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Number of items: 63.

Schmidt, Nina, Irle, Inga, Ripkens, Kamilla, Lux, Vanda, Nelles, Jasmin, Johannes, Christian, Parry, Lee, Greenow, Kirsty, Amir, Sarah, Campioni, Mara, Baldi, Alfonso, Oka, Chio, Kawaichi, Masashi, Clarke, Alan R. and Ehrmann, Michael 2016. Epigenetic silencing of serine protease HTRA1 drives polyploidy. BMC Cancer 16 (1) , 399. 10.1186/s12885-016-2425-8
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Poepsel, Simon, Sprengel, Andreas, Sacca, Barbara, Kaschani, Farnusch, Kaiser, Markus, Gatsogiannis, Christos, Raunser, Stefan, Clausen, Tim and Ehrmann, Michael 2015. Determinants of amyloid fibril degradation by the PDZ protease HTRA1. Nature Chemical Biology 11 (11) , pp. 862-869. 10.1038/nchembio.1931
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Beaufort, Nathalie, Scharrer, Eva, Lux, Vanda, Ehrmann, Michael, Haffner, Christof and Dichgans, Martin 2015. Reply to Liu et al.: Loss of TGF-β signaling in CARASIL pathogenesis. Proceedings of the National Academy of Sciences of the United States of America 112 (14) , E1694. 10.1073/pnas.1501817112

Ehrmann, Michael, Kaschani, Farnusch and Kaiser, Markus 2015. Chemical proteomics versus Leishmaniasis. Chemistry & Biology 22 (3) , pp. 309-310. 10.1016/j.chembiol.2015.03.001
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Beaufort, Nathalie, Scharrer, Eva, Kremmer, Elisabeth, Lux, Vanda, Ehrmann, Michael, Huber, Robert, Houlden, Henry, Werring, David, Haffner, Christof and Dichgans, Martin 2014. Cerebral small vessel disease-related protease HtrA1 processes latent TGF-β binding protein 1 and facilitates TGF-β signaling. Proceedings of the National Academy of Sciences of the United States of America 111 (46) , 16496. 10.1073/pnas.1418087111

Thompson, Natalie J., Merdanovic, Melisa, Ehrmann, Michael, van Duijn, Esther and Heck, Albert J. R. 2014. Substrate occupancy at the onset of oligomeric transitions of DegP. Structure 22 (2) , pp. 281-290. 10.1016/j.str.2013.11.010
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Mastny, Markus, Heuck, Alexander, Kurzbauer, Robert, Heiduk, Anja, Boisguerin, Prisca, Volkmer, Rudolf, Ehrmann, Michael, Rodrigues, Christopher D. A., Rudner, David Z. and Clausen, Tim 2013. CtpB assembles a gated protease tunnel regulating cell-cell signaling during spore formation in Bacillus subtilis. Cell 155 (3) , pp. 647-658. 10.1016/j.cell.2013.09.050

Gloeckl, Sarina, Ong, Vanissa A., Patel, Pooja, Tyndall, Joel D. A., Timms, Peter, Beagley, Kenneth W., Allan, John A., Armitage, Charles W., Turnbull, Lynne, Whitchurch, Cynthia B., Merdanovic, Melisa, Ehrmann, Michael, Powers, James C., Oleksyszyn, Jozef, Verdoes, Martijn, Bogyo, Matthew and Huston, Wilhelmina M. 2013. Identification of a serine protease inhibitor which causes inclusion vacuole reduction and is lethal to Chlamydia trachomatis. Molecular Microbiology 89 (4) , pp. 676-689. 10.1111/mmi.12306

Stolze, Sara C., Meltzer, Michael, Ehrmann, Michael and Kaiser, Markus 2013. Ahp cyclodepsipeptides: the Impact of the Ahp residue on the "Canonical Inhibition" of S1 serine proteases. ChemBioChem 14 (11) , pp. 1301-1308. 10.1002/cbic.201300180

Merdanovic, Melisa, Mönig, Timon, Ehrmann, Michael and Kaiser, Markus 2013. Diversity of allosteric regulation in proteases. ACS Chemical Biology 8 (1) , pp. 19-26. 10.1021/cb3005935

