, Olivier, Coto, Eliecer, Alvarez, Victoria, Bosco, Paolo, Siciliano, Gabriele, Mancuso, Michelangelo, Panza, Francesco, Solfrizzi, Vincenzo, Nacmias, Benedetta, Sorbi, Sandro, Bossù, Paola, Piccardi, Paola, Arosio, Beatrice, Annoni, Giorgio, Seripa, Davide, Pilotto, Alberto, Scarpini, Elio, Galimberti, Daniela, Brice, Alexis, Hannequin, Didier, Licastro, Federico, Jones, Lesley, Holmans, Peter Alan, Jonsson, Thorlakur, Riemenschneider, Matthias, Morgan, Kevin, Younkin, Steven G., Owen, Michael John, O'Donovan, Michael Conlon, Amouyel, Philippe and Williams, Julie 2011. Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nature Genetics 43 (5) , pp. 429-435. 10.1038/ng.803 |
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Jones, Lesley and Hughes, Alis 2011. Pathogenic mechanisms in Huntington's Disease. International Review of Neurobiology 98 , pp. 373-418. 10.1016/B978-0-12-381328-2.00015-8 |
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Sims, Rebecca, Dwyer, Sarah Lynne, Harold, Denise, Gerrish, Amy, Hollingworth, Paul, Chapman, Jade Alice, Denning, Nicola, Abraham, Richard Alun, Ivanov, Dobril, Pahwa, Jaspreet Singh, Escott-Price, Valentina, Dowzell, Kimberley Frances, Thomas, Charlene, Stretton, Alexandra, Lovestone, Simon, Powell, John, Proitsi, Petroula, Lupton, Michelle K., Brayne, Carol, Rubinsztein, David C., Gill, Michael, Lawlor, Brian, Lynch, Aoibhinn, Morgan, Kevin, Brown, Kristelle S., Passmore, Peter A., Craig, David, McGuiness, Bernadette, Todd, Stephen, Johnston, Janet A., Holmes, Clive, Mann, David, Smith, A. David, Love, Seth, Kehoe, Patrick G., Hardy, John, Mead, Simon, Fox, Nick, Rossor, Martin, Collinge, John, Livingston, Gill, Bass, Nicholas J., Gurling, Hugh, McQuillin, Andrew, Jones, Lesley, Holmans, Peter Alan, O'Donovan, Michael Conlon, Owen, Michael John and Williams, Julie 2011. No evidence that extended tracts of homozygosity are associated with Alzheimer's disease. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 156 (7) , pp. 764-771. 10.1002/ajmg.b.31216 |
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Hughes, Alis and Jones, Lesley 2011. Huntingtin localisation studies - a technical review. Plos Currents 3 , RRN1211. 10.1371/currents.RRN1211 |
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Craddock, Nicholas John, Jones, Lesley, Jones, Ian Richard, Kirov, George, Green, Elaine Karen, Grozeva, Detelina Valentinova, Escott-Price, Valentina, Nikolov, Ivan, Hamshere, Marian Lindsay, Vukcevic, D., Caesar, S., Gordon-Smith, Katherine, Fraser, Christine, Russell, E., Norton, Nadine, Breen, G., St Clair, D., Collier, D. A., Young, A. H., Ferrier, I. N., Farmer, A, McGuffin, P., Holmans, Peter Alan, Donnelly, Peter, Owen, Michael John and O'Donovan, Michael Conlon 2010. Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype [Corrigendum]. Molecular Psychiatry 15 (11) , p. 1121. 10.1038/mp.2010.62 |
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Jones, Lesley, Holmans, Peter Alan, Hamshere, Marian Lindsay, Harold, Denise, Moskvina, Valentina, Ivanov, Dobril, Pocklington, Andrew, Abraham, Richard Alun, Hollingworth, Paul, Sims, Rebecca, Gerrish, Amy, Pahwa, Jaspreet Singh, Jones, Nicola, Stretton, Alexandra, Morgan, Angharad Rhys, Lovestone, Simon, Powell, John, Proitsi, Petroula, Lupton, Michelle K., Brayne, Carol, Rubinsztein, David C., Gill, Michael, Lawlor, Brian, Lynch, Aoibhinn, Morgan, Kevin, Brown, Kristelle S., Passmore, Peter A., Craig, David, McGuinness, Bernadette, Todd, Stephen, Holmes, Clive, Mann, David, Smith, A. David, Love, Seth, Kehoe, Patrick G., Mead, Simon, Fox, Nick, Rossor, Martin, Collinge, John, Maier, Wolfgang, Jessen, Frank, Schürmann, Britta, Heun, Reinhard, Kölsch, Heike, van den Bussche, Hendrik, Heuser, Isabella, Peters, Oliver, Kornhuber, Johannes, Wiltfang, Jens, Dichgans, Martin, Frölich, Lutz, Hampel, Harald, Hüll, Michael, Rujescu, Dan, Goate, Alison M., Kauwe, John S. K., Cruchaga, Carlos, Nowotny, Petra, Mayo, Kevin, Morris, John C., Livingston, Gill, Bass, Nicholas J., Gurling, Hugh, McQuillin, Andrew, Gwilliam, Rhian, Deloukas, Panos, Al-Chalabi, Ammar, Shaw, Christopher E., Singleton, Andrew B., Guerreiro, Rita, Mühleisen, Thomas W., Nöthen, Markus M., Moebus, Susanne, Jöckel, Karl-Heinz, Klopp, Norman, Wichmann, H.-Erich, Rüther, Eckhard, Carrasquillo, Minerva M., Pankratz, V. Shane, Younkin, Steven G., Hardy, John, O'Donovan, Michael Conlon, Williams, Julie and Owen, Michael John
2010.
Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease.
PLoS ONE
5
(11)
, e13950.
10.1371/journal.pone.0013950
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Brooks, Simon Philip, Jones, Lesley and Dunnett, Stephen Bruce 2010. Frontostriatal pathology in the (C57BL/6J) YAC128 mouse uncovered by the operant delayed alternation task [Meeting abstract]. Journal of Neurology, Neurosurgery and Psychiatry 81 (1) , A9-A10. 10.1136/jnnp.2010.222570.29 |
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Hughes, Alis, Ersoy, N., Elliston, Linda Anne and Jones, Lesley 2010. Protein localisation studies: Where is Huntingtin hiding? [Meeting abstract]. Journal of Neurology, Neurosurgery and Psychiatry 81 (1) , A1. 10.1136/jnnp.2010.222570.3 |
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Hollingworth, Paul, Harold, Denise, Jones, Lesley, Owen, Michael John and Williams, Julie 2010. Alzheimer's disease genetics: current knowledge and future challenges. International Journal of Geriatric Psychiatry 26 (8) , pp. 793-802. 10.1002/gps.2628 |
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Jones, Lesley, Harold, Denise and Williams, Julie 2010. Genetic evidence for the involvement of lipid metabolism in Alzheimer's disease. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1801 (8) , pp. 754-761. 10.1016/j.bbalip.2010.04.005 |
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Trueman, Rebecca C., Brooks, Simon Philip, Jones, Lesley and Dunnett, Stephen Bruce 2009. Rule learning, visuospatial function and motor performance in the Hdh(Q92) knock-in mouse model of Huntington's disease. Behavioural Brain Research 203 (2) , pp. 215-222. 10.1016/j.bbr.2009.05.006 |
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Wood, Ian C., Gray, Nicola K. and Jones, Lesley 2009. Gene expression in neuronal disease. Biochemical Society Transactions 37 (6) , pp. 1261-1262. 10.1042/BST0371261 |
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Packer, Amy N., Xing, Yi, Harper, Scott Q., Jones, Lesley and Davidson, Beverley L. 2008. The bifunctional microRNA miR-9/miR-9* regulates REST and CoREST and is downregulated in Huntington's disease. Journal of Neuroscience 28 (53) , pp. 14341-14346. 10.1523/JNEUROSCI.2390-08.2008 |
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Hodges, Angela Kaye, Hughes, Gareth, Brooks, Simon Philip, Elliston, Linda Anne, Holmans, Peter Alan, Dunnett, Stephen Bruce and Jones, Lesley 2008. Brain gene expression correlates with changes in behavior in the R6/1 mouse model of Huntington's disease. Genes, Brain and Behavior 7 (3) , pp. 288-299. 10.1111/j.1601-183X.2007.00350.x |
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Trueman, Rebecca C., Brooks, Simon Philip, Jones, Lesley and Dunnett, Stephen Bruce 2008. Time course of choice reaction time deficits in the Hdh Q92/Q92 knock-in mouse model of Huntington's disease. Behavioural Brain Research 189 (2) , pp. 317-334. 10.1016/j.bbr.2008.01.020 |
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Bray, Nicholas John, Holmans, Peter Alan, van den Bree, Marianne Bernadette, Jones, Lesley, Elliston, Linda Anne, Hughes, Gareth, Richards, Alexander, Williams, Nigel Melville, Craddock, Nicholas John, Owen, Michael John and O'Donovan, Michael Conlon 2008. Cis- and trans- loci influence expression of the schizophrenia susceptibility gene DTNBP1. Human Molecular Genetics 17 (8) , pp. 1169-1174. 10.1093/hmg/ddn006 |
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Li, Y., Grupe, A., Rowland, C., Holmans, Peter Alan, Segurado, Ricardo, Abraham, Richard Alun, Jones, Lesley, Catanese, J., Ross, D., Mayo, K., Martinez, M., Hollingworth, Paul, Goate, A., Cairns, N. J., Racette, B. A., Perlmutter, J. S., O'Donovan, Michael Conlon, Morris, J. C., Brayne, C., Rubinsztein, D. C., Lovestone, S., Thal, L. J., Owen, Michael John and Williams, Julie 2008. Evidence that common variation in NEDD9 is associated with susceptibility to late-onset Alzheimer's and Parkinson's disease. Human Molecular Genetics 17 (5) , pp. 759-767. 10.1093/hmg/ddm348 |
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Strand, A. D., Baquet, Z. C., Aragaki, A. K., Holmans, Peter Alan, Yang, L., Cleren, C., Beal, M. F., Jones, Lesley, Kooperberg, C., Olson, J. M. and Jones, K. R. 2007. Expression profiling of Huntington's disease models suggests that brain-derived neurotrophic factor depletion plays a major role in striatal degeneration. Journal of Neuroscience 27 (43) , pp. 11758-11768. 10.1523/JNEUROSCI.2461-07.2007 |
