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Cook, Sophie R, Bladen, Cerys, Smith, Johanna, Maguire, Emily, Copner, Jordan, Fenn, Gareth D, Wager, Kim, Waller-Evans, Helen and Lloyd-Evans, Emyr
2020.
Visualisation of cholesterol and ganglioside GM1 in zebrafish models of Niemann-Pick type C disease and Smith-Lemli-Opitz syndrome using light sheet microscopy.
Histochemistry and Cell Biology
154
, pp. 565-578.
10.1007/s00418-020-01925-2
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Badell Grau, Rafael A., Cuff, Jordan Patrick, Kelly, Brendan P., Waller-Evans, Helen and Lloyd-Evans, Emyr
2020.
Investigating the prevalence of reactive online searching in the COVID-19 pandemic.
Journal of Medical Internet Research
22
(10)
, e19791.
10.2196/19791
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Lloyd-Evans, Emyr and Waller-Evans, Helen
2020.
Biosynthesis and signalling functions of central and peripheral nervous system neurosteroids in health and disease.
Essays in Biochemistry
64
(3)
, pp. 591-606.
10.1042/EBC20200043
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Harwood, John L. and Lloyd-Evans, Emyr, eds. 2020. Essays in biochemistry volume 64, issue 3: lipid mediators. Portland Press. |
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Cook, Sophie R., Badell-Grau, Rafael A., Kirkham, Emily D., Jones, Kimberley M., Kelly, Brendan M., Winston, Jincy, Waller-Evans, Helen, Allen, Nicholas D. and Lloyd-Evans, Emyr
2020.
Detrimental effect of zwitterionic buffers on lysosomal homeostasis in cell lines and iPSC-derived neurons.
AMRC Open Research
2
, 21.
10.12688/amrcopenres.12903.1
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Day, Adam H., Ubler, Martin H., Best, Hannah L., Lloyd-Evans, Emyr, Mart, Robert J., Fallis, Ian A., Allemann, Rudolf K., Al-Wattar, Eman A. H., Keymer, Nathaniel I., Buurma, Niklaas J. and Pope, Simon J. A.
2020.
Targeted cell imaging properties of a deep red luminescent iridium(III) complex conjugated with a c-Myc signal peptide.
Chemical Science
11
(6)
, pp. 1599-1606.
10.1039/C9SC05568A
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Carreira, A.C., Santos, T.C., Lone, M.A., Zupancic, E., Lloyd-Evans, Emyr, de Almeida, R.F.M., Hornemann, T. and Silva, L.C. 2019. Mammalian sphingoid bases: Biophysical, physiological and pathological properties. Progress in Lipid Research 75 , 100988. 10.1016/j.plipres.2019.100988 |
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Balogi, Zsolt, Multhoff, Gabrielle, Jensen, Thomas Kirkegaard, Lloyd-Evans, Emyr, Yamashima, Tetsumori, Jäättelä, Marja, Harwood, John L. and Vígh, László 2019. Hsp70 interactions with membrane lipids regulate cellular functions in health and disease. Progress in Lipid Research 74 , pp. 18-30. 10.1016/j.plipres.2019.01.004 |
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Morimoto, Marie, Waller-Evans, Helen, Ammous, Zineb, Song, Xiaofei, Strauss, Kevin A., Pehlivan, Davut, Gonzaga-Jauregui, Claudia, Puffenberger, Erik G., Holst, Charles R., Karaca, Ender, Brigatti, Karlla W., Maguire, Emily, Coban-Akdemir, Zeynep H., Amagata, Akiko, Lau, C. Christopher, Chepa-Lotrea, Xenia, Macnamara, Ellen, Tos, Tulay, Isikay, Sedat, Nehrebecky, Michele, Overton, John D., Klein, Matthew, Markello, Thomas C., Posey, Jennifer E., Adams, David R., Lloyd-Evans, Emyr, Lupski, James R., Gahl, William A. and Malicdan, May Christine V. 2018. Bi-allelic CCDC47 variants cause a disorder characterized by woolly hair, liver dysfunction, dysmorphic features, and global developmental delay. American Journal of Human Genetics 103 (5) , pp. 794-807. 10.1016/j.ajhg.2018.09.014 |
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Lange, Jenny, Haslett, Luke J., Lloyd-Evans, Emyr, Pocock, Jennifer M., Sands, Mark S., Williams, Brenda P. and Cooper, Jonathan D.
2018.
Compromised astrocyte function and survival negatively impact neurons in infantile neuronal ceroid lipofuscinosis.
Acta Neuropathologica Communications
6
, 74.
