ORCA
Online Research @ Cardiff
Browse by Current Cardiff authors
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Number of items: 16.
| Beswick, Paul, Wahab, Ben, Honey, Mark A., Paradowski, Michael, Jiang, Ke, Lochner, Martin, Murrell-Lagnado, Ruth D. and Thompson, Andrew J. 2019. A challenge finding P2X1 and P2X4 ligands. Neuropharmacology 157 , p. 107674. 10.1016/j.neuropharm.2019.107674 |
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| West, Ryan A., O'Doherty, Oran G., Askwith, Trevor, Atack, John, Beswick, Paul, Laverick, Jamie, Paradowski, Michael, Pennicott, Lewis E., Rao, Srinivasa P.S., Williams, Gareth and Ward, Simon 2017. African trypanosomiasis: Synthesis & SAR enabling novel drug discovery of ubiquinol mimics for trypanosome alternative oxidase. European Journal of Medicinal Chemistry 141 , pp. 676-689. 10.1016/j.ejmech.2017.09.067 |
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Hornyak, Peter, Askwith, Trevor, Walker, Sarah, Komulainen, Emilia, Paradowski, Michael, Pennicott, Lewis E., Bartlett, Edward J., Brissett, Nigel C., Raoof, Ali, Watson, Mandy, Jordan, Allan M., Ogilvie, Donald J., Ward, Simon E., Atack, John R., Pearl, Laurence H., Caldecott, Keith W. and Oliver, Antony W.
2016.
Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2.
Biochemical Journal
473
(13)
, pp. 1869-1879.
10.1042/BCJ20160180
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| Re:Viral Ltd 2016. Spiro-indolines for the treatment and prophylaxis of respiratory syncytial virus infection (RSV). WO2016055780A1. [Patent]. |
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| Moore, Thomas O., Paradowski, Michael and Ward, Simon 2016. An atom-efficient and convergent approach to the preparation of NS5A inhibitors by C-H activation. Organic and Biomolecular Chemistry 14 (12) , pp. 3307-3313. 10.1039/C6OB00340K |
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| Wakenhut, Florian, Tran, Thien Duc, Pickford, Chris, Shaw, Stephen, Westby, Mike, Smith-Burchnell, Caroline, Watson, Lesa, Paradowski, Michael, Milbank, Jared, Stonehouse, David, Cheung, Kathy, Wybrow, Robert, Daverio, Felice, Crook, Samuel, Statham, Keith, Leese, David, Stead, Darren, Adam, Fiona, Hay, Duncan, Roberts, Lee R., Chiva, Jean-Yves, Nichols, Carly, Blakemore, David C., Goetz, Gilles H., Che, Ye, Gardner, Iain, Dayal, Satish, Pike, Andrew, Webster, Rob and Pryde, David C. 2014. The discovery of potent nonstructural protein 5A (NS5A) inhibitors with a unique resistance profile—part 2. ChemMedChem 9 (7) , pp. 1387-1396. 10.1002/cmdc.201400046 |
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| Tran, Thien Duc, Wakenhut, Florian, Pickford, Chris, Shaw, Stephen, Westby, Mike, Smith-Burchnell, Caroline, Watson, Lesa, Paradowski, Michael, Milbank, Jared, Brimage, Rebecca A., Halstead, Rebecca, Glen, Rebecca, Wilson, Craig P., Adam, Fiona, Hay, Duncan, Chiva, Jean-Yves, Nichols, Carly, Blakemore, David C., Gardner, Iain, Dayal, Satish, Pike, Andrew, Webster, Rob and Pryde, David C. 2014. The discovery of potent nonstructural protein 5A (NS5A) inhibitors with a unique resistance profile-Part 1. ChemMedChem 9 (7) , pp. 1378-1386. 10.1002/cmdc.201400045 |
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| Burrows, Andrew D., Jurcic, Monika, Keenan, Luke L., Lane, Rebecca A., Mahon, Mary F., Warren, Mark R., Nowell, Harriott, Paradowski, Michael and Spencer, John 2013. Incorporation by coordination and release of the iron chelator drug deferiprone from zinc-based metal-organic frameworks. Chemical Communications 49 (96) , pp. 11260-11262. 10.1039/c3cc45689g |
