Browse by Current Cardiff authors

Grimes, Leanne, Griffiths, Julia, Pasqualetto, Gaia, Brancale, Andrea, Kemp, Paul J., Young, Mark T. and van der Goes van Naters, Wynand 2020. Drosophila taste neurons as an agonist-screening platform for P2X receptors. Scientific Reports 10 (1) , 8292. 10.1038/s41598-020-65169-9

Smith-Geater, Charlene, Hernandez, Sarah J., Lim, Ryan G., Adam, Miriam, Wu, Jie, Stocksdale, Jennifer T., Wassie, Brook T., Gold, Maxwell Philip, Wang, Keona Q., Miramontes, Ricardo, Kopan, Lexi, Orellana, Iliana, Joy, Shona, Kemp, Paul J., Allen, Nicholas D., Fraenkel, Ernest and Thompson, Leslie M. 2020. Aberrant development corrected in adult-onset Huntington's disease iPSC-derived neuronal cultures via WNT signaling modulation. Stem Cell Reports 14 (3) , pp. 406-419. 10.1016/j.stemcr.2020.01.015

Garcia, Veronica J., Rushton, David J., Tom, Colton M., Allen, Nicholas D., Kemp, Paul J., Svendsen, Clive N. and Mattis, Virginia B. 2019. Huntington's disease patient-derived astrocytes display electrophysiological impairments and reduced neuronal support. Frontiers in Neuroscience 13 , 669. 10.3389/fnins.2019.00669

Telezhkin, Vsevolod, Straccia, Marco, Yarova, Polina, Pardo, Monica, Yung, Sun, Vinh, Ngoc-Nga, Hancock, Jane M., Barriga, Gerardo Garcia-Diaz, Brown, David A., Rosser, Anne E., Brown, Jonathan T., Canals, Josep M., Randall, Andrew D., Allen, Nicholas D. and Kemp, Paul J. 2018. Kv7 channels are upregulated during striatal neuron development and promote maturation of human iPSC-derived neurons. Pflügers Archiv European Journal of Physiology 470 (9) , pp. 1359-1376. 10.1007/s00424-018-2155-7

Lim, Ryan G., Salazar, Lisa L., Wilton, Daniel K., King, Alvin R., Stocksdale, Jennifer T., Sharifabad, Delaram, Lau, Alice L., Stevens, Beth, Reidling, Jack C., Winokur, Sara T., Casale, Malcolm S., Thompson, Leslie M., Pardo, Mónica, Díaz-Barriga, A. Gerardo García, Straccia, Marco, Sanders, Phil, Alberch, Jordi, Canals, Josep M., Kaye, Julia A., Dunlap, Mariah, Jo, Lisa, May, Hanna, Mount, Elliot, Anderson-Bergman, Cliff, Haston, Kelly, Finkbeiner, Steven, Kedaigle, Amanda J., Gipson, Theresa A., Yildirim, Ferah, Ng, Christopher W., Milani, Pamela, Housman, David E., Fraenkel, Ernest, Allen, Nicholas D., Kemp, Paul J., Atwal, Ranjit Singh, Biagioli, Marta, Gusella, James F., MacDonald, Marcy E., Akimov, Sergey S., Arbez, Nicolas, Stewart, Jacqueline, Ross, Christopher A., Mattis, Virginia B., Tom, Colton M., Ornelas, Loren, Sahabian, Anais, Lenaeus, Lindsay, Mandefro, Berhan, Sareen, Dhruv and Svendsen, Clive N. 2017. Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice. Nature Neuroscience 20 (5) , pp. 648-660. 10.1038/nn.4532

Kemp, Paul J, Rushton, David J., Yarova, Polina, Schnell, Christian, Geater, Charlene, Hancock, Jane M., Wieland, Annalena, Hughes, Alis, Badder, Luned, Cope, Emma Louise, Riccardi, Daniela, Randall, Andrew, Brown, Jonathan T., Allen, Nicholas Denby and Telezhkin, Vsevolod 2016. Improving and accelerating the differentiation and functional maturation of human stem cell-derived neurons: role of extracellular calcium and GABA. The Journal of Physiology 594 (22) , pp. 6583-6594. 10.1113/JP270655

Stephen P., Brazier, Telezhkin, Vsevolod and Kemp, Paul 2016. Functional interactions between BKCa a-subunit and Annexin A5: implications in apoptosis. Oxidative Medicine and Cellular Longevity 2016 , 1607092. 10.1155/2016/1607092

Zhang, Gaofeng, Edmundson, Mathew, Telezhkin, Vsevolod, Gu, Yu, Wei, Xiaoqing, Kemp, Paul J. and Song, Bing 2016. The role of Kv1.2 channel in electrotaxis cell migration. Journal of Cellular Physiology 231 (6) , pp. 1375-1384. 10.1002/jcp.25259

Young, Fraser I., Telezhkin, Vsevolod, Youde, Sarah J., Langley, Martin S., Stack, Maria, Kemp, Paul J., Waddington, Rachel J., Sloan, Alastair J. and Song, Bing 2016. Clonal heterogeneity in the neuronal and glial differentiation of dental pulp stem/progenitor cells. Stem Cells International , 1290561. 10.1155/2016/1290561