Nigro, A., Menon, R., Bergamaschi, A., Clovis, Y. M., Baldi, A., Ehrmann, Michael, Comi, G., De Pietri Tonelli, D., Farina, C., Martino, G. and Muzio, L. 2012. MiR-30e and miR-181d control Radial Glia cell proliferation via HtrA1 modulation. Cell Death and Disease 3 , e360. 10.1038/cddis.2012.98

Tiaden, Andre N., Klawitter, Marina, Lux, Vanda, Mirsaidi, Ali, Bahrenberg, Gregor, Glanz, Stephan, Quero, Lilian, Liebscher, Thomas, Wuertz, Karin, Ehrmann, Michael and Richards, Peter J. 2012. Detrimental role for human high temperature requirement serine protease A1 (HTRA1) in the pathogenesis of intervertebral disc (IVD) degeneration. Journal of Biological Chemistry 287 (25) , pp. 21335-21345. 10.1074/jbc.M112.341032

Lütticke, Christiane, Hauske, Patrick, Lewandrowski, Urs, Sickmann, Albert, Kaiser, Markus and Ehrmann, Michael 2012. E. coli LoiP (YggG), a metalloprotease hydrolyzing Phe-Phe bonds. Molecular BioSystems 8 (6) , pp. 1775-1782. 10.1039/c2mb05506f

Stolze, Sara C., Meltzer, Michael, Ehrmann, Michael and Kaiser, Markus 2012. Development of a solid-phase approach to the natural product class of Ahp-containing cyclodepsipeptides. European Journal of Organic Chemistry 2012 (8) , pp. 1616-1625. 10.1002/ejoc.201101757

Weski, Juliane, Meltzer, Michael, Spaan, Lina, Mönig, Timon, Oeljeklaus, Julian, Hauske, Patrick, Vouilleme, Lars, Volkmer, Rudolf, Boisguerin, Prisca, Boyd, Dana, Huber, Robert, Kaiser, Markus and Ehrmann, Michael 2012. Chemical biology approaches reveal conserved features of a C-terminal processing PDZ protease. Chembiochem 13 (3) , pp. 402-408. 10.1002/cbic.201100643

Malet, Hélène, Canellas, Flavia, Sawa, Justyna, Yan, Jun, Thalassinos, Konstantinos, Ehrmann, Michael, Clausen, Tim and Saibil, Helen R. 2012. Newly folded substrates inside the molecular cage of the HtrA chaperone DegQ. Nature Structural & Molecular Biology 19 (2) , pp. 152-157. 10.1038/nsmb.2210

Tiaden, André N, Breiden, Maike, Mirsaidi, Ali, Weber, Fabienne A., Bahrenberg, Gregor, Glanz, Stephan, Cinelli, Paolo, Ehrmann, Michael and Richards, Peter J. 2012. Human serine protease HTRA1 positively regulates osteogenesis of human bone marrow-derived mesenchymal stem cells and mineralization of differentiating bone-forming cells through the modulation of extracellular matrix protein. Stem Cells 30 (10) , pp. 2271-2282. 10.1002/stem.1190

Weski, Juliane and Ehrmann, Michael 2012. Genetic analysis of 15 protein folding factors and proteases of the escherichia coli cell envelope. Journal of Bacteriology 194 (12) , pp. 3225-3233. 10.1128/JB.00221-12

Merdanovic, Melisa, Clausen, Tim, Kaiser, Markus, Huber, Robert and Ehrmann, Michael 2011. Protein quality control in the bacterial periplasm. Annual Review of Microbiology 65 (1) , pp. 149-168. 10.1146/annurev-micro-090110-102925

Sinha, Sharmistha, Lopes, Dahabada H. J., Du, Zhenming, Pang, Eric S., Shanmugam, Akila, Lomakin, Aleksey, Talbiersky, Peter, Tennstaedt, Annette, McDaniel, Kirsten, Bakshi, Reena, Kuo, Pei-Yi, Ehrmann, Michael, Benedek, George B., Loo, Joseph A., Klärner, Frank-Gerrit, Schrader, Thomas, Wang, Chunyu and Bitan, Gal 2011. Lysine-specific molecular tweezers are broad-spectrum inhibitors of assembly and toxicity of amyloid proteins. Journal of the American Chemical Society 133 (42) , pp. 16958-16969. 10.1021/ja206279b

