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Number of items: 69.

Creeth, H. D. J. and John, R. M. 2020. The placental programming hypothesis: placental endocrine insufficiency and the co-occurrence of low birth weight and maternal mood disorders. Placenta 98 , pp. 52-59. 10.1016/j.placenta.2020.03.011
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Sumption, L. A., Garay, S. M. and John, R. M. 2020. Low serum placental lactogen at term is associated with postnatal symptoms of depression and anxiety in women delivering female infants. Psychoneuroendocrinology 116 , 104655. 10.1016/j.psyneuen.2020.104655
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Harrison, David J., Creeth, Hugo D. J., Tyson, Hannah R., Boque-Sastre, Raquel, Isles, Anthony R., Palme, Rupert, Touma, Chadi and John, Rosalind M. 2020. Unified behavioral scoring for preclinical models. Frontiers in Neuroscience 14 , 313. 10.3389/fnins.2020.00313

Savory, K., Garay, S.M., Sumption, L.A., Kelleher, Jemima, Daughters, K., Janssen, A.B., Van Goozen, S. and John, R.M. 2020. Prenatal symptoms of anxiety and depression associated with sex differences in both maternal perceptions of one year old infant temperament and researcher observed infant characteristics. Journal of Affective Disorders 264 , pp. 383-392. 10.1016/j.jad.2019.11.057

Garay, Samantha M., Savory, Katrina A., Sumption, Lorna A., Penketh, Richard J.A., Jones, Ian R., Janssen, Anna B. and John, Rosalind M. 2019. Seasonal variation in salivary cortisol but not symptoms of depression and trait anxiety in pregnant women undergoing an elective caesarean section. Psychoneuroendocrinology 108 , pp. 14-19. 10.1016/j.psyneuen.2019.05.029

Seifinejad, Ali, Li, Sha, Mikhail, Cyril, Vassalli, Anne, Pradervand, Sylvain, Arribat, Yoan, Pezeshgi Modarres, Hassan, Allen, Bridget, John, Rosalind M., Amati, Francesca and Tafti, Mehdi 2019. Molecular codes and in vitro generation of hypocretin and melanin concentrating hormone neurons. Proceedings of the National Academy of Sciences 116 (34) , pp. 17061-17070. 10.1073/pnas.1902148116

John, Rosalind M. 2019. Prenatal adversity modulates the quality of maternal care via the exposed offspring. BioEssays 41 (6) , 1900025. 10.1002/bies.201900025

Creeth, H. D. J., McNamara, G. I., Isles, A. R. and John, R. M. 2019. Imprinted genes influencing the quality of maternal care. Frontiers in Neuroendocrinology 53 , 100732. 10.1016/j.yfrne.2018.12.003

Garay, Samantha M, Savory, Katrina A, Sumption, Lorna, Penketh, Richard, Janssen, Anna B and John, Rosalind M 2019. The Grown in Wales Study: Examining dietary patterns, custom birthweight centiles and the risk of delivering a small-for-gestational age (SGA) infant. PLoS ONE 14 (3) , e0213412. 10.1371/journal.pone.0213412

Tucci, Valter, Isles, Anthony R., Kelsey, Gavin, Ferguson-Smith, Anne C., Tucci, Valter, Bartolomei, Marisa S., Benvenisty, Nissim, Bourchis, Déborah, Charalambous, Marika, Dulac, Catherine, Feil, Robert, Glaser, Juliane, Huelsmann, Lisa, John, Rosalind M., McNamara, Gráinne I., Moorwood, Kim, Muscatelli, Francoise, Sasaki, Hiroyuki, Strassmann, Beverly I., Vincenz, Claudius, Wilkins, Jon, Isles, Anthony R., Kelsey, Gavin and Ferguson-Smith, Anne C. 2019. Genomic imprinting and physiological processes in mammals. Cell 176 (5) , pp. 952-965. 10.1016/j.cell.2019.01.043

Isles, Anthony R. and John, Rosalind M. 2019. Genomic imprinting and neurobehavioral programming by adverse early life environments: evidence from studying Cdkn1c. Current Opinion in Behavioral Sciences 25 , pp. 31-35. 10.1016/j.cobeha.2018.06.008