Telezhkin, Vsevolod, Schnell, Christian, Yarova, Polina L., Yung, Sun, Sanders, Philip, Cope, Emma, Hughes, Alis, Thompson, Belinda A, Geater, Charlene, Hancock, Jane M., Joy, Shona, Badder, Luned, Connor-Robson, Natalie, Comella, Andrea, Straccia, Marco, Bombau, Georgina, Brown, Jon T, Canals, Josep M., Randall, Andrew D., Allen, Nicholas Denby and Kemp, Paul J. 2016. Forced cell-cycle exit and modulation of GABAA, CREB and GSK3β signaling promote functional maturation of induced pluripotent stem cell-derived neurons. American Journal of Physiology - Cell Physiology , ajpcell.00166.2015. 10.1152/ajpcell.00166.2015

Yarova, P. L., Davies, C., Price, S.A., Huang, Q., Graca, J. A ., Maleki-Toyserkani, S., Lowe, A. P. P., Kidd, E. J., Ford, W.R., Broadley, K. J., Ward, J. P. T., Corrigan, J. C., Prakash, Y. S., Kemp, P. J. and Riccardi, D. 2016. Inhaled calcilytics: effects on airway inflammation and remodeling. Respiratory Drug Delivery 1 , pp. 1-12.

Brennan, Sarah C., Wilkinson, William J., Tseng, Hsiu-Er, Finney, Brenda, Monk, Bethan, Dibble, Holly, Quilliam, Samantha, Warburton, David, Galietta, Luis J., Kemp, Paul J. and Riccardi, Daniela 2016. The extracellular calcium-sensing receptor regulates human fetal lung development via CFTR. Scientific Reports 6 , 21975. 10.1038/srep21975

Schepelmann, M., Yarova, P. L., Lopez-Fernandez, I., Davies, T. S., Brennan, S. C., Edwards, P. J., Aggarwal, A., Graca, J., Rietdorf, K., Matchkov, V., Fenton, R. A., Chang, W., Krssak, M., Stewart, A., Broadley, K. J., Ward, D. T., Price, S. A., Edwards, D. H., Kemp, P. J. and Riccardi, D. 2016. The vascular Ca2+-sensing receptor regulates blood vessel tone and blood pressure. American Journal of Physiology - Cell Physiology 310 (3) , C193-C204. 10.1152/ajpcell.00248.2015

Straccia, Marco, Garcia-Diaz Barriga, Gerardo, Sanders, Phil, Bombau, Georgina, Carrere, Jordi, Mairal, Pedro Belio, Vinh, Ngoc-Nga, Yung, Sun, Kelly, Claire M., Svendsen, Clive N, Kemp, Paul J., Arjomand, Jamshid, Schoenfeld, Ryan C., Alberch, Jordi, Allen, Nicholas Denby, Rosser, Anne Elizabeth and Canals, Josep M. 2015. Quantitative high-throughput gene expression profiling of human striatal development to screen stem cell-derived medium spiny neurons. Molecular Therapy - Methods & Clinical Development 2 , 15030. 10.1038/mtm.2015.30

Hänggi, Pascal, Telezhkin, Vsevolod, Kemp, Paul J., Schmugge, Markus, Gassmann, Max, Goede, Jeroen S., Speer, Oliver and Bogdanova, Anna 2015. Functional plasticity of the N-methyl-d-aspartate receptor in differentiating human erythroid precursor cells. American Journal of Physiology - Cell Physiology 308 (12) , C993-C1007. 10.1152/ajpcell.00395.2014

Yarova, Polina L., Stewart, Alecia L., Sathish, Venkatachalem, Britt, Rodney D. Jnr., Thompson, Michael A., Lowe, Alexander P. P., Freeman, Michelle, Aravamadun, Bharathi, Kita, Hitohito, Brennan, Sarah C., Schepelmann, Martin, Davies, Thomas, Yung, Sun, Cholisoh, Zakky, Kidd, Emma J., Ford, William R., Broadley, Kenneth J., Rietdorf, Katja, Chang, Wenham, Bin Khayat, Mohamed E., Ward, Donald T., Corrigan, Christopher J., Ward, Jeremy P. T., Kemp, Paul J., Pabelick, Christina M., Prakash, Y. S. and Riccardi, Daniela 2015. Calcium-sensing receptor antagonists abrogate airways hyperresponsiveness and inflammation in allergic asthma. Science Translational Medicine 7 (284) , 284ra60. 10.1126/scitranslmed.aaa0282

Kemp, Paul J. and Telezhkin, Vsevolod 2014. Oxygen sensing by the carotid body: is it all just rotten eggs? Antioxidants & Redox Signaling 20 (5) , pp. 794-804. 10.1089/ars.2013.5377

Lembrechts, Robrecht, Brouns, Inge, Schnorbusch, Kathy, Pintelon, Isabel, Kemp, Paul J., Timmermans, Jean-Pierre, Riccardi, Daniela and Adriaensen, Dirk 2013. Functional expression of the multimodal extracellular calcium-sensing receptor in pulmonary neuroendocrine cells. Journal of Cell Science 126 (19) , pp. 4490-4501. 10.1242/jcs.131656

Matsa, E., Dixon, J. E., Medway, C., Georgiou, O., Patel, M. J., Morgan, K., Kemp, Paul J., Staniforth, A., Mellor, I. and Denning, C. 2013. Allele-specific RNA interference rescues the long-QT syndrome phenotype in human-induced pluripotency stem cell cardiomyocytes. European Heart Journal 35 (16) , pp. 1078-1087. 10.1093/eurheartj/eht067