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Morgan, A.R., Turic, Darko, Jehu, Luke, Hamilton, G., Hollingworth, Paul, Escott-Price, Valentina, Jones, Lesley, Lovestone, S., Brayne, C., Rubinsztein, D.C., Lawlor, B., Gill, M., O'Donovan, Michael Conlon, Owen, Michael John and Williams, Julie 2007. Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 144B (6) , pp. 762-770. 10.1002/ajmg.b.30509 |
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Harold, Denise, Jehu, Luke, Turic, Darko, Hollingworth, Paul, Moore, P., Summerhayes, P., Escott-Price, Valentina, Foy, C., Archer, N., Hamilton, B.A., Lovestone, S., Powell, J., Brayne, C., Rubinsztein, D.C., Jones, Lesley, O'Donovan, Michael Conlon, Owen, Michael John and Williams, Julie 2007. Interaction between theADAM12 andSH3MD1 genes may confer susceptibility to late-onset Alzheimer's disease. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 144B (4) , pp. 448-452. 10.1002/ajmg.b.30456 |
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Kuhn, Alexandre, Goldstein, Darlene R., Hodges, Angela Kaye, Strand, Andrew D., Sengstag, Thierry, Kooperberg, Charles, Becanovic, Christina, Pouladi, Mahmud A., Sathasivam, Kirupa, Cha, Jang-Ho J., Hannon, Anthony J., Hayden, Michael R., Leavitt, Blair A., Dunnett, Stephen Bruce, Ferrante, Robert J., Albin, Roger, Shelbourne, Peggy, Delorenzi, Mauro, Augood, Sarah J., Faull, Richard L. M., Olson, James M., Bates, Gillian P., Jones, Lesley and Luthi-Carter, Ruth 2007. Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage. Human Molecular Genetics 16 (15) , pp. 1845-1861. 10.1093/hmg/ddm133 |
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Strand, Andrew D., Aragaki, Aaron K., Baquet, Zachary C., Hodges, Angela, Cunningham, Philip, Holmans, Peter Alan, Jones, Kevin R., Jones, Lesley, Kooperberg, Charles and Olson, James M. 2007. Conservation of regional gene expression in mouse and human brain. PLOS Genetics 3 (4) , e59. 10.1371/journal.pgen.0030059 |
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Trueman, Rebecca C., Brooks, Simon Philip, Jones, Lesley and Dunnett, Stephen Bruce 2007. The operant serial implicit learning task reveals early onset motor learning deficits in the HdhQ92 knock-in mouse model of Huntington's disease. European Journal of Neuroscience 25 (2) , pp. 551-558. 10.1111/j.1460-9568.2007.05307.x |
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Bray, Nicholas John, Holmans, Peter Alan, van Den Bree, Marianne Bernadette, Williams, Nigel Melville, Jones, Lesley, Craddock, Nicholas John, Owen, Michael John and O'Donovan, Michael Conlon 2006. Cis- and trans-acting loci influence expression of DTNBP1, a susceptibility gene for schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 141B (7) , pp. 723-724. |
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Georgieva, Lyudmila, Escott-Price, Valentina, Peirce, Timothy Rowan, Norton, Nadine, Bray, Nicholas John, Jones, Lesley, Holmans, Peter Alan, Macgregor, Stuart, Zammit, Stanley, Wilkinson, Jennifer Camilla, Williams, Hywel John, Nikolov, Ivan, Williams, Nigel Melville, Ivanov, Dobril, Davis, Kenneth L., Haroutunian, Vahram, Buxbaum, Joseph D., Craddock, Nicholas John, Kirov, George, Owen, Michael John and O'Donovan, Michael Conlon 2006. Convergent evidence that oligodendrocyte lineage transcription factor 2 (OLIG2) and interacting genes influence susceptibility to schizophrenia. Proceedings of the National Academy of Sciences of the United States of America (PNAS) ISSN 1091-6490 103 (33) , pp. 12469-12474. 10.1073/pnas.0603029103 |
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Brooks, Simon, Betteridge, H., Trueman, R.C., Jones, Lesley and Dunnett, S.B. 2006. Selective extra-dimensional set shifting deficit in a knock-in mouse model of Huntington's disease. Brain Research Bulletin 69 (4) , pp. 452-7. 10.1016/j.brainresbull.2006.02.011 |
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Jones, Lesley, Goldstein, Darlene R., Hughes, Gareth, Strand, Andrew D., Collin, Francois, Dunnett, Stephen Bruce, Kooperberg, Charles, Aragaki, Aaron, Olson, James M., Augood, Sarah J., Faull, Richard LM, Luthi-Carter, Ruth, Escott-Price, Valentina and Hodges, Angela K. 2006. Assessment of the relationship between pre-chip and post-chip quality measures for Affymetrix GeneChip expression data. BioMed Central Bioinformatics 7 (1) , 211. 10.1186/1471-2105-7-211 |