Garcia-Martin, I., Penketh, Richard, Janssen, A. B., Jones, R. E., Grimstead, Julia, Baird, Duncan and John, Rosalind 2018. Meformin and insulin treatment prevent placental telomere attrition in boys exposed to maternal diabetes. PLoS ONE 13 (12) , : e0208533. 10.1371/journal.pone.0208533

Millership, Steven J., Tunster, Simon J., Van de Pette, Mathew, Choudhury, Agharul I., Irvine, Elaine E., Christian, Mark, Fisher, Amanda G., John, Rosalind M., Scott, James and Withers, Dominic J. 2018. Neuronatin deletion causes postnatal growth restriction and adult obesity in 129S2/Sv mice. Molecular Metabolism 18 , pp. 97-106. 10.1016/j.molmet.2018.09.001

Tunster, Simon J., Van de Pette, Mathew, Creeth, Hugo D. J., Lefebvre, Louis and John, Rosalind M. 2018. Fetal growth restriction in a genetic model of sporadic Beckwith-Wiedemann syndrome. Disease Models and Mechanisms 11 , dmm035832. 10.1242/dmm.035832

John, Rosalind and Rougelle, Clare 2018. Developmental epigenetics: phenotype and the flexible epigenome. Frontiers in Cell and Developmental Biology 6 , 130. 10.3389/fcell.2018.00130

Tunster, Simon J., Boque Sastre, Raquel, McNamara, Grainne, Hunter, Susan M., Creeth, Hugo D. J. and John, Rosalind M. 2018. Peg3 deficiency results in sexually dimorphic losses and gains in the normal repertoire of placental hormones. Frontiers in Cell and Developmental Biology 6 , 123. 10.3389/fcell.2018.00123

Van de Pette, Mathew, Tunster, Simon J. and John, Rosalind M. 2018. Loss of imprinting of Cdkn1c protects against age and diet-induced obesity. International Journal of Molecular Sciences 19 (9) , 2734. 10.3390/ijms19092734

Janssen, Anna, Savory, Katrina, Garay, Samantha, Sumption, Lorna, Watkins, William, Garcia-Martin, Isabel, Savory, Nicola, Anouk, Ridgway, Isles, Anthony, Penketh, Richard, Jones, Ian and John, Rosalind 2018. Persistence of anxiety symptoms after elective caesarean delivery. Bjpsych Open 4 (5) , pp. 354-360. 10.1192/bjo.2018.48

Millership, Steven J., Da Silva Xavier, Gabriela, Choudhury, Agharul I., Bertazzo, Sergio, Chabosseau, Pauline, Pedroni, Silvia M.A., Irvine, Elaine E., Montoya, Alex, Faull, Peter, Taylor, William R., Kerr-Conte, Julie, Pattou, Francois, Ferrer, Jorge, Christian, Mark, John, Rosalind M., Latreille, Mathieu, Liu, Ming, Rutter, Guy A., Scott, James and Withers, Dominic J. 2018. Neuronatin regulates pancreatic β cell insulin content and secretion. Journal of Clinical Investigation 128 (8) , pp. 3369-3381. 10.1172/JCI120115

Creeth, H. D. J., McNamara, G. I., Tunster, S. J., Boque Sastre, R., Allen, B., Sumption, L., Eddy, J. B., Isles, A. R. and John, R. M. 2018. Maternal care boosted by paternal imprinting in mammals. PLoS Biology 16 (7) , e2006599. 10.1371/journal.pbio.2006599

McNamara, G. I., Davis, B. A., Browne, M., Humby, T., Dalley, J. W., Xia, J., John, R. M. and Isles, A. R. 2018. Dopaminergic and behavioral changes in a loss-of-imprinting model of Cdkn1c. Genes, Brain and Behavior 17 (2) , pp. 149-157. 10.1111/gbb.12422

McNamara, Grainne, John, Rosalind and Isles, Anthony 2018. Territorial behaviour and social stability in the mouse require correct expression of imprinted Cdkn1c. Frontiers in Behavioral Neuroscience 12 , 28. 10.3389/fnbeh.2018.00028

McNamara, G. I., Creeth, H. D. J., Harrison, D. J., Tansey, K. E., Andrews, R. M., Isles, A. R. and John, R. M. 2018. Loss of offspring Peg3 reduces neonatal ultrasonic vocalizations and increases maternal anxiety in wild-type mothers. Human Molecular Genetics 27 (3) 10.1093/hmg/ddx412