Brennan, Sarah C., Finney, Brenda, Lazarou, Maria, Rosser, Anne Elizabeth, Scherf, Caroline, Adriaensen, Dirk, Kemp, Paul J. and Riccardi, Daniela 2013. Fetal calcium regulates branching morphogenesis in the developing human and mouse lung: involvement of voltage-gated calcium channels. PLoS ONE 8 (11) , e80294. 10.1371/journal.pone.0080294

Rushton, David J., Mattis, Virginia B., Svendsen, Clive N., Allen, Nicholas Denby and Kemp, Paul J. 2013. Stimulation of GABA-induced Ca2+ influx enhances maturation of human induced pluripotent stem cell-derived neurons. PLoS ONE 8 (11) , e81031. 10.1371/journal.pone.0081031

Shore, Andrew, Karamitri, Angeliki, Kemp, Paul J., Speakman, John R., Graham, Neil S. and Lomax, Michael A. 2013. Cold-induced changes in gene expression in brown adipose tissue, white adipose tissue and liver. PLoS ONE 8 (7) , e68933. 10.1371/journal.pone.0068933

Shore, Andrew, Emes, Richard D., Wessely, Frank, Kemp, Paul, Cillo, Clemente, D'Armiento, Maria, Hoggard, Nigel and Lomax, Michael A. 2013. A Comparative approach to understanding tissue-specific expression of uncoupling protein 1 expression in adipose tissue. Frontiers in Genetics 3 , 304. 10.3389/fgene.2012.00304

Mattis, V. B., Svendsen, S. P., Ebert, A., Svendsen, C. N., King, A. R., Casale, M., Winokur, S. T., Batugedara, G., Vawter, M., Donovan, P. J., Lock, L. F., Thompson, L. M., Atwal, R. S., Zhu, Y., Fossale, E., Gillis, T., Mysore, J., Li, J.-H., Seong, I. S., Shen, Y., Chen, X., Wheeler, V. C., MacDonald, M. E., Gusella, J. F., Akimov, S., Arbez, N., Juopperi, T., Ratovitski, T., Chiang, J. H., Kim, W. R., Chighladze, E., Watkin, E., Zhong, C., Makri, G., Cole, R. N., Margolis, R. L., Song, H., Ming, G., Ross, C. A., Kaye, J. A., Daub, A., Sharma, P., Mason, A. R., Finkbeiner, S., Rushton, David J., Brazier, Stephen Paul, Battersby, Alysia Agnes, Redfern, Amanda Jane, Tseng, Hsiu-Er, Harrison, Alexander William John, Kemp, Paul J., Allen, Nicholas Denby, Castiglioni, V., Onorati, M., Cattaneo, E., Yu, J., Thomson, J. A. and Arjomand, J. 2012. Induced pluripotent stem cells from patients with Huntington's Disease show CAG-repeat-expansion-associated phenotypes. Cell Stem Cell 11 (2) , pp. 264-278. 10.1016/j.stem.2012.04.027

Wray, Selina, Self, Matthew, Lewis, Patrick A., Taanman, Jan-Willem, Ryan, Natalie S., Mahoney, Colin J., Liang, Yuying, Devine, Michael J., Sheerin, Una-Marie, Houlden, Henry, Morris, Huw Rees, Healy, Daniel, Marti-Masso, Jose-Felix, Preza, Elisavet, Barker, Suzanne, Sutherland, Margaret, Corriveau, Roderick A., D'Andrea, Michael, Schapira, Anthony H. V., Uitti, Ryan J., Guttman, Mark, Opala, Grzegorz, Jasinska-Myga, Barbara, Puschmann, Andreas, Nilsson, Christer, Espay, Alberto J., Slawek, Jaroslaw, Gutmann, Ludwig, Boeve, Bradley F., Boylan, Kevin, Stoessl, A. Jon, Ross, Owen A., Maragakis, Nicholas J., Van Gerpen, Jay, Gerstenhaber, Melissa, Gwinn, Katrina, Dawson, Ted M., Isacson, Ole, Marder, Karen S., Clark, Lorraine N., Przedborski, Serge E., Finkbeiner, Steven, Rothstein, Jeffrey D., Wszolek, Zbigniew K., Rossor, Martin N., Hardy, John, Kemp, Paul J. and Allen, Nicholas Denby 2012. Creation of an open-access, mutation-defined fibroblast resource for neurological disease research. PLoS ONE 7 (8) , e43099. 10.1371/journal.pone.0043099

Riccardi, Daniela and Kemp, Paul J. 2012. The calcium-sensing receptor beyond extracellular calcium homeostasis: Conception, development, adult physiology, and disease. Annual Review of Physiology 74 , pp. 271-297. 10.1146/annurev-physiol-020911-153318

Wilkinson, William James and Kemp, Paul J. 2011. Carbon monoxide: an emerging regulator of ion channels. The Journal of Physiology 589 (13) , pp. 3055-3062. 10.1113/jphysiol.2011.206706

Telezhkin, Vsevolod, Brazier, Stephen P., Mears, Ruth, Müller, Carsten T., Riccardi, Daniela and Kemp, Paul J. 2011. Cysteine residue 911 in C-terminal tail of human BKCaα channel subunit is crucial for its activation by carbon monoxide. Pflugers Archiv-European Journal of Physiology 461 (6) , pp. 665-675. 10.1007/s00424-011-0924-7