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Hodges, Angela Kaye, Strand, Andrew D., Aragaki, Aaron K., Kuhn, Alexandre, Sengstag, Thierry, Hughes, Gareth, Elliston, Linda Anne, Hartog, Catherine, Goldstein, Darlene R., Thu, Doris, Hollingsworth, Zane R., Collin, Francois, Synek, Beth, Holmans, Peter Alan, Young, Anne B., Wexler, Nancy S., Delorenzi, Mauro, Kooperberg, Charles, Augood, Sarah J., Faull, Richard L. M., Olson, James M., Jones, Lesley and Luthi-Carter, Ruth 2006. Regional and cellular gene expression changes in human Huntington's disease brain. Human Molecular Genetics 15 (6) , pp. 965-977. 10.1093/hmg/ddl013 |
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Harold, Denise, Macgregor, S., Patterson, C. E., Hollingworth, P., Moore, P., Owen, Michael John, Williams, Julie, O'Donovan, Michael Conlon, Passmore, P., McIlroy, S. and Jones, Lesley 2006. A single nucleotide polymorphism in CHAT influences response to acetylcholinesterase inhibitors in Alzheimer's disease. Pharmacogenetics and genomics 16 (2) , pp. 75-77. |
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Grupe, Andrew, Li, Yonghong, Rowland, Charles, Nowotny, Petra, Hinrichs, Anthony L., Smemo, Scott, Kauwe, John S. K., Maxwell, Taylor J., Cherny, Sara, Doil, Lisa, Tacey, Kristina, Luchene, Ryan van, Myers, Amanda, Wavrant-De Vrièze, Fabienne, Kaleem, Mona, Hollingworth, Paul, Jehu, Luke, Foy, Catherine, Archer, Nicola, Hamilton, Gillian, Holmans, Peter Alan, Morris, Chris M., Catanese, Joseph, Sninsky, John, White, Thomas J., Powell, John, Hardy, John, O'Donovan, Michael Conlon, Lovestone, Simon, Jones, Lesley, Morris, John C., Thal, Leon, Owen, Michael John, Williams, Julie and Goate, Alison 2006. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. The American Journal of Human Genetics 78 (1) , pp. 78-88. |
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Hodges, A., Strand, A. D., Aragaki, A. K., Sengstag, T., Hughes, G., Elliston, Linda Anne, Hartog, C., Goldstein, D. R., Thu, D., Hollingsworth, Z. R., Collin, F., Synek, B., Holmans, Peter Alan, Young, A. B., Wexler, N. S., Delorenzi, M., Kooperberg, C., Augood, S. J., Faull, R. L. M., Olson, J. M., Luthi-Carter, R. and Jones, Lesley 2005. Regional specificity of transcriptional changes in early grade Huntington's disease brain. Journal of Neurology, Neurosurgery and Psychiatry 76 , A16-A16. |
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Brooks, Simon P., Higgs, G., Trueman, R. C., Dunnett, Stephen Bruce, Cheng, P., Redfern, A. R. and Jones, Lesley 2005. Longitudinal behavioural characterisation of the Q92 mouse line. Journal of Neurology, Neurosurgery and Psychiatry 76 , A48-A48. |
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Hughes, G. P., Brooks, Simon P., Hodges, A. H., Holmans, Peter Alan, Thomas, J. M., Goldstein, D., Dunnett, Stephen Bruce and Jones, Lesley 2005. Integrating behaviour and brain gene expression in Huntington's disease transgenic mouse models. Journal of Neurology, Neurosurgery and Psychiatry 76 , A41-A41. |
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Jones, Lesley, Elliston, Linda Anne, Caswell, R. and Ersoy, N. 2005. Mutant huntingtin represses transcription from the thyroid hormone receptor. Journal of Neurology, Neurosurgery and Psychiatry 76 , A17-A17. |
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Redfern, A., Hughes, G., McGuffin, P., Aitchison, K., Vollmayr, B., Gass, P., O'Donovan, Michael Conlon, Craddock, Nicholas John and Jones, Lesley 2005. Global gene expression profiling in the hippocampus and frontal cortex of Escitalopram-treated Learned Helplessness rats. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 138B (1) , p. 107. |
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Brooks, S. P., Pask, T., Jones, Lesley and Dunnett, Stephen Bruce 2005. Behavioural profiles of inbred mouse strains used as transgenic backgrounds. II: cognitive tests. Genes, Brain and Behavior 4 (5) , pp. 307-317. 10.1111/j.1601-183X.2004.00109.x |
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Holmans, Peter Alan, Hamshere, Marian Lindsay, Hollingworth, P., Rice, Frances, Tunstall, N., Jones, S., Moore, P., Wavrant DeVrieze, F., Myers, A., Crook, R., Compton, D., Marshall, H., Meyer, D., Shears, S., Booth, J., Ramic, D., Williams, Nigel Melville, Norton, N., Abraham, R., Kehoe, P., Williams, H., Rudrasingham, V., O'Donovan, Michael Conlon, Jones, Lesley, Hardy, J., Goate, A., Lovestone, S., Owen, Michael John and Williams, Julie 2005. Genome screen for loci influencing age at onset and rate of decline in late onset Alzheimer's disease. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 135B (1) , pp. 24-32. 10.1002/ajmg.b.30114 |
