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Number of items: 133.

Sewell, Andrew K. and Legut, Mateusz 2018. Designer T-cells and T-cell receptors for customised cancer immunotherapies. Current Opinion in Pharmacology 41 , pp. 96-103. 10.1016/j.coph.2018.05.005
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Zhao, Xiang, Sankaran, Shvetha, Yap, Jiawei, Too, Chien Tei, Ho, Zi Zong, Dolton, Garry, Legut, Mateusz, Ren, Ee Chee, Sewell, Andrew K., Bertoletti, Antonio, MacAry, Paul A., Brzostek, Joanna and Gascoigne, Nicholas R. J. 2018. Nonstimulatory peptide?MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling. Nature Communications 9 , 2716. 10.1038/s41467-018-05288-0
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Dolton, Garry, Zervoudi, Efthalia, Rius Rafael, Cristina, Wall, Aaron, Thomas, Hannah L., Fuller, Anna, Yeo, Lorraine, Legut, Mateusz, Wheeler, Sophie, Attaf, Meriem, Chudakov, Dmitriy M., Choy, Ernest, Peakman, Mark and Sewell, Andrew K. 2018. Optimized peptide-MHC multimer protocols for detection and isolation of autoimmune T-cells. Frontiers in Immunology 9 , 1378. 10.3389/fimmu.2018.01378
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Yeo, Lorraine, Woodwyk, Alyssa, Sood, Sanjana, Lorenc, Anna, Eichmann, Martin, Pujol-Autonell, Irma, Melchiotti, Rosella, Skowera, Ania, Fidanis, Efthymios, Dolton, Garry M., Tungatt, Katie, Sewell, Andrew K., Heck, Susanne, Saxena, Alka, Beam, Craig A. and Peakman, Mark 2018. Autoreactive T effector memory differentiation mirrors b cell function in type 1 diabetes. The Journal of Clinical Investigation 128 (8) , pp. 3460-3474. 10.1172/JCI120555
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Tungatt, Katie, Dolton, Garry, Morgan, Sophie B., Attaf, Meriem, Fuller, Anna, Whalley, Thomas, Hemmink, Johanneke D., Porter, Emily, Szomolay, Barbara, Montoya, Maria, Hammond, John A., Miles, John J., Cole, David K., Townsend, Alain, Bailey, Mick, Rizkallah, Pierre J., Charleston, Bryan, Tchilian, Elma and Sewell, Andrew K. 2018. Induction of influenza-specific local CD8 T-cells in the respiratory tract after aerosol delivery of vaccine antigen or virus in the Babraham inbred pig. PLoS Pathogens 14 (5) , e1007017. 10.1371/journal.ppat.1007017
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Holland, Christopher J., MacLachlan, Bruce J., Bianchi, Valentina, Hesketh, Sophie J., Morgan, Richard, Vickery, Owen, Bulek, Anna M., Fuller, Anna, Godkin, Andrew, Sewell, Andrew K., Rizkallah, Pierre J., Wells, Stephen and Cole, David K. 2018. In silico and structural analyses demonstrate that intrinsic protein motions guide T cell receptor complementarity determining region loop flexibility. Frontiers in Immunology 9 , 674. 10.3389/fimmu.2018.00674
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Miles, John J., Tan, Mai Ping, Dolton, Garry, Edwards, Emily S. J., Galloway, Sarah A. E., Laugel, Bruno, Clement, Mathew, Makinde, Julia, Ladell, Kristin, Matthews, Katherine K., Watkins, Thomas S., Tungatt, Katie, Wong, Yide, Lee, Han Siean, Clark, Richard J., Pentier, Johanne, Attaf, Meriem, Lissina, Anya, Ager, Ann, Gallimore, Awen, Rizkallah, Pierre J., Gras, Stephanie, Rossjohn, Jamie, Burrows, Scott R., Cole, David K., Price, David A. and Sewell, Andrew K. 2018. Peptide mimic for influenza vaccination using nonnatural combinatorial chemistry. The Journal of Clinical Investigation 128 (4) , pp. 1569-1580. 10.1172/JCI91512
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Rius Rafael, Cristina, Attaf, Meriem, Tungatt, Katie, Bianchi, Valentina, Legut, Mateusz, Bovay, Amandine, Donia, Marco, Straten, Per thor, Peakman, Mark, Svane, Inge Marie, Ott, Sascha, Connor, Thomas, Szomolay, Barbara, Dolton, Garry and Sewell, Andrew 2018. Peptide-MHC class 1 tetramers can fail to detect relevant functional T-cell clonotypes and underestimate antigen-reactive T-cell populations. The Journal of Immunology 200 (7) , pp. 2263-2279. 10.4049/jimmunol.1700242
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Bovay, Amandine, Zoete, Vincent, Dolton, Garry, Bulek, Anna M., Cole, David K., Rizkallah, Pierre J., Fuller, Anna, Beck, Konrad, Michielin, Olivier, Speiser, Daniel E., Sewell, Andrew K. and Fuertes Marraco, Silvia A. 2018. T cell Receptor Alpha Variable 12-2 bias in the immunodominant response to Yellow fever virus. European Journal of Immunology 48 (2) , pp. 258-272. 10.1002/eji.201747082
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Legut, Mateusz, Dolton, Garry, Mian, Afsar, Ottmann, Oliver and Sewell, Andrew 2018. CRISPR-mediated TCR replacement generates superior anticancer transgenic T-cells. Blood 131 (3) , pp. 311-322. 10.1182/blood-2017-05-787598
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Maciocia, Paul M, Wawrzyniecka, Patrycja A, Philip, Brian, Ricciardelli, Ida, Akarca, Ayse U, Onuoha, Shimobi C, Legut, Mateusz, Cole, David, Sewell, Andrew, Gritti, Giuseppe, Somja, Joan, Piris, Miguel A, Peggs, Karl S, Linch, David C, Marafioti, Teresa and Pule, Martin A 2017. Targeting the T cell receptor β-chain constant region for immunotherapy of T cell malignancies. Nature Medicine 23 (12) , pp. 1416-1423. 10.1038/nm.4444
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Maciocia, Paul M., Wawrzyniecka, Patrycja A., Philip, Brian, Ricciardelli, Ida, Akarca, Ayse U., Onuoha, Shimobi, Legut, Mateusz, Cole, David, Sewell, Andrew K., Gritti, Giuseppe, Somja, Joan, Piris, Miguel A., Peggs, Karl S., Linch, David C., Marafioti, Teresa and Pule, Martin A. 2017. Targeting T-cell receptor B-constant for immunotherapy of T-cell malignancies. Nature Medicine 23 , pp. 1416-1423. 10.1038/nm.4444
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Cole, David, Fuller, Anna, Dolton, Garry, Zervoudi, Efthalia, Legut, Mateusz, Miles, Kim, Blanchfield, Jennifer L, Madura, Florian, Holland, Christopher J, Bulek, Anna M, Bridgeman, John, Miles, John, Schauenburg, Andrea, Beck, Konrad, Evavold, Brian D, Rizkallah, Pierre and Sewell, Andrew 2017. Dual molecular mechanisms govern escape at immunodominant HLA A2-restricted HIV epitope. Frontiers in Immunology 8 , 1503. 10.3389/fimmu.2017.01503
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Jones, Nicholas, Cronin, James G., Dolton, Garry, Panetti, Silvia, Schauenburg, Andrea, Galloway, Sarah A. E., Sewell, Andrew K., Cole, David K., Thornton, Catherine A. and Francis, Nigel J. 2017. Metabolic adaptation of human CD4+ and CD8+ T-Cells to T-Cell receptor-mediated stimulation. Frontiers in Immunology 8 , 1516. 10.3389/fimmu.2017.01516
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Donia, Marco, Kjeldsen, Julie Westerlin, Andersen, Rikke, Wulff Westergaard, Marie Christine, Bianchi, Valentina, Legut, Mateusz, Attaf, Meriem, Szomolay, Barbara, Ott, Sascha, Dolton, Garry, Lyngaa, Rikke, Hadrup, Sine Reker, Sewell, Andrew and Svane, Inge Marie 2017. PD-1+ polyfunctional T cells dominate the periphery after tumour-infiltrating lymphocyte therapy for cancer. Clinical Cancer Research 23 (19) , pp. 5779-5788. 10.1158/1078-0432.CCR-16-1692
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Shugay, M., Bagaev, D. V., Zvyagin, I. V., Vroomans, R. M., Crawford, J. C., Dolton, Garry M., Komech, Ekaterina A., Sycheva, Anastasiya L., Koneva, Anna E., Egorov, Evgeniy S., Eliseev, Alexey V., Van Dyk, E., Dash, P., Attaf, Meriem, Ruis, Cristina, Ladell, Kristin Ingrid, McLaren, James E., Matthews, Katherine K., Clemens, Ella B., Douek, Daniel C., Luciani, Fabio, Van Baarle, D., Kedzierska, Katherine, Kesmir, Can, Thomas, Paul G., Price, David, Sewell, Andrew K. and Chudakov, Dimitry M. 2017. VDJdb: a curated database of T-cell receptor sequences with known antigen specificity. Nucleic Acids Research 10.1093/nar/gkx760
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Fuller, Anna, Wall, Aaron, Crowther, Michael, Lloyd, Angharad, Zhurov, Alexei, Sewell, Andrew K., Cole, David and Beck, Konrad 2017. Thermal stability of heterotrimeric pMHC proteins as determined by circular dichroism spectroscopy. Bio-Protocol 7 (13) , e2366. 10.21769/BioProtoc.2366
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MacLachlan, Bruce James, Greenshields-Watson, Alexander, Mason, Georgina H, Schauenburg, Andrea J, Bianchi, Valentina, Rizkallah, Pierre J, Sewell, Andrew K, Fuller, Anna and Cole, David K 2017. Using X-ray crystallography, biophysics, and functional assays to determine the mechanisms governing T-cell receptor recognition of cancer antigens. Journal of Visualized Experiments (120) , e54991. 10.3791/54991
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Cole, David, van den Berg, Hugo A., Lloyd, Angharad, Crowther, Michael D, Beck, Konrad, Ekeruche-Makinde, Julia, Miles, John J., Bulek, Anna Marta, Dolton, Garry Michael, Schauenburg, Andrea J A, Wall, Aaron, Fuller, Anna, Clement, Mathew, Laugel, Bruno Frederic, Rizkallah, Pierre, Wooldridge, Linda and Sewell, Andrew K 2017. Structural mechanism underpinning cross-reactivity of a CD8+ T-cell clone that recognises a peptide derived from human telomerase reverse transcriptase. Journal of Biological Chemistry 292 (3) , pp. 802-813. 10.1074/jbc.M116.741603
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Tan, M., Dolton, Garry Michael, Gerry, Andrew B., Brewer, Joanna E., Bennett, Alan D., Pumphrey, Nick, Jakobsen, Bent K. and Sewell, Andrew K. 2017. HLA class I-redirected anti-tumour CD4+T-cells require a higher TCR binding affinity for optimal activity than CD8+T-cells. Clinical and Experimental Immunology 187 (1) , pp. 124-137. 10.1111/cei.12828
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Attaf, Meriem and Sewell, Andrew K. 2016. Disease etiology and diagnosis by TCR repertoire analysis goes viral. European Journal of Immunology 46 (11) , pp. 2516-2519. 10.1002/eji.201646649