10.1186/s40478-018-0575-4
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Fineran, Paul, Lloyd-Evans, Emyr, Lack, Nathan A., Platt, Nick, Davis, Lianne C., Morgan, Anthony J., Höglinger, Doris, Tatituri, Raju Venkata V., Clark, Simon, Williams, Ian M., Tynan, Patricia, Al Eisa, Nada, Nazarova, Evgeniya, Williams, Ann, Galione, Antony, Ory, Daniel S., Besra, Gurdyal S., Russell, David G., Brenner, Michael B., Sim, Edith and Platt, Frances M. 2017. Pathogenic mycobacteria achieve cellular persistence by inhibiting the Niemann-Pick Type C disease cellular pathway. Wellcome Open Research 1 , 18. 10.12688/wellcomeopenres.10036.2 |
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Lloyd-Evans, Emyr and Haslett, Luke 2016. The lysosomal storage disease continuum with ageing-related neurodegenerative disease. Ageing Research Reviews 32 , pp. 104-121. 10.1016/j.arr.2016.07.005 |
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Lloyd-Evans, Emyr 2016. On the move, lysosomal CAX drives Ca2+ transport and motility. Journal of cell biology 212 (7) , pp. 755-757. 10.1083/jcb.201603037 |
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Oswald, Matthew C. W., West, Ryan J. H., Lloyd-Evans, Emyr and Sweeney, Sean T. 2015. Identification of dietary alanine toxicity and trafficking dysfunction in a Drosophila model of hereditary sensory and autonomic neuropathy type 1. Human Molecular Genetics 24 (24) , pp. 6899-6909. 10.1093/hmg/ddv390 |
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Lee, Ju-Hyun, McBrayer, Mary Kate, Wolfe, Devin M., Haslett, Luke J., Kumar, Asok, Sato, Yutaka, Lie, Pearl P.Y., Mohan, Panaiyur, Coffey, Erin E., Kompella, Uday, Mitchell, Claire H., Lloyd-Evans, Emyr and Nixon, Ralph A.
2015.
Presenilin 1 maintains Lysosomal Ca2+ homeostasis via TRPML1 by regulating vATPase-mediated lysosome acidification.
Cell Reports
12
(9)
, pp. 1430-1444.
10.1016/j.celrep.2015.07.050
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Chandrachud, Uma, Walker, Mathew W., Simas, Alexandra M., Heetveld, Sasja, Petcherski, Anton, Klein, Madeleine, Oh, Hyejin, Wolf, Pavlina, Zhao, Wen-Ning, Norton, Stephanie, Haggarty, Stephen J., Lloyd-Evans, Emyr and Cotman, Susan L. 2015. Unbiased cell-based screening in a neuronal cell model of Batten Disease highlights an interaction between Ca2+Homeostasis, autophagy, and CLN3 protein function. Journal of Biological Chemistry 290 (23) , 14361-14380.. 10.1074/jbc.M114.621706 |
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Waller-Evans, Helen and Lloyd-Evans, Emyr 2015. Regulation of TRPML1 function. Biochemical Society Transactions 43 (3) , pp. 442-446. 10.1042/BST20140311 |
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Walker, Mathew W. and Lloyd-Evans, Emyr 2015. A rapid method for the preparation of ultrapure, functional lysosomes using functionalized superparamagnetic iron oxide nanoparticles. Methods in Cell Biology 126 , pp. 21-43. 10.1016/bs.mcb.2014.10.019 |
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Platt, Frances M., Wassif, Christopher, Colaco, Alexandria, Dardis, Andrea, Lloyd-Evans, Emyr, Bembi, Bruno and Porter, Forbes D. 2014. Disorders of cholesterol metabolism and their unanticipated convergent mechanisms of disease. Annual Review of Genomics and Human Genetics 15 (1) , pp. 173-194. 10.1146/annurev-genom-091212-153412 |
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Morgan, Anthony J., Platt, Frances M., Lloyd‑Evans, Emyr and Galione, Antony 2011. Molecular mechanisms of endolysosomal Ca2+ signalling in health and disease. Biochemical Journal 439 (3) , pp. 349-374. 10.1042/BJ20110949 |
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Lloyd-Evans, Emyr and Platt, Frances M. 2011. Lysosomal Ca2+ homeostasis: Role in pathogenesis of lysosomal storage diseases. Cell Calcium 50 (2) , pp. 200-205. 10.1016/j.ceca.2011.03.010 |