Finney, Brenda, Wilkinson, William James, Searchfield, Lydia, Cole, Martin, Bailey, Stacey Louise, Kemp, Paul J. and Riccardi, Daniela 2011. An exon 5-less splice variant of the extracellular calcium-sensing receptor rescues absence of the full-length receptor in the developing mouse lung. Experimental Lung Research 37 (5) , pp. 269-278. 10.3109/01902148.2010.545471

Cayzac, S. H., Rocher, A., Obeso, A., Gonzalez, C., Riccardi, Daniela and Kemp, Paul J. 2011. Spermine attenuates carotid body glomus cell oxygen sensing by inhibiting L-type Ca2+ channels. Respiratory Physiology & Neurobiology 175 (1) , pp. 80-89. 10.1016/j.resp.2010.09.009

Kelly, Claire, Precious, Sophie Victoria, Torres, Eduardo Miguel, Harrison, Alexander William John, Williams, Deborah, Scherf, Caroline, Weyrauch, Ulrike Marie, Lane, Emma Louise, Allen, Nicholas Denby, Penketh, Richard, Amso, Nazar Najib, Kemp, Paul J., Dunnett, Stephen Bruce and Rosser, Anne Elizabeth 2011. Medical terminations of pregnancy: A viable source of tissue for cell replacement therapy for neurodegenerative disorders. Cell Transplantation 20 (4) , pp. 503-513. 10.3727/096368910X546580

Wilkinson, William James, Benjamin, Audra, Proost, Ian, Orogo-Wenn, Maria, Yamazaki, Yasuo, Staub, Olivier, Morita, Takashi, Adriaensen, Dirk, Riccardi, Daniela, Walters, Dafydd and Kemp, Paul J. 2011. Alveolar epithelial CNGA1 channels mediate cGMP-stimulated, amiloride-insensitive, lung liquid absorption. Pflügers Archiv European Journal of Physiology 462 (2) , pp. 267-279. 10.1007/s00424-011-0971-0

Wilkinson, William James and Kemp, Paul J. 2011. The carbon monoxide donor, CORM-2, is an antagonist of ATP-gated, human P2X4 receptors. Purinergic Signalling 7 (1) , pp. 57-64. 10.1007/s11302-010-9213-8

Telezhkin, V., Brazier, S. P., Cayzac, S. H., Wilkinson, William James, Riccardi, Daniela and Kemp, Paul J 2010. Mechanism of inhibition by hydrogen sulfide of native and recombinant BKCa channels. Respiratory Physiology & Neurobiology 172 (3) , pp. 169-178. 10.1016/j.resp.2010.05.016

Warburton, David, El-Hashash, Ahmed, Carraro, Gianni, Tiozzo, Caterina, Sala, Frederic, Rogers, Orquidea, Langhe, Stijn De, Kemp, Paul J., Riccardi, Daniela and Torday, John 2010. Lung organogenesis. Current Topics in Developmental Biology 90 , pp. 73-158. 10.1016/S0070-2153(10)90003-3

Shore, Andrew, Karamitri, A., Kemp, Paul J., Speakman, J. R. and Lomax, M. A. 2010. Role of Ucp1 enhancer methylation and chromatin remodelling in the control of Ucp1 expression in murine adipose tissue. Diabetologia 53 (6) , pp. 1164-1173. 10.1007/s00125-010-1701-4

Wilkinson, William James, Gadeberg, H.C., Harrison, A. W. J., Allen, Nicholas Denby, Riccardi, Daniela and Kemp, Paul J 2009. Carbon monoxide is a rapid modulator of recombinant and native P2X(2) ligand-gated ion channels. British Journal of Pharmacology 158 (3) , pp. 862-871. 10.1111/j.1476-5381.2009.00354.x

Kemp, Paul J., Telezhkin, Vsevolod, Wilkinson, William James, Mears, Ruth, Hanmer, Stuart, Gadeberg, Hanne C., Müller, Carsten T., Riccardi, Daniela and Brazier, Stephen Paul 2009. Enzyme-linked oxygen sensing by potassium channels. Annals of the New York Academy of Sciences 1177 , pp. 112-118. 10.1111/j.1749-6632.2009.05025.x

Brazier, Stephen P., Telezhkin, Vsevolod, Mears, Ruth, Müller, T., Riccardi, Daniela and Kemp, Paul J. 2009. Cysteine residues in the C-terminal tail of the human BKCaα subunit are important for channel sensitivity to carbon monoxide. Presented at: International Society of Arterial Chemoreception. 17th Meeting, Valladolid, Spain, 1-5 July 2008. Arterial Chemoreceptors. Advances in Experimental Medicine and Biology , vol. 648. Netherlands: Springer Netherlands, pp. 49-56. 10.1007/978-90-481-2259-2_5

Riccardi, Daniela, Finney, B. A., Wilkinson, Willam James and Kemp, Paul J 2009. Novel regulatory aspects of the extracellular Ca2+-sensing receptor, CaR. Pflugers Archiv-European Journal of Physiology 458 (6) , pp. 1007-1022. 10.1007/s00424-009-0681-z

De Proost, I., Pintelon, I., Wilkinson, William James, Goethals, S., Brouns, I., Van Nassauw, L., Riccardi, Daniela, Timmermans, J. P., Kemp, Paul J and Adriaensen, D. 2009. Purinergic signaling in the pulmonary neuroepithelial body microenvironment unraveled by live cell imaging. The FASEB Journal 23 (4) , pp. 1153-1160. 10.1096/fj.08-109579