Sawa, Justyna, Malet, Helene, Krojer, Tobias, Canellas, Flavia, Ehrmann, Michael and Clausen, Tim 2011. Molecular adaptation of the DegQ protease to exert protein quality control in the bacterial cell envelope. Journal of Biological Chemistry 286 (35) , pp. 30680-30690. 10.1074/jbc.M111.243832

Wu, Junchen, Zawistowski, Adam, Ehrmann, Michael, Yi, Tao and Schmuck, Carsten 2011. Peptide functionalized polydiacetylene liposomes act as a gluorescent turn-on sensor for bacterial Lipopolysaccharide. Journal of the American Chemical Society 133 (25) , pp. 9720-9723. 10.1021/ja204013u

Kley, Juliane, Schmidt, Bastian, Boyanov, Boril, Stolt-Bergner, Peggy C., Kirk, Rebecca, Ehrmann, Michael, Knopf, Ronit R., Naveh, Leah, Adam, Zach and Clausen, Tim 2011. Structural adaptation of the plant protease Deg1 to repair photosystem II during light exposure. Nature Structural & Molecular Biology 18 (6) , pp. 728-731. 10.1038/nsmb.2055

Truebestein, Linda, Tennstaedt, Annette, Mönig, Timon, Krojer, Tobias, Canellas, Flavia, Kaiser, Markus, Clausen, Tim and Ehrmann, Michael 2011. Substrate-induced remodeling of the active site regulates human HTRA1 activity. Nature Structural & Molecular Biology 18 (3) , pp. 386-388. 10.1038/nsmb.2013

Clausen, Tim, Kaiser, Markus, Huber, Robert and Ehrmann, Michael 2011. HTRA proteases: regulated proteolysis in protein quality control. Nature Reviews Molecular Cell Biology 12 (3) , pp. 152-162. 10.1038/nrm3065

Stolze, Sara C., Meltzer, Michael, Ehrmann, Michael and Kaiser, Markus 2010. Solid phase total synthesis of the 3-amino-6-hydroxy-2-piperidone (Ahp) cyclodepsipeptide and protease inhibitor Symplocamide A. Chemical Communications 46 (46) , pp. 8857-8859. 10.1039/c0cc02889d

Campioni, Mara, Severino, Anna, Manente, Lucrezia, Tuduce, Ioana L., Toldo, Stefano, Caraglia, Michele, Crispi, Stefania, Ehrmann, Michael, He, Xiaoping, Maguire, Jacie, De Falco, Maria, De Luca, Antonia, Shridhar, Viji and Baldi, Alfonso 2010. The serine protease HtrA1 specifically interacts and degrades the tuberous sclerosis complex 2 protein. Molecular Cancer Research 8 (9) , pp. 1248-1260. 10.1158/1541-7786.MCR-09-0473

Merdanovic, Melisa, Mamant, Nicolette, Meltzer, Michael, Poepsel, Simon, Auckenthaler, Alexandra, Melgaard, Rie, Hauske, Patrick, Nagel-Steger, Luitgard, Clarke, Anthony R, Kaiser, Markus, Huber, Robert and Ehrmann, Michael 2010. Determinants of structural and functional plasticity of a widely conserved protease chaperone complex. Nature Structural & Molecular Biology 17 (7) , pp. 837-843. 10.1038/nsmb.1839

Sawa, Justyna, Heuck, Alexander, Ehrmann, Michael and Clausen, Tim 2010. Molecular transformers in the cell: lessons learned from the DegP protease-chaperone. Current Opinion in Structural Biology 20 (2) , pp. 253-258. 10.1016/j.sbi.2010.01.014

Hasenbein, Sonja, Meltzer, Michael, Hauske, Patrick, Kaiser, Markus, Huber, Robert, Clausen, Tim and Ehrmann, Michael 2010. Conversion of a regulatory into a degradative protease. Journal of Molecular Biology 397 (4) , pp. 957-966. 10.1016/j.jmb.2010.02.027

Merdanovic, Melisa, Mamant, Nicolette, Meltzer, Michael, Poepsel, Simon, Auckenthaler, Alexandra, Melgaard, Rie, Hauske, Patrick, Nagel-Steger, Luitgard, Clarke, Anthony, Kaiser, Markus, Huber, Robert and Ehrmann, Michael 2010. Determinants of structural and functional plasticity of a widely conserved protease chaperone complex. Nature Structural & Molecular Biology 17 (7) , pp. 837-843. 10.1038/nsmb.1839