Pageon, Sophie V., Tabarin, Thibault, Yamamoto, Yui, Ma, Yuanqing, Bridgeman, John S, Cohnen, André, Benzing, Carola, Gao, Yijun, Crowther, Michael D, Tungatt, Katie, Dolton, Garry, Sewell, Andrew, Price, David A, Acuto, Oreste, Parton, Robert G., Gooding, J. Justin, Rossy, Jérémie, Rossjohn, Jamie and Gaus, Katharina 2016. Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination. Proceedings of the National Academy of Sciences 113 (37) , E5454-E5463. 10.1073/pnas.1607436113
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Hanson, W. Miachel, Chen, Zhe, Jackson, Laurie K., Attaf, Meriem, Sewell, Andrew K., Heemstra, Jennifer M. and Phillips, John D. 2016. Reversible oligonucleotide chain blocking enables bead capture and amplification of T-Cell receptor alpha and beta chain mRNAs. Journal of the American Chemical Society 138 (35) , pp. 11073-11076. 10.1021/jacs.6b04465
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Laugel, Bruno, Lloyd, Angharad, Meermeier, Erin W., Crowther, Michael D., Connor, Thomas, Dolton, Garry Michael, Miles, John James, Burrows, Scott R., Gold, Marielle C., Lewinsohn, David M. and Sewell, Andrew K. 2016. Engineering of isogenic cells deficient for MR1 with a CRISPR/Cas9 lentiviral system: tools to study microbial antigen processing and presentation to human MR1-restricted T cells. The Journal of Immunology 197 (3) , pp. 971-982. 10.4049/jimmunol.1501402
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Meermeier, Erin W., Laugel, Bruno F., Sewell, Andrew K., Corbett, Alexandra J., Rossjohn, Jamie, McCluskey, James, Harriff, Melanie J., Franks, Tamera, Gold, Marielle C. and Lewinsohn, David M. 2016. Human TRAV1-2-negative MR1-restricted T cells detect S. pyogenes and alternatives to MAIT riboflavin-based antigens. Nature Communications 7 , 12506. 10.1038/ncomms12506
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Stadinski, Brian D., Shekhar, Karthik, Gomez-Tourio, Iria, Jung, Jonathan, Sasaki, Katsuhiro, Sewell, Andrew K., Peakman, Mark, Chakraborty, Arup K. and Huseby, Eric S. 2016. Hydrophobic CDR3 residues promote the development of self-reactive T cells. Nature Immunology 17 (8) , pp. 946-955. 10.1038/ni.3491
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Cole, David, Bulek, Anna Marta, Dolton, Garry Michael, Schauenberg, Andrea J., Szomolay, Barbara, Rittase, William, Trimby, Andrew, Jothikumar, Prithiviraj, Fuller, Anna, Skowera, Ania, Rossjohn, Jamie, Zhu, Cheng, Miles, John J., Peakman, Mark, Wooldridge, Linda, Rizkallah, Pierre and Sewell, Andrew K. 2016. Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity. The Journal of Clinical Investigation 126 (6) , pp. 2191-2204. 10.1172/JCI85679
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Caucheteux, Stephan M., Mitchell, John P., Ivory, Matthew O., Hirosue, Sachiko, Hakobyan, Svetlana, Dolton, Garry, Ladell, Kristin Ingrid, Miners, Kelly Louise, Price, David, Kan-Mitchell, June, Sewell, Andrew K., Nestle, Frank, Moris, Arnaud, Karoo, Richard O., Birchall, James Caradoc, Swartz, Melody A., Hubbel, Jeffrey A., Blanchet, Fabien P. and Piguet, Vincent 2016. Polypropylene sulfide nanoparticle p24 vaccine promotes dendritic cell-mediated specific immune responses against HIV-1. Journal of Investigative Dermatology 136 (6) , pp. 1172-1181. 10.1016/j.jid.2016.01.033
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Szomolay, Barbara, Liu, Jie, Brown, Paul E, Miles, John J, Clement, Mathew, Llewellyn-Lacey, Sian, Dolton, Garry, Ekeruche-Makinde, Julia, Lissina, Anya, Schauenburg, Andrea, Sewell, Andrew, Burrows, Scott R, Roederer, Mario, Price, David, Wooldridge, Linda and van den Berg, Hugo A 2016. Identification of human viral protein-derived ligands recognized by individual MHCI-restricted T-cell receptors. Immunology and Cell Biology 94 (6) , pp. 573-582. 10.1038/icb.2016.12
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Theaker, Sarah M., Rius Rafael, Cristina, Greenshields-Watson, Alexander, Lloyd, Angharad, Trimby, Andrew R., Fuller, Anna, Miles, John James, Cole, David, Peakman, Mark, Sewell, Andrew K. and Dolton, Garry Michael 2016. T-cell libraries allow simple parallel generation of multiple peptide-specific human T-cell clones. Journal of Immunological Methods 430 , pp. 43-50. 10.1016/j.jim.2016.01.014
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Bianchi, Valentina, Bulek, Anna, Fuller, Anna, Lloyd, Angharad, Attaf, Meriem, Rizkallah, Pierre, Dolton, Garry, Sewell, Andrew K. and Cole, David 2016. A Molecular Switch Abrogates Glycoprotein 100 (gp100) T-cell Receptor (TCR) Targeting of a Human Melanoma Antigen. Journal of Biological Chemistry 291 (17) , pp. 8951-8959. 10.1074/jbc.M115.707414
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Tsai, M.-H., Muenchhoff, M., Adland, E., Carlqvist, A., Roider, J., Cole, David, Sewell, Andrew K, Carlson, J., Ndung'u, T. and Goulder, P. J. R. 2016. Paediatric non-progression following grandmother-to-child HIV transmission. Retrovirology 13 (1) , p. 65. 10.1186/s12977-016-0300-y
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Holland, C. J., Dolton, Garry Michael, Scurr, Martin John, Ladell, Kristin Ingrid, Schauenburg, Andrea J. A., Miners, Kelly Louise, Madura, F., Sewell, Andrew K., Price, David, Cole, David and Godkin, Andrew James 2015. Enhanced detection of antigen-specific CD4+ T cells using altered peptide flanking residue peptide-MHC class II multimers. The Journal of Immunology 195 (12) , pp. 5827-5836. 10.4049/jimmunol.1402787
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Dolton, Garry Michael, Tungatt, Katie, Lloyd, Angharad, Bianchi, Valentina, Theaker, Sarah M., Trimby, Andrew R., Holland, Christopher J., Donia, Marco, Godkin, Andrew James, Cole, David, Straten, Per Thor, Peakman, Mark, Svane, Inge Marie and Sewell, Andrew K. 2015. More tricks with tetramers: a practical guide to staining T cells with peptide-MHC multimers. Immunology 146 (1) , pp. 11-22. 10.1111/imm.12499