Telezhin, V., Brazier, Stephen Paul, Cayzac, S., Müller, Carsten Theodor, Riccardi, Daniela and Kemp, Paul J. 2009. Hydrogen Sulfide inhibits human BKCa channels. Advances in Experimental Medicine and Biology 648 , pp. 65-72. 10.1007/978-90-481-2259-2_7

Cayzac, S., Rocher, A., Obeso, A., Gonzalez, C., Kemp, Paul J. and Riccardi, Daniela 2009. Effects of the polyamine spermine on arterial chemoreception. Presented at: International Society of Arterial Chemoreception. 17th Meeting, Valladolid, Spain, 1-5 July 2008. Published in: Gonzalez, Constancio, Nurse, Colin A. and Peers, Chris eds. Arterial chemoreceptors. Advances in Experimental Medicine and Biology , vol. 648. Netherlands: Springer Netherlands, pp. 97-104. 10.1007/978-90-481-2259-2_11

Kemp, Paul J. and Peers, C. 2009. Enzyme-linked acute oxygen sensing in airway and arterial chemoreceptors. In: Gonzalez, Constancio, Nurse, Colin A. and Peers, Chris eds. Arterial Chemoreceptors, Advances in Experimental Medicine and Biology, vol. 648. Netherlands: Springer Netherlands, pp. 39-48. (10.1007/978-90-481-2259-2_4)

Finney, Brenda, Del Moral, Pierre M., Wilkinson, William James, Cayzac, Sebastien, Cole, Martin, Warburton, David, Kemp, Paul J. and Riccardi, Daniela 2008. Regulation of mouse lung development by the extracellular calcium-sensing receptor, CaR. Journal of Physiology 586 (24) , pp. 6007-6019. 10.1113/jphysiol.2008.161687

De Proost, Ian, Pintelon, Isabel, Brouns, Inge, Kroese, Alfons B. A., Riccardi, Daniela, Kemp, Paul J, Timmermans, Jean-Pierre and Adriaensen, Dirk 2008. Functional live cell imaging of the pulmonary neuroepithelial body microenvironment. American Journal of Respiratory Cell and Molecular Biology 39 (2) , pp. 180-189. 10.1165/rcmb.2008-0011OC

Williams, S. E., Brazier, Stephen Paul, Baban, Nian, Telezhkin, Vsevolod, Muller, Carsten Theodor, Riccardi, Daniela and Kemp, Paul J 2008. A structural motif in the C-terminal tail of slo1 confers carbon monoxide sensitivity to human BKCa channels. Pflugers Archiv-European Journal of Physiology 456 (3) , pp. 561-572. 10.1007/s00424-007-0439-4

Timmermans, J. P., De, Proost, Pintelon, I., Wilkinson, William J., Goethals, S., Brouns, I., Van Nassauw, L., Riccardi, Daniela, Kemp, Paul J. and Adriaensen, D. 2008. Expression of P2X receptors in LAD-2 cells and human lung mast cells [Abstract]. Purinergic Signalling 4 (S1) , S159. 10.1007/s11302-008-9116-0

Wilkinson, William J., Hanne, G., Harrison, Alexander William John, Allen, Nicholas Denby, Riccardi, Daniela and Kemp, Paul J. 2008. Carbon monoxide is a rapid modulator of recombinant and native P2X2 ligand-gated ion channels [Abstract]. Purinergic Signalling 4 (S1) , p. 26. 10.1007/s11302-008-9116-0

Dvorak, Melita M., De Joussineau, Cyrille, Carter, D. Howard, Pisitkun, Trairak, Knepper, Mark A., Gamba, Gerardo, Kemp, Paul J. and Riccardi, Daniela 2007. Thiazide Diuretics Directly Induce Osteoblast Differentiation and Mineralized Nodule Formation by Interacting with a Sodium Chloride Co-Transporter in Bone. Journal of the American Society of Nephrology 18 (9) , pp. 2509-2516. 10.1681/ASN.2007030348

Kemp, Paul J. and Peers, Chris 2007. Oxygen sensing by ion channels. Essays in Biochemistry 43 , pp. 77-90. 10.1042/bse0430077

Joannides, A. J., Webber, D. J., Raineteau, O., Kelly, Claire, Irvine, K.-A., Watts, C., Rosser, Anne Elizabeth, Kemp, Paul J., Blakemore, W. F., Compston, A., Caldwell, M. A., Allen, Nicholas Denby and Chandran, S. 2007. Environmental signals regulate lineage choice and temporal maturation of neural stem cells from human embryonic stem cells. Brain 130 (5) , pp. 1263-1275. 10.1093/brain/awm070

Kemp, Paul J., Archer, Stephen L., Schumacher, Paul T., Gurney, Alison, Duchen, Michael, Kummer, Wolfgang, Chandel, Navdeep S., Gonzalez, Constancio, Kumar, Prem and Sylvester, James T. 2006. General discussion III. Novartis Foundation Symposium 272 , pp. 214-217.

Chandel, Navdeep S., Kemp, Paul J., Prabhakar, Nanduri, Duchen, Michael, Acker, Helmut, Archer, Stephen L., Kummer, Wolfgang, Buckler, Keith J., Lopez-Barneo, Jose and Murphy, Michael P. 2006. Discussion. Novartis Foundation Symposium 272 , pp. 151-156.

