Browse by Current Cardiff authors

Cassels, Nicola, Wild, John, Margrain, Thomas, Blyth, Chris, Chong, Victor and Acton, Jennifer 2019. Microperimetry in age-related macular degeneration: An evidence-base for Pattern Deviation probability analysis in microperimetry. Translational Vision Science & Technology 8 (6) , 48. 10.1167/tvst.8.6.48

Dunn, Matt J., Harris, Christopher M., Ennis, Fergal A., Margrain, Tom H., Woodhouse, J Margaret, McIlreavy, Lee and Erichsen, Jonathan T. 2019. An automated segmentation approach to calibrating infantile nystagmus waveforms. Behavior Research Methods 51 (5) , pp. 2074-2084. 10.3758/s13428-018-1178-5

Morny, Enyam Komla A., Patel, Kishan, Votruba, Marcela, Binns, Alison and Margrain, Thomas 2019. The relationship between the photopic negative response and retinal ganglion cell topography. Investigative Ophthalmology & Visual Science 60 (6) , pp. 1879-1887. 10.1167/iovs.18-25272

Nollett, Claire, Ryan, Barbara, Bray, Nathan, Bunce, Catey, Casten, Robin, Edwards, Rhiannon T., Gillespie, David, Smith, Daniel J., Stanford, Miles and Margrain, Tom H. 2019. Depressive symptoms in people with a vision impairment: A cross-sectional study to identify who is most at risk. BMJ Open 9 (1) , e026163. 10.1136/bmjopen-2018-026163

Robinson, D. Grant, Margrain, Tom H., Dunn, Matt J., Bailey, Clare and Binns, Alison M. 2018. Low-­level night-­time light-­therapy for age-­related macular degeneration: a randomized clinical trial. Investigative Ophthalmology & Visual Science 59 (11) , pp. 4531-4541. 10.1167/iovs.18-24284

Robinson, D. Grant, Margrain, Tom H., Bailey, Claire and Binns, Alison M. 2018. An evaluation of a battery of functional and structural tests as predictors of likely risk of progression of age-related macular degeneration. Investigative Ophthalmology & Visual Science 60 , pp. 580-589. 10.1167/iovs.18-25092

Cassels, Nicola, Wild, John, Margrain, Thomas Hengist, Chong, Victor and Acton, Jennifer 2018. The use of microperimetry in assessing visual function in age-related macular degeneration. Survey of Ophthalmology 63 (1) , pp. 40-55. 10.1016/j.survophthal.2017.05.007

Ravenscroft, Dafydd, Deng, Jingjing, Xie, Xianghua, Terry, Louise, Margrain, Tom H., North, Rachel V. and Wood, Ashley 2017. AMD classification in choroidal OCT using hierarchical texton mining. Presented at: ACIVS 2017, Antwerp, Belgium, 18-21 Sep 2017. Published in: Blanc-Talon, Jacques, Penne, Rudi, Philips, Wilfried, Popescu, Dan and Scheunders, Paul eds. Advanced Concepts for Intelligent Vision Systems. Lecture Notes in Artificial Intelligence Cham, Switzerland: Springer, pp. 237-248. 10.1007/978-3-319-70353-4_21

Dunn, Matthew, Debbie Wiggins, Debbie, Woodhouse, Joy Margaret, Margrain, Thomas Hengist, Harris, Christopher M. and Erichsen, Jonathan Thor 2017. The effect of gaze angle on visual acuity in infantile nystagmus. Investigative Ophthalmology and Visual Science 58 (1) , pp. 642-650. 10.1167/iovs.16-20370

Acton, Jennifer H., Molik, Bablin, Court, Helen and Margrain, Tom H. 2016. Effect of a home visit-based low vision rehabilitation intervention on visual function outcomes: an exploratory randomized controlled trial. Investigative Ophthalmology & Visual Science 57 (15) , pp. 6662-6667. 10.1167/iovs.16-19901

Terry, Louise, Cassels, Nicola, Lu, Kelly, Acton, Jennifer, Margrain, Thomas, North, Rachel, Fergusson, James, White, Nicholas and Wood, Ashley 2016. Automated Retinal Layer Segmentation Using Spectral Domain Optical Coherence Tomography: Evaluation of Inter-Session Repeatability and Agreement between Devices. Plos One 11 (9) , e0162001. 10.1371/journal.pone.0162001

van der Aa, HPA, Margrain, Thomas, van Rens, GHMB, Heymans, MW and van Nispen, RMA 2016. Psychosocial interventions to improve mental health in adults with vision impairment: systematic review and meta-analysis. Ophthalmic And Physiological Optics 36 (5) , pp. 584-606. 10.1111/opo.12313

