Browse by Current Cardiff authors

Mohammed, Rebar N, Wehenkel, Sophie C, Galkina, E, Yates, E, Preece, G, Newman, Andrew, Watson, Angharad, Ohme, Julia, Bridgeman, John S, Durairaj, Ruban, Moon, Owen, Ladell, Kristin, Miners, Kelly, Dolton, Garry, Troeberg, L, Kashiwagi, M, Murphy, G, Nagase, H, Price, David A, Matthews, R James, Knauper, V and Ager, Ann 2019. ADAM17-dependent proteolysis of L-selectin promotes early clonal expansion of cytotoxic T cells. Scientific Reports 9 , 5487. 10.1038/s41598-019-41811-z

Li, Na, van Unen, Vincent, Abdelaal, Tamim, Guo, Nannan, Kasatskaya, Sofya A., Ladell, Kristin, McLaren, James E., Egorov, Evgeny S., Izraelson, Mark, Chuva de Sousa Lopes, Susana M., Höllt, Thomas, Britanova, Olga V, Eggermont, Jeroen, de Miranda, Noel F. C. C., Chudakov, Dmitriy M., Price, David A., Lelieveldt, Boudewijn P. F. and Koning, Frits 2019. Memory CD4+ T cells are generated in the human fetal intestine. Nature Immunology 20 , pp. 301-312. 10.1038/s41590-018-0294-9 Item availability restricted.

Mayassi, Toufic, Ladell, Kristin, Gudjonson, Herman, McLaren, James, Shaw, Dustin G., Tran, Mai T., Rokicka, Jagoda J., Lawrence, Ian, Grenier, Jean-Christophe, van Unen, Vincent, Ciszewski, Cezary, Dimaano, Matthew, Sayegh, Hoda E., Kumar, Vinod, Wijmenga, Cisca, Green, Peter H.R., Gokhale, Ranjana, Jericho, Hilary, Semrad, Carol E., Guandalini, Stefano, Dinner, Aaron R., Kupfer, Sonia S., Reid, Hugh H., Barreiro, Luis B., Rossjohn, Jamie, Price, David A. and Jabri, Bana 2019. Chronic inflammation permanently reshapes tissue-resident immunity in celiac disease. Cell 176 (5) , pp. 967-981. 10.1016/j.cell.2018.12.039 Item availability restricted.

McLaren, James, Clement, Mathew, Marsden, Morgan, Miners, Kelly L., Llewellyn-Lacey, Sian, Grant, Emma J., Rubina, Anzelika, Gimeno Brias, Silvia, Gostick, Emma, Stacey, Maria A., Orr, Selinda J., Stanton, Richard J., Ladell, Kristin, Price, David A. and Humphreys, Ian R. 2019. IL-33 augments virus-specific memory T Cell inflation and potentiates the efficacy of an attenuated cytomegalovirus-based vaccinea. Journal of Immunology 202 (2) , ji1701757. 10.4049/jimmunol.1701757

Shimauchi, Takatoshi, Caucheteux, Stephan, Finsterbusch, Katja, Turpin, Jocelyn, Blanchet, Fabien, Ladell, Kristin, Triantafilou, Kathy, Czubala, Magdalena, Tatsuno, Kazuki, Easter, Tammy, Ahmed, Zahra, Bayliss, Rebecca, Hakobyan, Svetlana, Price, David A., Tokura, Yoshiki and Piguet, Vincent 2019. Dendritic cells promote the spread of human T-cell leukemia virus type-1 via bidirectional interactions with CD4 + T-cells. Journal of Investigative Dermatology 139 (1) , pp. 157-166. 10.1016/j.jid.2018.06.188 Item availability restricted.

Boelen, Lies, Debebe, Bisrat, Silveira, Marcos, Salam, Arafa, Makinde, Julia, Roberts, Chrissy h., Wang, Edward, Frater, John, Gilmour, Jill, Twigger, Katie, Ladell, Kristin, Miners, Kelly L., Jayaraman, Jyothi, Traherne, James A., Price, David A., Qi, Ying, Martin, Maureen P., Macallan, Derek C., Thio, Chloe L., Astemborski, Jacquie, Kirk, Gregory, Donfield, Sharyne M., Buchbinder, Susan, Khakoo, Salim I., Goedert, James J., Trowsdale, John, Carrington, Mary, Kollnberger, Simon and Asquith, Becca 2018. Inhibitory killer cell immunoglobulin-like receptors strengthen CD8+ T cell-mediated control of HIV-1, HCV, and HTLV-1. Science Immunology 3 (29) , eaao2892. 10.1126/sciimmunol.aao2892

Pogorelyy, Mikhail V., Fedorova, Alla D., McLaren, James E., Ladell, Kristin, Bagaev, Dmitri V., Eliseev, Alexey V., Mikelov, Artem I., Koneva, Anna E., Zvyagin, Ivan V., Price, David A., Chudakov, Dmitry M. and Shugay, Mikhail 2018. Exploring the pre-immune landscape of antigen-specific T cells. Genome Medicine 10 , 68. 10.1186/s13073-018-0577-7

Powell, Wendy E., Hanna, Stephanie J., Hocter, Claire N., Robinson, Emma, Davies, Joanne, Dunseath, Gareth J., Luzio, Stephen, Farewell, Daniel, Wen, Li, Dayan, Colin M., Price, David A., Ladell, Kristin and Wong, F. Susan 2018. Loss of CXCR3 expression on memory B cells in individuals with long-standing type 1 diabetes. Diabetologia 61 (8) , pp. 1794-1803. 10.1007/s00125-018-4651-x

Costa del Amo, Pedro, Beneytez, Julio Lahoz, Boelen, Lies, Ahmed, Raya, Miners, Kelly L., Zhang, Yan, Roger, Laureline, Jones, Rhiannon E., Marraco, Silvia A. Fuertes, Speiser, Daniel E., Baird, Duncan M., Price, David A., Ladell, Kristin, Macallan, Derek and Asquith, Becca 2018. Human TSCM cell dynamics in vivo are compatible with long-lived immunological memory and stemness. PLoS Biology 16 (6) , e2005523. 10.1371/journal.pbio.2005523

