ORCA
Online Research @ Cardiff
Browse by Current Cardiff authors
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Number of items: 13.
Bassetto, Marcella and Slusarczyk, Magdalena
2019.
Therapeutic use of fluorinated nucleosides – progress in patents.
Pharmaceutical Patent Analyst
7
(6)
, p. 277.
10.4155/ppa-2018-0028
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Slusarczyk, Magdalena, Ferrari, Valentina, Serpi, Michaela, Gonczy, Blanka, Balzarini, Jan and McGuigan, Christopher
2018.
Symmetrical diamidates as a class of phosphate prodrugs to deliver the 5'-monophosphate form of anticancer nucleoside analogues.
ChemMedChem
13
(21)
, pp. 2305-2316.
10.1002/cmdc.201800504
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Slusarczyk, Magdalena, Serpi, Michaela and Pertusati, Fabrizio
2018.
Phosphoramidates and phosphonamidates (ProTides) with antiviral activity.
Antiviral Chemistry and Chemotherapy
26
, pp. 1-31.
10.1177/2040206618775243
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| Slusarczyk, Magdalena, Ferla, Salvatore, Brancale, Andrea and McGuigan, Christopher 2018. Synthesis and biological evaluation of 6-substituted-5-fluorouridine ProTides. Bioorganic and Medicinal Chemistry 26 (3) , pp. 551-565. 10.1016/j.bmc.2017.11.037 |
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| Cavaliere, Alessandra, Probst, Katrin, Westwell, Andrew and Slusarczyk, Magdalena 2017. Fluorinated nucleosides as an important class of anticancer and antiviral agents. Future Medicinal Chemistry 9 (15) |
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| Serpi, Michaela, De Biasi, Roberto, Pertusati, Fabrizio, Slusarczyk, Magdalena and McGuigan, Christopher 2017. Synthetic approaches for the preparation of phosphoramidate prodrugs of 2’-deoxypseudoisocytidine. ChemistryOpen 6 (3) , pp. 424-436. 10.1002/open.201700019 |
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McGuigan, Christopher, Serpi, Michaela, Slusarczyk, Magdalena, Ferrari, Valentina, Pertusati, Fabrizio, Meneghesso, Silvia, Derudas, Marco, Farleigh, Laura, Zanetta, Paola and Bugert, Joachim
2016.
Anti-flavivirus activity of different tritylated pyrimidine and purine nucleoside analogues.
ChemistryOpen
5
(3)
, pp. 227-235.
10.1002/open.201500216
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Slusarczyk, Magdalena, Huerta Lopez, Monica, Balzarini, Jan, Mason, Malcolm, Jiang, Wen G., Blagden, Sarah, Thompson, Emely, Ghazaly, Essam and McGuigan, Christopher
2014.
Application of ProTide technology to Gemcitabine: A successful approach to overcome the key cancer resistance mechanisms leads to a new agent (NUC-1031) in clinical development.
Journal of Medicinal Chemistry
57
(4)
, pp. 1531-1542.
10.1021/jm401853a
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| McGuigan, Christopher, Bourdin, Claire, Derudas, Marco, Hamon, Nadege, Hinsinger, Karen, Kandil, Sahar, Madela, Karolina, Meneghesso, Silvia, Pertusati, Fabrizio, Serpi, Michaela, Slusarczyk, Magdalena, Chamberlain, Stanley, Kolykhalov, Alexander, Vernachio, John, Vanpouille, Christophe, Introini, Andrea, Margolis, Leonid and Balzarini, Jan 2013. Design, synthesis and biological evaluation of phosphorodiamidate prodrugs of antiviral and anticancer nucleosides. European Journal of Medicinal Chemistry 70 , pp. 326-340. 10.1016/j.ejmech.2013.09.047 |
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| Ghazaly, Essam Ahmed, Joel, Simon, Gribben, John G., Mohammad, Tariq, Emiloju, Oluwadunni, Stavraka, Chara, Hopkins, Tom, Gabra, Hani, Wasan, Harpreet, Habib, Nagy A., Leonard, Robert C. F., McGuigan, Christopher, Slusarczyk, Magdalena and Blagden, Sarah Patricia 2013. ProGem1: Phase I first-in-human study of the novel nucleotide NUC-1031 in adult patients with advanced solid tumors [Abstract]. Journal of Clinical Oncology 31 (15) , abstr. 2576. |
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| McGuigan, Christopher, Murziani, Paola, Slusarczyk, Magdalena, Gonczy, Blanka, Vande Voorde, Johan, Liekens, Sandra and Balzarini, Jan 2011. Phosphoramidate ProTides of the anticancer agent FUDR successfully deliver the preformed bioactive monophosphate in cells and confer advantage over the parent nucleoside. Journal of Medicinal Chemistry 54 (20) , pp. 7247-7258. 10.1021/jm200815w |
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| Voorde, J. V., Liekens, S., McGuigan, Christopher, Murziani, Paola G. S., Slusarczyk, Magdalena and Balzarini, J. 2011. The cytostatic activity of NUC-3073, a phosphoramidate prodrug of 5-fluoro-2 '-deoxyuridine, is independent of activation by thymidine kinase and insensitive to degradation by phosphorolytic enzymes. Biochemical Pharmacology 82 (5) , pp. 441-452. 10.1016/j.bcp.2011.05.024 |
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| Slusarczyk, Magdalena, De Borggraeve, Wim M., Hoornaert, Georges, Deroose, Frederik and Linders, Joannes T. M. 2008. Synthesis and biological evaluation of methylene-bridged analogs of the potent cannabinoid receptor antagonist rimonabant. European Journal of Organic Chemistry 2008 (8) , pp. 1350-1357. 10.1002/ejoc.200700960 |
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