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Genetic advances in Autism

Thapar, Anita and Rutter, Michael 2020. Genetic advances in Autism. Journal of Autism and Developmental Disorders 10.1007/s10803-020-04685-z

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Abstract

In the last 40 years, there has been a huge increase in autism genetics research and a rapidly growing number of discoveries. We now know autism is one of the most highly heritable disorders with negligible shared environmental contributions. Recent discoveries also show that rare variants of large effect size as well as small effect common gene variants all contribute to autism risk. These discoveries challenge traditional diagnostic boundaries and highlight huge heterogeneity in autism. In this review, we consider some of the key findings that are shaping current understanding of autism and what these discoveries mean for clinicians.

Item Type: Article
Date Type: Published Online
Status: In Press
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Publisher: Springer Verlag (Germany)
ISSN: 0162-3257
Funders: Wellcome Trust, MRC
Date of First Compliant Deposit: 17 September 2020
Date of Acceptance: 25 August 2020
Last Modified: 10 Jun 2021 09:07
URI: http://orca.cf.ac.uk/id/eprint/134896

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