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Toxin-antitoxin systems and their role in disseminating and maintaining antimicrobial resistance

Yang, Qiue and Walsh, Timothy 2017. Toxin-antitoxin systems and their role in disseminating and maintaining antimicrobial resistance. FEMS Microbiology Reviews 41 (3) , pp. 343-353. 10.1093/femsre/fux006

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Toxin–antitoxin systems (TAs) are ubiquitous among bacteria and play a crucial role in the dissemination and evolution of antibiotic resistance, such as maintaining multi-resistant plasmids and inducing persistence formation. Generally, activities of the toxins are neutralised by their conjugate antitoxins. In contrast, antitoxins are more liable to degrade under specific conditions such as stress, and free active toxins interfere with essential cellular processes including replication, translation and cell-wall synthesis. TAs have also been shown to be responsible for plasmid maintenance, stress management, bacterial persistence and biofilm formation. We discuss here the recent findings of these multifaceted TAs (type I–VI) and in particular examine the role of TAs in augmenting the dissemination and maintenance of multi-drug resistance in bacteria.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: Q Science > QR Microbiology
R Medicine > R Medicine (General)
Uncontrolled Keywords: toxin–antitoxins, addictive systems, antimicrobial resistance, persistence
Publisher: Wiley-Blackwell
ISSN: 0168-6445
Funders: MRC
Date of First Compliant Deposit: 5 June 2017
Date of Acceptance: 11 February 2017
Last Modified: 06 Jan 2021 02:28

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