Miles, John J., Tan, Mai Ping, Dolton, Garry, Edwards, Emily S. J., Galloway, Sarah A. E., Laugel, Bruno, Clement, Mathew, Makinde, Julia, Ladell, Kristin, Matthews, Katherine K., Watkins, Thomas S., Tungatt, Katie, Wong, Yide, Lee, Han Siean, Clark, Richard J., Pentier, Johanne, Attaf, Meriem, Lissina, Anya, Ager, Ann, Gallimore, Awen, Rizkallah, Pierre J., Gras, Stephanie, Rossjohn, Jamie, Burrows, Scott R., Cole, David K., Price, David A. and Sewell, Andrew K. 2018. Peptide mimic for influenza vaccination using nonnatural combinatorial chemistry. The Journal of Clinical Investigation 128 (4) , pp. 1569-1580. 10.1172/JCI91512

Wun, Kwok S., Reijneveld, Josephine F., Cheng, Tan-Yun, Ladell, Kristin, Uldrich, Adam P., Le Nours, Jérôme, Miners, Kelly L., McLaren, James E., Grant, Emma J., Haigh, Oscar L., Watkins, Thomas S., Suliman, Sara, Iwany, Sarah, Jimenez, Judith, Calderon, Roger, Tamara, Kattya L., Leon, Segundo R., Murray, Megan B., Mayfield, Jacob A., Altman, John D., Purcell, Anthony W., Miles, John J., Godfrey, Dale I., Gras, Stephanie, Price, David A., Van Rhijn, Ildiko, Moody, D. Branch and Rossjohn, Jamie 2018. T cell autoreactivity directed toward CD1c itself rather than toward carried self lipids. Nature Immunology 19 , pp. 397-406. 10.1038/s41590-018-0065-7

James, Eddie A., Abreu, Joana R. F., McGinty, John W., Odegard, Jared M., Fillié, Yvonne E., Hocter, Claire N., Culina, Slobodan, Ladell, Kristin, Price, David A., Alkanani, Aimon, Rihanek, Marynette, Fitzgerald-Miller, Lisa, Skowera, Ania, Speake, Cate, Gottlieb, Peter, Davidson, Howard W., Wong, F. Susan, Roep, Bart and Mallone, Roberto 2018. Combinatorial detection of autoreactive CD8+ T cells with HLA-A2 multimers: a multi-centre study by the Immunology of Diabetes Society T Cell Workshop. Diabetologia 61 (3) , pp. 658-670. 10.1007/s00125-017-4508-8

McCully, Michelle L., Ladell, Kristin, Andrews, Robert, Jones, Rhiannon E., Miners, Kelly L., Roger, Laureline, Baird, Duncan M., Cameron, Mark J., Jessop, Zita M., Whitaker, Iain S., Davies, Eleri L., Price, David A. and Moser, Bernhard 2018. CCR8 expression defines tissue-resident memory T cells in human skin. The Journal of Immunology 200 (5) , pp. 1639-1650. 10.4049/jimmunol.1701377

Culina, Slobodan, Lalanne, Ana Ines, Afonso, Georgia, Cerosaletti, Karen, Pinto, Sheena, Sebastiani, Guido, Kuranda, Klaudia, Nigi, Laura, Eugster, Anne, Østerbye, Thomas, Maugein, Alicia, McLaren, James, Ladell, Kristin, Larger, Etienne, Beressi, Jean-Paul, Lissina, Anna, Appay, Victor, Davidson, Howard W., Buus, Søren, Price, David, Kuhn, Matthias, Bonifacio, Ezio, Battaglia, Manuela, Caillat-Zucman, Sophie, Dotta, Francesco, Scharfmann, Raphael, Kyewski, Bruno and Mallone, Roberto 2018. Islet-reactive CD8+ T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors. Science Immunology 3 (20) , eaao4013. 10.1126/sciimmunol.aao4013

Lissina, Anna, McLaren, James E., Ilander, Mette, Andersson, Emma I., Lewis, Catherine S., Clement, Mathew, Herman, Andrew, Ladell, Kristin, Llewellyn-Lacey, Sian, Miners, Kelly L., Gostick, Emma, Melenhorst, J. Joseph, Barrett, A. John, Price, David A., Mustjoki, Satu and Wooldridge, Linda 2018. Divergent roles for antigenic drive in the aetiology of primary versus dasatinib-associated CD8+ TCR-Vβ+ expansions. Scientific Reports 8 (1) , 2534. 10.1038/s41598-017-18062-x

Van Braeckel-Budimir, Natalija, Gras, Stephanie, Ladell, Kristin, Josephs, Tracy M., Pewe, Lecia, Urban, Stina L., Miners, Kelly, Farenc, Carine, Price, David, Rossjohn, Jamie and Harty, John T. 2017. A T cell receptor locus harbors a malaria-specific immune response gene. Immunity 47 (5) , pp. 835-847. 10.1016/j.immuni.2017.10.013

Culshaw, Abigail, Ladell, Kristin, Gras, Stephanie, McLaren, James, Miners, Kelly, Farenc, Carine, van den Heuvel, Heleen, Gostick, Emma, Dejnirattisai, Wanwisa, Wangteeraprasert, Apirath, Duangchinda, Thaneeya, Chotiyarnwong, Pojchong, Limpitikul, Wannee, Vasanawathana, Sirijitt, Malasit, Prida, Dong, Tao, Rossjohn, Jamie, Mongkolsapaya, Juthathip, Price, David and Screaton, Gavin R 2017. Germline bias dictates cross-serotype reactivity in a common dengue-virus-specific CD8+ T cell response. Nature Immunology 18 (11) , pp. 1228-1237. 10.1038/ni.3850

Anguille, Sébastien, Van de Velde, Ann L., Smits, Evelien L., Van Tendeloo, Viggo F., Juliusson, Gunnar, Cools, Nathalie, Nijs, Griet, Stein, Barbara, Lion, Eva, Van Driessche, Ann, Vandenbosch, Irma, Verlinden, Anke, Gadisseur, Alain P., Schroyens, Wilfried A., Muylle, Ludo, Vermeulen, Katrien, Maes, Marie-Berthe, Deiteren, Kathleen, Malfait, Ronald, Gostick, Emma, Lammens, Martin, Couttenye, Marie M., Jorens, Philippe, Goossens, Herman, Price, David, Ladell, Kristin, Oka, Yoshihiro, Fujiki, Fumihiro, Oji, Yusuke, Sugiyama, Haruo and Berneman, Zwi N. 2017. Dendritic cell vaccination as postremission treatment to prevent or delay relapse in acute myeloid leukemia. Blood 130 (15) , pp. 1713-1721. 10.1182/blood-2017-04-780155