Meltzer, Michael, Hasenbein, Sonja, Mamant, Nicolette, Merdanovic, Melisa, Poepsel, Simon, Hauske, Patrick, Kaiser, Markus, Huber, Robert, Krojer, Tobias, Clausen, Tim and Ehrmann, Michael 2009. Structure, function and regulation of the conserved serine proteases DegP and DegS of Escherichia coli. Research in Microbiology 160 (9) , pp. 660-666. 10.1016/j.resmic.2009.07.012

Hauske, Patrick, Meltzer, Michael, Ottmann, Christian, Krojer, Tobias, Clausen, Tim, Ehrmann, Michael and Kaiser, Markus 2009. Selectivity profiling of DegP substrates and inhibitors. Bioorganic & Medicinal Chemistry 17 (7) , pp. 2920-2924. 10.1016/j.bmc.2009.01.073

Hauske, Patrick, Mamant, Nicolette, Hasenbein, Sonja, Nickel, Sabrina, Ottmann, Christian, Clausen, Tim, Ehrmann, Michael and Kaiser, Markus 2009. Peptidic small molecule activators of the stress sensor DegS. Molecular Biosystems 5 (9) , pp. 980-985. 10.1039/b902089f

Krojer, Tobias, Sawa, Justyna, Schäfer, Eva, Saibil, Helen R., Ehrmann, Michael and Clausen, Tim 2008. Structural basis for the regulated protease and chaperone function of DegP. Nature 453 (7197) , pp. 885-890. 10.1038/nature07004

Krojer, Tobias, Pangerl, Karen, Kurt, Juliane, Sawa, Justyne, Stingl, Christoph, Mechtler, Karl, Huber, Robert, Ehrmann, Michael and Clausen, Tim 2008. Interplay of PDZ and protease domain of DegP ensures efficient elimination of misfolded proteins. Proceedings of the National Academy of Sciences 105 (22) , pp. 7702-7707. 10.1073/pnas.0803392105

Meltzer, Michael, Hasenbein, Sonja, Hauske, Patrick, Kucz, Nicolette, Merdanovic, Melisa, Grau, Sandra, Beil, Alexandra, Jones, Darran Dafydd, Krojer, Tobias, Clausen, Tim, Ehrmann, Michael and Kaiser, Markus 2008. Allosteric activation of HtrA protease DegP by stress signals during bacterial protein quality control. Angewandte Chemie - International Edition 47 (7) , pp. 1332-1334. 10.1002/anie.200703273

Baldi, Alfonso, Mottolese, Marcella, Vincenzi, Bruno, Campioni, Mara, Mellone, Pasquale, Di Marino, Mariapia, di Crescenzo, Vincenzo G., Visca, Paolo, Menegozzo, Simona, Spugnini, Enrico P., Citro, Gennaro, Ceribelli, Anna, Mirri, Alessandra, Chien, Jeremy, Shridhar, Viji, Ehrmann, Michael, Santini, Mario and Facciolo, Francesco 2008. The serine protease HtrA1 is a novel prognostic factor for human mesothelioma. Pharmacogenomics 9 (8) , pp. 1069-1077. 10.2217/14622416.9.8.1069

Hauske, Patrick, Ottmann, Christian, Meltzer, Michael, Ehrmann, Michael and Kaiser, Markus 2008. Allosteric regulation of proteases. Chembiochem 9 (18) , pp. 2920-2928. 10.1002/cbic.200800528

Launay, S., Maubert, E., Lebeurrier, N., Tennstaedt, A., Campioni, M., Docagne, F., Gabriel, C., Dauphinot, L., Potier, M. C., Ehrmann, Michael, Baldi, A. and Vivien, D. 2008. HtrA1-dependent proteolysis of TGF-β controls both neuronal maturation and developmental survival. Cell Death and Differentiation 15 (9) , pp. 1408-1416. 10.1038/cdd.2008.82

Hasenbein, Sonja, Merdanovic, Melisa and Ehrmann, Michael 2007. Determinants of regulated proteolysis in signal transduction. Genes & Development 21 (1) , pp. 6-10. 10.1101/gad.1507807

