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Stem cells in the eye

Huang, Chao, Albon, Julie, V. Ljubimov, Alexander and Grant, Maria B. 2020. Stem cells in the eye. Principles of Tissue Engineering Fifth Edition, Elsevier Inc., pp. 1115-1133. (10.1016/B978-0-12-818422-6.00062-9)

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Abstract

Stem cells have the capacity for differentiation and self-renewal. In the eye, endogenous retinal cells have been identified to express stem cell characteristics, which are crucial for maintaining and repairing the eye during physiological condition. On the other hand, exogenous stem cells are examined as an alternative source for stem cell therapy. Here, we review the properties of endogenous retinal stem cells in particular Müller, ciliary-epithelial, corneal epithelial, and retinal pigment epithelial (RPE) cells, together with exogenous stem cells, including induced pluripotent stem cells (iPSCs)/embryonic stem cells, mesenchymal stem cells, and hematopoietic stem cells and discuss the potential advantages as cell therapies for retinal degeneration diseases.

Item Type: Book Section
Date Type: Publication
Status: Published
Schools: Optometry and Vision Sciences
Publisher: Elsevier Inc.
ISBN: 9780128184226
Last Modified: 08 Apr 2021 13:15
URI: http://orca.cf.ac.uk/id/eprint/140369

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