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Morton, A. Jennifer, Hunt, Mark J., Hodges, Angela Kaye, Lewis, Paul David, Redfern, Amanda Jane, Dunnett, Stephen Bruce and Jones, Lesley 2005. A combination drug therapy improves cognition and reverses gene expression changes in a mouse model of Huntington's disease. European Journal of Neuroscience 21 (4) , pp. 855-870. 10.1111/j.1460-9568.2005.03895.x |
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Hughes, Alis, Errington, Rachel Jane, Fricker-Gates, Rosemary and Jones, Lesley 2004. Endophilin A3 forms filamentous structures that colocalise with microtubules but not with actin filaments. Molecular Brain Research 128 (2) , pp. 182-192. 10.1016/j.molbrainres.2004.06.016 |
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Brooks, S. P., Pask, T., Jones, Lesley and Dunnett, S. B. 2004. Behavioural profiles of inbred mouse strains used as transgenic backgrounds. I: motor tests. Genes, Brain and Behavior 3 (4) , pp. 206-215. 10.1111/j.1601-183X.2004.00072.x |
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Myers, Amanda J., Marshall, Helen, Holmans, Peter Alan, Compton, Danielle, Crook, Richard J.P., Mander, Adrian P., Nowotny, Petra, Smemo, Scott, Dunstan, Melanie, Jehu, Luke, Wang, Jen C., Hamshere, Marian Lindsay, Morris, John C., Norton, Joanne, Chakraventy, Sumi, Tunstall, Nigel, Lovestone, Simon, Petersen, Ronald, O'Donovan, Michael Conlon, Jones, Lesley, Williams, Julie, Owen, Michael John, Hardy, John and Goate, Alison 2004. Variation in the urokinase-plasminogen activator gene does not explain the chromosome 10 linkage signal for late onset AD. American Journal of Medical Genetics 124B (1) , pp. 29-37. 10.1002/ajmg.b.20036 |
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Busby, Victoria, Goossens, Steven, Nowotny, Petra, Hamilton, Gillian, Smemo, Scott, Harold, Denise, Turic, Dragana, Jehu, Luke, Myers, Amanda, Womick, Meredith, Woo, Daniel, Compton, Danielle, Doil, Lisa M., Tacey, Kristina M., Lau, Kit F., Al-Saraj, Safa, Killick, Richard, Pickering-Brown, Stuart, Moore, Pamela, Hollingworth, Paul, Archer, Nicola, Foy, Catherine, Walter, Sarah, Lovestone, Simon, O'Donovan, Michael Conlon, Owen, Michael John, Jones, Lesley, Williams, Julie and Holmans, Peter Alan 2004. Alpha-T-Catenin Is Expressed in Human Brain and Interacts With the Wnt Signaling Pathway But Is Not Responsible for Linkage to Chromosome 10 in Alzheimer's Disease. Neuromolecular Medicine 5 (2) , pp. 133-146. 10.1385/NMM:5:2:133 |
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Harold, Denise, Peirce, Timothy, Escott-Price, Valentina, Lovestone, Simon, Powell, John, Foy, Catherine, Archer, Nicola, Walter, Sarah, Edmonson, Amanda, McIlroy, Stephen, Craig, David, Passmore, Peter A., Goate, Alison, Hardy, John, O'Donovan, Michael Conlon, Williams, Julie, Liddell, Malcolm, Owen, Michael John, Jones, Lesley, Myers, Amanda, Jones, Susan, Hollingworth, Paul and Moore, Pamela 2003. Sequence variation in the CHAT locus shows no association with late-onset Alzheimer's disease. Human Genetics 113 (3) , pp. 258-267. 10.1007/s00439-003-0960-2 |
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Reid, Suzanne J., Rees, Mark I., van Roon-Mom, Willeke M.C., Jones, Lesley, MacDonald, Marcy E., Sutherland, Greg, During, Matthew J., Faull, Richard L.M., Owen, Michael John, Dragunow, Mike and Snell, Russell G. 2003. Molecular investigation of TBP allele length:. Neurobiology of Disease 13 (1) , pp. 37-45. 10.1016/S0969-9961(03)00014-7 |
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von Horsten, S., Schmitt, I., Nguyen, H. P., Holzmann, C., Schmidt, T., Walther, T., Bader, M., Pabst, R., Kobbe, P., Krotova, J., Stiller, D., Kask, A., Vaarmann, A., Rathke-Hartlieb, S., Schulz, J. B., Grasshoff, U., Bauer, I., Vieira-Saecker, A. M. M., Paul, M., Jones, Lesley, Lindenberg, K. S., Landwehrmeyer, B., Bauer, A., Li, X.-J. and Riess, O. 2003. Transgenic rat model of Huntington's disease. Human Molecular Genetics 12 (6) , pp. 617-624. 10.1093/hmg/ddg075 |
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Jones, Lesley, Gane, A. M., Herbert, D., Willey, D. L., Rutter, A. J., Kille, P., Dancer, J. E. and Harwood, J. L. 2003. beta-Ketoacyl-acyl carrier protein synthase III from pea (Pisum sativum L.): properties, inhibition by a novel thiolactomycin analogue and isolation of a cDNA clone encoding the enzyme. Planta 216 (5) , pp. 752-761. |
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van Roon-Mom, Willeke M.C, Reid, Suzanne J, Jones, Lesley, MacDonald, Marcy E, Faull, Richard L.M and Snell, Russell G 2002. Insoluble TATA-binding protein accumulation in Huntington's disease cortex. Molecular Brain Research 109 (1-2) , pp. 1-10. 10.1016/S0169-328X(02)00450-3 |