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| Lane, Charlotte A.L., Hay, Duncan, Mowbray, Charles E., Paradowski, Michael, Selby, Matthew D., Swain, Nigel A. and Williams, David H. 2012. Synthesis of novel histamine H4 receptor antagonists. Bioorganic and Medicinal Chemistry Letters 22 (2) , pp. 1156-1159. 10.1016/j.bmcl.2011.11.098 |
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| Egan, Ben A., Paradowski, Michael, Thomas, Lynne H. and Marquez, Rodolfo 2011. http://dx.doi.org/10.1016/j.tet.2011.10.036. Tetrahedron 67 (50) , pp. 9700-9707. 10.1016/j.tet.2011.10.036 |
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| Hay, Duncan A., Adam, Fiona M., Bish, Gerwyn, Calo, Frederick, Dixon, Rachel, Fray, M. Jonathan, Hitchin, James, Jones, Peter, Paradowski, Michael, Parsons, Gemma C., Proctor, Katie J.W., Pryde, David C., Smith, Nicholas N. and Tran, Thien-Duc 2011. A flexible synthesis of C-6 and N-1 analogues of a 4-amino-1,3-dihydroimidazo[4,5-c]pyridin-2-one core. Tetrahedron Letters 52 (44) , pp. 5728-5732. 10.1016/j.tetlet.2011.08.119 |
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| Mowbray, Charles E., Bell, Andrew S., Clarke, Nicholas P., Collins, Michelle, Jones, Rhys M., Lane, Charlotte A.L., Liu, Wai L., Newman, Sandra D., Paradowski, Michael, Schenck, Emanuel J., Selby, Mathew D., Swain, Nigel A. and Williams, David H. 2011. Challenges of drug discovery in novel target space. The discovery and evaluation of PF-3893787: A novel histamine H4 receptor antagonist. Bioorganic and Medicinal Chemistry Letters 21 (21) , pp. 6596-6602. 10.1016/j.bmcl.2011.07.125 |
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| Adam, Fiona M., Bish, Gerwyn, Calo, Frederick, Carr, Christopher L., Castro, Nieves, Hay, Duncan, Hodgson, Paul B., Jones, Peter, Knight, Craig J., Paradowski, Michael, Parsons, Gemma C., Proctor, Katie J. W., Pryde, David C., Rota, Filippo, Smith, Mya C., Smith, Nicholas, Tran, Thien-Duc, Hitchin, James and Dixon, Rachel 2011. Development of a practical synthesis of toll-like receptor agonist PF-4171455: 4-Amino-1-benzyl-6-trifluoromethyl-1,3-dihydroimidazo [4,5-c] pyridin-2-one. Organic Process Research and Development 15 (4) , pp. 788-796. 10.1021/op200021a |
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| Egan, Ben A., Paradowski, Michael, Thomas, Lynne H. and Marquez, Rodolfo 2011. Regiocontrolled rearrangement of isobenzofurans. Organic Letters 13 (8) , pp. 2086-2089. 10.1021/ol200498k |
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| Pryde, David C., Tran, Thien-Duc, Jones, Peter, Parsons, Gemma C., Bish, Gerwyn, Adam, Fiona M., Smith, Mya C., Middleton, Donald S., Smith, Nick N., Calo, Frederick, Hay, Duncan, Paradowski, Michael, Proctor, Katie J. W., Parkinson, Tanya, Laxton, Carl, Fox, David N. A., Horscroft, Nigel J., Ciaramella, Giuseppe, Jones, Hannah M., Duckworth, Jonathan, Benson, Neil, Harrison, Anthony and Webster, Rob 2011. The discovery of a novel prototype small molecule TLR7 agonist for the treatment of hepatitis C virus infection. MedChemComm 2 (3) , p. 185. 10.1039/C0MD00197J |
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| Paradowski, Michael, Lane, Charlotte and Peakman, Torren 2011. Synthesis of a Novel Octahydro Pyrrolo[3,4-c]pyrrole Cyclic Amidine via 1,3-Dipolar Cycloaddition of Azomethine Ylides. SYNLETT 2011 (11) , pp. 1543-1546. 10.1055/s-0030-1260768 |
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