ORCA
Online Research @ Cardiff
Browse by Current Cardiff authors
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Number of items: 27.
| Ouaray, Zahra, Singh, Isha, Georgiadis, Millie M. and Richards, Nigel G. J. 2019. Building better enzymes: molecular basis of improved non-natural nucleobase incorporation by an evolved DNA polymerase. Protein Science 10.1002/pro.3762 |
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Zhu, Wen, Radadiya, Ashish, Bisson, Claudine, Wenzel, Sabine, Nordin, Brian E., Martínez-Márquez, Francisco, Imasaki, Tsuyoshi, Sedelnikova, Svetlana E., Coricello, Adriana, Baumann, Patrick, Berry, Alexandria H., Nomanbhoy, Tyzoon K., Kozarich, John W., Jin, Yi, Rice, David W., Takagi, Yuichiro and Richards, Nigel G. J.
2019.
High-resolution crystal structure of human asparagine synthetase enables analysis of inhibitor binding and selectivity.
Communications Biology
2
(1)
, 345.
10.1038/s42003-019-0587-z
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| Zhu, Wen, Reinhardt, Laurie A. and Richards, Nigel G. J. 2018. Second-shell hydrogen bond impacts transition-state structure in bacillus subtilis oxalate decarboxylase. Biochemistry 57 (24) , pp. 3425-3432. 10.1021/acs.biochem.8b00214 |
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| Waltho, Jonathan P, Jin, Yi, Molt Jr., Robert W., Pellegrini, Erika, Cliff, Matthew J, Bowler, Matthew W., Richards, Nigel G. J. and Blackburn, G. Michael 2017. Assessing the influence of mutation on GTPase transition states using x-ray crystallography, 19F NMR, and DFT approaches. Angewandte Chemie - International Edition 56 (33) , pp. 9732-9735. 10.1002/anie.201703074 |
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| Malhotra, Shashwat, Singh, Seema, Rana, Neha, Tomar, Shilpi, Bhatnagar, Priyanka, Gupta, Mohit, Singh, Suraj K., Singh, Brajendra K., Chhillar, Anil K., Prasad, Ashok K., Len, Christophe, Kumar, Pradeep, Gupta, Kailash C., Varma, Anjani J., Kuhad, Ramesh C., Sharma, Gainda L., Parmar, Virinder S. and Richards, Nigel 2017. Chemoenzymatic synthesis, nanotization and anti- aspergillus activity of optically enriched fluconazole analogues. Antimicrobial Agents and Chemotherapy 61 (8) , e00273-17. 10.1128/AAC.00273-17 |
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| Sheng, Xiang, Zhu, Wen, Huddleston, Jamison, Xiang, Dao Fen, Raushel, Frank M., Richards, Nigel G. J. and Himo, Fahmi 2017. A combined experimental-theoretical study of the ligW-catalyzed decarboxylation of 5-carboxyvanillate in the metabolic pathway for lignin degradation. ACS Catalysis 7 (8) , pp. 4968-4974. 10.1021/acscatal.7b01166 |
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| Richards, Nigel G. J. and Georgiadis, Millie M. 2017. Toward an expanded genome: structural and computational characterization of an artificially expanded genetic information system. Accounts of Chemical Research 50 (6) , pp. 1375-1382. 10.1021/acs.accounts.6b00655 |
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| Zhu, Wen and Richards, Nigel G. J. 2017. Biological functions controlled by manganese redox changes in mononuclear Mn-dependent enzymes. Essays in Biochemistry 61 (2) , pp. 259-270. 10.1042/EBC20160070 |
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| Blackburn, G. Michael, Cherfils, Jacqueline, Moss, Gerard P., Richards, Nigel G. J., Waltho, Jonathan P., Williams, Nicholas H. and Wittinghofer, Alfred 2017. How to name atoms in phosphates, polyphosphates, their derivatives and mimics, and transition state analogues for enzyme-catalysed phosphoryl transfer reactions (IUPAC Recommendations 2016). Pure and Applied Chemistry 89 (5) , pp. 653-675. 10.1515/pac-2016-0202 |
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| Molt, Robert, Georgiadis, Millie M. and Richards, Nigel G. J. 2017. Consecutive non-natural PZ nucleobase pairs in DNA impact helical structure as seen in 50 μs molecular dynamics simulations. Nucleic Acids Research 45 (7) , pp. 3643-3653. 10.1093/nar/gkx144 |
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| Jin, Yi, Richards, Nigel G. J., Waltho, Jonathan P. and Blackburn, G. Michael 2017. Metal fluorides as analogues for studies on phosphoryl transfer enzymes. Angewandte Chemie - International Edition 56 (15) , pp. 4110-4128. 10.1002/anie.201606474 |
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| Blackburn, George Michael, Jin, Yi, Richards, Nigel G.J. and Waltho, Jonathan P 2017. Metal fluorides as analogs for studies on phosphoryl transfer enzymes. Angewandte Chemie 129 (15) , pp. 4172-4192. 10.1002/ange.201606474 |
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| Kumar, Amit, Khan, Abdullah, Malhotra, Shashwat, Mosurkal, Ravi, Dhawan, Ashish, Pandey, Mukesh K., Singh, Brajendra K., Kumar, Rajesh, Prasad, Ashok K., Sharma, Sunil K., Samuelson, Lynne A., Cholli, Ashok L., Len, Christophe, Richards, Nigel G.J., Kumar, Jayant, Haag, Rainer, Watterson, Arthur C. and Parmar, Virinder S. 2016. Synthesis of macromolecular systems via lipase catalyzed biocatalytic reactions: applications and future perspectives. Chemical Society Reviews 45 (24) , pp. 6855-6887. 10.1039/C6CS00147E |
