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Endothelium-derived relaxing factor inhibits in vitro platelet aggregation

Furlong, B., Henderson, A. H., Lewis, M. J. and Warden-Smith, Jeremy 1987. Endothelium-derived relaxing factor inhibits in vitro platelet aggregation. British Journal of Pharmacology 90 (4) , pp. 687-692.

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We studied the effects of endothelium-derived relaxing factor (EDRF), bovine retractor penis muscle inhibitory factor and sodium nitroprusside, three stimulants of guanylate cyclase, on the in vitro aggregation of washed human platelets. Platelet aggregation induced either by collagen or by the thromboxane A2 analogue U46619 was inhibited by all three agents. The anti-aggregatory effect of each agent was inhibited by haemoglobin. The anti-aggregatory effect of EDRF was potentiated by superoxide dismutase. These findings are discussed in relation to a potential role for EDRF in haemostasis.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: R Medicine > RM Therapeutics. Pharmacology
Publisher: Wiley-Blackwell
ISSN: 0007-1188
Last Modified: 17 Mar 2021 02:35

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