Motozono, Chihiro, Pearson, James A., De Leenheer, Evy, Rizkallah, Pierre, Beck, Konrad, Trimby, Andrew R., Sewell, Andrew K., Wong, Florence Susan and Cole, David 2015. Distortion of the major histocompatibility complex class I binding groove to accommodate an insulin-derived 10-Mer peptide. Journal of Biological Chemistry 290 (31) , pp. 18924-18933. 10.1074/jbc.M114.622522
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Attaf, Meriem, Legut, Mateusz, Cole, David and Sewell, Andrew K. 2015. The T cell antigen receptor: the Swiss army knife of the immune. Clinical and Experimental Immunology 181 (1) , pp. 1-18. 10.1111/cei.12622
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Motozono, Chihiro, Bridgeman, John S., Price, David, Sewell, Andrew K. and Ueno, T. 2015. Clonotypically similar hybrid ab T cell receptors can exhibit markedly different surface expression, antigen specificity and cross-reactivity. Clinical and Experimental Immunology 180 (3) , pp. 560-570. 10.1111/cei.12610
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Gilham, David Edward, Anderson, John, Bridgeman, John Stephen, Hawkins, Robert Edward, Exley, Mark Adrian, Stauss, Hans, Maher, John, Pule, Martin, Sewell, Andrew K., Bendle, Gavin, Lee, Steven, Qasim, Waseem, Thrasher, Adrian and Morris, Emma 2015. Adoptive t-cell therapy for cancer in the United Kingdom: a review of activity for the British Society of Gene and Cell Therapy Annual Meeting 2015. Human Gene Therapy 26 (5) , pp. 276-285. 10.1089/hum.2015.024

Legut, Mateusz, Cole, David and Sewell, Andrew K. 2015. The promise of γδ T cells and the γδ T cell receptor for cancer immunotherapy. Cellular and Molecular Immunology 12 , pp. 656-668. 10.1038/cmi.2015.28
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Neller, Michelle A., Ladell, Kristin Ingrid, McLaren, James Edward, Matthews, Katherine K., Gostick, Emma, Pentier, Johanne, Dolton, Garry Michael, Schauenburg, Andrea J. A., Koning, Dan, Fontaine Costa, Ana Isabel C. A., Watkins, Thomas S., Venturi, Vanessa, Smith, Corey, Khanna, Rajiv, Miners, Kelly Louise, Clement, Mathew, Wooldridge, Linda, Cole, David, van Baarle, Debbie, Sewell, Andrew K., Burrows, Scott R., Price, David and Miles, John James 2015. Naive CD8+ T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics. Immunology and Cell Biology 93 , pp. 625-633. 10.1038/icb.2015.17
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Skowera, Ania, Ladell, Kristin Ingrid, McLaren, James Edward, Dolton, Garry Michael, Matthews, Katherine K., Gostick, Emma, Kronenberg-Versteeg, Deborah, Eichmann, Martin, Knight, Robin R., Heck, Susanne, Powrie, Jake, Bingley, Polly J., Dayan, Colin Mark, Miles, John J., Sewell, Andrew K., Price, David and Peakman, Mark 2015. β-Cell-specific CD8 T Cell phenotype in Type 1 diabetes reflects chronic autoantigen exposure. Diabetes 64 (3) , pp. 916-925. 10.2337/db14-0332

Kløverpris, Henrik N., Cole, David, Fuller, Anna, Carlson, Jonathan, Beck, Konrad, Schauenburg, Andrea J. A., Rizkallah, Pierre, Buus, Søren, Sewell, Andrew K. and Goulder, Philip 2015. A molecular switch in immunodominant HIV-1-specific CD8 T-cell epitopes shapes differential HLA-restricted escape. Retrovirology 12 (1) , 20. 10.1186/s12977-015-0149-5
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Madura, Florian, Rizkallah, Pierre, Holland, Christopher J., Fuller, Anna, Bulek, Anna Marta, Godkin, Andrew James, Schauenburg, Andrea J. A., Cole, David and Sewell, Andrew K. 2015. Structural basis for ineffective T-cell responses to MHC anchor residue-improved 'heteroclitic' peptides. European Journal of Immunology 45 (2) , pp. 584-591. 10.1002/eji.201445114
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Attaf, Meriem, Huseby, Eric and Sewell, Andrew K. 2015. αβ T cell receptors as predictors of health and disease. Cellular and Molecular Immunology 12 , pp. 391-399. 10.1038/cmi.2014.134
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Knight, R. R., Dolton, Garry Michael, Kronenberg-Versteeg, D., Eichmann, M., Zhao, M., Huang, G. C., Beck, Konrad, Cole, David, Sewell, Andrew K., Skowera, A. and Peakman, M. 2015. A distinct immunogenic region of glutamic acid decarboxylase 65 is naturally processed and presented by human islet cells to cytotoxic CD8 T cells. Clinical and Experimental Immunology 179 (1) , pp. 100-107. 10.1111/cei.12436

Tan, Mai, Gerry, A. B., Brewer, J. E., Melchiori, L., Bridgeman, John S., Bennett, A. D., Pumphrey, N. J., Jakobsen, B. K., Price, D. A., Ladell, Kristin Ingrid and Sewell, Andrew K. 2015. T cell receptor binding affinity governs the functional profile of cancer-specific CD8+T cells. Clinical and Experimental Immunology 180 (2) , pp. 255-270. 10.1111/cei.12570
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Skowera, Ania, Ladell, Kristin, McLaren, James E., Dolton, Garry, Matthews, Katherine K., Gostick, Emma, Kronenberg-Versteeg, Deborah, Eichmann, Martin, Knight, Robin R., Heck, Susanne, Powrie, Jake, Bingley, Polly J., Dayan, Colin M., Miles, John J., Sewell, Andrew K., Price, David A. and Peakman, Mark 2015. β-cell-specific CD8 T cell phenotype in type 1 diabetes reflects chronic autoantigen exposure. Diabetes 64 (3) , pp. 916-925. 10.2337/db14-0332
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Straetemans, Trudy, Berrevoets, Cor, Coccoris, Miriam, Treffers-Westerlaken, Elike, Wijers, Rebecca, Cole, David, Dardalhon, Valerie, Sewell, Andrew K., Taylor, Naomi, Verweij, Jaap and Debets, Reno 2014. Recurrence of melanoma following T cell treatment: continued antigen expression in a tumor that evades T cell recruitment. Molecular Therapy 23 (2) , pp. 396-406. 10.1038/mt.2014.215