Nollett, Claire L., Bray, Nathan, Bunce, Catey, Casten, Robin J., Edwards, Rhiannon T., Hegel, Mark T., Janikoun, Sarah, Jumbe, Sandra E., Ryan, Barbara, Shearn, Julia, Smith, Daniel J., Stanford, Miles, Xing, Wen and Margrain, Tom H. 2016. Depression in visual impairment trial (DEPVIT): a randomised clinical trial of depression treatments in people with low vision. Investigative Ophthalmology & Visual Science 57 (10) , pp. 4247-4254. 10.1167/iovs.16-19345

Deng, Jingjing, Xie, Xianghua, Terry, Louise, Wood, Ashley, White, Nick, Margrain, Tom H. and North, Rachel V. 2016. Age-related macular degeneration detection and stage classification using choroidal OCT images. Presented at: ICIAR 2016, Póvoa de Varzim, Portugal, 13-15 Jul 2016. Published in: Campilho, Aurélio and Karray, Fakhri eds. Image Analysis and Recognition: ICIAR 2016. Lecture Notes in Computer Science Cham, Switzerland: Springer Verlag, pp. 707-715. 10.1007/978-3-319-41501-7_79

Acton, Jennifer H., Molik, Bablin, Binns, Alison, Court, Helen Jane and Margrain, Thomas Hengist 2016. Effect of rehabilitation worker input on visual function outcomes in individuals with low vision: study protocol for a randomised controlled trial. Trials 17 , 105. 10.1186/s13063-016-1235-2

Nollett, Claire, Bray, Nathan, Bunce, Catey, Casten, Robin J., Edwards, Rhiannon T., Hegel, Mark T., Janikoun, Sarah, Jumbe, Sandra, Ryan, Barbara, Shearn, Julia, Smith, Daniel J., Stanford, Miles, Xing, Wen and Margrain, Thomas 2016. High prevalence of untreated depression in patients accessing low-vision services. Ophthalmology 123 (2) , pp. 440-441. 10.1016/j.ophtha.2015.07.009

Morny, Emyan Komla A., Margrain, Tom H., Binns, Alison M. and Votruba, Marcela 2015. Electrophysiological ON and OFF responses in autosomal dominant optic atrophy. Investigative Ophthalmology & Visual Science 56 (13) , pp. 7629-7637. 10.1167/iovs.15-17951

van der Aa, Hilde P A, van Rens, Ger H M B, Comijs, Hannie C, Margrain, Tom H., Gallindo-Garre, Francisca, Twisk, Jos W R and van Nispen, Ruth M A 2015. Stepped care for depression and anxiety in visually impaired older adults: multicentre randomised controlled trial. BMJ 351 , -. 10.1136/bmj.h6127

Dunn, Matthew, Margrain, Thomas Hengist, Woodhouse, Joy Margaret and Erichsen, Jonathan Thor 2015. Visual processing in infantile nystagmus is not slow. Investigative Ophthalmology & Visual Science 56 (9) , pp. 5094-5101. 10.1167/iovs.15-16977

Dunn, Matthew, Margrain, Thomas Hengist, Woodhouse, Joy Margaret, Ennis, Fergal, Harris, Christopher M. and Erichsen, Jonathan Thor 2014. Author response: grating visual acuity in infantile nystagmus in the absence of image motion. Investigative Ophthalmology and Visual Science 55 (8) , pp. 4955-4957. 10.1167/iovs.14-15070

Gaffney, Allannah J., Margrain, Thomas Hengist, Bunce, Catey V. and Binns, Alison 2014. How effective is eccentric viewing training? A systematic literature review. Ophthalmic and Physiological Optics 34 (4) , pp. 427-437. 10.1111/opo.12132

McKeague, Claire, Margrain, Tom, Bailey, Clare and Binns, Alison 2014. Low-level night-time light therapy for age-related macular degeneration (ALight): study protocol for a randomized controlled trial. Trials 15 , 246. 10.1186/1745-6215-15-246