Hasselblatt, H., Kurzbauer, R., Wilken, C., Krojer, T., Sawa, J., Kurt, J., Kirk, R., Hasenbein, S., Ehrmann, Michael and Clausen, T. 2007. Regulation of the  E stress response by DegS: how the PDZ domain keeps the protease inactive in the resting state and allows integration of different OMP-derived stress signals upon folding stress. Genes & Development 21 (20) , pp. 2659-2670. 10.1101/gad.445307

Severino, Anna, Campioni, Mara, Straino, Stefania, Salloum, Fadi N., Schmidt, Nina, Herbrand, Ulrike, Frede, Stilla, Toietta, Gabriele, Di Rocco, Giuliana, Bussani, Rossana, Silvestri, Furio, Piro, Maddalena, Liuzzo, Giovanna, Biasucci, Luigi M., Mellone, Pasquale, Feroce, Florinda, Capogrossi, Maurizio, Baldi, Feliciano, Fandrey, Joachim, Ehrmann, Michael, Crea, Filippo, Abbate, Antonio and Baldi, Alfonso 2007. Identification of protein disulfide isomerase as a cardiomyocyte survival factor in ischemic cardiomyopathy. Journal of the American College of Cardiology 50 (11) , p. 1029. 10.1016/j.jacc.2007.06.006

Eser, Markus, Henrichs, Tanja, Boyd, Dana and Ehrmann, Michael 2007. Target‐directed proteolysis In vivo. Methods in Enzymology 421 , pp. 68-83. 10.1016/S0076-6879(06)21008-5

Richards, Peter James, Nowell, Mari Ann, Horiuchi, Sankichi, McLoughlin, Rachel Mary, Fielding, Ceri Alan, Grau, Sandra, Yamamoto, Naoki, Ehrmann, Michael, Rose-John, Stefan, Williams, Anwen Sian, Topley, Nicholas and Jones, Simon Arnett 2006. Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis. Arthritis & Rheumatism 54 (5) , pp. 1662-1672. 10.1002/art.21818

Grau, Sandra, Richards, Peter J., Kerr, Briedgeen, Hughes, Clare Elizabeth, Caterson, Bruce, Williams, Anwen Sian, Junker, Uwe, Jones, Simon Arnett, Clausen, Tim and Ehrmann, Michael 2006. The role of human HtrA1 in arthritic disease. The Journal of Biological Chemistry 281 (10) , pp. 6124-6129. 10.1074/jbc.M500361200

Chien, J., Aletti, G., Baldi, A., Catalano, V., Muretto, P., Keeney, G. L., Kalli, K. R., Staub, J., Ehrmann, Michael, Cliby, W. A., Lee, Y. K., Bible, K. C., Hartmann, L. C., Kaufmann, S. H. and Shridhar, V. 2006. Serine protease HtrA1 modulates chemotherapy-induced cytotoxicity. The Journal of Clinical Investigation 116 (7) , pp. 1994-2004. 10.1172/JCI27698

Henrichs, Tanja, Mikhaleva, Natasha, Conz, Charlotte, Deuerling, Elke, Boyd, Dana, Zelazny, Adrian, Bibi, Eitan, Ban, Nenad and Ehrmann, Michael 2005. Target-directed proteolysis at the ribosome. Proceedings of the National Academy of Sciences of the USA , pp. 4246-4251. 10.1073/pnas.0408520102

Ehrmann, Michael 2005. Protein folding in the periplasm and outer membrane of E. coli. In: Buchner, Johannes and Kiefhaber, Thomas eds. Protein Folding Handbook, Weinheim: Wiley-VCH, p. 938. (10.1002/9783527619498.ch61)

Tian, Xiaodan, Cecal, Roxana, McLaurin, JoAnne, Manea, Marilena, Stefanescu, Raluca, Grau, Sandra, Harnasch, Mona, Amir, Sarah, Ehrmann, Michael, St George-Hyslop, Peter, Kohlmann, Markus and Przybylski, Michael 2005. Identification and structural characterisation of carboxy-terminal polypeptides and antibody epitopes of Alzheimer's amyloid precursor protein using high-resolution mass spectrometry. European Journal of Mass Spectrometry 11 (1) , pp. 547-556. 10.1255/ejms.722