Shugay, M., Bagaev, D. V., Zvyagin, I. V., Vroomans, R. M., Crawford, J. C., Dolton, Garry M., Komech, Ekaterina A., Sycheva, Anastasiya L., Koneva, Anna E., Egorov, Evgeniy S., Eliseev, Alexey V., Van Dyk, E., Dash, P., Attaf, Meriem, Ruis, Cristina, Ladell, Kristin Ingrid, McLaren, James E., Matthews, Katherine K., Clemens, Ella B., Douek, Daniel C., Luciani, Fabio, Van Baarle, D., Kedzierska, Katherine, Kesmir, Can, Thomas, Paul G., Price, David, Sewell, Andrew K. and Chudakov, Dimitry M. 2017. VDJdb: a curated database of T-cell receptor sequences with known antigen specificity. Nucleic Acids Research 10.1093/nar/gkx760

Murrell, Isa, Bedford, Carmen, Ladell, Kristin Ingrid, Miners, Kelly Louise, Price, David, Tomasec, Peter, Wilkinson, Gavin William Grahame and Stanton, Richard James 2017. The pentameric complex drives immunologically covert cell -cell transmission of wild-type human cytomegalovirus. Proceedings of the National Academy of Sciences of the United States of America 114 (23) , pp. 6104-6109. 10.1073/pnas.1704809114

Davey, Martin S., Willcox, Carrie R., Joyce, Stephen P., Ladell, Kristin, Kasatskaya, Sofya A., McLaren, James E., Hunter, Stuart, Salim, Mahboob, Mohammed, Fiyaz, Price, David A., Chudakov, Dmitriy M. and Willcox, Benjamin E. 2017. Clonal selection in the human Vδ1 T cell repertoire indicates γδ TCR-dependent adaptive immune surveillance. Nature Communications 8 , 14760. 10.1038/ncomms14760

Dockree, Tamsin, Holland, Christopher J., Clement, Mathew, Ladell, Kristin Ingrid, McLaren, James Edward, Van Den Berg, Hugo A., Gostick, Emma, Llewellyn-Lacey, Sian, Man, Stephen Tzekwung, Bailey, Mick, Burrows, Scott, Price, David and Wooldridge, Linda 2017. CD8+ T-cell specificity is compromised at a defined MHCI/CD8 affinity threshold. Immunology and Cell Biology 95 (1) , pp. 68-76. 10.1038/icb.2016.85

Ahmed, Raya, Roger, Laureline, Costa del Amo, Pedro, Miners, Kelly Louise, Jones, Rhiannon E., Boelen, Lies, Fali, Tinhinane, Elemans, Marjet, Zhang, Yan, Appay, Victor, Baird, Duncan Martin, Asquith, Becca, Price, David, Macallan, Derek C. and Ladell, Kristin Ingrid 2016. Human stem cell-like memory T cells are maintained in a state of dynamic flux. Cell Reports 17 (11) , pp. 2811-2818. 10.1016/j.celrep.2016.11.037

Watson, H. Angharad, Dolton, Garry Michael, Ohme, Julia, Ladell, Kristin Ingrid, Vigar, Miriam, Wehenkel, Sophie, Hindley, James, Mohammed, Rebar, Miners, Kelly, Luckwell, Rhys A, Price, David, Matthews, R James and Ager, Ann 2016. Purity of transferred CD8+ T cells is crucial for safety and efficacy of combinatorial tumor immunotherapy in the absence of SHP-1. Immunology and Cell Biology 94 , pp. 802-808. 10.1038/icb.2016.45

Caucheteux, Stephan M., Mitchell, John P., Ivory, Matthew O., Hirosue, Sachiko, Hakobyan, Svetlana, Dolton, Garry, Ladell, Kristin Ingrid, Miners, Kelly Louise, Price, David, Kan-Mitchell, June, Sewell, Andrew K., Nestle, Frank, Moris, Arnaud, Karoo, Richard O., Birchall, James Caradoc, Swartz, Melody A., Hubbel, Jeffrey A., Blanchet, Fabien P. and Piguet, Vincent 2016. Polypropylene sulfide nanoparticle p24 vaccine promotes dendritic cell-mediated specific immune responses against HIV-1. Journal of Investigative Dermatology 136 (6) , pp. 1172-1181. 10.1016/j.jid.2016.01.033

Pearson, James A., Thayer, Terri, McLaren, James Edward, Ladell, Kristin, De Leenheer, Evy, Phillips, Amy, Davies, Joanne, Kakabadse, Dimitri, Miners, Kelly Louise, Morgan, Peter, Wen, Li, Price, David and Wong, Florence Susan 2016. Proinsulin expression shapes the TCR repertoire but fails to control the development of low-avidity insulin-reactive CD8+T cells. Diabetes 65 (6) , pp. 1679-1689. 10.2337/db15-1498

Du, V. Y., Bansal, A., Carlson, J., Salazar-Gonzalez, J. F., Salazar, M. G., Ladell, Kristin Ingrid, Gras, S., Josephs, T. M., Heath, S. L., Price, David, Rossjohn, Jamie, Hunter, E. and Goepfert, P. A. 2016. HIV-1-specific CD8 T cells exhibit limited cross-reactivity during acute infection. The Journal of Immunology 196 (8) , pp. 3276-3286. 10.4049/jimmunol.1502411

Ridley, Anna, Hatano, Hiroko, Wong-Baeza, Isabel, Shaw, Jacqueline, Matthews, Katherine K., Al-Mossawi, Hussein, Ladell, Kristin Ingrid, Price, David, Bowness, Paul and Kollnberger, Simon 2016. Activation-induced killer cell immunoglobulin-like receptor 3DL2 binding to HLA-B27 licenses pathogenic T cell differentiation in spondyloarthritis. Arthritis & Rheumatology 68 (4) , pp. 901-914. 10.1002/art.39515

