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Assessment of microbiota:host interactions at the vaginal mucosa interface

Pruski, Pamela, Lewis, Holly V., Lee, Yun S., Marchesi, Julian R., Bennett, Phillip R., Takats, Zoltan and MacIntyre, David A. 2018. Assessment of microbiota:host interactions at the vaginal mucosa interface. Methods 149 , pp. 74-84. 10.1016/j.ymeth.2018.04.022

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There is increasing appreciation of the role that vaginal microbiota play in health and disease throughout a woman’s lifespan. This has been driven partly by molecular techniques that enable detailed identification and characterisation of microbial community structures. However, these methods do not enable assessment of the biochemical and immunological interactions between host and vaginal microbiota involved in pathophysiology. This review examines our current knowledge of the relationships that exist between vaginal microbiota and the host at the level of the vaginal mucosal interface. We also consider methodological approaches to microbiomic, immunologic and metabolic profiling that permit assessment of these interactions. Integration of information derived from these platforms brings the potential for biomarker discovery, disease risk stratification and improved understanding of the mechanisms regulating vaginal microbial community dynamics in health and disease.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: Elsevier
ISSN: 1046-2023
Date of First Compliant Deposit: 5 June 2018
Date of Acceptance: 22 April 2018
Last Modified: 29 Jun 2019 15:26

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