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Phages enter the fight against colorectal cancer

Kannen, Vinicius, Parry, Lee and Martin, Francis L. 2019. Phages enter the fight against colorectal cancer. Trends in Cancer 5 (10) , pp. 577-579. 10.1016/j.trecan.2019.08.002

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Intestinal microbiota undergo significant changes in colorectal cancer (CRC). Zheng et al. (Nat. Biomed. Eng., 2019) observe detrimental overpopulation of Fusobacterium nucleatum in mice and patients, suppressing the beneficial butyrate-producing Clostridium butyricum. Phage-guided irinotecan-loaded dextran nanoparticles promote release of bacterial-derived butyrate, while F. nucleatum and CRC cells are eliminated. These findings describe a possible novel therapeutic strategy for CRC.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
European Cancer Stem Cell Research Institute (ECSCRI)
Publisher: Elsevier
ISSN: 2405-8033
Date of First Compliant Deposit: 2 September 2019
Date of Acceptance: 16 August 2019
Last Modified: 24 Nov 2020 16:18

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