Stepanek, Ondrej, Prabhakar, Arvind S., Osswald, Celine, King, Carolyn G., Bulek, Anna Marta, Naeher, Dieter, Beaufils-Hugot, Marina, Abanto, Michael L., Galati, Virginie, Hausmann, Barbara, Lang, Rosemarie, Cole, David, Huseby, Eric S., Sewell, Andrew K., Chakraborty, Arup K. and Palmer, Ed 2014. Coreceptor scanning by the T cell receptor provides a mechanism for T cell tolerance. Cell 159 (2) , pp. 333-345. 10.1016/j.cell.2014.08.042

Dolton, Garry Michael, Lissina, A., Skowera, A., Ladell, Kristin Ingrid, Tungatt, Katie, Jones, Emma, Kronenberg-Versteeg, D., Akpovwa, Hephzibah, Pentier, Johanne, Holland, C. J., Godkin, Andrew James, Cole, David, Neller, M. A., Miles, John James, Price, David, Peakman, M. and Sewell, Andrew K. 2014. Comparison of peptide-major histocompatibility complex tetramers and dextramers for the identification of antigen-specific T cells. Clinical and Experimental Immunology 177 (1) , pp. 47-63. 10.1111/cei.12339
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Motozono, Chihiro, Kuse, N, Sun, X., Rizkallah, Pierre, Fuller, Anna, Oka, S., Cole, David, Sewell, Andrew K. and Takiguchi, M. 2014. Molecular basis of a dominant T cell response to an HIV reverse transcriptase 8-mer epitope presented by the protective allele HLA-B*51:01. The Journal of Immunology 192 (7) , pp. 3428-3434. 10.4049/jimmunol.1302667
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Bhati, Mugdha, Cole, David, McCluskey, James, Sewell, Andrew K. and Rossjohn, Jamie 2014. The versatility of the αβ T-cell antigen receptor. Protein Science 23 (3) , pp. 260-272. 10.1002/pro.2412

Tungatt, Katie, Bianchi, Valentina, Crowther, Michael D., Powell, Wendy, Schauenburg, Andrea J. A., Trimby, Andrew R., Donia, M., Miles, John James, Holland, Christopher J., Cole, David, Godkin, Andrew James, Peakman, M., Straten, P. T., Svane, I. M., Sewell, Andrew K. and Dolton, Garry Michael 2014. Antibody stabilization of peptide-MHC multimers reveals functional T cells bearing extremely low-affinity TCRs. The Journal of Immunology 194 (1) , pp. 463-474. 10.4049/jimmunol.1401785
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van den Berg, Hugo A., Ladell, Kristin, Miners, Kelly, Laugel, Bruno, Llewellyn-Lacey, Sian, Clement, Mathew, Cole, David, Gostick, Emma, Wooldridge, Linda, Sewell, Andrew K., Bridgeman, John S. and Price, David 2013. Cellular-level versus receptor-level response threshold hierarchies in T-cell activation. Frontiers in Immunology 4 , 250. 10.3389/fimmu.2013.00250
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Pentier, Johanne M., Sewell, Andrew K. and Miles, John James 2013. Advances in T-Cell Epitope Engineering. Frontiers in Immunology 4 , 133. 10.3389/fimmu.2013.00133
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Madura, Florian, Rizkallah, Pierre, Miles, Kim Michelle, Holland, Christopher J., Bulek, Anna Marta, Fuller, Anna, Schauenburg, Andrea J. A., Miles, John James, Liddy, Nathaniel, Sami, M., Li, Y., Hossain, M., Baker, B. M., Jakobsen, B. K., Sewell, Andrew K. and Cole, David 2013. T-cell receptor specificity maintained by altered thermodynamics. Journal of Biological Chemistry 288 (26) , pp. 18766-18775. 10.1074/jbc.M113.464560

Motozono, Chihiro, Miles, John J., Hasan, Zafrul, Gatanaga, Hiroyuki, Meribe, Stanley C., Price, David, Oka, Shinichi, Sewell, Andrew K. and Ueno, Takamasa 2013. CD8+ T cell cross-reactivity profiles and HIV-1 immune escape towards an HLA-B35-restricted immunodominant Nef epitope. PLoS ONE 8 (6) , e66152. 10.1371/journal.pone.0066152
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Challier, John, Bruniquel, Denis, Sewell, Andrew K. and Laugel, Bruno 2013. Adenosine and cAMP signalling skew human dendritic cell differentiation towards a tolerogenic phenotype with defective CD8+ T-cell priming capacity. Immunology 138 (4) , pp. 402-410. 10.1111/imm.12053

Welton, Joanne, Morgan, Matthew, Martí, Salvador, Stone, Michael, Moser, Bernhard, Sewell, Andrew K., Turton, Jane and Eberl, Matthias 2013. Monocytes and γδ T cells control the acute phase response to intravenous zoledronate: insights from a phase IV safety trial. Journal of Bone and Mineral Research (JBMR) 28 (3) , pp. 464-471. 10.1002/jbmr.1797
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Eukeruche-Makinde, Julia, Miles, John J., Van Den Berg, Hugo A., Skowera, Ania, Cole, David K., Dolton, Garry Michael, Schauenburg, Andrea, Tan, Mai Ping, Pentier, Johanne, Llewellyn-Lacey, Sian, Miles, Kim M., Bulek, Anna, Clement, Mathew, Dockree, Tamsin, Trimby, Andrew R., Bailey, Mick, Rizkallah, Pierre, Rossjohn, Jamie, Peakman, Mark, Burrows, Scott, Sewell, Andrew K. and Wooldridge, Linda 2013. Peptide length determines the outcome of TCR/peptide-MHCI engagement. Blood -New York- 121 (7) , pp. 1112-1123. 10.1182/blood-2012-06-437202

Ekeruche, Julia, Miles, John James, van den Berg, Hugo A., Skowera, Ania, Cole, David, Dolton, Garry Michael, Schauenburg, Andrea J. A., Tan, Mai Ping, Pentier, Johanne, Llewellyn-Lacey, Sian, Miles, Kim Michelle, Bulek, Anna Marta, Clement, Mathew, Williams, Tamsin, Trimby, Andrew R., Bailey, Mick, Rizkallah, Pierre, Rossjohn, Jamie, Peakman, Mark, Price, David, Burrows, Scott R., Sewell, Andrew K. and Wooldridge, Linda 2013. Peptide length determines the outcome of TCR/peptide-MHCI engagement. Blood 121 (7) , pp. 1112-1123. 10.1182/blood-2012-06-437202

Cole, David, Miles, Kim Michelle, Madura, Florian, Holland, Christopher J., Schauenburg, Andrea J. A., Godkin, Andrew James, Bulek, Anna Marta, Fuller, Anna, Akpovwa, Hephzibah, Pymm, Phillip G., Liddy, N., Sami, M., Li, Y., Rizkallah, Pierre, Jakobsen, B. K. and Sewell, Andrew K. 2013. T-cell Receptor (TCR)-Peptide Specificity Overrides Affinity-enhancing TCR-Major Histocompatibility Complex Interactions. Journal of Biological Chemistry 289 (2) , pp. 628-638. 10.1074/jbc.M113.522110
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Knight, Robin R., Kronenberg, Deborah, Zhao, Min, Huang, Guo Cai, Eichmann, Martin, Bulek, Anna Marta, Wooldridge, Linda, Cole, David, Sewell, Andrew K., Peakman, Mark and Skowera, Ania 2013. Human β-cell killing by autoreactive preproinsulin-specific cd8 t cells is predominantly granule-mediated with the potency dependent upon t-cell receptor avidity. Diabetes 62 (1) , pp. 205-213. 10.2337/db12-0315