Skowera, Ania, Ladell, Kristin, McLaren, James E., Dolton, Garry, Matthews, Katherine K., Gostick, Emma, Kronenberg-Versteeg, Deborah, Eichmann, Martin, Knight, Robin R., Heck, Susanne, Powrie, Jake, Bingley, Polly J., Dayan, Colin M., Miles, John J., Sewell, Andrew K., Price, David A. and Peakman, Mark 2016. β-cell-specific CD8 T cell phenotype in type 1 diabetes reflects chronic autoantigen exposure. Diabetes 64 (3) , pp. 916-925. 10.2337/db14-0332

Holland, C. J., Dolton, Garry Michael, Scurr, Martin John, Ladell, Kristin Ingrid, Schauenburg, Andrea J. A., Miners, Kelly Louise, Madura, F., Sewell, Andrew K., Price, David, Cole, David and Godkin, Andrew James 2015. Enhanced detection of antigen-specific CD4+ T cells using altered peptide flanking residue peptide-MHC class II multimers. The Journal of Immunology 195 (12) , pp. 5827-5836. 10.4049/jimmunol.1402787

Ladell, Kristin Ingrid, Hazenberg, M. D., Fitch, M., Emson, C., McEvoy-Hein Asgarian, B. K., Mold, J. E., Miller, C., Busch, R., Price, David, Hellerstein, M. K. and McCune, J. M. 2015. Continuous antigenic stimulation of DO11.10 TCR transgenic mice in the presence or absence of IL-1: possible implications for mechanisms of T cell depletion in HIV disease. The Journal of Immunology 195 (9) , pp. 4096-4105. 10.4049/jimmunol.1500799

Colbeck, Emily, Hindley, James P., Smart, Kathryn, Jones, Emma, Bloom, Anja, Bridgeman, Hayley, McPherson, Rhoanne C., Turner, Darryl G., Ladell, Kristin Ingrid, Price, David, O'Connor, Richard A., Anderton, Stephen M., Godkin, Andrew James and Gallimore, Awen Myfanwy 2015. Eliminating roles for T-bet and IL-2 but revealing superior activation and proliferation as mechanisms underpinning dominance of regulatory T cells in tumors. Oncotarget 6 (28) , pp. 24649-24659. 10.18632/oncotarget.5584

Neller, Michelle A., Ladell, Kristin Ingrid, McLaren, James Edward, Matthews, Katherine K., Gostick, Emma, Pentier, Johanne, Dolton, Garry Michael, Schauenburg, Andrea J. A., Koning, Dan, Fontaine Costa, Ana Isabel C. A., Watkins, Thomas S., Venturi, Vanessa, Smith, Corey, Khanna, Rajiv, Miners, Kelly Louise, Clement, Mathew, Wooldridge, Linda, Cole, David, van Baarle, Debbie, Sewell, Andrew K., Burrows, Scott R., Price, David and Miles, John James 2015. Naive CD8+ T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics. Immunology and Cell Biology 93 , pp. 625-633. 10.1038/icb.2015.17

Petersen, J., van Bergen, J., Loh, K. L., Kooy-Winkelaar, Y., Beringer, D. X., Thompson, A., Bakker, S. F., Mulder, C. J. J., Ladell, Kristin, McLaren, James Edward, Price, David, Rossjohn, Jamie, Reid, H. H. and Koning, F. 2015. Determinants of gliadin-specific T cell selection in celiac disease. The Journal of Immunology 194 (12) , pp. 6112-6122. 10.4049/jimmunol.1500161

Kloverpris, H. N., McGregor, R., McLaren, James Edward, Ladell, Kristin, Harndahl, M., Stryhn, A., Carlson, J. M., Koofhethile, C., Gerritsen, B., Ke mir, C., Chen, F., Riddell, L., Luzzi, G., Leslie, A., Walker, B. D., Ndung'u, T., Buus, S., Price, David and Goulder, P. J. 2015. CD8+ TCR bias and immunodominance in HIV-1 infection. The Journal of Immunology 194 (11) , pp. 5329-5345. 10.4049/jimmunol.1400854

Kløverpris, Henrik N., McGregor, Reuben, McLaren, James E., Ladell, Kristin Ingrid, Harndahl, Mikkel, Stryhn, Anette, Carlson, Jonathan M., Koofhethile, Catherine, Gerritsen, Bram, Kesmir, Can, Chen, Fabian, Riddell, Lynn, Luzzi, Graz, Leslie, Alasdair, Walker, Bruce D., Ndung'u, Thumbi, Buus, Søren, Price, David and Goulder, Philip J. 2015. CD8+TCR bias and immunodominance in HIV-1 infection. The Journal of Immunology 194 (11) , pp. 5329-5345. 10.4049/jimmunol.1400854

Roberto, A., Castagna, L., Zanon, V., Bramanti, S., Crocchiolo, R., McLaren, James Edward, Gandolfi, S., Tentorio, P., Sarina, B., Timofeeva, I., Santoro, A., Carlo-Stella, C., Bruno, B., Carniti, C., Corradini, P., Gostick, Emma, Ladell, Kristin Ingrid, Price, David, Roederer, M., Mavilio, D. and Lugli, E. 2015. Role of naive-derived T memory stem cells in T-cell reconstitution following allogeneic transplantation. Blood 125 (18) , pp. 2855-2864. 10.1182/blood-2014-11-608406

Skowera, Ania, Ladell, Kristin Ingrid, McLaren, James Edward, Dolton, Garry Michael, Matthews, Katherine K., Gostick, Emma, Kronenberg-Versteeg, Deborah, Eichmann, Martin, Knight, Robin R., Heck, Susanne, Powrie, Jake, Bingley, Polly J., Dayan, Colin Mark, Miles, John J., Sewell, Andrew K., Price, David and Peakman, Mark 2015. β-Cell-specific CD8 T Cell phenotype in Type 1 diabetes reflects chronic autoantigen exposure. Diabetes 64 (3) , pp. 916-925. 10.2337/db14-0332

Parkinson, Nicholas J., Roddis, Matthew, Ferneyhough, Ben, Zhang, Gang, Marsden, Adam J., Maslau, Siarhei, Sanchez-Pearson, Yasmin, Barthlott, Thomas, Humphreys, Isla, Ladell, Kristin Ingrid, Price, David, Ponting, Chris P., Hollander, Georg and Fischer, Michael D. 2015. Violation of the 12/23 rule of genomic V(D)J recombination is common in lymphocytes. Genome Research 25 (2) , pp. 226-234. 10.1101/gr.179770.114

