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Application of adipose-derived stromal cells in fat grafting: Basic science and literature review

Moustaki, Margarita, Papadopoulos, Othon, Verikokos, Christos, Karypidis, Dimitrios, Masud, Dhalia, Kostakis, Alkiviadis, Papastefanaki, Florentia, Roubelakis, Maria G. and Perrea, Despoina 2017. Application of adipose-derived stromal cells in fat grafting: Basic science and literature review. Experimental and Therapeutic Medicine 14 (3) , pp. 2415-2433. 10.3892/etm.2017.4811

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Autologous fat is considered the ideal material for soft‑tissue augmentation in plastic and reconstructive surgery. The primary drawback of autologous fat grafting is the high resorption rate. The isolation of mesenchymal stem cells from adipose tissue inevitably led to research focusing on the study of combined transplantation of autologous fat and adipose derived stem cells (ADSCs) and introduced the theory of ʻcell‑assisted lipotransferʼ. Transplantation of ADSCs is a promising strategy, due to the high proliferative capacity of stem cells, their potential to induce paracrine signalling and ability to differentiate into adipocytes and vascular cells. The current study examined the literature for clinical and experimental studies on cell‑assisted lipotransfer to assess the efficacy of this novel technique when compared with traditional fat grafting. A total of 30 studies were included in the present review. The current study demonstrates that cell‑assisted lipotransfer has improved efficacy compared with conventional fat grafting. Despite relatively positive outcomes, further investigation is required to establish a consensus in cell‑assisted lipotransfer.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Spandidos Publications
ISSN: 1792-0981
Date of First Compliant Deposit: 4 May 2018
Date of Acceptance: 6 January 2017
Last Modified: 16 Jul 2019 13:50

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