ORCA
Online Research @ CardiffÂ
Browse by Current Cardiff authors
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Number of items: 16.
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Kandil, Sahar, Pannecouque, Christophe, Chapman, Fiona M., Westwell, Andrew D. and McGuigan, Christopher
2019.
Polyfluoroaromatic stavudine (d4T) ProTides exhibit enhanced anti-HIV activity.
Bioorganic and Medicinal Chemistry Letters
29
(24)
, 126721.
10.1016/j.bmcl.2019.126721
Item availability restricted. |
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| Pertusati, Fabrizio, Ferla, Salvatore, Bassetto, Marcella, Brancale, Andrea, Kandil, Sahar, Westwell, Andrew D. and McGuigan, Christopher 2019. A new series of bicalutamide, enzalutamide and enobosarm derivatives carrying pentafluorosulfanyl (SF5) and pentafluoroethyl (C2F5) substituents: Improved antiproliferative agents against prostate cancer. European Journal of Medicinal Chemistry 180 , pp. 1-14. 10.1016/j.ejmech.2019.07.001 |
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| Kandil, Sahar, Lee, Kok Yung, Davies, Laurie, Rizzo, Sebastiano A., Dart, D. Alwyn and Westwell, Andrew D. 2019. Discovery of deshydroxy bicalutamide derivatives as androgen receptor antagonists. European Journal of Medicinal Chemistry 167 , pp. 49-60. 10.1016/j.ejmech.2019.01.054 |
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Dart, D. Alwyn, Kandil, Sahar, Tommasini-Ghelfi, Serena, Almeida, Gilberto Serrano de, Bevan, Charlotte L., Jiang, Wen Guo and Westwell, Andrew
2018.
Novel trifluoromethylated enobosarm analogues with potent antiandrogenic activity in vitro and tissue selectivity in vivo.
Molecular Cancer Therapeutics
17
(9)
, pp. 1846-1858.
10.1158/1535-7163.MCT-18-0037
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| Kandil, Sahar, Prencipe, Filippo, Jones, Samuel, Hiscox, Stephen and Westwell, Andrew D. 2018. The discovery of new and more potent chloropyramine (C4) analogues for the potential treatment of invasive breast cancer. Chemical Biology and Drug Design 91 (1) , pp. 314-321. 10.1111/cbdd.13083 |
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| Kandil, Sahar, Balzarini, Jan, Rat, Stephanie, Brancale, Andrea, Westwell, Andrew D. and McGuigan, Christopher 2016. ProTides of BVdU as potential anticancer agents upon efficient intracellular delivery of their activated metabolites. Biorganic and Medicinal Chemistry Letters 26 (23) , pp. 5618-5623. 10.1016/j.bmcl.2016.10.077 |
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Bassetto, Marcella, Ferla, Salvatore, Pertusati, Fabrizio, Kandil, Sahar, Westwell, Andrew, Brancale, Andrea and McGuigan, Christopher
2016.
Design and synthesis of novel bicalutamide and enzalutamide derivatives as antiproliferative agents for the treatment of prostate cancer.
European Journal of Medicinal Chemistry
118
, pp. 230-243.
10.1016/j.ejmech.2016.04.052
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Ferla, Salvatore, Bassetto, Marcella, Pertusati, Fabrizio, Kandil, Sahar, Westwell, Andrew D., Brancale, Andrea and McGuigan, Christopher
2016.
Rational design and synthesis of novel anti-prostate cancer agents bearing a 3,5-bis-trifluoromethylphenyl moiety.
Bioorganic and Medicinal Chemistry Letters
26
(15)
, pp. 3636-3640.