Wood, Ashley, Margrain, Thomas Hengist and Binns, Alison 2014. Detection of Early Age-related macular degeneration using novel functional parameters of the focal cone electroretinogram. PLoS ONE 9 (5) , e96742. 10.1371/journal.pone.0096742

Dunn, Matt J., Margrain, Tom H., Woodhouse, J. Margaret, Ennis, Fergal A., Harris, Christopher M. and Erichsen, Jonathan T. 2014. Grating visual acuity in infantile nystagmus in the absence of image motion. Investigative Ophthalmology & Visual Science 55 (4) , pp. 2682-2686. 10.1167/iovs.13-13455

Gaffney, Allannah J., Binns, Alison and Margrain, Thomas Hengist 2014. Measurement of cone dark adaptation: a comparison of four psychophysical methods. Documenta Ophthalmologica 128 (1) , pp. 33-41. 10.1007/s10633-013-9418-6

Jones, Philip Hugh, Harris, C. M., Woodhouse, Joy Margaret, Margrain, Thomas Hengist, Ennis, Fergal and Erichsen, Jonathan Thor 2013. Stress and visual function in infantile nystagmus syndrome. Investigative Ophthalmology and Visual Science 54 (13) , pp. 7943-7951. 10.1167/iovs.13-12560

Gaffney, Allannah J., Binns, Alison and Margrain, Thomas Hengist 2013. The effect of pre-adapting light intensity on dark adaptation in early age-related macular degeneration. Documenta Ophthalmologica 127 (3) , pp. 191-199. 10.1007/s10633-013-9400-3

van der Aa, Hilde P. A., van Rens, Ger H. M. B., Comijs, Hannie C., Bosmans, Judith E., Margrain, Thomas Hengist and van Nispen, Ruth M. A. 2013. Stepped-care to prevent depression and anxiety in visually impaired older adults - design of a randomised controlled trial. BMC Psychiatry 13 , 209. 10.1186/1471-244X-13-209

Jones, Philip Hugh, Wiggins, Deborah, Margrain, Thomas Hengist, Woodhouse, Joy Margaret, Harris, Christopher M. and Erichsen, Jonathan Thor 2012. The impact of stress on visual performance in congenital nystagmus. In: Harris, Christopher M., Gottlob, Irene and Sanders, John eds. The Challenge of Nystagmus, Nystagmus Network, pp. 239-260.

Khadka, Jyoti, Ryan, Barbara, Margrain, Thomas Hengist, Woodhouse, Joy Margaret and Davies, Nathan 2012. Listening to voices of children with a visual impairment: A focus group study. British Journal of Visual Impairment 30 (3) , pp. 182-196. 10.1177/0264619612453105

Gaffney, Allannah J., Binns, Alison and Margrain, Thomas Hengist 2012. Aging and cone dark adaptation. Optometry and Vision Science 89 (8) , pp. 1219-1224. 10.1097/OPX.0b013e318263c6b1

Binns, Alison, Bunce, Catey, Dickinson, Chris, Harper, Robert, Tudor-Edwards, Rhiannon, Woodhouse, Joy Margaret, Linck, Pat, Suttie, Alan, Jackson, Jonathan, Lindsay, Jennifer, Wolffsohn, James, Hughes, Lindsey and Margrain, Thomas Hengist 2012. How effective is low vision service provision? A systematic review. Survey of Ophthalmology 57 (1) , pp. 34-65. 10.1016/j.survophthal.2011.06.006

Margrain, Thomas Hengist, Nollett, Claire, Shearn, Julia, Stanford, Miles, Edwards, Rhiannon Tudor, Ryan, Barbara, Bunce, Catey, Casten, Robin, Hegel, Mark T. and Smith, Daniel J. 2012. The depression in Visual Impairment Trial (DEPVIT): trial design and protocol. BMC Psychiatry 12 (1) , 57. 10.1186/1471-244X-12-57

Margrain, Thomas, Smith, Daniel and Nollett, Claire 2012. Depression and Vision Loss in Ageing. Optometry in Practice 13 (2)

Wood, Ashley, Binns, Alison, Margrain, Thomas Hengist, Drexler, Wolfgang, Povazay, Boris Wolfgang Ladislaus, Esmaeelpour Hajyar, Marieh and Sheen, Nicholas John Leighton 2011. Retinal and choroidal thickness in early age-related macular degeneration. American Journal of Ophthalmology 152 (6) , pp. 1030-1038. 10.1016/j.ajo.2011.05.021

