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Real-time microscopic observation of biological interactions with microwave fields

Williams, C.F., Lees, J., Lloyd, D., Geroni, G.M., Jones, S., Ambala, S., Baradat, W., Comat, G., Aboubakary, A., Voisin, S. and Porch, A. 2018. Real-time microscopic observation of biological interactions with microwave fields. Presented at: International Microwave Biomedical Conference (IMBioC), Philadelphia, USA, 14-15 Jun 2018. International Microwave Biomedical Conference (IMBioC). IEEE, p. 199. 10.1109/IMBIOC.2018.8428902

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Here we describe the design and fabrication of novel coplanar waveguide applicators, which facilitate real-time observation of separated electric and magnetic field effects on biological systems. S 11 parameters and temperature changes across these waveguides was characterized, and the feasibility of simultaneous microwave excitation and microscope observation was confirmed by tracking the motility of a protozoan fish parasite, Spironucleus vortens. This paves the way for in-depth studies into the biophysical effects of electromagnetic fields (up to 3GHz) on a range of biological systems. Applications extend from optimization of therapeutic intervention (e.g. thermal ablation and elec-troporation) to understanding putatively hazardous effects from environmental sources of non-ionizing radiation.

Item Type: Conference or Workshop Item (Paper)
Date Type: Published Online
Status: Published
Schools: Engineering
Publisher: IEEE
ISBN: 9781538659199
Last Modified: 02 Mar 2021 02:28

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