Costa, Ana I., Koning, Dan, Ladell, Kristin, McLaren, James Edward, Grady, Bart P. X., Schellens, Ingrid M. M., van Ham, Petra, Nijhuis, Monique, Borghans, José A. M., Kesmir, Can, Price, David, van Baarle, Debbie and Silvestri, G. 2015. Complex T-cell receptor repertoire dynamics underlie the CD8+T-cell response to HIV-1. Journal of Virology 89 (1) , pp. 110-119. 10.1128/JVI.01765-14

Tan, Mai, Gerry, A. B., Brewer, J. E., Melchiori, L., Bridgeman, John S., Bennett, A. D., Pumphrey, N. J., Jakobsen, B. K., Price, D. A., Ladell, Kristin Ingrid and Sewell, Andrew K. 2014. T cell receptor binding affinity governs the functional profile of cancer-specific CD8+T cells. Clinical and Experimental Immunology 180 (2) , pp. 255-270. 10.1111/cei.12570

Pearson, James, Thayer, T. C., McLaren, James Edward, Miners, Kelly Louise, Ladell, Kristin Ingrid, Price, David and Wong, Florence Susan 2014. Analysis of the repertoire of insulin-reactive CD8(+) T cells [Abstract]. Immunology 143 (S2) , p. 152. 10.1111/imm.12406

Willis, Gareth R., Connolly, Katherine, Ladell, Kristin Ingrid, Davies, Thomas S., Guschina, Irina, Ramji, Dipak, Miners, Kelly Louise, Price, David, Clayton, Aled, James, Philip Eurig and Rees, Dafydd Aled 2014. Young women with polycystic ovary syndrome have raised levels of circulating annexin V-positive platelet microparticles. Human Reproduction 29 (12) , pp. 2756-2769. 10.1093/humrep/deu281

Bengsch, Bertram, Ladell, Kristin Ingrid, Martin, Bianca, McLaren, James Edward, Nitschke, Katja, Neumann-Haefelin, Christoph, Price, David and Thimme, Robert 2014. Identification of a TSCM phenotype HCV-specific CD8+T cell response with superior functionality in chronic HCV infection [Abstract]. Hepatology 60 , 1071A-1072A.

Connolly, Katherine, Willis, Gareth, Datta, Dev B.N., Ellins, Elizabeth, Ladell, Kristin, Price, David, Guschina, Irina, Rees, Dafydd Aled and James, Philip 2014. Lipoprotein-apheresis reduces circulating microparticles in individuals with familial hypercholesterolemia. Journal of Lipid Research 55 , pp. 2064-2072. 10.1194/jlr.M049726

Taylor, Graham S., Jia, Hui, Harrington, Kevin, Lee, Lip Wai, Turner, James, Ladell, Kristin, Price, David, Tanday, Manjit, Matthews, Jen, Roberts, Claudia, Edwards, Ceri, McGuigan, Lesley, Hartley, Andrew, Wilson, Steve, Hui, Edwin P., Chan, Anthony T.C., Rickinson, Alan B. and Steven, Neil M. 2014. A recombinant modified vaccinia Ankara vaccine encoding Epstein-Barr virus (EBV) target antigens: a phase I trial in UK patients with EBV-positive cancer. Clinical Cancer Research 20 (19) , pp. 5009-5022. 10.1158/1078-0432.CCR-14-1122-T

Kløverpris, Henrik N., McGregor, Reuben, McLaren, James Edward, Ladell, Kristin Ingrid, Stryhn, Anette, Koofhethile, Catherine, Brener, Jacqui, Chen, Fabian, Riddell, Lynn, Graziano, Luzzi, Klenerman, Paul, Leslie, Alasdair, Buus, Søren, Price, David and Goulder, Philip 2014. Programmed death-1 expression on HIV-1-specific CD8+ T cells is shaped by epitope specificity, T-cell receptor clonotype usage and antigen load. AIDS 28 (14) , pp. 2007-2021. 10.1097/QAD.0000000000000362

Gold, M. C., McLaren, James Edward, Reistetter, J. A., Smyk-Pearson, S., Ladell, Kristin, Swarbrick, G. M., Yu, Y. Y. L., Hansen, T. H., Lund, O., Nielsen, M., Gerritsen, B., Kesmir, C., Miles, John James, Lewinsohn, D. A., Price, David and Lewinsohn, D. M. 2014. MR1-restricted MAIT cells display ligand discrimination and pathogen selectivity through distinct T cell receptor usage. Journal of Experimental Medicine 211 (8) , pp. 1601-1610. 10.1084/jem.20140507

Dolton, Garry Michael, Lissina, A., Skowera, A., Ladell, Kristin Ingrid, Tungatt, Katie, Jones, Emma, Kronenberg-Versteeg, D., Akpovwa, Hephzibah, Pentier, Johanne, Holland, C. J., Godkin, Andrew James, Cole, David, Neller, M. A., Miles, John James, Price, David, Peakman, M. and Sewell, Andrew K. 2014. Comparison of peptide-major histocompatibility complex tetramers and dextramers for the identification of antigen-specific T cells. Clinical and Experimental Immunology 177 (1) , pp. 47-63. 10.1111/cei.12339

Ondondo, Beatrice, Jones, Emma, Hindley, James, Cutting, Scott, Smart, Kathryn, Bridgeman, Hayley, Matthews, Katherine K., Ladell, Kristin Ingrid, Price, David, Jackson, David G., Godkin, Andrew James, Ager, Ann and Gallimore, Awen Myfanwy 2014. Progression of carcinogen-induced fibrosarcomas is associated with the accumulation of naïve CD4+ T cellsviablood vessels and lymphatics. International Journal of Cancer 134 (9) , pp. 2156-2167. 10.1002/ijc.28556

Melamed, Anat, Witkover, Aviva D., Laydon, Daniel J., Brown, Rachael, Ladell, Kristin, Miners, Kelly, Rowan, Aileen G., Gormley, Niall, Price, David, Taylor, Graham P., Murphy, Edward L. and Bangham, Charles R. M. 2014. Clonality of HTLV-2 in natural infection. PLoS Pathogens 10 (3) , e1004006. 10.1371/journal.ppat.1004006