Wood, Ashley, Margrain, Thomas Hengist and Binns, Alison 2011. The effect of bleach duration and age on the ERG photostress test. Graefe's Archive for Clinical and Experimental Ophthalmology 249 (9) , pp. 1359-1365. 10.1007/s00417-011-1627-7

Court, Helen Jane, Ryan, Barbara, Bunce, C. and Margrain, Thomas Hengist 2011. How effective is the new community-based Welsh low vision service? British Journal of Ophthalmology 95 (2) , pp. 178-184. 10.1136/bjo.2010.179606

Dickinson, C., Linck, P., Tudor-Edwards, R., Binns, Alison, Bunce, C., Harper, R., Jackson, J., Lindsay, J., Suttie, A., Wolffsohn, J., Woodhouse, M. and Margrain, Thomas Hengist 2011. A profile of low vision services in England: the Low Vision Service Model Evaluation (LOVSME) project [Editorial]. Eye 25 (7) , pp. 829-831. 10.1038/eye.2011.112

Gaffney, Allannah J., Binns, Alison and Margrain, Thomas Hengist 2011. Topography of Cone Dark Adaptation Deficits in Age-Related Maculopathy. Optometry and Vision Science 88 (9) , pp. 1080-1087. 10.1097/OPX.0b013e3182223697

Gaffney, Allannah J., Binns, Alison and Margrain, Thomas Hengist 2011. The repeatability of the Goldmann-Weekers adaptometer for measuring cone adaptation. Documenta Ophthalmologica 122 (2) , pp. 71-75. 10.1007/s10633-011-9261-6

Khadka, Jyoti, Ryan, Barbara, Margrain, Thomas Hengist, Court, Helen Jane and Woodhouse, Joy Margaret 2010. Development of the 25-item Cardiff Visual Ability Questionnaire for Children (CVAQC). British Journal of Ophthalmology 94 (6) , pp. 730-735. 10.1136/bjo.2009.171181

Kolarik, Andrew Joseph, Margrain, Thomas Hengist and Freeman, Tom C. A. 2010. Precision and accuracy of ocular following: influence of age and type of eye movement. Experimental Brain Research 201 (2) , pp. 271-282. 10.1007/s00221-009-2036-6

O'Connor, Emer, Margrain, Thomas Hengist and Freeman, Tom C. A. 2010. Age, eye movement and motion discrimination. Vision Research 50 (23) , pp. 2588-2599. 10.1016/j.visres.2010.08.015

Ryan, Barbara and Margrain, Thomas Hengist 2010. Research findings no 28: All Wales visual impairment database. [Project Report]. London, UK: Thomas Pocklington Trust.

Ryan, Barbara, Margrain, Thomas Hengist, Reidy, Angela and Minassian, Darwin 2010. Occasional paper no 24: All Wales visual impairment database. [Project Report]. London, UK: Thomas Pocklington Trust.

Ryan, Barbara, White, Sean Damian, Wild, John Millington, Court, Helen and Margrain, Thomas Hengist 2010. The newly established primary care based Welsh Low Vision Service is effective and has improved access to low vision services in Wales. Ophthalmic And Physiological Optics 30 (4) , pp. 358-364. 10.1111/j.1475-1313.2010.00729.x

Court, Helen, Greenland, Katy and Margrain, Thomas Hengist 2010. Measuring patient anxiety in primary care: Rasch analysis of the 6-item Spielberger State Anxiety Scale. Value In Health 13 (6) , pp. 813-819. 10.1111/j.1524-4733.2010.00758.x

Ryan, Barbara and Margrain, Thomas Hengist 2010. Registration for people with sight impairment: Fit for purpose? British Journal of Ophthalmology 94 (12) , pp. 1692-1693. 10.1136/bjo.2009.178558

Court, Helen, Greenland, Katy and Margrain, Thomas Hengist 2009. Predicting state anxiety in optometric practice. Optometry and Vision Science 86 (11) , pp. 1295-1302. 10.1097/OPX.0b013e3181bb4212