Buckler, Keith J., Gurney, A., Nurse, Colin A., Lopez-Barneo, Jose, Kemp, Paul J., Kummer, Wolfgang, Sylvester, J. T., Kumar, P., Archer, S. L. and Chandel, N. S. 2006. Discussion. Novartis Foundation Symposium 272 , pp. 228-233.

Kemp, Paul J., Williams, Sandile E., Mason, Helen S., Wootton, Philippa, Iles, David E., Riccardi, Daniela and Peers, Chris 2006. Functional proteomics of BK potassium channels: Defining the acute oxygen sensor. In: Chadwick, Derek J. and Goode, Jamie eds. Signalling Pathways in Acute Oxygen Sensing: Novartis Foundation Symposium 272, Novartis Foundation Symposia, Wiley-Blackwell, pp. 141-151. (10.1002/9780470035009.ch12)

Peers, C., Kemp, Paul J., Boyle, J. P., Porter, K. E., Pearson, H. A., Smith, I. F. and Kemp, P. J. 2006. Hypoxic regulation of Ca2+ signalling in astrocytes and endothelial cells. In: Chadwick, Derek and Goode, Jamie eds. Signalling Pathways in Acute Oxygen Sensing: Novartis Foundation Symposium 272, Wiley-Blackwell, pp. 119-127. (10.1002/9780470035009.ch10)

Kemp, Paul J., Peers, Chris, Riccardi, Daniela, Iles, David E., Mason, Helen S., Wootton, Philippa and Williams, Sandile E. 2006. In search of the acute oxygen sensor: Functional proteomics and acute regulation of large-conductance, calcium-activated potassium channels by hemeoxygenase-2. In: Hayashida, Yoshiaki, Gonzalez, Constancio and Kondo, Hisatake eds. The Arterial Chemoreceptors, Vol. 580. Advances in Experimental Medicine and Biology, Springer, pp. 137-146. (10.1007/0-387-31311-7_21)

Duchen, Michael, Prabhakar, Nanduri, Peers, Chris, Chandel, Navdeep S., Lopez-Barneo, Jose, Weir, Kenneth, Murphy, Michael P., Shumacker, Paul T., Rich, Peter R., Nurse, Colin A., Sylvester, James T. and Kemp, Paul J. 2006. Discussion. Novartis Foundation Symposium 272 , pp. 100-105.

Kummer, Wolfgang, Murphy, Michael P., Lopez-Barnes, Jose, Buckler, Keith J., Acker, Helmut, Rich, Peter R., Kemp, Paul J., Gonzalez, Constancio and Duchen, Michael 2006. Discussion. Novartis Foundation Symposium 272 , pp. 114-118.

Kemp, Paul J., Williams, Sandile E. J., Mason, Helen S., Wootton, Phillippa, Iles, David E., Riccardi, Daniela and Peers, Chris 2006. General discussion II. Novartis Foundation Symposium (272) , pp. 131-140.

Peers, C., Kang, P., Boyle, J. P., Porter, K. E., Pearson, H. A., Smith, I. F. and Kemp, Paul J. 2006. General discussion I. Novartis Foundation Symposium (272) , pp. 33-36.

Peers, Chris, Aley, Parvinder, K., Boyle, John P., Porter, Karen E., Pearson, Hugh A., Smith, Ian F. and Kemp, Paul J. 2006. Hypoxic regulation of Ca2+ signalling in astrocytes and endothelial cells. In: Hayashida, Yoshiaki, Gonzalez, Constancio and Konda, Hisataki eds. The Arterial Chemoreceptors, Vol. 580. Advances in Experimental Medicine and Biology, Kluwer, pp. 185-190. (10.1007/0-387-31311-7_28)

Joannides, Alexis J., Fiore-Hériché, Christelle, Battersby, Alysia A., Athauda-Arachchi, Pandula, Bouhon, Isabelle A., Williams, Lydia, Westmore, Kristine, Kemp, Paul J., Compston, Alastair, Allen, Nicholas Denby and Chandran, Siddharthan 2006. A scaleable and defined system for generating neural stem cells from human embryonic stem cells. Stem Cells 25 (3) , pp. 731-737. 10.1634/stemcells.2006-0562

Kemp, Paul J. 2006. Detecting acute changes in oxygen: will the real sensor please stand up? Experimental Physiology 91 (5) , pp. 829-834. 10.1113/expphysiol.2006.034587

Bourke, Steven, Mason, Helen S., Borok, Zea, Kim, Kwang-Jin, Crandall, Edward D. and Kemp, Paul J. 2005. Development of a lung slice preparation for recording ion channel activity in alveolar epithelial type I cells. Respiratory Research 6 , 40. 10.1186/1465-9921-6-40

Kemp, Paul J. 2005. Hemeoxygenase-2 as an O2 sensor in K+ channel-dependent chemotransduction. Biochemical and Biophysical Research Communications 338 (1) , pp. 648-652. 10.1016/j.bbrc.2005.08.110

Brazier, Stephen P., Mason, Helen S., Bateson, Alan N. and Kemp, Paul J. 2005. Cloning of the human TASK-2 (KCNK5) promoter and its regulation by chronic hypoxia. Biochemical and Biophysical Research Communications 336 (4) , pp. 1251-1258. 10.1016/j.bbrc.2005.09.007

