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Number of items: 37.

Haiyan, An and Shelkovnikova, Tatyana A 2019. Stress granules regulate paraspeckles: RNP granule continuum at work. Cell Stress

Serio, Tricia R., Park, Sangeun, Park, Sei-Kyoung, Watanabe, Naruaki, Hashimoto, Tadafumi, Iwatsubo, Takeshi, Shelkovnikova, Tatyana A. and Liebman, Susan W. 2019. Calcium-responsive transactivator (CREST) toxicity is rescued by loss of PBP1/ATXN2 function in a novel yeast proteinopathy model and in transgenic flies. PLoS Genetics 15 (8) , e1008308. 10.1371/journal.pgen.1008308

An, Haiyan, Skelt, Lucy, Notaro, Antonietta, Highley, J Robin, Fox, Archa H, La Bella, Vincenzo, Buchman, Vladimir and Shelkovnikova, Tatyana A 2019. ALS-linked FUS mutations confer loss and gain of function in the nucleus by promoting excessive formation of dysfunctional paraspeckles. Acta Neuropathologica Communications 7 , 7. 10.1186/s40478-019-0658-x

Shelkovnikova, Tatyana, An, Haiyan, Skelt, Lucy, Tregoning, John S, Humphreys, Ian R and Buchman, Vladimir L 2019. Antiviral immune response as a trigger of FUS proteinopathy in amyotrophic lateral sclerosis. Cell Reports

An, Haiyan, Tan, Jing Tong and Shelkovnikova, Tatyana A. 2019. Stress granules regulate stress-induced paraspeckle assembly. Journal of Cell Biology 218 (12) , pp. 4127-4140. 10.1083/jcb.201904098

An, Haiyan, Williams, Non G and Shelkovnikova, Tatyana A. 2018. NEAT1 and paraspeckles in neurodegenerative diseases: A missing lnc found? Non-coding RNA Research 3 (4) , pp. 243-252. 10.1016/j.ncrna.2018.11.003

Shelkovnikova, Tatyana, Kukharsky, Michail S., An, Haiyan, Dimasi, Pasquale, Alexeeva, Svetlana, Shabir, Osman, Heath, Paul R. and Buchman, Vladimir 2018. Protective paraspeckle hyper-assembly downstream of TDP-43 loss of function in amyotrophic lateral sclerosis. Molecular Neurodegeneration 13 , 30. 10.1186/s13024-018-0263-7

Dimasi, Pasquale, Quintiero, Annamaria, Shelkovnikova, Tatyana and Buchman, Vladimir L. 2017. Modulation of p-eIF2α cellular levels and stress granule assembly/disassembly by trehalose. Scientific Reports 7 , 44088. 10.1038/srep44088

Shelkovnikova, Tatyana, Dimasi, Pasquale, Kukharsky, Michail, An, Haiyan, Quintiero, Annamaria, Schirmer, Claire, Buée, Luc, Galas, Marie-Christine and Buchman, Vladimir 2017. Chronically stressed or stress-preconditioned neurons fail to maintain stress granule assembly. Cell Death and Disease 8 , e2788. 10.1038/cddis.2017.199

Scekic-Zahirovic, Jelena, Sendscheid, Oliver, El Oussini, Hajer, Jambeau, Mélanie, Sun, Ying, Mersmann, Sina, Wagner, Marina, Dieterle, Stéphane, Sinniger, Jerome, Dirrig-Grosch, Sylvie, Drenner, Kevin, Birling, Marie‐Christine, Qiu, Jinsong, Zhou, Yu, Li, Hairi, Fu, Xiang‐Dong, Rouaux, Caroline, Shelkovnikova, Tatyana, Witting, Anke, Ludolph, Albert C., Kiefer, Friedemann, Storkebaum, Erik, Lagier-Tourenne, Clotilde and Dupuis, Luc 2016. Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss. EMBO Journal 35 (10) , pp. 1077-1097. 10.15252/embj.201592559