Matthews, Philippa C., Koyanagi, Madoka, Kloverpris, Henrik N., Harndahl, Mikkel, Stryhn, Anette, Akahoshi, Tomohiro, Gatanaga, Hiroyuki, Oka, Shinichi, Juarez Molina, Claudia, Valenzuela Ponce, Humberto, Avila Rios, Santiago, Cole, David, Carlson, Jonathan, Payne, Rebecca P., Ogwu, Anthony, Bere, Alfred, Ndung'u, Thumbi, Gounder, Kamini, Chen, Fabian, Riddell, Lynn, Luzzi, Graz, Shapiro, Roger, Brander, Christian, Walker, Bruce, Sewell, Andrew K., Reyes Teran, Gustavo, Heckerman, David, Hunter, Eric, Buus, Søren, Takiguchi, Masafumi and Goulder, Philip J. R. 2012. Differential clade-specific HLA-B*3501 association with HIV-1 disease outcome is linked to immunogenicity of a single gag epitope. Journal of Virology 86 (23) , pp. 12643-12654. 10.1128/JVI.01381-12
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Ekeruche, Julia, Clement, Mathew, Cole, David, Edwards, Emily S. J., Ladell, Kristin Ingrid, Miles, John James, Matthews, Katherine K., Fuller, Anna, Lloyd, Katy A., Madura, Florian, Dolton, Garry Michael, Pentier, Johanne, Lissina, Anna, Gostick, Emma, Baxter, Tiffany K., Baker, Brian M., Rizkallah, Pierre, Price, David, Wooldridge, Linda and Sewell, Andrew K. 2012. T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting. Journal of Biological Chemistry 287 (44) , pp. 37269-37281. 10.1074/jbc.M112.386409

Ekeruche-Makinde, Julia, Clement, Mathew, Cole, David K., Edwards, Emily S. J., Ladell, Kristin, Miles, John J., Matthews, Katherine K., Fuller, Anna, Lloyd, Katy A., Madura, Florian, Dolton, Garry M., Pentier, Johanne, Lissina, Anna, Gostick, Emma, Baxter, Tiffany K., Baker, Brian M., Rizkallah, Pierre J., Price, David A., Wooldridge, Linda and Sewell, Andrew K. 2012. T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting. Journal of Biological Chemistry 287 (44) , pp. 37269-37281. 10.1074/jbc.M112.386409
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Cole, David K., Laugel, Bruno, Clement, Mathew, Price, David A., Wooldridge, Linda and Sewell, Andrew K. 2012. The molecular determinants of CD8 co-receptor function. Immunology 137 (2) , pp. 139-148. 10.1111/j.1365-2567.2012.03625.x

Cole, David, Laugel, Bruno Frederic, Clement, Mathew, Price, David, Wooldridge, Linda and Sewell, Andrew K. 2012. The molecular determinants of CD8 co-receptor function. Immunology 137 (2) , pp. 139-148. 10.1111/j.1365-2567.2012.03625.x

Holland, Christopher J., Rizkallah, Pierre, Vollers, Sabrina, Calvo-Calle, J. Mauricio, Madura, Florian, Fuller, Anna, Sewell, Andrew K., Stern, Lawrence J., Godkin, Andrew James and Cole, David 2012. Minimal conformational plasticity enables TCR cross-reactivity to different MHC class II heterodimers. Scientific Reports 2 , 629. 10.1038/srep00629

Sewell, Andrew K. 2012. Why must T cells be cross-reactive? Nature Reviews Immunology 12 (9) , pp. 669-677. 10.1038/nri3279

Bulek, Anna Marta, Madura, Florian, Fuller, Anna, Holland, Christopher J., Schauenburg, Andrea J. A., Sewell, Andrew K., Rizkallah, Pierre and Cole, David 2012. TCR/pMHC optimized protein crystallization screen. Journal of Immunological Methods 382 (1-2) , pp. 203-210. 10.1016/j.jim.2012.06.007

Liddy, Nathaniel, Bossi, Giovanna, Adams, Katherine J., Lissina, Anna, Mahon, Tara M., Hassan, Namir J., Gavarret, Jessie, Bianchi, Frayne C., Pumphrey, Nicholas J., Ladell, Kristin Ingrid, Gostick, Emma, Sewell, Andrew K., Lissin, Nikolai M., Harwood, Naomi E., Molloy, Peter E., Li, Yi, Cameron, Brian J., Sami, Malkit, Baston, Emma E., Todorov, Penio T., Paston, Samantha J., Dennis, Rebecca E., Harper, Jane V., Dunn, Steve M., Ashfield, Rebecca, Johnson, Andy, McGrath, Yvonne, Plesa, Gabriela, June, Carl H., Kalos, Michael, Price, David, Vuidepot, Annelise, Williams, Daniel D., Sutton, Deborah H. and Jakobsen, Bent K 2012. Monoclonal TCR-redirected tumor cell killing. Nature Medicine 18 (6) , pp. 980-987. 10.1038/nm.2764

Bulek, Anna, Cole, David, Skowera, Ania, Dolton, Garry, Gras, Stephanie, Madura, Florian, Fuller, Anna, Miles, John, Gostick, Emma, Price, David, Drijfhout, Jan W, Knight, Robin R, Huang, Guo C, Lissin, Nikolai, Molloy, Peter E, Wooldridge, Linda, Jakobsen, Bent K, Rossjohn, Jamie, Peakman, Mark, Rizkallah, Pierre and Sewell, Andrew 2012. Structural basis for the killing of human beta cells by CD8+ T cells in type 1 diabetes. Nature Immunology 13 (3) , pp. 283-289. 10.1038/ni.2206

Bulek, Anna Marta, Cole, David, Skowera, Ania, Dolton, Garry Michael, Gras, Stephanie, Madura, Florian, Fuller, Anna, Miles, John James, Gostick, Emma, Price, David, Drijfhout, Jan W., Knight, Robin R., Huang, Guo C., Lissin, Nikolai, Molloy, Peter E., Wooldridge, Linda, Jakobsen, Bent K., Rossjohn, Jamie, Peakman, Mark, Rizkallah, Pierre and Sewell, Andrew K. 2012. Structural basis for the killing of human beta cells by CD8+ T cells in type 1 diabetes. Nature Immunology 13 (3) , pp. 283-289. 10.1038/ni.2206

Cole, David, Gallagher, Kathleen, Lemercier, Brigitte, Holland, Christopher J., Junaid, Sayed, Hindley, James Phillip, Wynn, Katherine Kay, Gostick, Emma, Sewell, Andrew K., Gallimore, Awen Myfanwy, Ladell, Kristin Ingrid, Price, David, Gougeon, Marie-Lise and Godkin, Andrew James 2012. Modification of the carboxy-terminal flanking region of a universal influenza epitope alters CD4+ T-cell repertoire selection. Nature Communications 3 , 665. 10.1038/ncomms1665

Wooldridge, Linda, Ekeruche, Julia, van den Berg, Hugo A., Skowera, Anna, Miles, John James, Tan, Mai Ping, Dolton, Garry Michael, Clement, Mathew, Llewellyn-Lacey, Sian, Price, David, Peakman, Mark and Sewell, Andrew K. 2012. A single autoimmune T cell receptor recognizes more than a million different peptides. Journal of Biological Chemistry 287 (2) , pp. 1168-1177. 10.1074/jbc.M111.289488
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Bridgeman, John S., Sewell, Andrew K., Miles, John James, Price, David A. and Cole, David K. 2012. Structural and biophysical determinants of ab T-cell antigen recognition. Immunology 135 (1) , pp. 9-18. 10.1111/j.1365-2567.2011.03515.x

Clement, Mathew, Ladell, Kristin Ingrid, Ekeruche, Julia, Miles, John James, Edwards, Emily, Dolton, Garry Michael, Williams, Tamsin, Schauenburg, Andrea J. A., Cole, David, Lauder, Sarah Nicol, Gallimore, Awen Myfanwy, Godkin, Andrew James, Burrows, Scott R., Price, David, Sewell, Andrew K. and Wooldridge, Linda 2011. Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining. The Journal of Immunology 187 (2) , pp. 654-663. 10.4049/jimmunol.1003941