Garcia Martin, Isabel, Janssen, A.B., Jones, Robert, Grimstead, Julia W., Penketh, Richard J. A., Baird, Duncan M. and John, Rosalind M. 2017. Telomere length heterogeneity in placenta revealed with high-resolution telomere length analysis. Placenta 59 , pp. 61-68. 10.1016/j.placenta.2017.09.007

John, Rosalind Margaret 2017. Imprinted genes and the regulation of placental endocrine function: pregnancy and beyond. Placenta 56 , pp. 86-90. 10.1016/j.placenta.2017.01.099

Nomura, Yoko, John, Rosalind Margaret, Bugge Janssen, Anna, Davey, Charles, Finik, Jackie, Buthmann, Jessica, Glover, Vivette and Lambertini, Luca 2017. Neurodevelopmental consequences in offspring of mothers with preeclampsia during pregnancy: underlying biological mechanism via imprinting genes. Archives of Gynecology and Obstetrics 295 (6) , pp. 1319-1329. 10.1007/s00404-017-4347-3

Van de Pette, Mathew, Abbas, Allifia, Feytout, Amelie, McNamara, Gráinne, Bruno, Ludovica, To, Wilson K., Dimond, Andrew, Sardini, Alessandro, Webster, Zoe, McGinty, James, Paul, Eleanor J., Ungless, Mark A., French, Paul M. W., Withers, Dominic J., Uren, Anthony, Ferguson-Smith, Anne C., Merkenschlager, Matthias, John, Rosalind M. and Fisher, Amanda G. 2017. Visualizing changes in Cdkn1c expression links early-Life adversity to imprint mis-regulation in adults. Cell Reports 18 (5) 10.1016/j.celrep.2017.01.010

McNamara, Grainne Iseult, Davis, Brittany Ann, Dwyer, Dominic Michael, John, Rosalind M. and Isles, Anthony Roger 2016. Behavioural abnormalities in a novel mouse model for Silver Russell Syndrome. Human Molecular Genetics 25 (24) , pp. 5407-5417. 10.1093/hmg/ddw357

Janssen, Anna, Capron, Lauren E., O'Donnell, Kieran, Tunster, Simon J., Ramchandani, Paul G., Alexander, Heazell E. P., Glover, Vivette and John, Rosalind Margaret 2016. Maternal prenatal depression is associated with decreased placental expression of the imprinted gene PEG3. Psychological Medicine 46 (14) , pp. 2999-3011. 10.1017/S0033291716001598

Tunster, Simon James, McNamara, Grainne, Creeth, Hugo and John, Rosalind Margaret 2016. Increased dosage of the imprinted Ascl2 gene restrains two key endocrine lineages of the mouse Placenta. Developmental Biology 418 (1) , pp. 55-65. 10.1016/j.ydbio.2016.08.014

Janssen, Anna B., Kertes, Darlene A., McNamara, Grainne, Braithwaite, Elizabeth C., Creeth, Hugo, Glover, Vivette I. and John, Rosalind Margaret 2016. A role for the placenta in programming maternal mood and childhood behavioural disorders. Journal of Neuroendocrinology 28 (8) 10.1111/jne.12373

Van De Pette, Matthew, Tunster, Simon J., McNamara, Grainne I., Shelkovnikova, Tatyana, Millership, Steven, Benson, Lindsay, Peirson, Stuart, Christian, Mark, Vidal-Puig, Antonio and John, Rosalind M. 2016. Cdkn1c boosts the development of brown adipose tissue in a murine model of Silver Russell Syndrome. PLoS Genetics 12 (3) , e1005916. 10.1371/journal.pgen.1005916

Janssen, Anna Bugge, Tunster, Simon James, Heazell, Alexander E. P. and John, Rosalind Margaret 2016. Placental PHLDA2 expression is increased in cases of fetal growth restriction following reduced fetal movements. BMC Medical Genetics 17 (1) , 17. 10.1186/s12881-016-0279-1

Tunster, Simon James, Creeth, Hugo and John, Rosalind Margaret 2016. The imprinted Phlda2 gene modulates a major endocrine compartment of the placenta to regulate placental demands for maternal resources. Developmental Biology 409 (1) , pp. 251-260. 10.1016/j.ydbio.2015.10.015