Van De Pette, Matthew, Tunster, Simon James, McNamara, Grainne, Shelkovnikova, Tatyana, Millership, Steven, Benson, Lindsay, Peirson, Stuart, Christian, Mark, Vidal-Puig, Antonio and John, Rosalind Margaret 2016. Cdkn1c boosts the development of brown adipose tissue in a murine model of Silver Russell Syndrome. PLoS Genetics 12 (3) , e1005916. 10.1371/journal.pgen.1005916

Ninkina, Natalia, Connor-Robson, Natalie, Ustyugov, Alexey A., Tarasova, Tatiana, Shelkovnikova, Tatyana and Buchman, Vladimir L. 2015. A novel resource for studying function and dysfunction of α-synuclein: mouse lines for modulation of endogenous Snca gene expression. Scientific Reports 5 , 16615. 10.1038/srep16615

Kukharsky, Michail S, Quintiero, Annamaria, Matsumoto, Taisei, Matsukawa, Koji, An, Haiyan, Hashimoto, Tadafumi, Iwatsubo, Takeshi, Buchman, Vladimir L. and Shelkovnikova, Tatyana 2015. Calcium-responsive transactivator (CREST) protein shares a set of structural and functional traits with other proteins associated with amyotrophic lateral sclerosis. Molecular Neurodegeneration 10 , 20. 10.1186/s13024-015-0014-y

Peters, Owen Morgan, Shelkovnikova, Tatyana, Highley, John Robin, Cooper-Knock, Johnathan, Hortobágyi, Tibor, Troakes, Claire, Ninkina, Natalia and Buchman, Vladimir L. 2015. Gamma-synuclein pathology in amyotrophic lateral sclerosis. Annals of Clinical and Translational Neurology 2 (1) , pp. 29-37. 10.1002/acn3.143

Robinson, Hannah, Deykin, Alexey V., Bronovitsky, Evgeny V., Ovchinnikov, Ruslan K., Ustyugov, Alexey A., Shelkovnikova, Tatyana, Kukharsky, Michail S., Ermolkevich, Tatyana G., Goldman, Igor L., Sadchikova, Elena R., Kovrazhkina, Elena A., Bachurin, Sergey O., Buchman, Vladimir L. and Ninkina, Natalia 2015. Early lethality and neuronal proteinopathy in mice expressing cytoplasm-targeted FUS that lacks the RNA recognition motif. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 16 (5-6) , pp. 402-409. 10.3109/21678421.2015.1040994

Shelkovnikova, Tatyana, Robinson, Hannah, Southcombe, Joshua, Ninkina, Natalia and Buchman, Vladimir L. 2014. Multistep process of FUS aggregation in the cell cytoplasm involves RNA-dependent and RNA-independent mechanisms. Human Molecular Genetics 23 (19) , pp. 5211-5226. 10.1093/hmg/ddu243

Shelkovnikova, Tatyana, Robinson, Hannah, Troakes, C., Ninkina, Natalia and Buchman, Vladimir 2014. Compromised paraspeckle formation as a pathogenic factor in FUSopathies. Human Molecular Genetics 23 (9) , pp. 2298-2312. 10.1093/hmg/ddt622

Shelkovnikova, Tatyana, Ustiugov, A. A., Kokhan, V. S., Tarasova, T. V., Medvedeva, V. K., Khritankova, I. V., Bahcurin, S. O. and Ninkina, Natalia 2014. Study into molecular targets of a neuroprotective compound dimebon using a transgenic mice line. Biomeditsinskaia khimiia 60 (3) , pp. 354-363.

Deikin, A V, Kovrazhkina, E A, Ovchinnikov, R K, Bronovitskii, E V, Razinskia, O D, Smirnov, A P, Ermolkevich, T G, Eliakov, A B, Popov, A N, Fedorov, E N, Lytkina, O A, Kukharskii, M S, Tarasova, T V, Shelkovnikova, Tatyana A., Ustiugov, A A, Ninkina, Natalia, Gol'dman, I L, Sadchikova, E R, Baruchin, S O and Skvortsova, V I 2014. A mice model of amyotrophic lateral sclerosis expressing mutant human FUS protein. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 114 (8) , pp. 62-69.