Carson, Dennis, Margrain, Thomas Hengist and Patel, Anil 2009. Reply: Lipofuscin phototoxicity: Reality or myth? [Letter]. Journal of Cataract & Refractive Surgery 35 (8) , pp. 1479-1480. 10.1016/j.jcrs.2009.03.032

Carson, Dennis, Margrain, Thomas Hengist and Patel, Anil 2009. Reply: Refractive error and age-related lipofuscin accumulation-mediated retinal phototoxicity. Journal of Cataract & Refractive Surgery 35 (7) , pp. 1321-1322. 10.1016/j.jcrs.2009.02.021

Court, Helen Jane, Greenland, Katy and Margrain, Thomas Hengist 2009. Evaluating the association between anxiety and satisfaction. Optometry and Vision Science 86 (3) , pp. 216-221. 10.1097/OPX.0b013e318196cf59

Carson, Dennis, Margrain, Thomas Hengist and Patel, Anil 2009. Reply: Retinal phototoxicity in the aging pseudophakic and phakic eye [Letter]. Journal of Cataract & Refractive Surgery 35 (2) , pp. 210-211. 10.1016/j.jcrs.2008.11.017

Tumlinson, Alexandre Rex, Hermann, Boris, Hofer, Bernd, Povazay, Boris, Margrain, Thomas Hengist, Binns, Alison and Drexler, Wolfgang 2009. Techniques for extraction of depth-resolved in vivo human retinal intrinsic optical signals with optical coherence tomography. Japanese Journal of Ophthalmology 53 (4) , pp. 315-326. 10.1007/s10384-009-0684-5

Carson, Dennis, Margrain, Thomas hengist and Patel, Anil 2008. New approach to evaluate retinal protection by intraocular lenses against age-related lipofuscin accumulation-mediated retinal phototoxicity. Journal of Cataract & Refractive Surgery 34 (10) , pp. 1785-1792. 10.1016/j.jcrs.2008.06.034

Court, Helen, Greenland, Katy and Margrain, Thomas Hengist 2008. Evaluating patient anxiety levels during contact lens fitting. Optometry and Vision Science 85 (7) , pp. 574-580. 10.1097/OPX.0b013e31817dad7a

Ryan, Barbara, Court, Helen Jane and Margrain, Thomas Hengist 2008. Measuring low vision service outcomes: Rasch Analysis of the seven-item National Eye Institute visual function questionnaire. Optometry and Vision Science 85 (2) , pp. 112-121. 10.1097/OPX.0b013e31816225dc

Khadka, Jyoti, Woodhouse, Joy Margaret, Margrain, Thomas Hengist, Ryan, Barbara and Davies, Nathan 2008. Focusing children in focus groups [Abstract]. Ophthalmic and Physiological Optics 28 (1) , p. 99. 10.1111/j.1475-1313.2007.00530_11.x

Kolarik, Andrew Joseph, Freeman, Tom C. A. and Margrain, Thomas H. 2008. Age and eye movement [Abstract]. Perception 37 (2) , p. 314. 10.1068/ava07

Court, Helen, Greenland, Katy and Margrain, Thomas Hengist 2007. Content development of the optometric patient anxiety scale. Optometry and Vision Science 84 (8) , pp. 729-744. 10.1097/OPX.0b013e31812f7361

Binns, Alison and Margrain, Thomas Hengist 2007. Evaluating Retinal Function in Age-Related Maculopathy with the ERG Photostress Test. Investigative Ophthalmology and Visual Science 48 (6) , pp. 2806-2813. 10.1167/iovs.06-0392

Wiggins, Deborah, Woodhouse, Joy Margaret, Margrain, Thomas Hengist, Harris, Christopher M. and Erichsen, Jonathan Thor 2007. Infantile nystagmus adapts to visual demand. Investigative Ophthalmology and Visual Science 48 (5) , pp. 2089-2094. 10.1167/iovs.06-1108

Binns, Alison and Margrain, Thomas Hengist 2006. Development of a technique for recording the focal rod ERG. Ophtalmic and physiological optics 26 (1) , pp. 71-79. 10.1111/j.1475-1313.2005.00355.x

Qin, Xue-Jiao, Margrain, Thomas Hengist, To, Chi Ho, Bromham, Nathan Robert and Guggenheim, Jeremy Andrew 2005. Anisometropia is independently associated with both spherical and cylindrical ametropia. Investigative Ophthalmology & Visual Science 46 (11) , pp. 4024-4031. 10.1167/iovs.05-0120