Lissina, Anna, Fastenackels, Solène, Inglesias, Maria C., Ladell, Kristin, McLaren, James, Briceño, Olivia, Gostick, Emma, Papagno, Laura, Autran, Brigitte, Sauce, Delphine, Price, David, Saez-Cirion, Asier and Appay, Victor 2014. The link between CD8+ T-cell antigen-sensitivity and HIV-suppressive capacity depends on HLA restriction, target epitope and viral isolate. AIDS 28 (4) , pp. 477-486. 10.1097/QAD.0000000000000175

Bridgeman, John S., Ladell, Kristin Ingrid, Sheard, V. E., Miners, Kelly Louise, Hawkins, R. E., Price, David and Gilham, D. E. 2014. CD3ζ-based chimeric antigen receptors mediate T cell activation viacis- andtrans-signalling mechanisms: implications for optimization of receptor structure for adoptive cell therapy. Clinical and Experimental Immunology 175 (2) , pp. 258-267. 10.1111/cei.12216

Bernasconi, Michele, Ueda, Seigo, Krukowski, Patricia, Bornhauser, Beat C., Ladell, Kristin Ingrid, Dorner, Marcus, Sigrist, Juerg A., Campidelli, Cristina, Aslandogmus, Roberta, Alessi, Davide, Berger, Christoph, Pileri, Stefano A., Speck, Roberto F. and Nadal, David 2013. Early gene expression changes by Epstein-Barr virus infection of B-cells indicate CDKs and survivin as therapeutic targets for post-transplant lymphoproliferative diseases. International Journal of Cancer 133 (10) , pp. 2341-2350. 10.1002/ijc.28239

Scurr, Martin John, Ladell, Kristin Ingrid, Besneux, Matthieu, Christian, Adam, Hockey, T., Smart, Kathryn, Bridgeman, Hayley, Hargest, Rachel, Phillips, S., Davies, M., Price, David, Gallimore, Awen Myfanwy and Godkin, Andrew James 2013. Highly prevalent colorectal cancer-infiltrating LAP+ Foxp3- T cells exhibit more potent immunosuppressive activity than Foxp3+ regulatory T cells. Mucosal Immunology n/a 10.1038/mi.2013.62

van den Berg, Hugo A., Ladell, Kristin, Miners, Kelly, Laugel, Bruno, Llewellyn-Lacey, Sian, Clement, Mathew, Cole, David, Gostick, Emma, Wooldridge, Linda, Sewell, Andrew K., Bridgeman, John S. and Price, David 2013. Cellular-level versus receptor-level response threshold hierarchies in T-cell activation. Frontiers in Immunology 4 , 250. 10.3389/fimmu.2013.00250

Ladell, Kristin Ingrid, Hashimoto, Masao, Iglesias, Maria Candela, Wilmann, Pascal G., McLaren, James Edward, Gras, Stéphanie, Chikata, Takayuki, Kuse, Nozomi, Fastenackels, Solène, Gostick, Emma, Bridgeman, John S., Venturi, Vanessa, Arkoub, Zaïna Aït, Agut, Henri, van Bockel, David J., Almeida, Jorge R., Douek, Daniel C., Meyer, Laurence, Venet, Alain, Takiguchi, Masafumi, Rossjohn, Jamie, Price, David and Appay, Victor 2013. A molecular basis for the control of preimmune escape variants by HIV-specific CD8+ T cells. Immunity 38 (3) , pp. 425-436. 10.1016/j.immuni.2012.11.021

Chattopadhyay, P., Chelimo, K., Embury, P., Mulama, D., Sumba, P., Gostick, Emma, Ladell, Kristin Ingrid, Brodie, T., Vulule, J., Roederer, M., Moormann, A. and Price, David 2013. Holoendemic malaria exposure is associated with altered epstein-barr virus-specific CD8+ T-cell differentiation. Journal of Virology 87 (3) , pp. 1779-1788. 10.1128/JVI.02158-12

Koning, D., Costa, A. I., Hoof, I., Miles, John James, Nanlohy, N. M., Ladell, Kristin Ingrid, Matthews, Katherine K., Venturi, V., Schellens, I. M. M., Borghans, J. A. M., Kesmir, C., Price, David and van Baarle, D. 2013. CD8+ TCR repertoire formation is guided primarily by the peptide component of the antigenic complex. The Journal of Immunology 190 (3) , pp. 931-939. 10.4049/jimmunol.1202466

Ladell, Kristin Ingrid 2013. Antigen-specific T cell turnover and expansion in vivo during chronic immune stimulation. PhD Thesis, Cardiff University. Item availability restricted.

Humphreys, Ian R., Clement, Mathew, Marsden, Morgan, Ladell, Kristin Ingrid, McLaren, James Edward, Smart, Kathryn, Hindley, James Philip, Bridgeman, Hayley, van den Berg, Hugo A., Price, David, Ager, Ann, Wooldridge, Linda, Godkin, Andrew James and Gallimore, Awen Myfanwy 2012. Avidity of influenza-specific memory CD8+T-cell populations decays over time compromising antiviral immunity. European Journal of Immunology 42 (12) , pp. 3235-3242. 10.1002/eji.201242575

McCully, Michelle L., Ladell, Kristin Ingrid, Hakobyan, Svetlana, Mansel, Robert Edward, Price, David and Moser, Bernhard 2012. Epidermis instructs skin homing receptor expression in human T cells. Blood 120 (23) , pp. 4591-4598. 10.1182/blood-2012-05-433037

Hindley, James Phillip, Jones, Emma, Smart, Kathryn, Bridgeman, Hayley, Lauder, Sarah Nicol, Ondondo, Beatrice Omusiro, Cutting, Scott, Ladell, Kristin Ingrid, Wynn, Katherine Kay, Withers, David, Price, David, Ager, Ann, Godkin, Andrew James and Gallimore, Awen Myfanwy 2012. T-cell trafficking facilitated by high endothelial venules is required for tumor control after regulatory T cell depletion. Cancer Research 72 (21) , pp. 5473-5482. 10.1158/0008-5472.CAN-12-1912

Ekeruche-Makinde, Julia, Clement, Mathew, Cole, David K., Edwards, Emily S. J., Ladell, Kristin, Miles, John J., Matthews, Katherine K., Fuller, Anna, Lloyd, Katy A., Madura, Florian, Dolton, Garry M., Pentier, Johanne, Lissina, Anna, Gostick, Emma, Baxter, Tiffany K., Baker, Brian M., Rizkallah, Pierre J., Price, David A., Wooldridge, Linda and Sewell, Andrew K. 2012. T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting. Journal of Biological Chemistry 287 (44) , pp. 37269-37281. 10.1074/jbc.M112.386409

