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Lactose as a "Trojan horse" for quantum dot cell rransport

Benito-Alifonso, David, Tremel, Shirley, Hou, Bo, Lockyear, Harriet, Mantell, Judith, Fermin, David J., Verkade, Paul, Berry, Monica and Galan, M. Carmen 2014. Lactose as a "Trojan horse" for quantum dot cell rransport. Angewandte Chemie International Edition 53 (3) , pp. 810-814. 10.1002/anie.201307232

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A series of glycan‐coated quantum dots were prepared to probe the effect of glycan presentation in intracellular localization in HeLa and SV40 epithelial cells. We show that glycan density mostly impacts on cell toxicity, whereas glycan type affects the cell uptake and intracellular localization. Moreover, we show that lactose can act as a “Trojan horse” on bi‐functionalized QDs to help intracellular delivery of other non‐internalizable glycan moieties and largely avoid the endosomal/lysosomal degradative pathway.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Physics and Astronomy
Publisher: Wiley
ISSN: 1433-7851
Date of First Compliant Deposit: 25 February 2020
Last Modified: 25 Feb 2020 11:34

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