Binns, Alison and Margrain, Thomas Hengist 2005. Evaluation of retinal function using the Dynamic Focal Cone ERG. Ophthalmic and Physiological Optics 25 (6) , pp. 492-500. 10.1111/j.1475-1313.2005.00338.x

Margrain, Thomas Hengist, Ryan, Barbara and Wild, John Millington 2005. A revolution in Welsh low vision service provision. British Journal of Ophthalmology 89 (8) , pp. 933-934. 10.1136/bjo.2005.066142

Margrain, Thomas Hengist, Boulton, Michael Edwin, Marshall, J. and Sliney, D. H. 2004. Do blue light filters confer protection against age-related macular degeneration? Progress in Retinal and Eye Research 23 (5) , pp. 523-531. 10.1016/j.preteyeres.2004.05.001

Margrain, Thomas Hengist, Court, H. and Greenland, Katy 2004. Content development of the optometric patient anxiety scale. Progress in Retinal and Eye Research 23 (5) , pp. 523-531.

Margrain, Thomas Hengist, Greenland, Katy and Anderson, Jane 2003. Evaluating anxiety in patients attending optometric practice. Ophthalmic and Physiological Optics 23 (4) , pp. 287-293. 10.1046/j.1475-1313.2003.00118.x

Margrain, Thomas Hengist and Thomson, David 2002. Sources of variability in the clinical photostress test. Ophthalmic and Physiological Optics 22 (1) , pp. 61-67. 10.1046/j.1475-1313.2002.00005.x

Freeman, Tom C. A., Naji, Jenny J. and Margrain, Thomas Hengist 2002. Head-centred motion perception in the ageing visual system. Spatial Vision 15 (2) , pp. 117-127. 10.1163/15685680252875110

Margrain, Thomas Hengist 2000. Helping blind and partially sighted people to read: the effectiveness of low vision aids [Letter]. British Journal of Ophthalmology 84 (8) , pp. 919-921. 10.1136/bjo.84.8.919

Margrain, Thomas Hengist 1999. Minimising the impact of visual impairment: Low vision aids are a simple way of alleviating impairment [Editorial]. BMJ 318 (7197) , p. 1504.

Margrain, Thomas Hengist and Thomson, W. D. 1997. Recovery of spatial vision during dark adaptation in normal subjects. Ophthalmic and Physiological Optics 17 (6) , pp. 509-515. 10.1046/j.1475-1313.1997.97000331.x

Owen, Christopher G., Margrain, Thomas Hengist and Woodward, E. Geoffrey 1997. Use of contact lenses by firefighters: Part 2. Clinical evaluation. Ophthalmic and Physiological Optics 17 (3) , pp. 205-215. 10.1111/j.1475-1313.1997.opo_021.x

Owen, Christopher G., Margrain, Thomas Hengist and Woodward, E. Geoffrey 1997. Use of contact lenses by firefighters. Part 1: Questionnaire data. Ophthalmic and Physiological Optics 17 (2) , pp. 102-111. 10.1046/j.1475-1313.1997.96000592.x

Margrain, Thomas Hengist and Owen, Chris 1996. The misting characteristics of spectacle lenses. Ophthalmic and Physiological Optics 16 (2) , pp. 108-114. 10.1046/j.1475-1313.1996.95000232.x

Margrain, Thomas Hengist, Owen, Christopher G. and Woodward, E. Geoffrey 1996. Prevalence of spectacle and contact lens wear in the UK fire service. Ophthalmic and Physiological Optics 16 (1) , pp. 11-18. 10.1046/j.1475-1313.1996.95000089.x

Margrain, Thomas Hengist, Birch, J. and Owen, C. G. 1996. Colour vision requirements of firefighters. Occupational Medicine 46 (2) , pp. 114-124. 10.1093/occmed/46.2.114

Owen, C. G., Margrain, Thomas Hengist and Woodward, E. G. 1995. Aetiology and prevalence of eye injuries within the United Kingdom fire service. Eye 9 (6S) , pp. 54-58.

Margrain, Thomas Hengist and Birch, J. 1994. A suitable study to evaluate colour vision requirements for firefighters? Occupational Medicine 44 (5) , pp. 257-258. 10.1093/occmed/44.5.257