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| Molt, Robert, Watson, Thomas, Bazanté, Alexandre P., Bartlett, Rodney J. and Richards, Nigel G.J. 2016. Gas phase RDX decomposition pathways using coupled cluster theory. Physical Chemistry Chemical Physics 18 (37) , pp. 26069-26077. 10.1039/C6CP05121A |
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| Zhu, Wen, Easthon, Lindsey M., Reinhardt, Laurie A., Tu, Chingkuang, Cohen, Steven E., Silverman, David N, Allen, Karen N and Richards, Nigel G. J. 2016. Substrate binding mode and molecular basis of a specificity switch in oxalate decarboxylase. Biochemistry 85 (14) , pp. 2163-2173. 10.1021/acs.biochem.6b00043 |
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| Jin, Yi, Molt, Robert, Waltho, Jonathan P., Richards, Nigel G. J. and Blackburn, G. Michael 2016. 19F NMR and DFT analysis reveal structural and electronic transition state features for RhoA-catalyzed GTP hydrolysis. Angewandte Chemie - International Edition 55 (10) , pp. 3318-3322. 10.1002/anie.201509477 |
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| Kumar, Prashant, Singh, Anil K., Bahadur, Vijay, Len, Christophe, Richards, Nigel G. J., Parmar, Virinder S., Van der Eycken, Erik V. and Singh, Brajendra K. 2016. Microwave-assisted, metal-free, base-mediated C-N bond formation/cleavage: synthesis of benzimidazo[1,2-a]quinazoline derivatives. ACS Sustainable Chemistry & Engineering 4 (4) , pp. 2206-2210. 10.1021/acssuschemeng.5b01669 |
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| Zhu, Wen, Wilcoxen, Jarett, Britt, R. David and Richards, Nigel G. J. 2016. Formation of hexacoordinate Mn(III) in Bacillus subtilis oxalate decarboxylase requires catalytic turnover. Biochemistry 55 (3) , pp. 429-434. 10.1021/acs.biochem.5b01340 |
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| Vladimirova, Anna, Patskovsky, Yury, Fedorov, Alexander A., Bonanno, Jeffrey B., Fedorov, Elena V., Toro, Rafael, Hillerich, Brandan, Seidel, Ronald D., Richards, Nigel G. J., Almo, Steven C. and Raushel, Frank M. 2016. Substrate distortion and the catalytic reaction mechanism of 5-carboxyvanillate decarboxylase. Journal of the American Chemical Society 138 (3) , pp. 826-836. 10.1021/jacs.5b08251 |
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| Sharma, Pramod K., Balwani, Sakshi, Mathur, Divya, Malhotra, Shashwat, Singh, Brajendra K., Prasad, Ashok K., Len, Christophe, Van der Eycken, Erik V., Ghosh, Balaram, Richards, Nigel G. J. and Parmar, Virinder S. 2016. Synthesis and anti-inflammatory activity evaluation of novel triazolyl-isatin hybrids. Journal of Enzyme Inhibition and Medicinal Chemistry 31 (6) , pp. 1520-1526. 10.3109/14756366.2016.1151015 |
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| Hettmer, Simone, Schinzel, Anna C., Tchessalova, Daria, Schneider, Michaela, Parker, Christina L., Bronson, Roderick T., Richards, Nigel G. J., Hahn, William C. and Wagers, Amy J. 2015. Functional genomic screening reveals asparagine dependence as a metabolic vulnerability in sarcoma. eLife 4 , e09436.. 10.7554/eLife.09436 |
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| Georgiadis, Millie M., Singh, Isha, Kellett, Whitney F., Hoshika, Shuichi, Benner, Steven A. and Richards, Nigel G. J. 2015. Structural basis for a six nucleotide genetic alphabet. Journal of the American Chemical Society 137 (21) , pp. 6947-6955. 10.1021/jacs.5b03482 |
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| Molt, Robert, Lecher, A.M., Clark, T, Bartlett, R.J. and Richards, Nigel 2015. Facile Csp2 -Csp 2 bond cleavage in oxalic acid-derived radicals. Journal of the American Chemical Society 137 (9) , pp. 3248-3252. 10.1021/ja510666r |
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| Twahir, Umar T., Stedwell, Corey N., Lee, Cory T., Richards, Nigel G. J., Polfer, Nicolas C. and Angerhofer, Alexander 2015. Observation of superoxide production during catalysis of Bacillus subtilis oxalate decarboxylase at pH 4. Free Radical Biology and Medicine 80 , p. 59. 10.1016/j.freeradbiomed.2014.12.012 |
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| Miao, J, Richards, Nigel and Ge, H 2014. Rhodium-catalyzed direct synthesis of unprotected NH-sulfoximines from sulfoxides. Chemical Communications- Royal Society of Chemistry 50 (68) , pp. 9687-9689. 10.1039/c4cc04349a |
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| Brunk, E, Kellett, W.F., Richards, Nigel and Rothlisberger, U 2014. A mechanochemical switch to control radical intermediates. Biochemistry 53 (23) , pp. 3830-3838. 10.1021/bi500050k |
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| Campomanes, P., Kellett, W. F., Easthon, L. M., Ozarowski, A., Allen, K. N., Angerhofer, A., Rothlisberger, U. and Richards, Nigel 2014. Assigning the EPR fine structure parameters of the Mn(II) centers in bacillus subtilis oxalate decarboxylase by site-directed mutagenesis and DFT/MM calculations. Journal of the American Chemical Society 136 (6) , pp. 2313-2323. 10.1021/ja408138f |
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