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5-HT/GABA interaction in epilepsy

Deidda, Gabriele, Crunelli, Vincenzo and Di Giovanni, Giuseppe 2021. 5-HT/GABA interaction in epilepsy. Progress in Brain Research 259 , pp. 265-286. 10.1016/bs.pbr.2021.01.008

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Abstract

Epilepsy is a neurological condition characterized by synchronous neuronal oscillations (seizures) in the electroencephalogram. Seizures are classified in focal or generalized (depending on the brain territory interested during seizures), and in convulsive and/or not convulsive (depending on the presence or not of involuntary movements). The current pharmacological treatments are mainly based on GABA modulation although different neurotransmitters are also involved in epilepsy, including serotonin. However despite much extensive progress in the understanding of epilepsy mechanisms, still, a percentage of people with epilepsy are pharmaco-resistant calling for the need for new therapeutic targets. Here we review preclinical and human evidence showing that serotonin modulates epilepsy that this likely happens via a major modulation/interaction with GABA.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: ELSEVIER SCIENCE BV
ISSN: 0079-6123
Last Modified: 09 Feb 2021 15:30
URI: http://orca.cf.ac.uk/id/eprint/138336

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