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Disruption and de novo formation of nanotubular membrane extensions in SW620 colon carcinoma cell line during cell division

Castro, M, Grieneisen, V and de Almeida, R 2005. Disruption and de novo formation of nanotubular membrane extensions in SW620 colon carcinoma cell line during cell division. Cell Biology International 29 (11) , pp. 929-931. 10.1016/j.cellbi.2005.05.013

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Abstract

A novel biological principle of cell-to-cell interaction based on membrane continuity of nanotubular channels has recently been described. These contacts are extremely dynamic and sensitive to mechanical stress, which causes their rapid breakage and retraction. Here we demonstrate that functional mechanical stress generated during cell division can disrupt membrane nanotubes, which are formed de novo when filopodia-like projections on one cell make contact with a neighbouring cell, using the SW620 colon carcinoma cell line. Considering the general principal of decreasing cellecell interactions during tumour progression, our observation is appealing because this new phenomenon may be valid for neoplastic cells.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: Wiley: No OnlineOpen
ISSN: 1065-6995
Date of Acceptance: 23 May 2005
Last Modified: 26 Mar 2019 14:45
URI: http://orca.cf.ac.uk/id/eprint/120506

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