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Lloyd-Evans, Emyr, Waller-Evans, Helen, Peterneva, Ksenia and Platt, Frances M. 2010. Endolysosomal calcium regulation and disease. Biochemical Society Transactions 38 (6) , pp. 1458-1464. 10.1042/BST0381458 |
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Lloyd-Evans, Emyr and Platt, Frances M. 2010. Lipids on trial: The search for the offending metabolite in Niemann-Pick type C disease. Traffic 11 (4) , pp. 419-428. 10.1111/j.1600-0854.2010.01032.x |
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Ruas, Margarida, Rietdorf, Katja, Arredouani, Abdelilah, Davis, Lianne, Lloyd-Evans, Emyr, Koegel, Heidi, Funnell, Timothy, Morgan, Anthony John, Ward, John, Watanabe, Keiko, Cheng, Xiaotong, Churchill, Grant, Zhu, Michael, Platt, Frances, Wessel, Gary, Parrington, John and Galione, Antony 2010. Purified TPC isoforms form NAADP receptors with distinct roles for Ca2+ signaling and endolysosomal trafficking. Current Biology 20 (8) , pp. 703-709. 10.1016/j.cub.2010.02.049 |
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Lloyd-Evans, Emyr, Morgan, Anthony J., He, Xingxuan, Smith, David A., Elliot-Smith, Elena, Sillence, Daniel J., Churchill, Grant C., Schuchman, Edward H., Galione, Antony and Platt, Frances M. 2008. Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium. Nature Medicine 14 (11) , pp. 1247-1255. 10.1038/nm.1876 |
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Elliot-Smith, Elena, Speak, Anneliese, Lloyd-Evans, Emyr, Smith, David A., Spoel, Aarnoud C. van der, Jeyakumar, Mylvaganam, Butters, Terry, Dwek, Raymond, d'Azzo, Alessandra and Platt, Frances 2008. Beneficial effects of substrate reduction therapy in a mouse model of GM1 gangliosidosis. Molecular Genetics and Metabolism 94 (2) , pp. 204-211. 10.1016/j.ymgme.2008.02.005 |
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Pelled, Dori, Trajkovic-Bodennec, Selena, Lloyd-Evans, Emyr, Sidransky, Ellen, Schiffmann, Raphael and Futerman, Anthony H. 2005. Enhanced calcium release in the acute neuronopathic form of Gaucher disease. Neurobiology of Disease 18 (1) , pp. 83-88. 10.1016/j.nbd.2004.09.004 |
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Vruchte, D. T., Lloyd-Evans, Emyr, Veldman, R. J., Neville, D. C. A., Dwek, R. A., Platt, F. M., van Blitterswijk, W. J. and Sillence, D. J. 2004. Accumulation of glycosphingolipids in Niemann-Pick C disease disrupts endosomal transport. Journal of Biological Chemistry 279 (25) , pp. 26167-26175. 10.1074/jbc.M311591200 |
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Lachmann, Robin H., te Vruchte, Danielle, Lloyd-Evans, Emyr, Reinkensmeier, Gabriele, Sillence, Daniel J., Fernandez-Guillen, Luisa, Dwek, Raymond A., Butters, Terry D., Cox, Timothy M. and Platt, Frances M. 2004. Treatment with miglustat reverses the lipid-trafficking defect in Niemann–Pick disease type C. Neurobiology of Disease 16 (3) , pp. 654-658. 10.1016/j.nbd.2004.05.002 |
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Lloyd-Evans, Emyr, Pelled, D., Riebeling, C., Bodennec, J., de-Morgan, A., Waller, H., Schiffmann, R. and Futerman, A. H. 2003. Glucosylceramide and glucosylsphingosine modulate calcium mobilization from brain microsomes via different mechanisms. Journal of Biological Chemistry 278 (26) , pp. 23594-23599. 10.1074/jbc.M300212200 |
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Lloyd-Evans, Emyr, Pelled, Dori, Riebeling, Christian and Futerman, Anthony H. 2003. Lyso-glycosphingolipids mobilize calcium from brain microsomes via multiple mechanisms. Biochemical Journal 375 (3) , pp. 561-565. 10.1042/BJ20030613 |
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Pelled, D., Lloyd-Evans, Emyr, Riebeling, C., Jeyakumar, M., Platt, F. M. and Futerman, A. H. 2003. Inhibition of calcium uptake via the sarco/endoplasmic reticulum Ca2+-ATPase in a mouse model of Sandhoff disease and prevention by treatment with N-Butyldeoxynojirimycin. Journal of Biological Chemistry 278 (32) , pp. 29496-29501. 10.1074/jbc.M302964200 |
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