Miller, P., Kemp, Paul J. and Peers, C. 2005. Structural requirements for O2 sensing by the human tandem-P domain channel, hTREK1. Biochemical and Biophysical Research Communications 331 (4) , pp. 1253-1256. 10.1016/j.bbrc.2005.04.042

Aley, P. K., Porter, K. E., Boyle, J. P., Kemp, Paul J. and Peers, C. 2005. Hypoxic modulation of Ca2+ signaling in human venous endothelial cells: MULTIPLE ROLES FOR REACTIVE OXYGEN SPECIES. Journal of Biological Chemistry 280 (14) , pp. 13349-13354. 10.1074/jbc.M413674200

Williams, Sandile Elroy Johnathan, Wootton, Phillippa, Mason, Helen Sarah, Bould, Jonathan, Iles, David E., Riccardi, Daniela, Peers, Chris and Kemp, Paul J. 2004. Hemoxygenase-2 is an oxygen sensor for a calcium-sensitive potassium channel. Science , pp. 2993-2997. 10.1126/science.1105010

Miller, Paula, Peers, Chris and Kemp, Paul J. 2004. Polymodal regulation of hTREK1 by pH, arachidonic acid, and hypoxia: Physiological impact in acidosis and alkalosis. American Journal of Physiology - Cell Physiology 286 (2) , C272-C282. 10.1152/ajpcell.00334.2003

Kemp, Paul J., Peers, Chris, Lewis, Anthony and Miller, Paula 2004. Regulation of recombinant human brain tandem P domain K+ channels by hypoxia: A role for O2 in the control of neuronal excitability? Journal of Cellular and Molecular Medicine 8 (1) , pp. 38-44. 10.1111/j.1582-4934.2004.tb00258.x

Mason, H. S., Bourke, S. and Kemp, Paul J. 2004. Selective modulation of ligand-gated P2X purinoceptor channels by acute hypoxia is mediated by reactive oxygen species. Molecular Pharmacology 66 (6) , pp. 1525-1535. 10.1124/mol.104.000851

Peers, Chris and Kemp, Paul J. 2004. Ion channel regulation by chronic hypoxia in models of acute oxygen sensing. Cell Calcium 36 (3-4) , pp. 341-348. 10.1016/j.ceca.2004.02.005

Kemp, Paul J. and Kim, Kwang-Jin 2004. Spectrum of ion channels in alveolar epithelial cells: implications for alveolar fluid balance. AJP: Lung Cellular and Molecular Physiology 287 (3) , L460-L464. 10.1152/ajplung.00191.2004

Kemp, Paul J. and Peers, Chris 2004. Assessment of oxygen sensing by model airway and arterial chemoreceptors. Methods in Enzymology 381 , pp. 3-25. 10.1016/S0076-6879(04)81001-2

Kemp, Paul J., Iles, David and Peers, Chris 2004. Oxygen sensing by human recombinant K+ channels: assessment of the use of stable cell lines. Methods in Enzymology 381 , pp. 257-274. 10.1016/S0076-6879(04)81018-8

Williams, Sandile E., Wootton, Phillippa, Mason, Helen S., Iles, David E., Peers, C. and Kemp, Paul J. 2004. siRNA knock-down of γ-glutamyl transpeptidase does not affect hypoxic K+ channel inhibition. Biochemical and Biophysical Research Communications 314 (1) , pp. 63-68. 10.1016/j.bbrc.2003.12.052

Hammond, Lucy C., Bonnet, Claire, Kemp, Paul J., Yates, Michael S. and Bowmer, Christopher J. 2004. Chronic hypoxia up-regulates expression of adenosine A1 receptors in DDT1-MF2 cells. Biochemical Pharmacology 67 (3) , pp. 421-426. 10.1016/j.bcp.2003.09.003

Hartness, Matthew E., Brazier, Stephen Paul, Peers, Chris, Bateson, Alan N., Ashford, Michael L.J. and Kemp, Paul J. 2003. Post-transcriptional control of human maxiK potassium channel activity and acute oxygen sensitivity by chronic hypoxia. Journal of Biological Chemistry , pp. 51422-51432. 10.1074/jbc.M309463200

Kemp, Paul J., Searle, Gavin J., Hartness, Matthew E., Lewis, Anthony, Miller, Paula, Williams, Sandile, Wootton, Philippa, Adriaensen, Dirk and Peers, Chris 2003. Acute oxygen sensing in cellular models: relevance to the physiology of pulmonary neuroepithelial and carotid bodies. Anatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biology 270A (1) , pp. 41-50. 10.1002/ar.a.10008

Kemp, Paul J., Peers, C. and Lewis, A. 2003. Oxygen sensing by human recombinant large conductance, calcium-activated potassium channels. Regulation by acute hypoxia. Advances in Experimental Medicine and Biology 536 , pp. 209-215.