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Duce, James, Hartog, Cathy, Elliston, Linda Anne, Neal, James W., Nicholson, Louise F. B. and Jones, Lesley 2002. Transcriptional dysregulation in Huntington's disease. American Journal of Human Genetics 69 (4) , p. 545. 10.1007/978-1-4615-0715-4_49 |
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Myers, Amanda, Wavrant De-Vrieze, Fabienne, Holmans, Peter Alan, Hamshere, Marian Lindsay, Crook, Richard, Compton, Danielle, Marshall, Helen, Meyer, David, Shears, Shantia, Booth, Jeremy, Ramic, Dzanan, Knowles, Heather, Morris, John C., Williams, Nigel Melville, Norton, Nadine, Abraham, Richard, Kehoe, Pat, Williams, Hywel, Rudrasingham, Varuni, Rice, Frances, Giles, Peter, Tunstall, Nigel, Jones, Lesley, Lovestone, Simon, Williams, Julie, Owen, Michael John, Hardy, John and Goate, Alison 2002. Full genome screen for Alzheimer disease: Stage II analysis. American Journal Of Medical Genetics Part A 114 (2) , pp. 235-244. 10.1002/ajmg.10183 |
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Jones, Lesley 2002. The cell biology of Huntington's disease. In: Bates, G., Harper, P. S. and Jones, Aileen Lesley eds. Huntington's Disease (3rd ed.), Oxford Monographs on Medical Genetics, vol. 45. Oxford: Oxford University Press, pp. 348-386. |
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Abraham, Richard, Myers, Amanda, Wavrant-DeVrieze, Fabienne, Hamshere, Marian Lindsay, Thomas, Hollie Victoria, Marshall, Helen, Compton, Danielle, Spurlock, Gillian, Turic, Dragana, Hoogendoorn, Bastiaan, Kwon, Jennifer M., Petersen, Ronald C., Tangalos, Eric, Norton, Joanne, Morris, John C., Bullock, Roger, Liolitsa, Danae, Lovestone, Simon, Hardy, John, Goate, Alison, O'Donovan, Michael Conlon, Williams, Julie, Owen, Michael John and Jones, Lesley 2001. Substantial linkage disequilibrium across the insulin-degrading enzyme locus but no association with late-onset Alzheimer's disease. Human Genetics 109 (6) , pp. 646-652. 10.1007/s00439-001-0614-1 |
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Harper, Peter, Evans, R, Elliston, Linda, Ironside, J. W., Jones, Lesley and Lazarou, L. 2001. Huntington's disease intermediate allele and new variant CJD. American Journal of Human Genetics 69 (4) , p. 547. |
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Reid, S. J., Rees, M. I., van Roon-Mom, W. M. C., Jones, Lesley, McDonald, M. E., Sutherland, G. T., Owen, Michael John, Dragunow, M. and Snell, R. G. 2001. Expression and population studies of the TATA-box binding protein polyglutamine region at normal and expanded lengths. American Journal of Human Genetics 69 (4) , p. 424. |
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Jones, Lesley, Duce, J., Elliston, Linda and Harper, Peter 2001. The involvement of transcriptional repressor proteins in Huntington's disease. Journal of Medical Genetics 38 (Suppl1) , S65-S65. |
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Myers, A., Holmans, Peter Alan, Marshall, H., Kwon, J., Meyer, D., Ramic, D., Shears, S., Booth, J., DeVrieze, F. W., Crook, R., Hamshere, Marian Lindsay, Abraham, R., Tunstall, N., Rice, Frances, Carty, S., Lillystone, S., Kehoe, P., Rudrasingham, V., Jones, Lesley, Lovestone, S., Perez-Tur, J., Williams, Julie, Owen, Michael John, Hardy, J. and Goate, A. M. 2000. Susceptibility locus for Alzheimer's disease on chromosome 10. Science 290 (5500) , pp. 2304-2305. 10.1126/science.290.5500.2304 |
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Jones, Lesley, Herbert, D., Rutter, A. J., Dancer, J. E. and Harwood, J. L. 2000. Novel inhibitors of the condensing enzymes of the type II fatty acid synthase of pea (Pisum sativum). Biochemical Journal 347 (1) , pp. 205-209. 10.1042/bj3470205 |
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Boutell, J. M., Thomas, P., Neal, J. W., Weston, V. J., Duce, J., Harper, P. S. and Jones, Lesley 1999. Aberrant interactions of transcriptional repressor proteins with the Huntington's disease gene product, huntingtin. Human Molecular Genetics 8 (9) , pp. 1647-1655. 10.1093/hmg/8.9.1647 |
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Jones, Lesley 1999. The localization and interactions of huntingtin. Philosophical Transactions of the Royal Society of London Series B - Biological Sciences 354 (1386) , pp. 1021-1027. 10.1098/rstb.1999.0454 |