Miles, Kim Michelle, Miles, John James, Madura, Florian, Sewell, Andrew K. and Cole, David 2011. Real time detection of peptide-MHC dissociation reveals that improvement of primary MHC-binding residues can have a minimal, or no, effect on stability. Molecular Immunology 48 (4) , pp. 728-732. 10.1016/j.molimm.2010.11.004

Laugel, Bruno Frederic, Cole, David, Clement, Mathew, Wooldridge, Linda, Price, David and Sewell, Andrew K. 2011. The multiple roles of the CD8 coreceptor in T cell biology: opportunities for the selective modulation of self-reactive cytotoxic T cells. Journal of Leukocyte Biology 90 (6) , pp. 1089-1099. 10.1189/jlb.0611316

Cole, David, Edwards, Emily, Wynn, Katherine, Clement, Mathew, Miles, John James, Ladell, Kristin Ingrid, Ekeruche, Julia, Gostick, Emma, Adams, Katherine J., Skowera, Ania, Peakman, Mark, Wooldridge, Linda, Price, David A. and Sewell, Andrew K. 2010. Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognition. The Journal of Immunology 185 (4) , pp. 2600-2610. 10.4049/jimmunol.1000629

Wooldridge, Linda, Laugel, Bruno Frederic, Ekeruche, Julia, Clement, Mathew, van den Berg, Hugo A., Price, David and Sewell, Andrew K. 2010. CD8 controls T cell cross-reactivity. The Journal of Immunology 185 (8) , pp. 4625-4632. 10.4049/jimmunol.1001480

Miles, John James, Bulek, Anna Marta, Cole, David, Gostick, Emma, Schauenburg, Andrea J. A., Dolton, Garry Michael, Venturi, Vanessa, Davenport, Miles P., Tan, Mai Ping, Burrows, Scott R., Wooldridge, Linda, Price, David, Rizkallah, Pierre and Sewell, Andrew K. 2010. Genetic and structural basis for selection of a ubiquitous T cell receptor deployed in Epstein-Barr virus infection. PLoS Pathogens 6 (11) , e1001198. 10.1371/journal.ppat.1001198
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Schaubert, Keri L., Price, David A., Salkowitz, Janelle R., Sewell, Andrew K., Sidney, John, Asher, Tedi, Blondelle, Sylvie E., Adams, Sharon, Marincola, Francesco M., Joseph, Aviva, Sette, Alessandro, Douek, Daniel C., Ayyavoo, Velpandi, Storkus, Walter, Leung, Ming-Ying, Ng, Hwee, Yang, Otto O., Goldstein, Harris, Wilson, Darcy B. and Kan-Mitchell, June 2010. Generation of robust CD8+ T-cell responses against subdominant epitopes in conserved regions of HIV-1 by repertoire mining with mimotopes. European Journal of Immunology 40 (7) , pp. 1950-1962. 10.1002/eji.200940079

Wooldridge, Linda, Clement, Mathew, Lissina, Anna, Edwards, Emily, Ladell, Kristin Ingrid, Ekeruche, Julia, Hewitt, R. E., Laugel, Bruno Frederic, Gostick, Emma, Cole, David, Debets, R., Berrevoets, C., Miles, John James, Burrows, S. R., Price, David A. and Sewell, Andrew K. 2010. MHC Class I molecules with superenhanced CD8 binding properties bypass the requirement for cognate TCR recognition and nonspecifically activate CTLs. Journal of Immunology 184 (7) , pp. 3357-3366. 10.4049/jimmunol.0902398

Walker, L. J., Sewell, Andrew K. and Klenerman, P. 2010. T cell sensitivity and the outcome of viral infection. Clinical and Experimental Immunology 159 (3) , pp. 245-255. 10.1111/j.1365-2249.2009.04047.x

Chen, Ji-Li, Morgan, Anthony J., Stewart-Jones, Guillaume, Shepherd, Dawn, Bossi, Giovanna, Wooldridge, Linda, Hutchinson, Sarah L., Sewell, Andrew K., Griffiths, Gillian M., van der Merwe, P. Anton, Jones, E. Yvonne, Galione, Antony and Cerundolo, Vincenzo 2010. Ca2+ release from the endoplasmic reticulum of NY-ESO-1-specific T cells is modulated by the affinity of TCR and by the use of the CD8 coreceptor. The Journal of Immunology 184 (4) , pp. 1829-1839. 10.4049/jimmunol.0902103

Borbulevych, Oleg Y., Piepenbrink, Kurt H., Gloor, Brian E., Scott, Daniel R., Sommese, Ruth F., Cole, David, Sewell, Andrew K. and Baker, Brian M. 2009. T cell receptor cross-reactivity directed by antigen-dependent tuning of peptide-MHC molecular flexibility. Immunity 31 (6) , pp. 885-896. 10.1016/j.immuni.2009.11.003

Hoffman, M., Hickling, Steven, Filby, A., Wilburg, C., Cole, David, Turner, A., Sims, S., McLean, Andrew, Sewell, Andrew K., Klenerman, P., Frater, J. and Phillips, R. E. 2009. Novel tetramer technology for the detection of high affinity CD8 T cells [Conference poster abstract]. Retrovirology 6 (S3) , P409. 10.1186/1742-4690-6-S3-P409

Lissina, Anna, Ladell, Kristin Ingrid, Skowera, Ania, Clement, Mathew, Edwards, Emily, Seggewiss, Ruth, van den Berg, Hugo A., Gostick, Emma, Gallagher, Kathleen, Jones, Emma, Melenhorst, J. Joseph, Godkin, Andrew James, Peakman, Mark, Price, David, Sewell, Andrew K. and Wooldridge, Linda 2009. Protein kinase inhibitors substantially improve the physical detection of T-cells with peptide-MHC tetramers. Journal of Immunological Methods 340 (1) , pp. 11-24. 10.1016/j.jim.2008.09.014
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Jo, J., Aichele, U., Kersting, N., Klein, R., Aichele, P., Bisse, E., Sewell, Andrew K., Blum, H. E., Bartenschlager, R., Lohmann, V. and Thimme, R. 2009. Analysis of CD8+ T-Cell-Mediated Inhibition of Hepatitis C Virus Replication Using a Novel Immunological Model. Gastroenterology 136 (4) , pp. 1391-1401. 10.1053/j.gastro.2008.12.034

Cole, David, Yuan, Fang, Rizkallah, Pierre, Miles, John James, Gostick, Emma, Price, David, Gao, George F., Jakobsen, Bent K. and Sewell, Andrew K. 2009. Germ line-governed recognition of a cancer epitope by an immunodominant human T-cell receptor. Journal of Biological Chemistry 284 (40) , 27281-27289. 10.1074/jbc.M109.022509

Choudhuri, K., Parker, M., Milicic, A., Cole, David, Shaw, M. K., Sewell, Andrew K., Stewart-Jones, G., Dong, T., Gould, K. G. and van der Merwe, P. A. 2009. Peptide-Major Histocompatibility Complex Dimensions Control Proximal Kinase-Phosphatase Balance during T Cell Activation. Journal of Biological Chemistry 284 (38) , pp. 26096-26105. 10.1074/jbc.M109.039966

Horlock, Claire, Stott, Bryony, Dyson, Julian, Ogg, Graham, McPherson, Tess, Jones, Louise, Sewell, Andrew K., Wooldridge, Linda, Cole, David, Stebbing, Justin and Savage, Philip 2009. ELISPOT and functional T cell analyses using HLA mono-specific target cells. Journal of Immunological Methods 350 (1-2) , pp. 150-160. 10.1016/j.jim.2009.08.011

Wooldridge, Linda, Lissina, Anna, Cole, David, van den Berg, Hugo A., Price, David and Sewell, Andrew K. 2009. Tricks with tetramers: how to get the most from multimeric peptide-MHC. Immunology 126 (2) , pp. 147-164. 10.1111/j.1365-2567.2008.02848.x

