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Chronic diarrhea, bile acids, and Clostridia

Walters, Julian R.F. and Marchesi, Julian R. 2020. Chronic diarrhea, bile acids, and Clostridia. Journal of Clinical Investigation 130 (1) , pp. 77-79. 10.1172/JCI133117

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Abstract

Excessive fecal bile acid (BA) loss causes symptoms in a large proportion of people diagnosed with irritable bowel syndrome with diarrhea, a common functional bowel disorder. This BA diarrhea (BAD) results from increased hepatic synthesis of BAs, with impaired negative feedback regulation by the ileal hormone fibroblast growth factor 19 (FGF19). In this issue of the JCI, Zhao et al. investigated BA metabolism, including fecal BAs, serum BAs, and FGF19, in patients and controls. They identified associations between fecal bacterial BA metabolism and specific microbiota, especially Clostridium scindens. These findings have been tested in a mouse model using microbiota transplants and antibiotic treatment. This group of organisms has potential as a biomarker for BAD and to be a target for therapy.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: American Society for Clinical Investigation
ISSN: 0021-9738
Date of First Compliant Deposit: 14 January 2020
Date of Acceptance: 1 December 2019
Last Modified: 29 Mar 2020 00:15
URI: http://orca.cf.ac.uk/id/eprint/128544

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