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Wilkinson, F. L., Nguyen, T. M., Manilal, S. B., Thomas, P., Neal, J. W., Harper, P. S., Jones, Lesley and Morris, G. E. 1999. Localization of rabbit huntingtin using a new panel of monoclonal antibodies. Molecular Brain Research 69 (1) , pp. 10-20. 10.1016/S0169-328X(99)00097-2 |
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Sieradzan, K. A., Mechan, A. O., Jones, Lesley, Wanker, E. E., Nukina, N. and Mann, D. M. 1999. Huntington's disease intranuclear inclusions contain truncated, ubiquitinated huntingtin protein. Experimental Neurology 156 (1) , pp. 92-99. 10.1006/exnr.1998.7005 |
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Kehoe, P., Krawczak, M., Harper, P. S., Owen, Michael John and Jones, Lesley 1999. Age of onset in Huntington disease: sex specific influence of apolipoprotein E genotype and normal CAG repeat length. Journal of Medical Genetics 36 (2) , pp. 108-111. 10.1136/jmg.36.2.108 |
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Thomas, P., Wilkinson, F., Nguyen, T. M., Harper, P. S., Neal, J. W., Morris, G. E. and Jones, Lesley 1998. Full length huntingtin is not detected in intranuclear inclusions in Huntington's disease brain. Biochemical Society Transactions 26 (3) , S243. 10.1042/bst026s243 |
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Singhrao, S. K., Thomas, P., Wood, D. J., MacMillan, J. C., Neal, J. W., Harper, P. S. and Jones, Lesley 1998. Huntingtin protein colocalizes with lesions of neurodegenerative diseases: An investigation in Huntington's, Alzheimer's, and Pick's diseases. Experimental Neurology 150 (2) , pp. 213-222. 10.1006/exnr.1998.6778 |
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Boutell, J. M., Wood, J. D., Harper, P. S. and Jones, Lesley 1998. Huntingtin interacts with cystathionine beta-synthase. Human Molecular Genetics 7 (3) , pp. 371-378. 10.1093/hmg/7.3.371 |
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Jones, Lesley, Middle, F., Guy, Carol, Spurlock, G., Cairns, N. J., McGuffin, P., Craddock, Nicholas John, Owen, Michael John and O'Donovan, Michael Conlon 1997. No evidence for expanded polyglutamine sequences in bipolar disorder and schizophrenia. Molecular Psychiatry 2 (6) , pp. 478-482. 10.1038/sj.mp.4000297 |
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Boutell, J. M., Krusche, L. A., Harper, P. S. and Jones, Lesley 1997. Generation of clones with varying trinucleotide repeat sires using intrinsic instability in E-coli. American Journal of Human Genetics 61 (4) , A404-A404. |
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Singhrao, S. K., Thomas, P., Wood, J. D., Harper, P. S., Neal, J. W. and Jones, Lesley 1997. Huntingtin is associated with intracellular neuropathology in Huntington's, Alzheimer's and Pick's disease. American Journal of Human Genetics 61 (4) , A321-A321. |
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Jones, Lesley, Boutell, J. M., Wood, J. D. and Harper, P. S. 1997. Two proteins which interact with the N-terminus of huntingtin. American Journal of Human Genetics 61 (4) , A311-A311. |
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Jones, Lesley, Wood, J. D. and Harper, P. S. 1997. Huntington disease: advances in molecular and cell biology. Journal of Inherited Metabolic Disease 20 (2) , pp. 125-138. 10.1023/A:1005340302695 |
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Wood, J. D., MacMillan, J. C., Harper, P. S., Lowenstein, P. R. and Jones, Lesley 1996. Partial characterisation of murine huntingtin and apparent variations in the subcellular localisation of huntingtin in human, mouse and rat brain. Human Molecular Genetics 5 (4) , pp. 481-487. 10.1093/hmg/5.4.481 |
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Wood, J., MacMillan, J. C., Thomas, P., Lowenstein, P. R., Harper, P. S. and Jones, Lesley 1995. Characterising the Huntington's disease gene product. Biochemical Society Transactions 23 (4) , 595S. 10.1042/bst023595s |
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MacMillan, J. C., Thomas, P., Wood, J., Jones, Lesley, Harper, P. S. and Lowenstein, P. R. 1995. Light microscopic analysis of the distribution of the Huntington disease protein in murine brain. American Journal of Human Genetics 57 (4) , p. 1823. |
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Wood, J., MacMillan, J. C., Harper, P. S. and Jones, Lesley 1995. Subcellular-distribution and characterization of the Huntingtons-Disease gene-product in human and mouse brain. American Journal of Human Genetics 57 (4) , p. 1473. |