Shelkovnikova, Tatyana A. 2013. Modelling FUSopathies: focus on protein aggregation. Biochemical Society Transactions 41 (6) , pp. 1613-1617. 10.1042/BST20130212

Shelkovnikova, Tatyana, Robinson, Hannah, Connor-Robson, Natalie and Buchman, Vladimir L. 2013. Recruitment into stress granules prevents irreversible aggregation of FUS protein mislocalized to the cytoplasm. Cell Cycle 12 (19) , pp. 3194-3202. 10.4161/cc.26241

Shelkovnikova, Tatyana, Peters, Owen Morgan, Deykin, Alexey V., Connor-Robson, Natalie, Robinson, Hannah, Ustyugov, Aleksey, Bachurin, Sergey O., Ermolkevich, Tatyana G., Goldman, Igor L., Sadchikova, Elena R., Kovrazhkina, Elena A., Skvortsova, Veronica I., Ling, Shuo-Chien, Da Cruz, Sandrine, Parone, Philippe A., Buchman, Vladimir L. and Ninkina, Natalia 2013. Fused in sarcoma (FUS) protein lacking nuclear localization signal (NLS) and major RNA binding motifs triggers proteinopathy and severe motor phenotype in transgenic mice. Journal of Biological Chemistry 288 (35) , pp. 25266-25274. 10.1074/jbc.M113.492017

Peters, Owen Morgan, Shelkovnikova, Tatyana, Tarasova, Tatiana, Springe, Signe, Kukharsky, Michail S., Smith, Gaynor A., Brooks, Simon Philip, Kozin, Sergey A., Kotelevtsev, Yury, Bachurin, Sergey O., Ninkina, Natalia and Buchman, Vladimir L. 2013. Chronic administration of dimebon does not ameliorate amyloid-β pathology in 5xFAD transgenic mice. Journal of Alzheimer's Disease 36 (3) , pp. 589-596. 10.3233/JAD-130071

Bachurin, S.O, Ninkina, Natalia, Tarasova, T.V, Shelkovnikova, Tatyana, Kovrazhkina, E.A, Smirnov, A.P, Razinskaya, O and Skvortsova, V.I 2013. Modeling of lateral amyotrophic sclerosis: A non-genetic method. Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova 113 (9) , pp. 86-89.

Kokhan, V. S., Van'kin, G. I., Ninkina, Natalia, Shelkovnikova, Tatyana and Bachurin, S. O. 2012. Impaired spatial and working memory in ageing mice with targeted inactivation of α-synuclein gene. Doklady Biological Sciences 441 (1) , pp. 354-356. 10.1134/S0012496611060081

Peters, Owen Morgan, Millership, Steven, Shelkovnikova, Tatyana, Soto, Ileana, Keeling, Lora, Hann, Anthona, Marsh-Armstrong, Nicholas, Buchman, Vladimir L. and Ninkina, Natalia 2012. Selective pattern of motor system damage in gamma-synuclein transgenic mice mirrors the respective pathology in amyotrophic lateral sclerosis. Neurobiology of Disease 48 (1) , pp. 124-131. 10.1016/j.nbd.2012.06.016

Shelkovnikova, Tatyana, Ninkina, Natalia and Buchman, Vladimir L. 2012. In Vivo properties of mutant FUS variants. Febs Journal 279 (Supp1) , p. 446. 10.1111/j.1742-4658.2010.08705.x

Kokhan, V. S., Bolkunov, A. V., Ustiugov, A. A., Van'kin, G. I., Shelkovnikova, Tatyana, Redkozubova, O. M., Strekalova, T. V., Buchman, Vladimir L., Ninkina, Natalia and Bachurin, S. O. 2012. Targeted inactivation of the gene encoding gamma-synuclein affects anxiety levels and investigative activity in mice. Neuroscience and Behavioral Physiology 42 (6) , pp. 575-581. 10.1007/s11055-012-9603-1

