Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Metal-free selective mono-halodecarboxylation of heteroarenes under mild conditions

Henderson, Scott H., West, Ryan A., Ward, Simon E. ORCID: https://orcid.org/0000-0002-8745-8377 and Honey, Mark A. 2018. Metal-free selective mono-halodecarboxylation of heteroarenes under mild conditions. Royal Society Open Science 5 (6) , 180333. 10.1098/rsos.180333

[thumbnail of 180333.full.pdf]
Preview
PDF - Published Version
Available under License Creative Commons Attribution.

Download (784kB) | Preview

Abstract

The halodecarboxylation of heteroarene carboxylic acids by treatment with N-bromosuccinimide or N-chlorosuccinimide was performed. This procedure provides a convenient route to synthetically useful mono-halogenated heteroarene intermediates such as halo-indoles, -aza-indoles, -indazoles and -aza-indazoles. The mild conditions employed and simple protocol provides an advantage over traditional halodecarboxylation procedures that require expensive and toxic metal catalysts, basic conditions, time-consuming intermediate isolation and elevated reaction temperatures.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Royal Society, The
ISSN: 2054-5703
Date of First Compliant Deposit: 20 June 2018
Date of Acceptance: 10 April 2018
Last Modified: 05 May 2023 07:54
URI: https://orca.cardiff.ac.uk/id/eprint/112611

Citation Data

Cited 7 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item

Downloads

Downloads per month over past year

View more statistics