Ekeruche, Julia, Clement, Mathew, Cole, David, Edwards, Emily S. J., Ladell, Kristin Ingrid, Miles, John James, Matthews, Katherine K., Fuller, Anna, Lloyd, Katy A., Madura, Florian, Dolton, Garry Michael, Pentier, Johanne, Lissina, Anna, Gostick, Emma, Baxter, Tiffany K., Baker, Brian M., Rizkallah, Pierre, Price, David, Wooldridge, Linda and Sewell, Andrew K. 2012. T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting. Journal of Biological Chemistry 287 (44) , pp. 37269-37281. 10.1074/jbc.M112.386409

Liddy, Nathaniel, Bossi, Giovanna, Adams, Katherine J., Lissina, Anna, Mahon, Tara M., Hassan, Namir J., Gavarret, Jessie, Bianchi, Frayne C., Pumphrey, Nicholas J., Ladell, Kristin Ingrid, Gostick, Emma, Sewell, Andrew K., Lissin, Nikolai M., Harwood, Naomi E., Molloy, Peter E., Li, Yi, Cameron, Brian J., Sami, Malkit, Baston, Emma E., Todorov, Penio T., Paston, Samantha J., Dennis, Rebecca E., Harper, Jane V., Dunn, Steve M., Ashfield, Rebecca, Johnson, Andy, McGrath, Yvonne, Plesa, Gabriela, June, Carl H., Kalos, Michael, Price, David, Vuidepot, Annelise, Williams, Daniel D., Sutton, Deborah H. and Jakobsen, Bent K 2012. Monoclonal TCR-redirected tumor cell killing. Nature Medicine 18 (6) , pp. 980-987. 10.1038/nm.2764

Cole, David, Gallagher, Kathleen, Lemercier, Brigitte, Holland, Christopher J., Junaid, Sayed, Hindley, James Phillip, Wynn, Katherine Kay, Gostick, Emma, Sewell, Andrew K., Gallimore, Awen Myfanwy, Ladell, Kristin Ingrid, Price, David, Gougeon, Marie-Lise and Godkin, Andrew James 2012. Modification of the carboxy-terminal flanking region of a universal influenza epitope alters CD4+ T-cell repertoire selection. Nature Communications 3 , 665. 10.1038/ncomms1665

Doherty, T. Mark, Antrobus, Richard D., Lillie, Patrick J., Berthoud, Tamara K., Spencer, Alexandra J., McLaren, James E., Ladell, Kristin Ingrid, Lambe, Teresa, Milicic, Anita, Price, David, Hill, Adrian V. S. and Gilbert, Sarah C. 2012. A T Cell-inducing influenza vaccine for the elderly: safety and immunogenicity of MVA-NP+M1 in adults aged over 50 years. PLoS ONE 7 (10) , e48322. 10.1371/journal.pone.0048322

Clement, Mathew, Ladell, Kristin Ingrid, Ekeruche, Julia, Miles, John James, Edwards, Emily, Dolton, Garry Michael, Williams, Tamsin, Schauenburg, Andrea J. A., Cole, David, Lauder, Sarah Nicol, Gallimore, Awen Myfanwy, Godkin, Andrew James, Burrows, Scott R., Price, David, Sewell, Andrew K. and Wooldridge, Linda 2011. Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining. The Journal of Immunology 187 (2) , pp. 654-663. 10.4049/jimmunol.1003941

Kreutzman, A., Ladell, Kristin Ingrid, Koechel, C., Gostick, Emma, Ekblom, M., Stenke, L., Melo, T., Einsele, H., Porkka, K., Price, David, Mustjoki, S. and Seggewiss, R. 2011. Expansion of highly differentiated CD8+ T-cells or NK-cells in patients treated with dasatinib is associated with cytomegalovirus reactivation. Leukemia 25 (10) , pp. 1587-1597. 10.1038/leu.2011.135

Hindley, James Philip, Ferreira, Cristina, Jones, Emma, Lauder, Sarah Nicol, Ladell, Kristin, Wynn, Katherine, Betts, Gareth James, Singh, Yogesh, Price, David, Godkin, Andrew James, Dyson, Julian and Gallimore, Awen Myfanwy 2011. Analysis of the T-cell receptor repertoires of tumor-infiltrating conventional and regulatory T cells reveals no evidence for conversion in carcinogen-induced tumors. Cancer Research 71 (3) , pp. 736-746. 10.1158/0008-5472.CAN-10-1797

van Bockel, David J., Price, David, Munier, Mee Ling, Venturi, Vanessa, Asher, Tedi E., Ladell, Kristin Ingrid, Greenaway, Hui Yee, Zaunders, John, Douek, Daniel C., Cooper, David A., Davenport, Miles P. and Kelleher, Anthony D. 2010. Persistent survival of prevalent clonotypes within an immunodominant HIV gag-specific CD8+ T cell response. The Journal of Immunology 186 (1) , pp. 359-371. 10.4049/jimmunol.1001807

Jones, Morgan, Ladell, Kristin Ingrid, Wynn, Katherine, Stacey, Maria A., Quigley, Maire F., Gostick, Emma, Price, David and Humphreys, Ian R. 2010. IL-10 restricts memory T cell inflation during cytomegalovirus infection. The Journal of Immunology 185 (6) , pp. 3583-3592. 10.4049/jimmunol.1001535

Cole, David, Edwards, Emily, Wynn, Katherine, Clement, Mathew, Miles, John James, Ladell, Kristin Ingrid, Ekeruche, Julia, Gostick, Emma, Adams, Katherine J., Skowera, Ania, Peakman, Mark, Wooldridge, Linda, Price, David A. and Sewell, Andrew K. 2010. Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognition. The Journal of Immunology 185 (4) , pp. 2600-2610. 10.4049/jimmunol.1000629

Wooldridge, Linda, Clement, Mathew, Lissina, Anna, Edwards, Emily, Ladell, Kristin Ingrid, Ekeruche, Julia, Hewitt, R. E., Laugel, Bruno Frederic, Gostick, Emma, Cole, David, Debets, R., Berrevoets, C., Miles, John James, Burrows, S. R., Price, David A. and Sewell, Andrew K. 2010. MHC Class I molecules with superenhanced CD8 binding properties bypass the requirement for cognate TCR recognition and nonspecifically activate CTLs. Journal of Immunology 184 (7) , pp. 3357-3366. 10.4049/jimmunol.0902398

