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Novel plasmid-mediated tet(X5) gene conferring resistance to tigecycline, eravacycline, and omadacycline in a clinical Acinetobacter baumannii Isolate

Wang, Liyuan, Liu, Dejun, Lv, Yuan, Cui, Lanqing, Li, Yun, Li, Tianmeng, Song, Huangwei, Hao, Yuxin, Shen, Jianzhong, Wang, Yang and Walsh, Timothy R. 2019. Novel plasmid-mediated tet(X5) gene conferring resistance to tigecycline, eravacycline, and omadacycline in a clinical Acinetobacter baumannii Isolate. Antimicrobial Agents and Chemotherapy 64 (1) , e01326-19. 10.1128/AAC.01326-19

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Abstract

A novel, plasmid-mediated, high-level tigecycline resistance tet(X) gene variant, tet(X5), was detected in a clinical Acinetobacter baumannii isolate from China in 2017. Tet(X5) shows 84.5% and 90.5% amino acid identity to Tet(X3) and Tet(X4), respectively, with similar binding sites and a comparable affinity for tetracyclines. The tet(X5)-containing plasmid could only be transferred to A. baumannii via electrotransformation. This report follows the recent study describing the identification of tet(X3) and tet(X4).

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Medicine
Publisher: American Society for Microbiology
ISSN: 0066-4804
Date of Acceptance: 24 September 2019
Last Modified: 17 Apr 2020 11:16
URI: http://orca.cf.ac.uk/id/eprint/131027

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