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Role of the complement pathway in inflammatory skin diseases: a focus on hidradenitis suppurativa

Ghias, Mondana H., Hyde, Michael J., Tomalin, Lewis E., Morgan, B. Paul, Alavi, Afsaneh, Lowes, Michelle A. and Piguet, Vincent 2020. Role of the complement pathway in inflammatory skin diseases: a focus on hidradenitis suppurativa. Journal of Investigative Dermatology 140 (3) , 531-536.e1. 10.1016/j.jid.2019.09.009

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Abstract

Although the role of immune dysregulation in hidradenitis suppurativa (HS) has yet to be elucidated, recent studies identified several complement abnormalities in patients with HS. The complement system serves a critical role in the modulation of immune response and regulation of cutaneous commensal bacteria. Complement is implicated in several inflammatory skin diseases including systemic lupus erythematosus, angioedema, pemphigus, bullous pemphigoid, and HS. A model of HS pathogenesis is proposed, integrating the role of commensal bacteria, cutaneous immune responses, and complement dysregulation. The role of complement in disease pathogenesis has led to the development of novel anticomplement agents and clinical trials investigating the efficacy of such treatments in HS.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Elsevier
ISSN: 0022-202X
Date of First Compliant Deposit: 17 January 2020
Date of Acceptance: 19 September 2019
Last Modified: 19 Jan 2021 06:40
URI: http://orca.cf.ac.uk/id/eprint/128699

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