Miller, P., Kemp, Paul J., Lewis, A., Chapman, C. G., Meadows, H. J, and Peers, C. 2003. Acute hypoxia occludes hTREK-1 modulation: re-evaluation of the potential role of tandem P domain K+ channels in central neuroprotection. The Journal of Physiology 548 (1) , pp. 31-37. 10.1113/jphysiol.2003.040048

Lewis, Anthony, Peers, Chris, Ashford, Michael L. J. and Kemp, Paul J. 2002. Hypoxia inhibits human recombinant large conductance, Ca2+-activated K+ (maxi-K) channels by a mechanism which is membrane delimited and Ca2+ sensitive. The Journal of Physiology 540 (3) , pp. 771-780. 10.1113/jphysiol.2001.013888

Kemp, Paul J., Lewis, Anthony, Hartness, Matthew E., Searle, Gavin J., Miller, Paula, O'Kelly, Ita and Peers, Chris 2002. Airway chemotransduction: from oxygen sensor to cellular effector. American Journal of Respiratory and Critical Care Medicine 166 , S17-S24. 10.1164/rccm.2206009

Kemp, Paul J., Hartness, Matthew E. and Peers, Chris 2002. Oxygen sensing by human recombinant large conductance, calcium-activated potassium channels:regulation by chronic hypoxia. In: Pequignot, Jean-Marc, Gonzalez, Constancio, Nurse, Colin A., Prabhakar, Nanduri R. and Dalmaz, Yvette eds. Chemoreception: From Cellular Signaling to Functional Plasticity, Advances in Experimental Medicine and Biology, Springer, pp. 573-581.

Kemp, Paul J., Peers, Chris, Miller, Paula and Lewis, Anthony 2002. Oxygen sensing by human recombinant tandem-P domain potassium channels. In: Pequinot, Jean-Marc, Gonzalez, Constancio, Nurse, Colin A., Prabhakar, Naduri R. and Dalmaz, Yvette eds. Chemoreception: From Cellular Signaling to Functional Plasticity, Advances in Experimental Medicine and Biology, Springer, pp. 201-208. (10.1007/978-1-4419-9280-2_26)

Plant, L. D., Kemp, Paul J., Peers, C., Henderson, Z. and Pearson, H. A. 2002. Hypoxic depolarization of cerebellar granule neurons by specific inhibition of TASK-1. Stroke 33 (9) , pp. 2324-2328. 10.1161/01.STR.0000027440.68031.B0

Searle, Gavin J., Hartness, Matthew E., Hoareau, Rachel, Peers, Chris and Kemp, Paul J. 2002. Lack of contribution of mitochondrial electron transport to acute O2 sensing in model airway chemoreceptors. Biochemical and Biophysical Research Communications 291 (2) , pp. 332-337. 10.1006/bbrc.2002.6428

Colebrooke, R. L., Smith, I. F., Kemp, Paul J. and Peers, C. 2002. Chronic hypoxia remodels voltage-gated Ca2+ entry in a human airway chemoreceptor cell line. Neuroscience Letters 318 (2) , pp. 69-72. 10.1016/S0304-3940(01)02479-X

Hartness, Matthew E., Lewis, Anthony, Searle, Gavin J., O'Kelly, Ita, Peers, Chris and Kemp, Paul J. 2001. Combined antisense and pharmacological approaches implicate hTASK as an airway O2-sensing K+ channel. Journal of Biological Chemistry , pp. 26499-26508. 10.1074/jbc.M010357200

Peers, Chris and Kemp, Paul J. 2001. Acute oxygen sensing: diverse but convergent mechanisms in airway and arterial chemoreceptors. Respiratory Research 2 , pp. 145-149. 10.1186/rr51

Kemp, Paul J., Kim, Kwang-Jin, Borok, Zea and Crandall, Edward D. 2001. Re-evaluating the Na+ conductance of adult rat alveolar type II pneumocytes: evidence for the involvement of cGMP-activated cation channels. The Journal of Physiology 536 (3) , pp. 693-701. 10.1111/j.1469-7793.2001.t01-1-00693.x

Baines, D. L., MacGregor, G. G. and Kemp, Paul J. 2001. Fatty acid modulation and sequence identity of fetal guinea pig alveolar type II cell amiloride-sensitive Na+ channel. Biochemical and Biophysical Research Communications 288 (3) , pp. 727-735. 10.1006/bbrc.2001.5828

O'Kelly, I., Peers, C. and Kemp, Paul J. 2001. NADPH oxidase does not account fully for O2-Sensing in model airway chemoreceptor cells. Biochemical and Biophysical Research Communications 283 (5) , pp. 1131-1134. 10.1006/bbrc.2001.4919

Lewis, A., Hartness, M. E., Chapman, C. G., Fearon, I. M., Meadows, H. J., Peers, C. and Kemp, Paul J. 2001. Recombinant hTASK1 Is an O2-sensitive K+ channel. Biochemical and Biophysical Research Communications 285 (5) , pp. 1290-1294. 10.1006/bbrc.2001.5310

Kemp, Paul J., Peers, Chris, Miller, Paula and Lewis, Anthony 2000. O2-sensing by model airway chemoreceptors: hypoxic inhibition of K+ channels in H146 cells. In: Pequignot, Jean-Marc, Gonzalez, Constancio, Nurse, Colin A., Prabhakar, Nanduri R. and Dalmaz, Yvette eds. Chemoreception: From Cellular Signaling to Functional Plasticity, Advances in Experimental Medicine and Biology, Springer, pp. 611-622. (10.1007/978-1-4419-9280-2_26)

O'Kelly, Ita, Lewis, Anthony and Kemp, Paul J. 2000. O2 Sensing by Airway Chemoreceptor-derived cells protein kinase C activation reveals functional evidence for involvement of NADPH oxidase. Journal of Biological Chemistry 275 (11) , pp. 7684-7692. 10.1074/jbc.275.11.7684