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Neural grafting in Parkinson's disease: unraveling the mechanisms underlying graft-induced dyskinesia

Lane, Emma Louise, Björklund, Anders, Dunnett, Stephen Bruce and Winkler, Christian 2010. Neural grafting in Parkinson's disease: unraveling the mechanisms underlying graft-induced dyskinesia. In: Björklund, A. and Cenci, M. A. eds. Recent Advances in Parkinson’s Disease: Translational and Clinical Research, Progress in Brain Research, vol. 184. London: Elsevier, pp. 295-309. (10.1016/S0079-6123(10)84015-4)

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The development of neural transplantation as a treatment for Parkinson’s disease has been compromised by a lack of functional efficacy and the appearance of transplant-induced motor side-effects in some patients. Since the first reports of these graft-induced dyskinesias (GID), and the realization of their impact on the progress of the field, a great deal of experimental work has been performed to determine the underlying cause(s) of this problematic side-effect. In this review we describe the clinical phenomenon of GID, explore the different representations of GID in rodent models, and examine the various hypotheses that have been postulated to be the cause. Based on the available clinical and preclinical data we outline strategies to avoid GID in future clinical trials using fetal cell transplants or cell preparations derived from stem cells.

Item Type: Book Section
Date Type: Publication
Status: Published
Schools: Pharmacy
Subjects: R Medicine > RM Therapeutics. Pharmacology
Uncontrolled Keywords: Parkinson’s disease; Transplantation; Dopamine; Dyskinesia; Graft-induced dyskinesia; l-dopa-induced dyskinesia; Amphetamine-induced dyskinesia
Publisher: Elsevier
ISBN: 9780444537508
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Last Modified: 04 Feb 2020 23:20

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