Janssen, Anna Bugge, Tunster, Simon James, Savory, N., Holmes, A., Beasley, J., Parveen, S. A. R., Penketh, R. and John, Rosalind Margaret 2015. Placental expression of imprinted genes varies with sampling site and mode of delivery. Placenta 36 (8) , pp. 790-795. 10.1016/j.placenta.2015.06.011

Kitamura, Akane, Miyauchi, Naoko, Hamada, Hirotaka, Hiura, Hitoshi, Chiba, Hatsune, Okae, Hiroaki, Sato, Akiko, John, Rosalind Margaret and Arima, Takahiro 2015. Epigenetic alterations in sperm associated with male infertility. Congenital Anomalies 55 (3) , pp. 133-144. 10.1111/cga.12113

Tunster, Simon James, Van De Pette, Mathew and John, Rosalind Margaret 2014. Isolating the role of elevated Phlda2 in asymmetric late fetal growth restriction in mice. Disease Models & Mechanisms 7 (10) , pp. 1185-1191. 10.1242/dmm.017079

Jensen, Anna B., Tunster, Simon James and John, Rosalind Margaret 2014. The significance of elevated placental PHLDA2 in human growth restricted pregnancies. Placenta 35 (8) , pp. 528-532. 10.1016/j.placenta.2014.04.018

Hiura, H., Sugawara, A., Ogawa, H., John, Rosalind Margaret, Miyauchi, N., Miyanari, Y., Horiike, T., Li, Y., Yaegashi, N., Sasaki, H., Kono, T. and Arima, T. 2014. A tripartite paternally methylated region within the Gpr1-Zdbf2 imprinted domain on mouse chromosome 1 identified by meDIP-on-chip [Correction]. Nucleic Acids Research 42 (16) , 10869. 10.1093/nar/gku624

Tunster, Simon James, Jensen, Anna B. and John, Rosalind Margaret 2013. Imprinted genes in mouse placental development and the regulation of fetal energy stores. Reproduction 145 (5) , R117-R137. 10.1530/REP-12-0511

John, Rosalind Margaret 2013. Epigenetic regulation of placental endocrine lineages and complications of pregnancy. Biochemical Society Transactions 41 (3) , pp. 701-709. 10.1042/BST20130002

Reed, Karen Ruth, Tunster, Simon James, Young, Madeleine, Carrico, Adam Stephen, John, Rosalind Margaret and Clarke, Alan Richard 2012. Entopic overexpression of Ascl2 does not accelerate tumourigenesis in ApcMin mice. Gut 61 (10) , pp. 1435-1438. 10.1136/gutjnl-2011-300842

Tunster, Simon James, Van De Pette, Mathew and John, Rosalind Margaret 2012. Impact of genetic background on placental glycogen storage in mice. Placenta 33 (2) , pp. 124-127. 10.1016/j.placenta.2011.11.011

Ackerman, W. E. IV, Bulmer, J. N., Carter, A. M, Chaillet, J. R., Chamley, L., Chen, C. P., Chuong, E. B., Coleman, S. J., Collet, G. P., Croy, B. A., de Mestre, A. M., Dickinson, H., Ducray, J., Enders, A. C., Fogarty, N. M. E., Gauster, M., Golos, T., Haider, S., Heazell, A. E., Holland, O. J., Huppertz, B., Husebekk, A., John, Rosalind Margaret, Johnsen, G. M., Jones, C. J. P., Kalionis, B., König, J., Lorenzon, A. R., Moffett, A., Moreira de Mello, J. C., Nuzzo, A. M., Parham, P., Parolini, O., Petroff, M. G., Pidoux, G., Ramírez-Pinilla, M. P., Robinson, W. P., Rolfo, A., Sadovsky, Y., Soma, H., Southcombe, J. H., Tilburgs, T. and Lash, G. E. 2012. IFPA Meeting 2011 workshop report III: Placental immunology; epigenetic and microRNA-dependent gene regulation; comparative placentation; trophoblast differentiation; stem cells. Placenta 33 (Suppl) , S15-S22. 10.1016/j.placenta.2011.11.022