Varela-Rohena, Angel, Molloy, Peter E., Dunn, Steven M., Li, Yi, Suhoski, Megan M., Carroll, Richard G., Milicic, Anita, Mahon, Tara, Sutton, Deborah H., Laugel, Bruno, Moysey, Ruth, Cameron, Brian J., Vuidepot, Annelise, Purbhoo, Marco A., Cole, David, Phillips, Rodney E., June, Carl H., Jakobsen, Bent K., Sewell, Andrew K. and Riley, James L. 2008. Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor. Nature Medicine 14 (12) , pp. 1390-1395. 10.1038/nm.1779

Skowera, Ania, Ellis, Richard J., Varela-Calviño, Ruben, Arif, Sefina, Huang, Guo Cai, Van-Krinks, Cassie, Zaremba, Anna, Rackham, Chloe, Allen, Jennifer S., Tree, Timothy I. M., Zhao, Min, Dayan, Colin Mark, Sewell, Andrew K., Unger, Wendy, Drijfhout, Jan W., Ossendorp, Ferry, Roep, Bart O. and Peakman, Mark 2008. CTLs are targeted to kill β cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope. Journal of Clinical Investigation 118 (10) , pp. 3390-3402. 10.1172/JCI35449
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Melenhorst, J. Joseph, Scheinberg, Phillip, Chattopadhyay, Pratip K., Lissina, Anna, Gostick, Emma, Cole, David, Wooldridge, Linda, van den Berg, Hugo A., Bornstein, Ethan, Hensel, Nancy F., Douek, Daniel C., Roederer, Mario, Sewell, Andrew K., Barrett, A. John and Price, David 2008. Detection of low avidity CD8+ T cell populations with coreceptor-enhanced peptide-major histocompatibility complex class I tetramers. Journal of Immunological Methods 338 (1-2) , pp. 31-39. 10.1016/j.jim.2008.07.008

Cole, David, Dunn, Steven M., Sami, Malkit, Boulter, Jonathan M., Jakobsen, Bent K. and Sewell, Andrew K. 2008. T cell receptor engagement of peptide-major histocompatibility complex class I does not modify CD8 binding. Molecular Immunology 45 (9) , pp. 2700-2709. 10.1016/j.molimm.2007.12.009

Weichsel, Ralf, Dix, Carolin, Wooldridge, Linda, Clement, Mathew, Fenton-May, Angharad, Sewell, Andrew K., Zezula, Josef, Greiner, Elizabeth, Gostick, Emma, Price, David, Einsele, Hermann and Seggewiss, Ruth 2008. Profound inhibition of antigen-specific T-cell effector functions by dasatinib. Clinical Cancer Research 14 (8) , pp. 2484-2491. 10.1158/1078-0432.CCR-07-4393

Chattopadhyay, Pratip K., Melenhorst, J. Joseph, Ladell, Kristin Ingrid, Gostick, Emma, Scheinberg, Phillip, Barrett, A. John, Wooldridge, Linda, Roederer, Mario, Sewell, Andrew K. and Price, David A. 2008. Techniques to improve the direct ex vivo detection of low frequency antigen-specific CD8+T cells with peptide-major histocompatibility complex class I tetramers. Cytometry Part A 73A (11) , pp. 1001-1009. 10.1002/cyto.a.20642

Scriba, Thomas J., Sierro, Sophie, Brown, Eric L., Phillips, Rodney E., Sewell, Andrew K. and Massey, Ruth C. 2008. The staphyloccous aureus eap protein activates expression of proinflammatory cytokines. Infection and Immunity 76 (5) , pp. 2164-2168. 10.1128/IAI.01699-07
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Kasprowicz, Victoria, Ward, Scott M., Turner, Alison, Grammatikos, Alexandros, Nolan, Brian E., Lewis-Ximenez, Lia, Sharp, Charles, Woodfruff, Jenny, Fleming, Vicki M., Sims, Stuart, Walker, Bruce D., Sewell, Andrew K., Lauer, Georg M. and Klenerman, Paul 2008. Defining the directionality and quality of influenza virus-specific CD8+ T cell cross-reactivity in individuals infected with hepatitis C virus. Journal of Clinical Investigation 118 (3) , pp. 1143-1153. 10.1172/JCI33082
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Laugel, Bruno Frederic, Berg, Hugo A. van den, Gostick, Emma, Cole, David, Wooldridge, Linda, Boulter, Jonathan M, Milicic, Anita, Price, David and Sewell, Andrew 2007. Different T cell receptor affinity thresholds and CD8 coreceptor dependence govern cytotxic T lymphocyte activation and tetramer properties. The Journal of Biological Chemistry 282 (33) , pp. 23799-22810. 10.1074/jbc.M700976200
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Cole, David, Pumphrey, Nicholas J., Boulter, Jonathan M., Sami, Malkit, Bell, John I., Gostick, Emma, Price, David, Gao, George F., Sewell, Andrew K. and Jakobsen, Bent K. 2007. Human TCR-binding affinity is governed by MHC class restriction. The Journal of Immunology 178 (9) , pp. 5727-5734. 10.4049/​jimmunol.178.9.5727

Wooldridge, Linda, Lissina, Anna, Vernazza, Jonathan, Gostick, Emma, Laugel, Bruno Frederic, Hutchinson, Sarah L., Mirza, Fareed, Dunbar, P. Rod, Boulter, Jonathan M., Glick, Meir, Cerundolo, Vincenzo, Berg, Hugo A. van den, Price, David and Sewell, Andrew 2007. Enhanced immunogenicity of CTL antigens through mutation of the CD8 binding MHC class I invariant region. European Journal of Immunology 37 (5) , pp. 1323-1333. 10.1002/eji.200636765

Gostick, Emma, Cole, David, Hutchinson, Sarah L., Wooldridge, Linda, Tafuro, Sabrina, Laugel, Bruno Frederic, Lissina, A., Oxenius, Annette, Boulter, Jonathan M., Price, David and Sewell, Andrew K. 2007. Functional and biophysical characterization of an HLA-A*6801-restricted HIV-specific T cell receptor. European Journal of Immunology 37 (2) , pp. 479-486. 10.1002/eji.200636243

Boulter, Jonathan M., Schmitz, Nicole, Sewell, Andrew K., Godkin, Andrew James, Bachmann, Martin F. and Gallimore, Awen Myfanwy 2007. Potent T cell agonism mediated by a very rapid TCR/pMHC interaction. European Journal of Immunology 37 (3) , pp. 798-806. 10.1002/eji.200636743

Yuan, Fang, Georgiou, Theonie, Hillon, Theresa, Gostick, Emma, Price, David, Sewell, Andrew K., Moysey, Ruth, Gavarret, Jessie, Vuidepot, Annelise, Sami, Malkit, Bell, John I., Gao, George F., Rizkallah, Pierre J. and Jakobsen, Bent K. 2007. Crystallization and preliminary X-ray structural studies of a Melan-A pMHC-TCR complex. Acta Crystallographica Section F: Structural Biology and Crystallization Communications 63 (9) , pp. 758-760. 10.1107/S1744309107037244
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Schaubert, K. L., Price, David, Frahm, N., Li, J., Ng, H. L., Joseph, A., Paul, E., Majumder, B., Ayyavoo, V., Gostick, E., Adams, S., Marincola, F. M., Sewell, Andrew K., Altfeld, M., Brenchley, J. M., Douek, D. C., Yang, O. O., Brander, C., Goldstein, H. and Kan-Mitchell, J. 2007. Availability of a diversely Avid CD8+ T cell repertoire specific for the subdominant HLA-A2-restricted HIV-1 gag p2419-27 epitope. The Journal of Immunology 178 (12) , pp. 7756-7766. 10.4049/jimmunol.178.12.7756

Laugel, Bruno, Price, David, Milicic, Anita and Sewell, Andrew K. 2007. CD8 exerts differential effects on the deployment of cytotoxic T lymphocyte effector functions. European Journal of Immunology 37 (4) , pp. 905-913. 10.1002/eji.200636718

Wooldridge, Linda, Scriba, Thomas J., Milicic, Anita, Laugel, Bruno Frederic, Gostick, Emma, Price, David, Phillips, Rodney E. and Sewell, Andrew 2006. Anti-coreceptor antibodies profoundly affect staining with peptide-MHC class I and class II tetramers. European Journal of Immunology 36 (7) , pp. 1847-1855. 10.1002/eji.200635886