10.1016/j.bmcl.2016.06.001
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| Kandil, Sahar, Wymant, Jennifer, Kariuki, Benson, Jones, Arwyn Tomos, McGuigan, Christopher and Westwell, Andrew David 2016. Novel cis-selective and non-epimerisable C3 hydroxy azapodophyllotoxins targeting microtubules in cancer cells. European Journal of Medicinal Chemistry 110 , pp. 311-325. 10.1016/j.ejmech.2015.12.037 |
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| Kandil, Sahar, Westwell, Andrew D. and McGuigan, Christopher 2016. 7-Substituted umbelliferone derivatives as androgen receptor antagonists for the potential treatment of prostate and breast cancer. Biorganic and Medicinal Chemistry Letters 26 (8) , pp. 2000-2004. 10.1016/j.bmcl.2016.02.088 |
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McGuigan, Christopher, Derudas, Marco, Gonczy, Blanka, Hinsinger, Karen, Kandil, Sahar, Pertusati, Fabrizio, Serpi, Michaela, Snoeck, Robert, Andrei, Graciela, Balzarini, Jan, McHugh, Timothy D., Maitra, Arundhati, Akorli, Ernest, Evangelopoulos, Dimitrios and Bhakta, Sanjib
2014.
ProTides of N-(3-(5-(2'-deoxyuridine))prop-2-ynyl)octanamide as potential anti-tubercular and anti-viral agents.
Bioorganic and Medicinal Chemistry
22
(9)
, pp. 2816-2824.
10.1016/j.bmc.2014.02.056
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| McGuigan, Christopher, Bourdin, Claire, Derudas, Marco, Hamon, Nadege, Hinsinger, Karen, Kandil, Sahar, Madela, Karolina, Meneghesso, Silvia, Pertusati, Fabrizio, Serpi, Michaela, Slusarczyk, Magdalena, Chamberlain, Stanley, Kolykhalov, Alexander, Vernachio, John, Vanpouille, Christophe, Introini, Andrea, Margolis, Leonid and Balzarini, Jan 2013. Design, synthesis and biological evaluation of phosphorodiamidate prodrugs of antiviral and anticancer nucleosides. European Journal of Medicinal Chemistry 70 , pp. 326-340. 10.1016/j.ejmech.2013.09.047 |
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| Kandil, Sahar, Biondaro, Sonia, Vlachakis, Dimitrios, Cummins, Anna-Claire, Coluccia, Antonio, Berry, Colin, Leyssen, Pieter, Neyts, Johan and Brancale, Andrea 2009. Discovery of a novel HCV helicase inhibitor by a de novo drug design approach. Bioorganic & Medicinal Chemistry Letters 19 (11) , pp. 2935-2937. 10.1016/j.bmcl.2009.04.074 |
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| Kandil, Sahar 2009. Computer aided drug design. PhD Thesis, Cardiff University. |
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| Romagnoli, R., Baraldi, P. G., Carrion, M. D., Cruz-Lopez, O., Cara, C. L., Tolomeo, M., Grimaudo, S., Di Cristina, A., Pipitone, M. R., Balzarini, J., Kandil, Sahar, Brancale, Andrea, Sarkar, T. and Hamel, E. 2008. Synthesis and biological evaluation of 2-amino-3-(3 ',4 ',5 '-trimethoxybenzoyl)-6-substituted-4,5,6,7-tetrahydrothieno 2,3-c pyridi ne derivatives as antimitotic agents and inhibitors of tubulin polymerization. Bioorganic & Medicinal Chemistry Letters 18 (18) , pp. 5041-5045. 10.1016/j.bmcl.2008.08.006 |
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| La Regina, G., Edler, M. C., Brancale, Andrea, Kandil, Sahar, Coluccia, A., Piscitelli, F., Hamel, E., De Martino, G., Matesanz, R., Diaz, J. F., Scovassi, A. I., Prosperi, E., Lavecchia, A., Novellino, E., Artico, M. and Silvestri, R. 2007. Arylthioindole inhibitors of tubulin polymerization. 3. Biological evaluation, structure-activity relationships and molecular modeling studies. Journal of Medicinal Chemistry 50 (12) , pp. 2865-2874. 10.1021/jm061479u |
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