Van Tendeloo, V. F., Van de Velde, A., Van Driessche, A., Cools, N., Anguille, S., Ladell, Kristin Ingrid, Gostick, Emma, Vermeulen, K., Pieters, K., Nijs, G., Stein, B., Smits, E. L., Schroyens, W. A., Gadisseur, A. P., Vrelust, I., Jorens, P. G., Goossens, H., de Vries, I. J., Price, David A., Oji, Y., Oka, Y., Sugiyama, H. and Berneman, Z. N. 2010. Induction of complete and molecular remissions in acute myeloid leukemia by Wilms' tumor 1 antigen-targeted dendritic cell vaccination. Proceedings of the National Academy of Sciences of the United States of America 107 (31) , pp. 13824-13829. 10.1073/pnas.1008051107

Harris, L. D., Klatt, N. R., Vinton, C., Briant, J. A., Tabb, B., Ladell, Kristin Ingrid, Lifson, Jeffrey, Estes, J. D., Price, David, Hirsch, V. M. and Brenchley, J. M. 2010. Mechanisms underlying γδ T-cell subset perturbations in SIV-infected Asian rhesus macaques. Blood 116 (20) , pp. 4148-4157. 10.1182/blood-2010-05-283549

Subramanya, Sandesh, Armant, Myriam, Salkowitz, Janelle R., Nyakeriga, Alice M., Haridas, Viraga, Hasan, Maroof, Bansal, Anju, Goepfert, Paul A., Wynn, Katherine, Ladell, Kristin Ingrid, Price, David, N, Manjunath, Kan-Mitchell, June and Shankar, Premlata 2010. Enhanced induction of HIV-specific Cytotoxic T Lymphocytes by Dendritic cell-targeted delivery of SOCS-1 siRNA. Molecular Therapy 18 (11) , pp. 2028-2037. 10.1038/mt.2010.148

Melenhorst, J. Joseph, Scheinberg, Phillip, Chattopadhyay, Pratip K., Gostick, Emma, Ladell, Kristin Ingrid, Roederer, Mario, Hensel, Nancy F., Douek, Daniel C., Barrett, A. John and Price, David 2009. High avidity myeloid leukemia-associated antigen-specific CD8+ T cells preferentially reside in the bone marrow. Blood 113 (10) , pp. 2238-2244. 10.1182/blood-2008-04-151969

Lissina, Anna, Ladell, Kristin Ingrid, Skowera, Ania, Clement, Mathew, Edwards, Emily, Seggewiss, Ruth, van den Berg, Hugo A., Gostick, Emma, Gallagher, Kathleen, Jones, Emma, Melenhorst, J. Joseph, Godkin, Andrew James, Peakman, Mark, Price, David, Sewell, Andrew K. and Wooldridge, Linda 2009. Protein kinase inhibitors substantially improve the physical detection of T-cells with peptide-MHC tetramers. Journal of Immunological Methods 340 (1) , pp. 11-24. 10.1016/j.jim.2008.09.014

Venturi, Vanessa, Chin, Hui Yee, Tedi, E. Asher, Ladell, Kristin Ingrid, Scheinberg, Phillip, Bornstein, Ethan, van Bockel, David, Kelleher, Anthony D., Douek, Daniel C., Price, David A. and Davenport, Miles P. 2008. TCR β-Chain sharing in human CD8+ T cell responses to cytomegalovirus and EBV. Journal of Immunology 181 (11) , pp. 7853-7862. 10.4049/​jimmunol.181.11.7853

Ladell, Kristin Ingrid, Hellerstein, M. K., Cesar, D., Busch, R., Boban, D. and McCune, J. M. 2008. Central memory CD8+ T cells appear to have a shorter lifespan and reduced abundance as a function of HIV disease progression. The Journal of Immunology 180 (12) , pp. 7907-7918. 10.4049/jimmunol.180.12.7907

Chattopadhyay, Pratip K., Melenhorst, J. Joseph, Ladell, Kristin Ingrid, Gostick, Emma, Scheinberg, Phillip, Barrett, A. John, Wooldridge, Linda, Roederer, Mario, Sewell, Andrew K. and Price, David A. 2008. Techniques to improve the direct ex vivo detection of low frequency antigen-specific CD8+T cells with peptide-major histocompatibility complex class I tetramers. Cytometry Part A 73A (11) , pp. 1001-1009. 10.1002/cyto.a.20642

Ladell, Kristin, Dorner, Marcus, Zauner, Ludwig, Berger, Christoph, Zucol, Franziska, Bernasconi, Michele, Niggli, Felix K., Speck, Roberto F. and Nadal, David 2007. Immune activation suppresses initiation of lytic Epstein-Barr virus infection. Cellular Microbiology 9 (8) , p. 2055. 10.1111/j.1462-5822.2007.00937.x

Giger, Bettina, Bonanomi, Athos, Odermatt, Bernhard, Ladell, Kristin Ingrid, Speck, Roberto F, Kojic, Dejan, Berger, Christoph, Niggli, Felix K and Nadal, David 2004. Human tonsillar tissue block cultures differ from autologous tonsillar cell suspension cultures in lymphocyte subset activation and cytokine gene expression. Journal of Immunological Methods 289 (1-2) , pp. 179-190. 10.1016/j.jim.2004.04.015

Keyser, Johanna, Schultz, Jan, Ladell, Kristin Ingrid, Elzaouk, Lina, Heinzerling, Lucie, Pavlovic, Jovan and Moelling, Karin 2004. IP-10-encoding plasmid DNA therapy exhibits anti-tumor and anti-metastatic efficiency. Experimental Dermatology 13 (6) , pp. 380-390. 10.1111/j.0906-6705.2004.00191.x

Ladell, Kristin Ingrid, Heinrich, J., Schweneker, M. and Moelling, K. 2003. A combination of plasmid DNAs encoding murine fetal liver kinase 1 extracellular domain, murine interleukin-12, and murine interferon-y inducible protein-10 leads to tumor regression and survival in melanoma-bearing mice. Journal of Molecular Medicine 81 (4) , pp. 271-278. 10.1007/s00109-003-0425-z