Laugel, Bruno, Price, David and Sewell, Andrew K. 2006. On the path to TCR-directed therapeutics. Nature Biotechnology 24 (6) , pp. 615-616. 10.1038/nbt0606-615b

Price, David, Brenchley, Jason M., Ruff, Laura E., Betts, Michael R., Hill, Brenna J., Roederer, Mario, Koup, Richard A., Migueles, Steven A., Gostick, Emma, Wooldridge, Linda, Sewell, Andrew, Connors, Mark and Douek, Daniel C. 2005. Avidity for antigen shapes clonal dominance in CD8+ T cell populations specific for persistent DNA viruses. Journal of Experimental Medicine 202 (10) , pp. 1349-61. 10.1084/jem.20051357
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Wooldridge, Linda, Berg, Hugo A. van den, Glick, Meir, Gostick, Emma, Laugel, Bruno Frederic, Hutchinson, Sarah L., Milicic, Anita, Brenchley, Jason M., Douek, Daniel C., Price, David and Sewell, Andrew 2005. Interaction between the CD8 coreceptor and major histocompatibility complex class I stabilizes T cell receptor-antigen complexes at the cell surface. The Journal of Biological Chemistry 280 (30) , pp. 27491-27501. 10.1074/jbc.M500555200

Sewell, Andrew, Philips, R., Walker, B. and Goulder, P. 2005. Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA. Journal of Experimental Medicine 201 (6) , pp. 891-902. 10.1084/jem.20041455
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Laugel, B., Boulter, J. M., Lissin, N., Vuidepot, A., Gostick, E., Crotty, L. E., Douek, D. C., Hemelaar, J., Price, David, Jakobsen, B. and Sewell, Andrew K. 2005. Design of soluble recombinant T Cell receptors for antigen targeting and T cell inhibition. Journal of Biological Chemistry 280 (3) , pp. 1882-1892. 10.1074/jbc.M409427200

Rezvani, K., Brenchley, J. M., Price, David, Kilical, Y., Gostick, E., Sewell, Andrew K., Li, J., Mielke, S., Douek, D. C. and Barrett, A. J. 2005. T-cell responses directed against multiple HLA-A*0201-restricted epitopes derived from Wilms' tumor 1 protein in patients with leukemia and healthy donors: identification, quantification, and characterization. Clinical Cancer Research 11 (24) , pp. 8799-8807. 10.1158/1078-0432.CCR-05-1314

Hewitt, R. E., Lissina, A., Green, A. E., Slay, E. S., Price, David and Sewell, Andrew K. 2005. The bisphosphonate acute phase response: rapid and copious production of proinflammatory cytokines by peripheral blood gd T cells in response to aminobisphosphonates is inhibited by statins. Clinical and Experimental Immunology 139 (1) , pp. 101-111. 10.1111/j.1365-2249.2005.02665.x

Green, A. E., Lissina, A., Hutchinson, S. L., Hewitt, R. E., Temple, B., James, D., Boulter, J. M., Price, David and Sewell, Andrew K. 2004. Recognition of nonpeptide antigens by human Vγ9Vδ2 T cells requires contact with cells of human origin. Clinical & Experimental Immunology 136 (3) , pp. 472-482. 10.1111/j.1365-2249.2004.02472.x

Wooldridge, Linda, Hutchinson, Sarah L., Choi, Ed M., Lissina, Anna, Jones, Emma, Mirza, Fareed, Dunbar, P. Rod, Price, David, Cerundolo, Vincenzo and Sewell, Andrew 2003. Anti-CD8 antibodies can inhibit or enhance peptide-MHC class I (pMHCI) multimer binding: this is paralleled by their effects on CTL activation and occurs in the absence of an interaction between pMHCI and CD8 on the cell surface. J Immunol 171 , pp. 6650-60.

Glick, M., Price, David, Vuidepot, A.-L., Andersen, T. B., Hutchinson, S. L., Laugel, B., Sewell, Andrew K., Boulter, J. M., Dunbar, P. R., Cerundolo, V., Oxenius, A., Bell, J. I., Richards, W. G. and Jakobsen, B. K. 2002. Novel CD8+ T cell antagonists based on 2-Microglobulin. Journal of Biological Chemistry 277 (23) , pp. 20840-20846. 10.1074/jbc.M201819200

Kelleher, Anthony D., Sewell, Andrew K. and Price, David 2002. Dyslipidemia due to retroviral protease inhibitors [Letter]. Nature Medicine 8 (4) , p. 308. 10.1038/nm0402-308a

Sewell, Andrew K., McMichael, A. J., Screaton, G. R. and Cerundolo, V. 2001. A novel approach to antigen-specific deletion of CTL with minimal cellular activation using alpha3 domain mutants of MHC class I/peptide complex. Immunity 14 (5) , pp. 591-602. 10.1016/S1074-7613(01)00133-9

Oxenius, Annette, Price, David, Dawson, Sara J., Tun, Tin, Easterbrook, Philippa J., Phillips, Rodney E. and Sewell, Andrew K. 2001. Cross-staining of cytotoxic T lymphocyte populations with peptide-MHC class I multimers of natural HIV-1 variant antigens. AIDS 15 (1) , pp. 121-122. 10.1097/00002030-200101050-00018

Purbhoo, M. A., Boulter, J. M., Price, David, Vuidepot, A.-L., Hourigan, C. S., Dunbar, P. R., Olson, K., Dawson, S. J., Phillips, R. E., Jakobsen, B. K., Bell, J. I. and Sewell, Andrew K. 2001. The human CD8 coreceptor effects cytotoxic T cell activation and antigen sensitivity primarily by mediating complete phosphorylation of the T cell receptor chain. Journal of Biological Chemistry 276 (35) , pp. 32786-32792. 10.1074/jbc.M102498200

Sewell, Andrew K. and Price, David 2001. Dendritic cells and transmission of HIV-1. Trends in Immunology 22 (4) , pp. 173-175. 10.1016/S1471-4906(01)01866-X

Oxenius, A., Price, David, Easterbrook, P. J., O'Callaghan, C. A., Kelleher, A. D., Whelan, J. A., Sontag, G., Sewell, Andrew K. and Phillips, R. E. 2000. Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+ and CD4+ T lymphocytes. Proceedings of the National Academy of Sciences of the United States of America 97 (7) , pp. 3382-3387. 10.1073/pnas.97.7.3382

Price, David, Klenerman, Paul, Booth, Bruce L, Phillips, Rodney E and Sewell, Andrew K 1999. Cytotoxic T lymphocytes, chemokines and antiviral immunity. Immunology Today 20 (5) , pp. 212-216. 10.1016/S0167-5699(99)01447-4

Sewell, Andrew K., Gerth, U. C., Price, David, Purbhoo, M. A., Boulter, J. M., Gao, G. F., Bell, J. I., Phillips, R. E. and Jakobsen, B. K. 1999. Antagonism of cytotoxic T-lymphocyte activation by soluble CD8. Nature Medicine 5 , pp. 399-404. 10.1038/7398

Lewis, J. W., Sewell, Andrew K., Price, David and Elliot, T. 1998. HLA-A*0201 presents TAP-dependent peptide epitopes to cytotoxic T lymphocytes in the absence of tapasin. European Journal of Immunology 28 , pp. 3214-3220.

Price, David, Sewell, Andrew K., Dong, Tao, Tan, Rusung, Goulder, Philip J. R., Rowland-Jones, Sarah L. and Phillips, Rodney E. 1998. Antigen-specific release of b-chemokines by anti-HIV-1 cytotoxic T lymphocytes. Current Biology 8 (6) , pp. 355-358. 10.1016/S0960-9822(98)70138-1

Sewell, Andrew K., Harcourt, Gillian C., Goulder, Philip J. R., Price, David and Phillips, Rodney E. 1997. Antagonism of cytotoxic T lymphocyte-mediated lysis by natural HIV-1 altered peptide ligands requires simultaneous presentation of agonist and antagonist peptides. European Journal of Immunology 27 (9) , pp. 2323-2329. 10.1002/eji.1830270929

This list was generated on Sat Nov 17 04:05:10 2018 GMT.