Bachurin, Sergey O., Shelkovnikova, Tatyana, Ustyugov, Alexey A., Peters, Owen Morgan, Khritankova, Ina, Afanasieva, Marina A., Tarasova, Tatyana V., Alentov, Igor I., Buchman, Vladimir L. and Ninkina, Natalia 2012. Dimebon slows progression of proteinopathy in γ-synuclein transgenic mice. Neurotoxicity Research 22 (1) , pp. 33-42. 10.1007/s12640-011-9299-y

Shelkovnikova, Tatyana, Kulikova, A.A., Tsvetkov, F.O., Peters, O., Bachurin, S.O., Bukhman, V.L. and Ninkina, N.N. 2012. [Proteinopathies--forms of neurodegenerative disorders with protein aggregation-based pathology]. Molekulyarnaya Biologiya 46 (3) , pp. 402-415.

Ustyugov, A. A., Shelkovnikova, Tatyana, Kokhan, V. S., Khritankova, I. V., Peters, Owen Morgan, Buchman, Vladimir L., Bachurin, S. O. and Ninkina, Natalia 2012. Dimebon reduces the levels of aggregated amyloidogenic protein forms in detergent-insoluble fractions in vivo. Bulletin of Experimental Biology and Medicine 152 (6) , pp. 731-733. 10.1007/s10517-012-1618-7

Shelkovnikova, Tatyana, Kulikova, A. A., Tsvetkov, Ph. O., Peters, Owen Morgan, Bachurin, S. O., Buchman, Vladimir L. and Ninkina, Natalia 2012. Proteinopathies, neurodegenerative disorders with protein aggregation-based pathology. Molecular Biology 46 (3) , pp. 362-374. 10.1134/S0026893312020161

Skrovtsova, V. I., Bachurin, S. O., Razinskaia, O. D., Smirnov, A. P., Kovrazhkina, E. A., Pochigaeva, K. I., Ninkina, Natalia, Shelkovnikova, Tatyana and Ustigiuov, A. A. 2011. New aspects of the pathogenesis of lateral amyotrophic sclerosis. Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova 111 (2) , pp. 4-9.

Shelkovnikova, Tatyana, Ustyugov, A. A., Smirnov, A. P., Skvortsova, V. I., Buchman, Vladimir L., Bachurin, S. O. and Ninkina, Natalia 2011. FUS gene mutations associated with familiar forms of amyotrophic lateral sclerosis affect cellular localization and aggregation properties of the encoded protein. Doklady Biochemistry and Biophysics 438 (1) , pp. 123-126. 10.1134/S1607672911030045

Shelkovnikova, Tatyana, Ustyugov, Alexey, Millership, Steven, Peters, Owen Morgan, Anichtchik, Oleg, Spillantini, Maria Grazia, Buchman, Vladimir L., Bachurin, Sergey and Ninkina, Natalia 2011. Dimebon does not ameliorate pathological changes caused by expression of truncated (1-120) human alpha-synuclein in dopaminergic neurons of transgenic mice. Neurodegenerative Diseases 8 (6) , pp. 430-437. 10.1159/000324989

Ninkina, Natalia and Shelkovnikova, Tatyana 2011. Targeted inactivation of gamma-synuclein gene affects anxiety and exploratory behaviour of mice. Zhurnal vysshe nervno deiatelnosti imeni I P Pavlova 6 (1) , pp. 85-93.

Bachurin, S. O., Ustyugov, A. A., Peters, O., Shelkovnikova, Tatyana, Buchman, Vladimir L. and Ninkina, Natalia 2009. Hindering of proteinopathy-induced neurodegeneration as a new mechanism of action for neuroprotectors and cognition enhancing compounds. Doklady Biochemistry and Biophysics 428 (1) , pp. 235-238. 10.1134/S1607672909050032

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