Lewis, R. M., Cleal, J. K., Ntani, G., Crozier, S. R., Mahon, P. A., Robinson, S. M., Harvey, N. C., Cooper, C., Inskip, H. M., Godfrey, K. M., Hanson, M. A. and John, Rosalind Margaret 2012. Relationship between placental expression of the imprinted PHLDA2 gene, intrauterine skeletal growth and childhood bone mass. Bone 50 (1) , pp. 337-342. 10.1016/j.bone.2011.11.003

John, Rosalind Margaret and Hemberger, Myriam 2012. A placenta for life. Reproductive BioMedicine Online 25 (1) , pp. 5-11. 10.1016/j.rbmo.2012.03.018

Hiura, H., Okae, H., Miyauchi, N., Sato, F., Sato, A., Van De Pette, M., John, Rosalind Margaret, Kagami, M., Nakai, K., Soejima, H., Ogata, T. and Arima, T. 2012. Characterization of DNA methylation errors in patients with imprinting disorders conceived by assisted reproduction technologies. Human Reproduction 27 (8) , pp. 2541-2548. 10.1093/humrep/des197

Clarke, Angus J., Cooper, David Neil, Krawczak, Michael, Tyler-Smith, Chris, Wallace, Helen M., Wilkie, Andrew O. M., Raymond, Frances, Chadwick, Ruth, Craddock, Nicholas John, John, Rosalind Margaret, Gallacher, John and Chiano, Mathias 2012. 'Sifting the significance from the data' - the impact of high-throughput genomic technologies on human genetics and health care. Human Genomics 6 , 11. 10.1186/1479-7364-6-11

John, Rosalind Margaret and Lefebvre, Louis 2011. Developmental regulation of somatic imprints. Differentiation 81 (5) , pp. 270-280. 10.1016/j.diff.2011.01.007

Tunster, Simon James, Van De Pette, Mathew and John, Rosalind Margaret 2011. BACs as tools for the study of genomic imprinting. Journal of Biomedicine and Biotechnology 2011 , 283013. 10.1155/2011/283013

Tunster, Simon James, Van De Pette, Mathew and John, Rosalind Margaret 2011. Fetal overgrowth in the Cdkn1c mouse model of Beckwith-Wiedemann syndrome. Disease Models & Mechanisms 4 (6) , pp. 814-821. 10.1242/dmm.007328

Wood, M. D., Hiura, H., Tunster, Simon James, Arima, T., Shin, J-Y, Higgins, M.J. and John, Rosalind Margaret 2010. Autonomous silencing of the imprinted Cdkn1c gene in stem cells. Epigenetics 5 (3) , pp. 214-221. 10.4161/epi.5.3.11275

Tunster, Simon James, Tycko, B and John, Rosalind Margaret 2010. The imprinted Phlda2 gene regulates extraembryonic energy stores. Molecular and Cellular Biology 30 (1) , pp. 295-306. 10.1128/MCB.00662-09

John, Rosalind Margaret 2010. Engineering mouse models to investigate the function of imprinting. Briefings in Functional Genomics 9 (4) , pp. 294-303. 10.1093/bfgp/elq010

Hiura, H., Sugawara, A., Ogawa, H., John, Rosalind Margaret, Miyauchi, N., Miyanari, Y., Horiike, T., Li, Y., Yaegashi, N., Sasaki, H., Kono, T. and Arima, T. 2010. A tripartite paternally methylated region within the Gpr1-Zdbf2 imprinted domain on mouse chromosome 1 identified by meDIP-on-chip. Nucleic Acids Research 38 (15) , pp. 4929-4945. 10.1093/nar/gkq200

Kobayashi, H., Hiura, H., John, Rosalind Margaret, Sato, A., Otsu, E., Kobayashi, N., Suzuki, R., Suzuki, F., Hayashi, C., Utsunomiya, T., Yaegashi, N. and Arima, T. 2009. DNA methylation errors at imprinted loci after assisted conception originate in the parental sperm. European Journal of Human Genetics 17 (1582-1) 10.1038/ejhg.2009.68

Sowpati, D.T., Thiagarajan, D., Sharma, S., Sultana, H., John, Rosalind Margaret, Surani, A., Mishra, R. K. and Khosla, S. 2008. An intronic DNA sequence within the mouse Neuronatin gene exhibits biochemical characteristics of an ICR and acts as a transcriptional activator in Drosophila. Mechanisms of Development 125 (11/12) , pp. 963-973. 10.1016/j.mod.2008.08.002 |

