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Quadrupole mass spectrometry in the monitoring and control of fermentations

Lloyd, David, Bohatka, Sandor and Szilagyi, Jeno 1985. Quadrupole mass spectrometry in the monitoring and control of fermentations. Biosensors 1 (2) , 179--212. 10.1016/0265-928X(85)80003-1

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The application of quadrupole mass Spectrometry to the monitoring of fermentation processes allows continuous and simultaneous non-invasive measurement of gases and volatile substrates, intermediates or products. Components are directly and continuously sampled through a silicone rubber membrane either from solution in the culture medium and/or in the influent or effluent gas streams. Gases measured include H2, CH4, O2, CO2, H2S, N2, N2O and (as calibration standard) Ar: vapours include methanol, ethanol, propanol, acetone, n-butanol, acetic acid and butyric acid. This versatility of detection is enhanced by off-line determinations of non-volatiles after pH adjustment (e.g. total CO2−3 or NH+4) or derivativization (e.g. some carboxylic or keto acids). Appropriate automation allows multicomponent analysis at many sampling points (i.e. simultaneously in many different fermentors).Applications are described for aerobic processes (antibiotic production, yeast fermentation, growth on methanol) and anaerobic processes (acetone-butanol fermentation, anaerobic digestion of farm and domestic wastes, and fermentation in the rumen). Future developments include exploitation of the high sensitivity, long-term stability and high specificity of mass spectrometric measurements to process control and optimization.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: MDPI
ISSN: 2079-6374
Last Modified: 28 Feb 2020 11:15

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