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Jones, Lesley, Dancer, Jane E. and Harwood, John L. 1995. Effect of thiolactomycin on fatty acid synthesis in peas. Phytochemistry 39 (3) , p. 511. 10.1016/0031-9422(95)00033-4 |
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Jones, Lesley, Dancer, J. E. and Harwood, J. L. 1994. The effect of thiolactomycin analogues on fatty acid synthesis in peas (Pisum sativum cv. Onward). Biochemical Society Transactions 22 (3) , 258S. 10.1042/bst022258s |
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Jones, Lesley, Lloyd, D and Harwood, J L 1993. Rapid induction of microsomal delta12(w 6)-desaturase activity in chilledAcanthamoeba castellanii. Biochemical Journal 296 (1) , pp. 183-188. 10.1042/bj2960183 |
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Jones, Lesley and Harwood, John L. 1993. Lipids and lipid metabolism in the marine alga Enteromorpha intestinalis. Phytochemistry 34 (4) , pp. 969-972. 10.1016/S0031-9422(00)90695-2 |
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Jones, Lesley and Harwood, J. 1993. Lipid-metabolism in the brown marine-algae fucus-vesiculosus and ascophyllum-nodosum. Journal of Experimental Botany 44 (264) , pp. 1203-1210. 10.1093/jxb/44.7.1203 |
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Jones, Lesley, Kille, Peter, Dancer, Jane E. and Harwood, John L. 1993. The cloning and overexpression ofE coliacyl carrier protein (ACP). Biochemical Society Transactions 21 (2) , 202S-202S. 10.1042/bst021202s |
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Jones, Lesley, Kille, Peter, Dancer, J. E. and Harwood, J. L. 1993. The cloning and overexpression of escherichia-coli acyl carrier protein. Grasas Y Aceites 44 (2) , pp. 116-117. |
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Jones, Lesley, Hann, A C, Harwood, J L and Lloyd, D 1993. Temperature-induced membrane-lipid adaptation inAcanthamoeba castellanii. Biochemical Journal 290 (1) , pp. 273-278. 10.1042/bj2900273 |
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Jones, Lesley and Harwood, John L. 1992. Lipid composition of the brown algae fucus vesiculosus and Ascophyllum nodosum. Phytochemistry 31 (10) , pp. 3397-3403. 10.1016/0031-9422(92)83693-S |
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Jones, Lesley, Harwood, John L. and Lloyd, David 1992. Induction of delta12-desaturase activity during temperature adaptation in Acanthamoeba castellanii. Biochemical Society Transactions 20 (2) , 170S-170S. 10.1042/bst020170s |
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Jones, Lesley, Pruitt, Nancy L., Lloyd, David and Harwood, John L. 1991. Temperature-induced Changes in the Synthesis of Unsaturated Fatty Acids byAcanthamoeba castellanii. The Journal of Protozoology 38 (6) , pp. 532-536. 10.1111/j.1550-7408.1991.tb06076.x |
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Jones, Lesley, Lloyd, D., Hann, A. C. and Harwood, J. L. 1991. Lipid changes in individual membranes of Acanthamoeba castellanii during temperature adaptation. Biochemical Society Transactions 19 (3) , 318S-318S. 10.1042/bst019318s |
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Jones, Lesley, Pruitt, Nancy L., Lloyd, David and Harwood, John L. 1990. Effect of growth temperature on fatty acid biosynthesis in Acanthamoeba castellanii. Biochemical Society Transactions 18 (4) , p. 627. 10.1042/bst0180627 |
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Harwood, John L. and Jones, Lesley 1989. Lipid Metabolism in Algae. Advances in Botanical Research 16 , pp. 1-53. 10.1016/S0065-2296(08)60238-4 |
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Pettitt, T.R., Jones, Lesley and Harwood, J.L. 1989. Lipids of the marine red algae, chondrus-crispus and polysiphonia-lanosa. Phytochemistry 28 (2) , pp. 399-405. |
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Pettitt, Trevor R., Jones, Lesley and Harwood, John L. 1989. Lipid metabolism in the red marine algae Chondrus crispus and Polysiphonia lanosa as modified by temperature. Phytochemistry 28 (8) , pp. 2053-2058. 10.1016/S0031-9422(00)97919-6 |
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Jones, Lesley and Harwood, J.L. 1988. Effects of heavy-metals on lipid-metabolism in marine-algae. Biochemical Society Transactions 16 (3) , pp. 275-276. |
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Jones, Lesley and Harwood, John L. 1987. Comparative aspects of lipid metabolism in marine algae. Biochemical Society Transactions 15 (3) , p. 482. 10.1042/bst0150482 |
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