Andrews, Stuart. Christopher, Wood, Michelle D., Tunster, Simon James, Barton, Sheila C., Surani, M. Azim and John, Rosalind Margaret 2007. Cdkn1c (p57Kip2) is the major regulator of embryonic growth within its imprinted domain on mouse distal chromosome 7. BMC Developmental Biology 7 , 53. 10.1186/1471-213x-7-53

Azuara, V., Perry, P., Sauer, S, Spivakov, M., Jorgensen, H. F., John, Rosalind Margaret, Gouti, M., Casanova, M., Warnes, G., Merkenschlager, M. and Fisher, A. G. 2006. Chromatin signatures of pluripotent cell lines. Nature Cell Biology 8 (5) , pp. 532-538. 10.1038/ncb1403

Arima, Takahiro, Yamasaki, Katsuhisa, John, Rosalind Margaret, Kato, Kiyoko, Sakumi, Kunihiko, Nakabeppu, Yusaku, Wake, Norio and Kono, Tomohiro 2006. The human HYMAI/PLAGL1 differentially methylated region acts as an imprint control region in mice. Genomics 88 (5) , pp. 650-658. 10.1016/j.ygeno.2006.07.005

Zvetkova, I., Apedaile, A., Ramsahoye, B., Mermoud, J. E., Crompton, L. A., John, Rosalind Margaret, Feil, R. and Brockdorff, N. 2005. Global hypomethylation of the genome in XX embryonic stem cells. Nature Genetics 37 (11) , pp. 1274-1279. 10.1038/ng1663

Baxter, Jonathan, Sauer, Stephan, Peters, Antoine, John, Rosalind Margaret, Williams, Ruth, Caparros, Marie-Laure, Arney, Katharine, Otte, Arie, Jenuwein, Thomas, Merkenschlager, Matthias and Fisher, Amanda G. 2004. Histone hypomethylation is an indicator of epigenetic plasticity in quiescent lymphocytes. EMBO Journal 23 (22) , pp. 4462-4472. 10.1038/sj.emboj.7600414

Salas, Martha, John, Rosalind Margaret, Saxena, Anjana, Barton, Sheila, Frank, Dale, Fitzpatrick, Galina, Higgins, Michael J. and Tycko, Benjamin 2004. Placental growth retardation due to loss of imprinting of Phlda2. Mechanisms of Development 121 (10) , pp. 1199-1210. 10.1016/j.mod.2004.05.017

John, Rosalind Margaret, Ainscough, Justin and Barton, Sheila C. 2002. A transgenic approach to studying imprinted genes: modified BACs and PACs. In: Ward, Andrew ed. Genomic Imprinting, Vol. 181. Methods in Molecular Biology, Humana Press, pp. 67-81. (10.1385/1-59259-211-2:67)

Ainscough, Justin, John, Rosalind Margaret and Barton, Sheila C. 2002. Production of YAC transgenic mice by pronuclear injection. In: Ward, Andrew ed. Genomic Imprinting, Vol. 181. Methods in Molecular Biology, Humana Press, pp. 55-65. (10.1385/1-59259-211-2:55)

John, Rosalind Margaret, Ainscough, J.F-X., Aparicio, S.A.J.R. and Surani, M.A. 2001. Imprinted Expression of Neuronatin from Modified BAC Transgenes Reveals Regulation by Distinct and Distant Enhancers. Developmental Biology 236 (2) , pp. 387-399. 10.1006/dbio.2001.0327

John, Rosalind Margaret, Ainscough, J.F., Barton, Sheila. C. and Surani, M. Azim 2001. Distant cis-elements regulate imprinted expression of the mouse p57Kip2 (Cdkn1c) gene: Implications for the human disorder, Beckwith–Wiedemann syndrome. Human Molecular Genetics Vol.10 (15) , pp. 1601-1609. 10.1093/hmg/10.15.1601

Ainscough, Justin, John, Rosalind Margaret, Barton, Sheila and Surani, M. Azim 2000. A skeletal muscle-specific mouse Igf2 repressor lies 40 kb downstream of the gene. Development 127 (18) , pp. 3923-3930.

John, Rosalind Margaret 2000. Genomic imprinting, mammalian evolution, and the mystery of egg-laying mammals. Cell 101 (6) , pp. 585-588.

This list was generated on Mon Oct 26 04:13:06 2020 GMT.

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