Ferritin heavy chain protects the developing wing from reactive oxygen species and ferroptosis

Mumbauer, Simone, Pascual, Justine, Kolotuev, Irina and Hamaratoglu, Fisun ORCID: https://orcid.org/0000-0002-1461-9248 2019. Ferritin heavy chain protects the developing wing from reactive oxygen species and ferroptosis. PLoS Genetics 15 (9) , e1008396. 10.1371/journal.pgen.1008396

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Abstract

The interplay between signalling pathways and metabolism is crucial for tissue growth. Yet, it remains poorly understood. Here, we studied the consequences of modulating iron metabolism on the growth of Drosophila imaginal discs. We find that reducing the levels of the ferritin heavy chain in the larval wing discs leads to drastic growth defects, whereas light chain depletion causes only minor defects. Mutant cell clones for the heavy chain lack the ability to compete against Minute mutant cells. Reactive oxygen species (ROS) accumulate in wing discs with reduced heavy chain levels, causing severe mitochondrial defects and ferroptosis. Preventing ROS accumulation alleviates some of the growth defects. We propose that the increased expression of ferritin in hippo mutant cells may protect against ROS accumulation.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Additional Information:	This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Publisher:	Public Library of Science
ISSN:	1553-7390
Date of First Compliant Deposit:	30 September 2019
Date of Acceptance:	2 September 2019
Last Modified:	05 May 2023 18:21
URI:	https://orca.cardiff.ac.uk/id/eprint/125738

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