Grau, S., Baldi, A., Bussani, R., Tian, X., Stefanescu, R., Przybylski, M., Richards, P., Jones, S. A., Shridhar, V., Clausen, T. and Ehrmann, Michael 2005. Implications of the serine protease HtrA1 in amyloid precursor protein processing. Proceedings of the National Academy of Sciences of the United States of America 102 (17) , pp. 6021-6026. 10.1073/pnas.0501823102

Wilken, Corinna, Kitzing, Karina, Kurzbauer, Robert, Ehrmann, Michael and Clausen, Tim 2004. Crystal structure of the DegS stress sensor: How a PDZ domain recognises misfolded protein and activates a protease. Cell 117 , pp. 483-494. 10.1016/S0092-8674(04)00454-4

Harnasch, Mona, Grau, Sandra, Behrends, Christian, Dove, Simon L., Hochschild, Ann, Iskandar, Maria-karnina, Xia, Weiming and Ehrmann, Michael 2004. Characterization of presenilin-amyloid precursor interaction using bacterial expression and two-hybrid systems for human membrane proteins. Molecular Membrane Biology 21 (6) , pp. 373-383. 10.1080/09687860400008429

Ehrmann, Michael and Clausen, Tim 2004. Proteolysis as a regulatory mechanism. Annual Review of Genetics 38 (1) , pp. 709-724. 10.1146/annurev.genet.38.072902.093416

Ehrmann, Michael and Eser, M. 2003. SecA-dependent quality control of intracellular protein localisation. Proceedings of the National Academy of Sciences 100 (23) , pp. 13231-13234. 10.1073/pnas.2234410100

Ehrle, Rainer, Mikhaleva, Natasha, Boyd, Dana, Davidson, Amy L. and Ehrmann, Michael 2003. Context-dependent effects of charged residues in transmembrane segments of MalF–PhoA fusions. Research in Microbiology 154 (9) , pp. 654-657. 10.1016/j.resmic.2003.07.001

Krojer, Tobias, Garrido-Franco, Marta, Huber, Robert, Ehrmann, Michael and Clausen, Tim 2002. Corrigendum: Crystal structure of DegP (HtrA) reveals a new protease-chaperone machine [Letter]. Nature 417 (6884) , p. 102. 10.1038/417102c

Krojer, Tobias, Garrido-Franco, Marta, Huber, Robert, Ehrmann, Michael and Clausen, Tim 2002. Crystal structure of DegP (HtrA) reveals a new protease-chaperone machine. Nature Nature , pp. 455-459. 10.1038/416455a

Clausen, Tim, Southan, Chris and Ehrmann, Michael 2002. The HtrA family of proteases: implications for protein composition and cell fate. Molecular Cell 10 (3) , pp. 443-455. 10.1016/S1097-2765(02)00658-5

Faber, Klaas Nico, Kram, Anita M., Ehrmann, Michael and Veenhuis, Marten 2001. A novel method to determine the topology of peroxisomal membrane proteins in vivo using the tobacco etch virus protease. Journal of Biological Chemistry 276 (39) , pp. 36501-36507. 10.1074/jbc.M105828200

Herskovits, Anat A., Seluanov, Andrei, Rajsbaum, Ricardo, ten Hagen-Jongman, Corinne M., Henrichs, Tanja, Bochkareva, Elena S., Phillips, Gregory J.l, Probst, Francis J., Nakae, Taiji, Ehrmann, Michael, Luirink, Joen and Bibi, Eitan 2001. Evidence for coupling of membrane targeting and function of the signal recognition particle(SRP) receptor FtsY. Embo Reports 2 (11) , pp. 1040-1046. 10.1093/embo-reports/kve226

Steinke, A., Grau, S., Davidson, A., Hofmann, E. and Ehrmann, Michael 2001. Characterization of transmembrane segments 3, 4, and 5 of MalF by mutational analysis. Journal of Bacteriology 183 (1) , pp. 375-381. 10.1128/JB.183.1.375-381.2001

Uhland, K., Mondigler, M., Spiess, C., Prinz, W. and Ehrmann, Michael 2000. Determinants of translocation and folding of TreF, a trehalase of Escherichia coli. Journal of Biological Chemistry 275 (31) , pp. 23439-23445. 10.1074/jbc.M002793200

This list was generated on Fri Dec 6 04:47:13 2019 GMT.